• Communications for Statistical Applications and Methods
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• 제24권4호
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• pp.325-337
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• 2017

In this paper, we proposed a new long-term lifetime distribution with four parameters inserted in a risk competitive scenario with decreasing, increasing and unimodal hazard rate functions, namely the Weibull-Poisson long-term distribution. This new distribution arises from a scenario of competitive latent risk, in which the lifetime associated to the particular risk is not observable, and where only the minimum lifetime value among all risks is noticed in a long-term context. However, it can also be used in any other situation as long as it fits the data well. The Weibull-Poisson long-term distribution is presented as a particular case for the new exponential-Poisson long-term distribution and Weibull long-term distribution. The properties of the proposed distribution were discussed, including its probability density, survival and hazard functions and explicit algebraic formulas for its order statistics. Assuming censored data, we considered the maximum likelihood approach for parameter estimation. For different parameter settings, sample sizes, and censoring percentages various simulation studies were performed to study the mean square error of the maximum likelihood estimative, and compare the performance of the model proposed with the particular cases. The selection criteria Akaike information criterion, Bayesian information criterion, and likelihood ratio test were used for the model selection. The relevance of the approach was illustrated on two real datasets of where the new model was compared with its particular cases observing its potential and competitiveness.

• 한국임상약학회지
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• 제28권1호
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• pp.40-50
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• 2018

Objective: This study presented the analysis period, the complexity of combined therapy and comparator choice as the key limitations in the economic evaluation of new drugs, and discussed programs for coping with these limitations. Methods: This study evaluated the post-evaluation, risk-sharing agreement, extra funding program, and flexible incremental cost-effectiveness ratio (ICER) threshold as actions or programs that would increase accessibility to costly new drugs. The study also presented the cases of other countries. The application of the post-evaluation was considered to deal with high uncertainty regarding new drugs. Results: The risk-sharing agreement was introduced in European countries as well as South Korea and has been responsible for the shift from using the financial schemes to outcome-based schemes. The drug funding program has had troubled in securing stable extra funds. The application of higher ICER in the economic evaluation of expensive and innovative oncology drugs was criticized because of the inequity between oncology patients and patients with other diseases. Conclusion: Therefore, introducing and applying actions that would increase the accessibility to costly new drugs in South Korea have been deemed necessary after careful reviews and discussions with various stakeholders (insurer, policy makers, pharmaceutical companies and patients).

• 융합보안논문지
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• 제15권5호
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• pp.9-15
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• 2015

클라우드 컴퓨팅은 서버의 추가 구축에 대한 비용절감, 데이터 스토리지 확대에 대한 비용 절감, 컴퓨터 자원에 대한 공유, 새로운 기술의 적용에 대한 편의성 등의 장점을 가지고 있다. 그러나 서비스 모델의 다양성으로 인하여 새로운 보안의 우려사항이 높아지고 있어, 이용자가 서비스의 안정성을 신뢰할 수 있도록 인증제도가 운영되고 있다. 이에 본 논문에서는 인증제도의 신뢰성을 확보하기 위해 기존 IT환경에서 적용되던 위험 분석 방법과 달리 공공 IaaS(Infrastructure as a Service) 클라우드 서비스 특징을 고려, 새로운 위험분석 방법을 제안한다.

• 신재생에너지
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• 제7권4호
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• pp.10-17
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• 2011

Recently, electricity industry is facing high market uncertainty which has ever had and which increase risks in power market. In this study, we analyze risk factors such as discount rates, initial investment (overnight cost), plant factor, fuel cost, carbon price, etc, for the perspective of investor. For the analysis of risk factors, we used LCOE method. The results of this study show that renewable energy is more affected by plant factor and overnight cost than other risk factors. First, Renewable energy has higher proportion of overnight cost in the total investment than that of other technologies. Second, renewable energy is free of fuel cost and carbon price so plant factor is the most important factor, in other words, competitiveness of renewable energy depends on plant factor. Furthermore, we conducted economic feasibility of wind power and PV in domestic case study. The minimum requirement condition to get profitability is that plant factor 15% and overnight cost \6,000,000/kW and 26%, \2,200,000/kW for PV and Wind Power, respectively.

• 약학회지
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• 제57권3호
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• pp.173-186
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• 2013

To ensure the safe use of pharmaceuticals in the market, US, EU and Japan reached a consensus to adopt ICH harmonised tripartite guideline "E2E Pharmacovigilance Planning" in 2004. Subsequently these regions established and implemented new pharmaceutical safety management systems for patients based on ICH E2E guideline and Risk Evaluation and Mitigation Strategy (REMS) in US or Risk Management Plan (RMP) in EU and Japan. In this study we investigated these new foreign systems and suggested a way to improve Korea's regulatory system for pharmaceutical safety management under Korea Pharmaceutical Law in the view of international harmonization.

• 품질경영학회지
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• 제42권4호
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• pp.543-562
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• 2014

Purpose: The purpose of this study is to suggest a modified approach that compensates some shortcomings of RPN with relevant strength of ASIL for Safety System and suggests systematic and logical approach for FMEA. Methods: By comparing the objectives, determination procedures, and key conceptual differences of RPN and ASIL, a refined method of risk evaluation and a new risk metric are devised. Results: While the traditional FMEA provides only rough evaluation of relative risk for each failure, the proposed method compensates its shortcomings with relevant strength of ASIL and provides a more logical and practical procedure of risk evaluation. Conclusion: The new metric RPM provides not only a comparative priority rank but also the degree of physical seriousness. Besides, it may have even more benefits for various applications if the severity can be expressed as mone tary amount of losses.

• 보건행정학회지
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• 제31권2호
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• pp.180-187
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• 2021

Background: This study analyzed the effect of applying the diagnosis-related group (DRG)-based payment system, which was implemented in July 2012 for hospitals and clinics nationwide, on the cesarean section rate. Methods: The subjects of the study were divided into new groups that participated in the payment system after July 2012 and maintenance groups that participated in the payment system before July 2012. As an analysis method, a difference-in-difference analysis, which is a quasi-experimental design, was used. The risk-adjusted cesarean section rate was used as a dependent variable. Results: Seven risk factors (malpresentation of fetus, eclampsia, multiple pregnancies, problems in the placenta, previous Cesarean section, cephalopelvic disproportion, problems in amniotic fluid) were included in the final risk-adjustment model, and found to have a statistically significant relationship with the cesarean section rate. Results showed that the risk-adjusted cesarean section rate increased significantly in new groups after the application of the DRG-based payment system. Conclusion: Study results provided policy implications for the reorganization of the DRG-based system should that reflects the demands of obstetricians, such as organizing a consultative body with obstetricians and establishing a reasonable fee.

• 한국수소및신에너지학회논문집
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• 제34권6호
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• pp.728-733
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• 2023

Efforts are continuing to change from fossil fuels used to hydrogen energy society. In order to become a hydrogen society, stable production and real-life applicability are important. As a result, hydrogen generation system linked to fuel cell are being developed. Through this, it is expected that production to power generation will be possible where desired by utilizing the existing urban gas piping network. Hydrogen generation system and hydrogen fuel cell have been subjected to risk assessment and have already been commercialized, but no risk assessment has been conducted on the integrated system linking them. Therefore, it is intended to secure its safety by conducting a risk analysis on the integrated system.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(환경)
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• pp.23-56
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• 1994

Recent criticisms of the conduct and use of risk assessment by regulatory agencies have led to a wide range of proposed remedies, including changes in regulatory statutes and the development of new methods for assessing risk. The mandate to this Committee was more limited. Our objective was to examine whether alterations in institutional arrangements or procedures, particularly the organizational separation of risk assessment from regulatory decision-making and the use of uniform guidelines for inferring risk from available scientific information, can improve federal risk assessment activities. Before undertaking to determine whether organizational and procedural reforms could improve the performance and use of risk assessment in the federal government, the Committee examined the state of risk assessment and the regulatory environment in which it is performed. In this chapter, we define risk assessment and differentiate it from other elements in the regulatory process, analyze the types of judgments made in risk assessment, and examine its current government context. Because one chronic health hazard, cancer, was highlighted in the Committee's congressional mandate and has dominated public concern about public health risks in recent years, most of our report focuses on it. Furthermore, because activities in four agencies--the Environmental Protection Agency (EPA), the Food and Drug Administration (FDA), the Occupational Safety and Health Administration (OSHA), and the Consumer Product Safety Commission (CPSC)--have given rise to many of the proposals for changes in risk assessment practices, our review focuses on these four agencies. The conclusions of this report, although directed primarily at risk assessment of potential carcinogens as performed by these four agencies, may be applicable to other federal programs to reduce health risks.

• 한국항해항만학회지
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• 제44권3호
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• pp.158-165
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• 2020

해상등부표는 선박 통항의 안전을 위해 필요한 시설로 파손 및 유실되는 경우 예상치 못한 예산 지출뿐 아니라 등부표 운용이 불가능해짐에 따라 선박 통항 안전에도 큰 영향을 미칠 수 있다. 본 연구에서는 해역의 교통흐름을 반영할 수 있는 해상교통평가지표를 적용하여 등부표 접촉사고의 위험성을 평가하고자 한다. 이를 위하여 평가대상 해역을 등부표 설치기수가 많고 등부표 접촉사고가 많이 발생하는 부산항 제5항로로 설정하고, 대상해역의 등부표 접촉사고 현황을 조사했다. 그리고 해상교통평가지표로 사용될 수 있는 해상위험평가도구인 IALA Waterway Risk Assessment Programme(IWRAP MkII)와 Potential Assessment of Risk Model(PARK Model)를 활용하여 등부표 접촉사고 발생의 위험성을 평가했다. 그 결과, 마산항 입출항 선박과 부산항신항 입출항 선박으로 교통흐름이 복잡한 경계해역 인근에 위치한 등부표와 항로를 따르지 않는 선박들이 항로를 가로지르는 운항패턴을 보이는 가덕수도 입구 인근에 위치한 등부표, 부산항신항 내항항로의 방파제 인근에 위치한 등부표가 접촉사고 위험성이 큰 것으로 평가되었다. 본 연구는 등부표 사고 위험성을 평가할 수 있는 통합 모델을 만드는 기초 자료로 활용될 수 있으며, 추후에 다양한 해역의 접촉사고 위험성을 평가하고, 미래교통량을 추정·적용하여 등부표 신설 시 안전한 등부표 설치 위치를 선정할 수 있을 것이다.