Safety and Health at Work

Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency (산업안전보건연구원)
권호 표지
DOI QR코드

DOI QR Code

Prenatal Exposures to Environmental Chemicals and Children's Neurodevelopment: An Update

  • Bellinger, David C. (Boston Children's Hospital, Harvard Medical School, Harvard School of Public Health)
  • Received : 2012.12.21
  • Accepted : 2013.02.06
  • Published : 2013.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

This review surveys the recent literature on the neurodevelopmental impacts of chemical exposures during pregnancy. The review focuses primarily on chemicals of recent concern, including phthalates, bisphenol-A, polybrominated diphenyl ethers, and perfluorinated compounds, but also addresses chemicals with longer histories of investigation, including air pollutants, lead, methylmercury, manganese, arsenic, and organophosphate pesticides. For some chemicals of more recent concern, the available literature does not yet afford strong conclusions about neurodevelopment toxicity. In such cases, points of disagreement among studies are identified and suggestions provided for approaches to resolution of the inconsistencies, including greater standardization of methods for expressing exposure and assessing outcomes.

Keywords

Cited by

  1. Blood Manganese Concentration is Elevated in Infants with Iron Deficiency vol.155, pp.2, 2013, https://doi.org/10.1007/s12011-013-9782-9
  2. Oxime-type acetylcholinesterase reactivators in pregnancy: an overview pp.1432-0738, 2013, https://doi.org/10.1007/s00204-013-1160-z
  3. Evaluation of Toxic Metals and Essential Elements in Children with Learning Disabilities from a Rural Area of Southern Brazil vol.11, pp.10, 2014, https://doi.org/10.3390/ijerph111010806
  4. Lead Exposure Disrupts Global DNA Methylation in Human Embryonic Stem Cells and Alters Their Neuronal Differentiation vol.139, pp.1, 2014, https://doi.org/10.1093/toxsci/kfu028
  5. Zebrafish as a Model for Developmental Neurotoxicity Assessment: The Application of the Zebrafish in Defining the Effects of Arsenic, Methylmercury, or Lead on Early Neurodevelopment vol.2, pp.3, 2014, https://doi.org/10.3390/toxics2030464
  6. In Utero Exposure to Toxic Air Pollutants and Risk of Childhood Autism vol.25, pp.6, 2014, https://doi.org/10.1097/EDE.0000000000000150
  7. Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators vol.29, pp.3, 2014, https://doi.org/10.1007/s11011-014-9565-9
  8. Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years vol.9, pp.12, 2014, https://doi.org/10.1371/journal.pone.0114003
  9. The Human Early-Life Exposome (HELIX): Project Rationale and Design pp.0091-6765, 2014, https://doi.org/10.1289/ehp.1307204
  10. Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA) vol.123, pp.10, 2015, https://doi.org/10.1289/ehp.1408803
  11. Lead Exposure in Different Organs of Mammals and Prevention by Curcumin–Nanocurcumin: a Review vol.168, pp.2, 2015, https://doi.org/10.1007/s12011-015-0366-8
  12. Select Prenatal Environmental Exposures and Subsequent Alterations of Gene-Specific and Repetitive Element DNA Methylation in Fetal Tissues vol.2, pp.2, 2015, https://doi.org/10.1007/s40572-015-0045-0
  13. Longitudinal associations of age and prenatal lead exposure on cortisol secretion of 12–24 month-old infants from Mexico City vol.15, pp.1, 2016, https://doi.org/10.1186/s12940-016-0124-1
  14. Endocrine disruptor phthalates in bottled water: daily exposure and health risk assessment in pregnant and lactating women vol.188, pp.9, 2016, https://doi.org/10.1007/s10661-016-5502-1
  15. Mechanisms of the Maternal Exposome and Implications for Health Outcomes vol.39, pp.2, 2016, https://doi.org/10.1097/ANS.0000000000000110
  16. Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I vol.12, pp.3, 2017, https://doi.org/10.1371/journal.pone.0172715
  17. Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS) vol.125, pp.8, 2017, https://doi.org/10.1289/EHP1250
  18. Review of reviews on exposures to synthetic organic chemicals and children’s neurodevelopment: Methodological and interpretation challenges vol.20, pp.8, 2017, https://doi.org/10.1080/10937404.2017.1370847
  19. Glazed clay pottery and lead exposure in Mexico: Current experimental evidence vol.20, pp.9, 2017, https://doi.org/10.1080/1028415X.2016.1193967
  20. Acute poisonings during pregnancy and in other non-pregnant women in emergency departments of four government hospitals, Addis Ababa, Ethiopia: 2010-2015 vol.22, pp.10, 2017, https://doi.org/10.1111/tmi.12940
  21. The role of pro-/anti-inflammation imbalance in Aβ42 accumulation of rat brain co-exposed to fine particle matter and sulfur dioxide vol.27, pp.8, 2017, https://doi.org/10.1080/15376516.2017.1337256
  22. Quantifying injury to common bottlenose dolphins from the Deepwater Horizon oil spill using an age-, sex- and class-structured population model vol.33, pp.1613-4796, 2017, https://doi.org/10.3354/esr00777
  23. Identification of Splicing Quantitative Trait Loci (sQTL) in Drosophila melanogaster with Developmental Lead (Pb2+) Exposure vol.8, pp.1664-8021, 2017, https://doi.org/10.3389/fgene.2017.00145
  24. Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death vol.80, pp.19-21, 2017, https://doi.org/10.1080/15287394.2017.1357370
  25. Assessment of heavy metal tolerance in two plant species growing in experimental disturbed polluted urban soil pp.1614-7480, 2017, https://doi.org/10.1007/s11368-017-1666-8
  26. Iron deficiency increases blood concentrations of neurotoxic metals in children vol.57, pp.8, 2014, https://doi.org/10.3345/kjp.2014.57.8.345
  27. Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature vol.14, pp.7, 2017, https://doi.org/10.3390/ijerph14070691
  28. Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children vol.125, pp.4, 2017, https://doi.org/10.1289/EHP265
  29. Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes pp.2196-5412, 2018, https://doi.org/10.1007/s40572-018-0173-4
  30. Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates vol.23, pp.11, 2018, https://doi.org/10.1590/1413-812320182311.15812016
  31. Lead Modulates trans- and cis-Expression Quantitative Trait Loci (eQTLs) in Drosophila melanogaster Heads vol.9, pp.1664-8021, 2018, https://doi.org/10.3389/fgene.2018.00395
  32. Family environmental and dietary implications for low-level prenatal lead exposure in Wujiang City, China vol.25, pp.13, 2018, https://doi.org/10.1007/s11356-017-1102-z