• Journal of Microbiology and Biotechnology
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• 제31권2호
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• pp.327-337
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• 2021

Fibrinolytic enzymes with a direct mechanism of action and safer properties are currently requested for thrombolytic therapy. This paper reports on a new enzyme capable of degrading blood clots directly without impairing blood coagulation. This enzyme is also non-cytotoxic and constitutes an alternative to other thrombolytic enzymes known to cause undesired side effects. Twenty-four Bacillus isolates were screened for production of fibrinolytic enzymes using a fibrin agar plate. Based on produced activity, isolate S127e was selected and identified as B. subtilis using the 16S rDNA gene sequence. This strain is of biotechnological interest for producing high fibrinolytic yield and consequently has potential in the industrial field. The purified fibrinolytic enzyme has a molecular mass of 27.3 kDa, a predicted pI of 6.6, and a maximal affinity for Ala-Ala-Pro-Phe. This enzyme was almost completely inhibited by chymostatin with optimal activity at 48℃ and pH 7. Specific subtilisin features were found in the gene sequence, indicating that this enzyme belongs to the BPN group of the S8 subtilisin family and was assigned as AprE127. This subtilisin increased thromboplastin time by 3.7% (37.6 to 39 s) and prothrombin time by 3.2% (12.6 to 13 s), both within normal ranges. In a whole blood euglobulin assay, this enzyme did not impair coagulation but reduced lysis time significantly. Moreover, in an in vitro assay, AprE127 completely dissolved a thrombus of about 1 cc within 50 min and, in vivo, reduced a thrombus prompted in a rat tail by 11.4% in 24 h compared to non-treated animals.

• Structural Engineering and Mechanics
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• 제84권4호
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• pp.489-502
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• 2022

This paper is aimed at developing an optimization-based Finite Element model updating approach for structural damage identification and quantification. A modal flexibility-based error function is introduced, which uses modal assurance criterion to formulate the updating problem as an optimization problem. Because of the inexplicit input/output relationship between the candidate solutions and the error function's output, a robust and efficient optimization algorithm should be employed to evaluate the solution domain and find the global extremum with high speed and accuracy. This paper proposes a new multi-stage Selective Particle Swarm Optimization (SPSO) algorithm to solve the optimization problem. The proposed multi-stage strategy not only fixes the premature convergence of the original Particle Swarm Optimization (PSO) algorithm, but also increases the speed of the search stage and reduces the corresponding computational costs, without changing or adding extra terms to the algorithm's formulation. Solving the introduced objective function with the proposed multi-stage SPSO leads to a smart feedback-wise and self-adjusting damage detection method, which can effectively assess the health of the structural systems. The performance and precision of the proposed method are verified and benchmarked against the original PSO and some of its most popular variants, including SPSO, DPSO, APSO, and MSPSO. For this purpose, two numerical examples of complex civil engineering structures under different damage patterns are studied. Comparative studies are also carried out to evaluate the performance of the proposed method in the presence of measurement errors. Moreover, the robustness and accuracy of the method are validated by assessing the health of a six-story shear-type building structure tested on a shake table. The obtained results introduced the proposed method as an effective and robust damage detection method even if the first few vibration modes are utilized to form the objective function.

• 디지털융복합연구
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• 제19권5호
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• pp.81-92
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• 2021

본 연구의 목적은 코로나-19가 몰고 온 갑작스러운 환경변화 중 여행산업의 변화에 있어서 가장 핵심이 될 디지털 건강/면역 여권(DHP, Digital Health Passport)에 대한 접근법을 제시하기 위해 수행되었다. 이를 위해, 최근 DHP에 관한 다양한 실증적 문헌 고찰을 통해 DHP에 대한 프레임워크를 제안했다. 본 프레임워크는 크게 여행 의도, 건강정보 제공 의도, 신기술 채택·수용 등으로 구성된다. 첫째, 여행 의도의 관점에서, DHP에 정보를 제공하는 것이 여행자의 여행 의도를 훼손하지 않아야 한다. 여행자로부터 받은 정보를 활용하여 여행자의 여행 즐거움을 배증 할 수 있어야 한다. 또한, 여행자에게 받은 데이터가 신뢰할 수 있는 방법으로 관리된다는 것을 확신시켜줄 필요가 있다. 둘째, 건강 관련 정보를 의무적 정보 제공의 관점에서만 보지 말고 여행자가 자신의 개인정보를 제공함으로써 얻을 수 있는 것이 무엇인지 인지시킬 필요가 있다. 마지막으로, 신기술의 관점에서 DHP에 대한 여행자들의 활용·수용 의도를 이해할 필요가 있다. 본 연구는 트래블 버블(Travel Bubble)을 실현하는 데 있어서 핵심기술인 DHP에 대한 여행자들의 반응을 예측하고 대응할 방안을 제안했다는 점에서 의의가 있다.

• 경영과학
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• 제31권4호
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• pp.151-163
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• 2014

The sports industry is expected to develop into a huge business through convergence with existing industries such as the broadcasting/information communications, health/medicine, and entertainment/leisure. This paper aims to extract and analyse the candidated promising sports industries at the national level in order to promote them in the long term, and adopts a policy-based approach to such efforts. To extract promising sports industries at the national level, a methodology that considers economic effects such as global competitiveness, technological characteristics, and the creation of jobs, as well as technical development projects, should be adopted. In this study, It was extracted 59 candidated promising sports industries using literature review and expert opinions. As a result of in-depth survey, we found some critical implications each area as follows; health club operation in the lifetime and participation sports area, female sports dance in the welfare sports area, new material sports shoes in the lifetime and welfare sports area, and dynamic training system in the professional sports area.

• Smart Structures and Systems
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• 제19권4호
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• pp.361-369
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• 2017

Electromechanical impedance method as an efficient tool in Structural Health Monitoring (SHM) utilizes the electromechanical impedance of piezoelectric materials which is directly related to the mechanical impedance of the host structure and will be affected by damages. In this paper, electromechanical impedance of piezoelectric patches attached to simply support rectangular plate is determined theoretically and experimentally in order to detect damage. A pairs of piezoelectric wafer active sensor (PWAS) patches are used on top and bottom of an aluminum plate to generate pure bending. The analytical model and experiments are carried out both for undamaged and damaged plates. To validate theoretical models, the electromechanical impedances of PWAS for undamaged and damaged plate using theoretical models are compared with those obtained experimentally. Both theoretical and experimental results demonstrate that by crack generation and intensifying this crack, natural frequency of structure decreases. Finally, in order to evaluate damage severity, damage metrics such as Root Mean Square Deviation (RMSD), Mean Absolute Percentage Deviation (MAPD), and Correlation Coefficient Deviation (CCD) are used based on experimental results. The results show that generation of crack and crack depth increasing can be detectable by CCD.

• 대한화장품학회지
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• 제30권3호
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• pp.307-311
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• 2004

화장품 산업에서 웰빙과 관련하여 inner beauty와 body shaping 상품을 비롯하여 SPA, esthetique, mass-customization, organics, naturals 등에 관련된 상품개발이 연구의 중요한 축을 이룰 것으로 보이며, 웰빙에 대한 고객의 기대로는 건강에 대한 관심과 함께 상품에 대한 안심감, 신뢰성, 윤리성이 우선되어야 할 것이다. 따라서 화장품 영역에서의 웰빙 관련 연구로는 지방 분해, 비타민, 폴리페놀, 오가닉과 함께 항노화에 관련된 체계적인 연구가 이루어져야 할 것이며 아울러 피부과학과 감성 공학을 바탕으로 효능증대, 피부흡수제어, 피부적합성, 제형 및 활성성분안정화, 지속성 증진, 신원료개발이 중요할 것이며, 특히 최근의 바이오 기술. 나노기술. 천연소재기술은 웰빙상품 개발의 초석이라 하겠다.

• 대한치과기공학회지
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• 제35권4호
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• pp.313-320
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• 2013

Purpose: The purpose of this study was to know the physical properties of UDMA dental composite resins containing two photosensitizers, PD, DA, as a photosensitizer instead of CQ. We want to know Remaining Double Bond(RDB) of UDMA unfilled resin and diametral tensile strength and flexural strength of composite resin containing PD and DA were compared with those of CQ, most widely used photosensitizer for dental composite resins. Methods: The RDB of UDMA studied by FT-IR spectroscopy increased with irradiation time. The composite resins were tested for their physical properties. The dental composite resins were made with UDMA as a monomer, silanized silica as filler, N,N-dimethylaminoethyl methacrylate (DAEM) as amine initiator, and one of the two kinds of new photosensitizers. Results: The relative RDB of UDMA was in the order: DA > CQ > PD but the physical properties of the composite resins show PD and DA with higher results compared with that containing CQ. The reason for the results is that PD and DA serve not only as a photosensitizer but also as a photo-crosslinking agent. Conclusion: PD and DA show as effective photosensizers, suitable for UDMA dental composite resin compare with a higher efficiency than CQ.

• 대한방사선기술학회지:방사선기술과학
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• 제24권2호
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• pp.13-17
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• 2001

When most patients are diagnosed with the quiet progressed hepatoma which often would make the operation impossible, the Interventional Radiology hepatic artery embolization is an extremely useful method for such patients. An existence of the malfunction is evaluated by gaining a portal vein image as a delayed phase image after injecting a contrast media into the superior mesenteric artery. However, it is difficult to make a definite judgement due to the extended exposure time with the peristalsis and the intestine gas obstructing the sharpness of the image when the Patient exposure time increases and due to the increased usage of contrast media and its side effect. The portal vein can be evaluated by obtaining the MIP image after reconstructing a 3-dimensional personal computer setting using the 2-dimensional from an enhancement abdomen CT image that is almost a requisite in operation to a hepatoma patient. Such method nay prevent a decrease in the quality of image based upon the time delay and intestine gas; also, because the patient exposure dose and contrast media usage may be reduced, it is a new, valuable way to decide the operational matter of hepatic artery embolization on a pre-angiography.

• Structural Monitoring and Maintenance
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• 제2권3호
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• pp.199-211
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• 2015

The safety and performance of bridges could be monitored and evaluated by Structural Health Monitoring (SHM) systems. These systems try to identify and locate the damages in a structure and estimate their severities. Current SHM systems are applied to a single bridge, and they have not been used to monitor the structural condition of a network of bridges. This paper propose a new method which will be used in Synthetic Rating Procedures (SRP) developed by the authors of this paper and utilizes SHM systems for monitoring and evaluating the condition of a network of bridges. Synthetic rating procedures are used to assess the condition of a network of bridges and identify their ratings. As an additional part of the SRP, the method proposed in this paper can continuously monitor the behaviour of a network of bridges and therefore it can assist to prevent the sudden collapses of bridges or the disruptions to their serviceability. The method could be an important part of a bridge management system (BMS) for managers and engineers who work on condition assessment of a network of bridges.

• The Journal of Asian Finance, Economics and Business
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• 제8권11호
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• pp.253-264
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• 2021

The COVID-19 pandemic has imposed a number of restrictions on the lives of people and services, forcing them to adopt a "New Normal" way of living. Contactless technologies provide a mechanism to reduce the risk of infection, encouraging people to use touchless payment methods. The aim of this study is to develop an integrated framework based on the Health Belief Model and the Unified Theory of Acceptance and Use of Technology to justify the use of mobile payment during the COVID-19 pandemic in Vietnam. Based on a survey of 434 samples, the proposed conceptual model was empirically justified using structural equation modeling (SEM). This study found that performance expectancy, effort expectancy, enjoyment, perceived severity, and perceived susceptibility significantly and positively influenced behavioral intention of using contactless payment technologies. In addition, this study discovered that effort expectancy, perceived severity, and perceived susceptibility all have a positive impact on performance expectancy, while enjoyment triggered users' effort expectancy. By adding novel insights into the literature on the acceptance of technology during the pandemic, this study makes a major contribution to justifying how contactless payment technologies can reduce the risk of getting infected by COVID-19.