• Title/Summary/Keyword: new damage index

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Effect of DA-6034, a New Flavonoid Derivative, on TNBS-Induced Colitis in the Rats (새로운 플라보노이드 유도체인 DA-6034의 TNBS 유발성 염증성대장염 모델에서의 치료효과)

  • Son, Mi-Won;Ko, Jun-Il;Kim, Hee-Kee;Jang, Dong-Kyung;Yoo, Moo-Hi;Kim, Won-Bae;Lee, Kang-Chun;Song, In-Sung
    • YAKHAK HOEJI
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    • v.42 no.2
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    • pp.205-213
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    • 1998
  • The efficacy of DA-6034, a new flavonoid derivative, was investigated in comparison with sulfasalazine in a trinitrobenzene sulfonic acid (TNBS)-induced rat colitis. Under light anaesthesia with ether, rats were subjected to intracolonic administration of 30mg TNBS in 50% ethanol (0.5ml) and were then sacrificed at 7 or 21 days after colitis induction. The TNBS control group (the saline treated colitic rat) exhibited ulceration and inflammation of the distal colon with formation of granuloma and pathologic connections. Moreover, an increase in colonic myeloperoxidase (MPO) activity (investigated as an index of leukocyte adhesion and accumulation) and an elevated colonic leukotriene $B_4$ ($LTB_4$) level were observed. The colitic rats received DA6034 (0.3-30mg/kg) or sulfasalazine (50-100mg/kg), prednisolone (0.3-3mg/kg) after the induction of colitis until they were sacrificed. Oral treatment with DA-6034 resulted in significant reductions of macroscopic colonic damage, colonic inflammation. DA6034 had a more potent effect than sulfasalazine and prednisolone on macroscopic colonic damage, while it has similar effect with prednisolone on the reduction of colonic $LTB_4$ synthesis and MPO activity. This study show, therefore, that DA-6034 is effective m attenuating the colonic lesion in an TNBS-induced colitis model. Furthermore, the results suggest that the effect of DA-6034 is partially related to its action on $LTB_4$ synthesis and MPO inhibition.

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Spatio-temporal enhancement of forest fire risk index using weather forecast and satellite data in South Korea (기상 예보 및 위성 자료를 이용한 우리나라 산불위험지수의 시공간적 고도화)

  • KANG, Yoo-Jin;PARK, Su-min;JANG, Eun-na;IM, Jung-ho;KWON, Chun-Geun;LEE, Suk-Jun
    • Journal of the Korean Association of Geographic Information Studies
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    • v.22 no.4
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    • pp.116-130
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    • 2019
  • In South Korea, forest fire occurrences are increasing in size and duration due to various factors such as the increase in fuel materials and frequent drying conditions in forests. Therefore, it is necessary to minimize the damage caused by forest fires by appropriately providing the probability of forest fire risk. The purpose of this study is to improve the Daily Weather Index(DWI) provided by the current forest fire forecasting system in South Korea. A new Fire Risk Index(FRI) is proposed in this study, which is provided in a 5km grid through the synergistic use of numerical weather forecast data, satellite-based drought indices, and forest fire-prone areas. The FRI is calculated based on the product of the Fine Fuel Moisture Code(FFMC) optimized for Korea, an integrated drought index, and spatio-temporal weighting approaches. In order to improve the temporal accuracy of forest fire risk, monthly weights were applied based on the forest fire occurrences by month. Similarly, spatial weights were applied using the forest fire density information to improve the spatial accuracy of forest fire risk. In the time series analysis of the number of monthly forest fires and the FRI, the relationship between the two were well simulated. In addition, it was possible to provide more spatially detailed information on forest fire risk when using FRI in the 5km grid than DWI based on administrative units. The research findings from this study can help make appropriate decisions before and after forest fire occurrences.

A Study on Plastic Fatigue of Structural Steel Elements under Cyclic Loading (반복하중을 받는 강구조 요소의 소성피로에 관한 연구)

  • Park, Yeon Soo;Park, Sun Joon;Kang, Sung Hoo;Yoon, Young Phil
    • Journal of Korean Society of Steel Construction
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    • v.9 no.2 s.31
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    • pp.193-204
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    • 1997
  • In order to quantify the relationships of the important physical factors relating failure to strong earthquake loading, the plastic fatigue problems for structural components under repeated loading were reviewed first. A new concept of very low cycle fatigue failure for structural components under severe cyclic excitations as in strong earthquakes was represented. Also, an experimental study was made of the very low cycle fatigue failure of structural steel elements. It was attempted to realize the ultimate failure in the course of loading repetitions of the order of several to twenty. The test specimen had a form of rectangular plate, representing a thin-plated element in a steel member as wide-flange cross section. It was subjected to uniaxial loading repeatedly, until complete failure takes place after undergoing inelastic buckling, plastic elongation and/or their combination. It was seen as a result that the state of the ultimate failure is closely related to the maximum strain at the extreme fiber in the cross section.

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A Study on the Plan for Advanced Noise-Policy in the 21st Century (21세기 소음정책 선진화 방안 고찰)

  • Yang, Geun-Ho;Park, Young-Min;Lee, Nae-Hyun;Chang, Yoon-Young
    • Journal of Environmental Impact Assessment
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    • v.18 no.1
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    • pp.21-30
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    • 2009
  • The study show that things about the noise control are indicated at The Noise & Vibration Control Act and the other Act. Also, the details program and total government ministries' program for the noise control are indicated what are the advance noise control plan. The study consist of the four part which are "Draw up the environmental noise infrastructure plan; the install shall be done the noisemap & the automatic noise measurement devices", "Resetting of environmental noise standard at the application area and Introduce of indoor noise; the guide for region classification of the noise standard & indoor noise", "Setting of aircraft noise standard and Program of measurement point operation; the noise-assessment-standard shall change from WECPN to new index($L_{den}$, $L_{dn}$, $L_{Aeq\;24h}$) & the operation and control of aircraft noise measurement changes from local environmental office to central control center" and "The method of noise regulation at construction site and the plan on making of standard for vibration regulation; It shall be made that the guideline of construction noise should include a target-construction, noise standard etc & the ministries shall unify control about construction vibration of the blasting vibration". The advance noise-policy will improve efficiency to deal with civil appeal & damage on residents about noise.

A New Methodology for the Assessment of Liquefaction Potential Based on the Dynamic Characteristics of Soils (I) : A Proposal of Methodology (지반의 동적특성에 기초한 액상화 평가법(I) : 이론제안)

  • 최재순;홍우석;박인준;김수일
    • Journal of the Korean Geotechnical Society
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    • v.18 no.1
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    • pp.91-99
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    • 2002
  • In this study, a new methodology for the assessment of liquefaction potential is proposed. Since there is no data on the liquefaction damage in Korea, the dynamic behavior of fully saturated soils is characterized through laboratory dynamic tests. There are two experimental parameters related to the soil liquefaction resistance characteristics : the one is the index of disturbance determined by $G/G_{max}$ curve and the other is a plastic shear strain trajectory evaluated from stress-strain curve. The proposed methodology takes advantage of the site response analysis based on real earthquake records to determine the driving effect of earthquake. In the evaluation of liquefaction resistance characteristics, it is verified experimentally that the magnitude of cyclic shear stress has no influence on the critical value of plastic shear strain trajectory at which the initial liquefaction occurs. Cyclic triaxial tests under the conditions of various cyclic stress ratios and torsional shear tests are carried out far the purpose of verification. Through this study, the critical value at the initial liquefaction is found unique regardless of the cyclic stress ratio. It is also f3und that liquefaction resistance curve drawn with disturbance and plastic shear strain trajectory can simulate the behavior of fully saturated soils under dynamic loads.

Distribution Characteristics Analysis of Pine Wilt Disease Using Time Series Hyperspectral Aerial Imagery (소나무재선충병 발생시기별 피해목 탐지를 위한 시계열 초분광 항공영상의 활용)

  • Kim, So-Ra;Kim, Eun-Sook;Nam, Youngwoo;Choi, Won Il;Kim, Cheol-Min
    • Korean Journal of Remote Sensing
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    • v.31 no.5
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    • pp.385-394
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    • 2015
  • Pine wilt disease has greatly damaged pine forests not only in East Asia including South Korea and China, but also in European region. The damage caused by pine wood nematode (Bursaphelenchus xylophilus) is expressed in bundles within stands and rapidly spreading, however, present field survey methods have limitations to detecting damaged trees at regional level. This study extracted the damaged trees by pine wilt disease using time series hyperspectral aerial photographs, and analyzed their distribution characteristics. Hyperspectral aerial photographs of 1 meter spatial resolution were obtained in June, September, and October. Damaged trees by pine wilt disease were extracted using Normalized Difference Vegetation Index (NDVI) and Vegetation Index green (VIgreen) of the September photograph. Among extracted damaged trees, dead trees with leaves and without leaves were classified, and the spectral reflectance values from the photographs obtained in June, September, and October were compared to extract new outbreaks in September and October. Based on the time series dispersion of extracted damaged trees, nearest neighbor analysis was conducted to analyze distribution characteristics of the damaged trees within the region where hyperspectral aerial photographs were acquired. As a result, 2,262 damaged trees were extracted in the study area, and 604 dead trees (dead trees in last year) with leaves in relation to the damaged time and 300 and 101 newly damaged trees in September and October were classified. The result of nearest neighbor analysis using the data shows that aggregated distribution was the dominant pattern both previous and current year in the study area. Also, 80% of the damaged trees in current year were found within 60 m of dead trees in previous year.

Resistance Resources for the Foxglove Aphid in Soybeans (콩에서 흡즙해충 싸리수염진딧물 저항성 자원의 발굴)

  • Koh, Hong-Min;Park, Sumin;Kim, Kyung Hye;Kim, Ji Min;Lee, Taeklim;Heo, Jinho;Lee, Ju Seok;Jung, Jinkyo;Kang, Sungteag
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.63 no.3
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    • pp.257-264
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    • 2018
  • The recent global climate change induced the drought, flooding, and insect pest outbreaks. These caused the severe damage to crop yield in the domesticated field and occurrence change of insect pest species. The sap-sucking insect pest, aphids are common in soybean [Glycine max (L.) Merr.] and cause serious yield losses. Thus, developing resistance cultivars is promising and efficient strategy to prevent the significant yield losses by aphid and screening germplasm is the essential procedure to achieve this goal. We tried to establish a resistance test indicator for foxglove aphid, Aulacorthum solani (Kaltenbach), in soybean and found that plant damage degree or infested plant damage is most suitable one. Also we screened around 1,200 of soybean germplasm including wild and cultivated species for its resistance to foxglove aphid from the various origins, and 67 soybeans, including PI 366121, showed antixenosis resistance, 31 germplasms among 67 antixenosis germplasms were showed antibiosis to foxglove aphid with non-choice test. The identified foxglove aphid resistant soybean resources showed significantly low rate in survival test. Furthermore, resistance type, (i.e., antibiosis or antixenosis) of each candidate were varied. In this research, we established the screening index for foxglove aphid resistance in soybean, and identified the resistance varieties. This result could be useful resources in breeding for new foxglove aphid resistance soybean cultivars, and provide fundamental information to investigate the resistance mechanism in soybean.

Decision Making of Seismic Performance Management for the Aged Road Facilities Based on Road-Network and Fragility Curve (취약도곡선을 이용한 도로망기반 노후도로시설물 내진성능관리 의사결정)

  • Kim, Dong-Joo;Choi, Ji-Hae
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.25 no.5
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    • pp.94-101
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    • 2021
  • According to the Facility Management System (FMS) operated by the Korea Authority of Land & Infrastructure Safety, it is expected that the number of aging facilities that have been in use for more than 30 years will increase rapidly to 13.9% in 2019 and 34.5% in 2929, and end up with a social problem. In addition, with the revision of "Common Application of Seismic Design Criteria" by the Ministry of Public Administration and Security in 2017, it is mandatory to re-evaluate all existing road facilities and if necessary seismic reinforcement should be done to minimize the magnitude of earthquake damage and perform normal road functions. The seismic performance management-decision support technology currently used in seismic performance management practice in Korea only determines the earthquake-resistance reinforcement priority based on the qualitative index value for the seismic performance of individual facilities. However with this practice, normal traffic functions cannot be guaranteed. A new seismic performance management decision support technology that can provide various judgment data required for decision making is needed to overcome these shortcomings and better perform seismic performance management from a road network perspective.

Synthesis of trans-(3R,5S)-Atorvastatin Ca and Curative Effect on Hyperlipidemia Induced by a High-Fat Diet in Rats (trans-(3R,5S)-Atorvastatin Ca의 합성 및 Rat에서 고지방식이로 유도된 고지혈증 치료효과)

  • Choi, Won-Sik;Nam, Seok-Woo;Lee, Gyung-Rak
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.11
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    • pp.4940-4950
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    • 2011
  • cis-(3R,5R)-Atorvastatin Ca (1) used for hyperlipidemia have four stereomers. However, It is very difficult to prepare stereoselective stereomers. In this paper, the reduction of 3,5-diketo atorvastatin ester (3) was performed using $Me_4NHB(OAc)_3$ in acetic acid as a reductant and showed excellent stereoselectivity in the double reduction of 3,5-diketo atorvastatin ester (3). As a result, reduction of compound 3 by $Me_4NHB(OAc)_3$ was purely obtained with cis-(3R,5R)-atorvastatin ester (4) of 1.5% and trans-(3R,5S)-atorvastatin ester (5) of 98.5%. Also, cis-(3R,5R)-atorvastatin Ca (1) and trans-(3R,5S)-atorvastatin Ca (7) were used to determine efficacy in the treatment of liver damage and hyperlipidemia induced by a high-fat diet in rats and to study the performance of the January 2010 experient was conducted. As a result, total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), and triglyceride (TG) levels of compound 1 and 7 groups were $93.0{\pm}0.5$, $43.5{\pm}0.8$, $40.4{\pm}1.4$, $45.6{\pm}0.9\;mg/d{\ell}$ and $110.0{\pm}0.7$, $33.3{\pm}0.6$, $65.8{\pm}1.9$, $54.8{\pm}1.2\;mg/d{\ell}$, respectively. Atherogenic index (AI) and cardiac risk factor (CRF) in compound 1 and 7 were $1.14{\pm}0.05$, $2.14{\pm}0.05$ and $2.31{\pm}0.06$, $3.31{\pm}0.06$, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were $51.9{\pm}4.6$, $16.0{\pm}2.1\;IU/{\ell}$ and $75.8{\pm}4.4$, $35.1{\pm}9.7\;IU/{\ell}$. Taken together, while compound 1 treat against high-fat diet-induced hyperlipidemia by attenuating hepatic lipid depots and reducing oxidative stress, compound 7 group had a low curative effect on hyperlipidemia induced by a high-fat diet in rats. These findings suggest that new method about synthesis of stereoselective stereomers and indicate that it may consider using in a clinical trial.

Studies on Dry Matter Production and Variation of Agronomic Characteristics of Determinate and Indeterminate Types of Soybean Cultivars (Glycine max L.) Under Different Growing Condition (유ㆍ무한형대두품종의 재배조건에 따른 건물생산 및 형질변이에 관한 연구)

  • Keun-Yong Park
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.17
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    • pp.45-78
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    • 1974
  • To provide useful information for developing new high yielding soybean varieties and for improving cultural practices, an investigation was made on variation of dry matter production and on relationship among several agronomic characters of soybean plants grown under different planting times and densities as well as under different fertilizer levels, using Kwang-kyo, Dong puk-tae, and Suke # 51 as determinate types and Shelby, SRF-300 and Harosoy as indeterminate types at the Crop Experiment Station during the period of 1972 and 1973. The results obtained were summarized as follow: 1. The dry weight, CGR and LAI at the initial flowering stage were high in the high plant population irrespective of varieties, planting times, and fertilizer levels. However, those characters of the indeterminate type were lower than those of the determinate types. The same characters of the indererminate type at the terminal leaf stage were either same or higher than those of the determinate types. 2. The dry weight of the determinate type at the initial flowering stage was similar to the indeterminate, type, when planting times were May 21 or June 15. The dry weights of both types of varieties were low when planted on July 10. When fertilizer levels were increased, the CGR, dry weight and LAI at the initial flowering stages were also increased. 3. Even though significant differences of LAI were obtained among the varieties within the same plant type, the indeterminate type was in general lower than that of the determinate type regardless of planting time and densities, or fertilizer levels, while the yield of the indeterminate type was comparable to the yield of the determinate type. 4. The high degree of leaf- and petiole-fall at the greenbean stage was highly associated with early planting and high levels of fertilizers. However, less amount of leaf- or petiole-fall was found when planted on July 10 or under low plant population. 5. The percent of stem weight was high under higher plant population, while the percent of leaf weight was high under lower plant population. When planting time was late, the percent of stem and petiole weight were reduced, while the leaf weight was increased. 6. The percent of pod weight of the determinate type at the terminal leaf stage was about 2% when planted on May 21, about 8% when planted on June 15, and about 9% when planted on July 10. The percent of pod weight of the indeterminate type at the terminal leaf stage were about 6 % when planted on May 21, 14% when planted on June 15 and 21% when planted on July 10. 7. Kwang kyo showed less degree of leaf-fall even when lodged due to high levels of fertilizer applied, while SRF-300 showed great damage due to lodging. 8. High yields were obtained when planted on May 21, but there were little yield differences between yields from May 21 and June 15 plantings. The reduction of yield due to late planting of July 10 was less apparent in the determinate type of varieties, while it was high in the indeterminate type. 9. The optimum plant population per are for high yield was 1, 250 to 2, 500 plants when planted on May 21, 2, 500 plants when planted on June 15, and 3, 333 plants when planted on July 10. 10. High correlation coefficients were obtained between dry matter weight and LAI at the terminal leaf stages, and between the dry matter weight and yield at the greenbean stages. The optimum dry weight for high yield in the determinate type was expected to be 25 kg. per are at the initial flowering stage and 50 kg. per are at the terminal leaf stage. In the indeterminate type the LAI and dry weight at the greenbean stage were 4 to 5 and 80 kg. per are, respectively. 11. Under the high plant population plant height was increased, while the stem diameter and the number of nodes and branches were reduced. Consequently, the percent of mainstem to main stem plus branches were increased, and the length of internode was also elongated. The ratios of stem weight, number of nodes and pods, and yield of main stem were increased when high plant population was associated with the early planting. The percent of main stem to branches for the indeterminate type was higher than that of the determinate type. 12. Under the high plant densities and late planting, the percent of the pod number and yields of main stem were increased, indicating that varieties with no or less branches were better adaptable under such conditions. 13. High degree of simple correlation coefficients was obtained between the LAI at the initial flowering stage and terminal leaf stage, and the total node number, dry matter and dry stem weight of both determinate and indeterminate types. Even though no significant correlation was found between the LAI at the initial flowering stage of the determinate type and the stem length and pod number per are, highly significant correlation coefficients were obtained between such characters in the indeterminate type of varieties. 14. The dry matter was positively correlated with the LAI, CGR, stem length, and pod number, node number and dry stem weight per are, while no significant correlation was found between the dry matter and stem diameter. 15. The correlation coefficients between lodging index and the LAI, dry weight, stem length and dry stem weight were highly significant. Negative correlation was obtained for the indeterminate type between the stem diameter and lodging index. The correlation coefficient between the stem diameter and lodging index was non-significant for the determinate type, while positive correlation was obtained between the yield and lodging index in the determinate type. The lodging index was also positively correlated with average length of internode of main stem. 16. The 100 seed weight appeared to be lowered under the high plant population and no fertilizer condition, and when planted late. Apparent differences of 100 seed weight were found between main stem and branches, being higher for the main stem than for the branches. 17. No variation of protein content was found due to different cultural practices. However, the oil content was apparently reduced when planted late.

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