• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.26-32
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• 2005

신경발달학적 신경영상학은 급속하게 발전하는 분야이고 사용되는 새로운 영상학적인 기술의 수도 해마다 급속하게 증가하고 있다. 신경발달학적인 관점에서 소아청소년 정신과적 장애들에서 아직 명확한 신경병리학적인 원인은 밝혀지지 않았으나, 점차로 많은 수의 논문에서 일관적인 뇌영상학적인 이상 소견들이 발표되고 있다. 이 논문에서는 신경발달학적인 관점에서 신경영상학적인 연구에서 과거와 현재 상황을 기술하고 제한점과 함께 미래에 대한 조망을 하고자 한다.

• Safety and Health at Work
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• 제4권1호
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• pp.1-11
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• 2013

This review surveys the recent literature on the neurodevelopmental impacts of chemical exposures during pregnancy. The review focuses primarily on chemicals of recent concern, including phthalates, bisphenol-A, polybrominated diphenyl ethers, and perfluorinated compounds, but also addresses chemicals with longer histories of investigation, including air pollutants, lead, methylmercury, manganese, arsenic, and organophosphate pesticides. For some chemicals of more recent concern, the available literature does not yet afford strong conclusions about neurodevelopment toxicity. In such cases, points of disagreement among studies are identified and suggestions provided for approaches to resolution of the inconsistencies, including greater standardization of methods for expressing exposure and assessing outcomes.

• 대한감각통합치료학회지
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• 제20권1호
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• pp.14-25
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• 2022

목적 : 본 연구는 두뇌타이밍 능력이 낮은 아동을 대상으로 상호작용식 메트로놈(Interactive Metromome; IM)을 이용한 두뇌타이밍 훈련을 적용한 후 읽기 능력에 미치는 효과를 파악하고자 하였다. 연구방법 : 2019년~2021년에 아동발달연구소에서 IM 훈련을 시행한 아동 중 타이밍 능력이 자신의 연령 평균보다 낮은 아동 8명의 자료를 수집하여 검사 전-검사 후의 변화를 비교하였다. 두뇌타이밍 훈련은 주당 2~3회기, 총 70회기 이상, 회기 당 40~50분으로 아동의 발달적 특성에 따라 적용되었다. 훈련 전후 두뇌타이밍의 변화는 IM의 전체형검사(Long Form Assessment; LFA), 읽기 능력은 기초학습기능 수행평가체제(Basic Academic Skills Assessment:Reading; BASA:R)로 측정하였다. 결과 : LFA의 두뇌타이밍 능력 평가결과 모든 아동의 전체 운동과제의 반응시간이 감소되어 두뇌타이밍 능력이 향상된 것으로 나타났고 통계학적으로도 유의한 차이를 보였다(p<.05). 또한 BASA:R의 읽기 검사와 빈칸채우기 검사의 원점수에서도 유의한 향상을 나타냈다(p<.05). 결론 : 본 연구는 두뇌타이밍 능력이 낮은 아동의 읽기 능력 향상을 위한 두뇌타이밍 훈련의 임상적 근거를 제시하였다는데 그 의의가 있다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.5-14
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• 2005

이전까지는 많은 정신장애가 유전으로 대표되는 생물학적 소인과 환경적 소인에 의한 것이라는 논의는 많았지만 실제 유전적 소인이 구체적으로 어떻게 장애의 발병과 임상 경과에 관여하는 지에 대한 명확한 증거를 갖기 어려웠다. 그러나 최근 들어 분자 생물학, 분자 유전학, 신경과학 등의 학문의 발달로 인해 유전 인자가 정상 또는 비정상 발달에 어떻게 기여 하는가에 대한 객관적 증거들이 많아지면서 좀더 이런 영향에 대한 조망이 용이해진 상황이다. 향후 이 분야들의 발달은 더욱 다양한 정신 장애에서 유전 인자의 역할을 밝혀 줄 것이며 정신과 임상 영역에서 유전적 검사를 통해 정신 장애를 진단하게 되는 것도 가능하게 해 줄 것이다.

• Journal of Korean Neurosurgical Society
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• 제59권3호
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• pp.242-246
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• 2016

Craniosynostosis is the premature fusion of calvarial sutures, resulting in deformed craniofacial appearance. Hence, for a long time, it has been considered an aesthetic disorder. Fused sutures restrict growth adjacent to the suture, but compensatory skull growth occurs to accommodate the growing brain. The primary goal for the management of this craniofacial deformity has been to release the constricted skull and reform the distorted shape of the skull vault. However, the intellectual and behavioral prognosis of affected children has also been taken into consideration since the beginning of the modern era of surgical management of craniosynostosis. A growing body of literature indicates that extensive surgery, such as the whole-vault cranioplasty approach, would result in better outcomes. In addition, the age at treatment is becoming a major concern for optimal outcome in terms of cosmetic results as well as neurodevelopment. This review will discuss major concerns regarding neurodevelopmental issues and related factors.

• BMB Reports
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• 제53권11호
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• pp.551-564
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• 2020

Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders. A precise and predictable developmental schedule requires highly coordinated gene expression programs that orchestrate the dynamics of the developing brain. Especially, recent discoveries have been showing that various mRNA chemical modifications can affect RNA metabolism including decay, transport, splicing, and translation in cell type- and tissue-specific manner, leading to the emergence of the field of epitranscriptomics. Moreover, accumulating evidences showed that certain types of RNA modifications are predominantly found in the developing brain and their dysregulation disrupts not only the developmental processes, but also neuronal activities, suggesting that epitranscriptomic mechanisms play critical post-transcriptional regulatory roles in development of the brain and etiology of brain disorders. Here, we review recent advances in our understanding of molecular regulation on transcriptome plasticity by RNA modifications in neurodevelopment and how alterations in these RNA regulatory programs lead to human brain disorders.

• 대한물리의학회지
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• 제8권2호
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• pp.175-182
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• 2013

PURPOSE: The purpose of this study was to investigate the effects of task oriented ADL exercise in different environments in patients with chronic stroke. METHODS: A total of 28 patients with hemiplegia resulting from stroke were included in this study. The patients were randomized into two groups. The control group(n=14) was received neurodevelopment therapy + task oriented ADL exercise and experimental group(n=14) was received neurodevelopment therapy + home based task oriented ADL exercise for 30 minutes twice per week during 6weeks. A task oriented ADL exercise pretest and postest design was used examine the change of FIM(Functional Independent Measure) and K-MBI(Korea-Modified Bathel Index) at the completion of 6 weeks task oriented ADL exercise. RESULTS: After 6 weeks, the experimental group compared with control group showed a significant improvement (p<.05) in FIM and K-MBI scores. CONCLUSION: The results indicate that the home based task oriented ADL exercise improves functions in the persons with chronic stroke.

• Physical Therapy Rehabilitation Science
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• 제4권2호
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• pp.66-72
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• 2015

Objective: The aim of this study was to investigate the effect of balance training with plantar flexor stretching on ankle dorsi flexion range of motion (ROM), balance, and gait ability in stroke patients. Design: A randomized controlled pilot trial. Methods: Thirty stroke patients volunteered to participate in this study. The subjects were randomly allocated to two groups: the experimental group (n=15) received the neurodevelopment therapy plus balance training with plantar flexor stretching for 20 minutes in one session. The control group (n=15) received the same neurodevelopment therapy plus plantar flexor static stretching for 20 minutes in one session. Both groups underwent sessions four times a week, for a total of 4 weeks. Measurements included passive range of motion (PROM), active range of motion (AROM) of ankle dorsiflexion using a goniometer, timed up and go (TUG), the functional reaching test (FRT), and the 10 m walk test (10 MWT). Results: There were significant improvements in AROM and PROM of ankle dorsiflexion, TUG, and FRT scores after the intervention in the experimental group (p<0.05). However, the control group showed no statistically significant differences except for PROM of ankle dorsiflexion. The experimental group showed a significant improvement in PROM, TUG, and FRT scores compared to the control group (p<0.05). Conclusions: Balance training with plantar flexor stretching improves ankle dorsiflexion ROM and balance ability in patients with stroke. Therefore, this therapeutic intervention will be effective for rehabilitation of stroke patients in the clinical setting.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권6호
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• pp.536-544
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• 2019

Purpose: Proper nutrition is essential for brain development during infancy, contributing to the continued development of cognitive, motor, and socio-emotional skills throughout life. Considering the insufficient published data in the Middle East and North Africa, experts drafted a questionnaire to assess the opinions and knowledge of physicians on the impact of nutrition on brain development and cognition in early life. Methods: The questionnaire consisted of two parts: The first focused on the responders' demographic and professional characteristics and the second questioned the role of nutrition in brain development and cognition. Descriptive statistics were used to summarize respondents' characteristics and their responses to questions. Results: A total of 1,500 questionnaires were distributed; 994 physicians responded. The majority of the surveyed physicians (64.4%) felt that nutrition impacts brain development in early childhood (0-4 years), with almost 90% of physicians agreeing/strongly agreeing that preventing iron, zinc, and iodine deficiency would improve global intelligence quotient. The majority of physicians (83%) agreed that head circumference was the most important measure of brain development. The majority of physicians (68.9%) responded that the period from the last trimester until 18 months postdelivery was crucial for brain growth and neurodevelopment, with 76.8% believing that infants breast-fed by vegan mothers have an increased risk of impaired brain development. Conclusion: The results of this study show that practicing physicians significantly agree that nutrition plays an important role in brain and cognitive development and function in early childhood, particularly during the last trimester until 18 months postdelivery.

• Clinical Nutrition Research
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• 제12권3호
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• pp.169-176
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• 2023

Glucose transporter type 1 (GLUT1) deficiency syndrome (DS) is a metabolic brain disorder caused by a deficiency resulting from SLC2A1 gene mutation and is characterized by abnormal brain metabolism and associated metabolic encephalopathy. Reduced glucose supply to the brain leads to brain damage, resulting in delayed neurodevelopment in infancy and symptoms such as eye abnormalities, microcephaly, ataxia, and rigidity. Treatment options for GLUT1 DS include ketogenic diet (KD), pharmacotherapy, and rehabilitation therapy. Of these, KD is an essential and the most important treatment method as it promotes brain neurodevelopment by generating ketone bodies to produce energy. This case is a focused study on intensive KD nutritional intervention for an infant diagnosed with GLUT1 DS at Gangnam Severance Hospital from May 2022 to January 2023. During the initial hospitalization, nutritional intervention was performed to address poor intake via the use of concentrated formula and an attempt was made to introduce complementary feeding. After the second hospitalization and diagnosis of GLUT1 DS, positive effects on the infant's growth and development, nutritional status, and seizure control were achieved with minimal side effects by implementing KD nutritional intervention and adjusting the type and dosage of anticonvulsant medications. In conclusion, for patients with GLUT1 DS, it is important to implement a KD with an appropriate ratio of ketogenic to nonketogenic components to supply adequate energy. Furthermore, individualized and intensive nutritional management is necessary to improve growth, development, and nutritional status.