• 한국산학기술학회논문지
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• 제21권11호
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• pp.44-52
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• 2020

본 연구는 아로마의 흡입법을 적용한 아로마테라피가 뇌파에 미치는 영향을 규명하기 위하여 진행되었다. 연구대상자는 모집공고에 의해 만 20세 이상~만 59세 이하의 남,여 64명을 대상으로 하였고, 실험군 32명, 대조군 32명을 무작위배정하였다. 실험군에게는 6가지 아로마블렌딩오일(Lavender, Bergamot, Mandarin, Lemon, Cedarwood, Roman Chamomile)을 적용하였으며, 대조군에게는 조조바오일을 적용하여 흡입법을 실시하였다. 실험 처치 전과 30분 후에 EEG측정을 위하여 뉴로하모니S(Neroharmony S)를 이용해, 실험군과 대조군의 BQ-test(SRQ, BRQ, ATQ, ACQ, EQ, ASQ, CQ, BQ)를 실시, 비교·분석하였다. 통계분석은 측정치의 사전점수를 통제한 공변량분석(ANCOVA)을 사용하였으며 연구결과, 분석된 8개 항목 중 3개 항목인 ATQ(p<.05), ACQ(p<.05), BQ(p<.05)에서 실험군과 대조군 간 유의한 차이가 나타났다. 즉, 아로마테라피가 주의력(뇌의 각성정도)을 높여줌으로써 집중력과 기억력이 강화되며, 좌·우뇌의 활성을 더욱 좋게해주어 정신적 활동과 사고 능력 및 행동성향의 균형유지에 도움을 준다. 또한 종합적인 뇌기능을 대변하여주는 BQ의 측정치가 처치 후 증가한 것을 나타나, 아로마테라피가 인체의 정신적·육체적인 건강상태를 유지시켜주는 데 큰 역할을 할 수 있는 효율적 방안임을 보여주고 있다.

• 감성과학
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• 제12권3호
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• pp.341-350
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• 2009

양궁의 슈팅과정에 대하여 정신 집중력과 긴장 이완도를 뇌파를 이용하여 평가하였다. 정신 집중과 긴장 이완 수준의 평가는 집중과 명상 알고리즘을 이용하여 수행되었다. 우수, 중급, 그리고 초급 양궁선수들이 야외 양궁장에서 근거리와 장거리 타깃을 대상으로 슈팅 훈련을 할 때 앞이마(Fp1)에 전극을 부착한 헤드밴드 형태의 휴대용 뇌파 시스템으로 뇌파를 기록하였다. 개인별로 기록된 뇌파는 집중과 명상 알고리즘을 이용하여 실시간으로 정신집중과 긴장이완 수준이 계산되었으며, 슈팅 과정에서 정신집중과 긴장이완 수준의 변화 형태가 분석되었다. 개인별로 각각의 슈팅에 대한 정신집중 및 긴장이완 수준 변화는 네 유형으로 분류되었으며, 이 변화 유형은 양궁 선수들의 경기력을 평가하는 신뢰성 있는 지표로 나타났다. 우수 선수의 경우 정신 집중과 긴장이완 수준이 슈팅과정의 진행에 따라 동시에 증가하는 형태로 나타났으며, 중급 선수의 경우 정신 집중도는 증가하는 반면 긴장 이완 수준은 감소하는 결과를 보여 주었다. 실시간으로 제공되는 정신 집중과 긴장 이완 수준의 변화는 양궁 선수들의 경기력 평가뿐만 아니라 훈련 시에 유익한 피드백이 되었다.

• 대한의용생체공학회:의공학회지
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• 제28권1호
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• pp.153-161
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• 2007

Stroke is the second most significant disease leading to death in Korea. The conventional therapeutic approach is mainly based on physical training, however, it usually provides the limited degree of recovery of the normal brain function. The electric stimulation therapy is a novel and candidate approach with high potential for stroke recovery. The feasibility was validated by preliminary rat experiments in which the motor function was recovered up to 80% of the normal performance level. It is thought to improve the neural plasticity of the nerve tissues around the diseased area in the stroked brain. However, there are not so much research achievements in the electric stimulation for stroke recovery as for the Parkinson's disease or Epilepsy. This study aims at the developments of a wireless variable pulse generator using ZigBee communication for future implantation into human brain. ZigBee is widely used in wireless personal area network (WPAN) and home network applications due to its low power consumption and simplicity. The developed wireless pulse generator controlled by ZigBee can generate various electric stimulations without any distortion. The electric stimulation includes monophasic and biphasic pulse with the variation of shape parameters, which can affect the level of recovery. The developed system can be used for the telerehabilitation of stroke patient by remote control of brain stimulation via ZigBee and internet. Furthermore, the ZigBee connection used in this study provides the potential neural signal transmission method for the Brain-Machine Interface (BMI).

• The Korean Journal of Physiology and Pharmacology
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• 제13권3호
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• pp.251-256
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• 2009

Previous observations suggest that Bis, a Bcl-2-binding protein, may playa role the neuronal and glial differentiation in vivo. To examine this further, we investigated Bis expression during the in vitro differentiation of P19 embryonic carcinoma cells induced by retinoic acid (RA). Western blotting and RT-PCR assays showed that Bis expression was temporarily decreased during the free floating stage and then began to increase on day 6 after the induction of differentiation. Double immunostaining indicated that Bis-expressing cells do not express several markers of differentiation, including NeuN, MAP-2 and Tuj-1. However, some of the Bis-expressing cells also were stained with GFAP-antibodies, indicating that Bis is involved glial differentiation. Using an shRNA strategy, we developed bis-knock down P19 cells and compared them with control P19 cells for the expression of NeuroD, Mash-1 and GFAP during RA-induced differentiation. Among these, only GFAP induction was significantly attenuated in Pl9-dnbis cells and the population showing GFAP immunoreactivity was also decreased. It is noteworthy that distribution of mature neurons and migrating neurons was disorganized, and the close association of migrating neuroblasts with astrocytes was not observed in P19-dnbis cells. These results suggest that Bis is involved in the migration-inducing activity of glial cells.

• Architectural research
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• 제18권3호
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• pp.83-90
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• 2016

Senescent effects are the gradual deterioration of function caused by biological aging. Senescent effects on color vision are not clearly understood even after considerable researches. Part of the reason is that the color vision is a complex phenomenon resulting from various factors such as organic systems, and the physical (neuro-optical) and the psychological (experiential) processes of color perception. We performed a field experiment on color perceptional differences due to aging vision. Our experiment was applied to two different groups in South Korea: an experimental group (46 subjects of over the age of 61 years) and a control group (49 subjects in their twenties). The experimental tools are comprised of (1) six gradual yellowing detector board (40%, 50%, 60%, 70%, 80%, 90%); (2) pairs of vivid-strong, vivid-deep, grayish-deep, deep-dull, and bright-light tones of Blue (B) and Purple (P) colors; (3) Red (R), Yellow (Y), Green (G), Blue (B), and Purple (P) colors of dull-tones and pale-tones; and (4) a questionnaire on the semantic differential scales of the color images and color differences. A diagnosis system of gradual yellow vision, developed by the authors for this study, was adapted to generate the color detecting boards. The results are as follows. (1) There are significant differences between the two groups in detecting colors that simulate 40% and 50% of yellow vision. (2) As to the color difference detecting ability between similar tones, the experimental group shows difficulties in pairs of vivid-strong tones and deep-dull tones of the B color. And (3), the emotional responses to the dull tone and the pale tone are not stable in the red, the yellow, blue, and purple. Thus, we empirically demonstrate the specific differences in color perception between the old and young groups.

• Journal of Korean Neurosurgical Society
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• 제57권5호
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• pp.335-341
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• 2015

Objective : The main causes of spinal cord ischemia are a variety of vascular pathologies causing acute arterial occlusions. We investigated neuro-protective effects of kefir on spinal cord ischemia injury in rats. Methods : Rats were divided into three groups : 1) sham operated control rats; 2) spinal cord ischemia group fed on a standard diet without kefir pretreatment; and 3) spinal cord ischemia group fed on a standard diet plus kefir. Spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. The spinal cord was removed after the procedure. The biochemical and histopathological changes were observed within the samples. Functional assessment was performed for neurological deficit scores. Results : The kefir group was compared with the ischemia group, a significant decrease in malondialdehyde levels was observed (p<0.05). Catalase and superoxide dismutase levels of the kefir group were significantly higher than ischemia group (p<0.05). In histopathological samples, the kefir group is compared with ischemia group, there was a significant decrease in numbers of dead and degenerated neurons (p<0.05). In immunohistochemical staining, hipoxia-inducible factor-$1{\alpha}$ and caspase 3 immunopositive neurons were significantly decreased in kefir group compared with ischemia group (p<0.05). The neurological deficit scores of kefir group were significantly higher than ischemia group at 24 h (p<0.05). Conclusion : Our study revealed that kefir pretreatment in spinal cord ischemia/reperfusion reduced oxidative stress and neuronal degeneration as a neuroprotective agent. Ultrastructural studies are required in order for kefir to be developed as a promising therapeutic agent to be utilized for human spinal cord ischemia in the future.

• 생물정신의학
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• 제22권4호
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• pp.179-186
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• 2015

Objectives Adrenergic alpha 1 and 2 receptors work as pathways to control the serotonergic neuron moderation and mirtazapine acts as antagonist of these receptors. The adrenoreceptor alpha 1a (ADRA1A) gene, which encodes adrenergic alpha 1 receptor, has Arg-347Cys genetic polymorphism and the polymorphism has strong relationship with many neuro-psychiatric diseases. In this study, we explored the relationship between ADRA1A R347C polymorphism and mirtazapine treatment response in Koreans with major depression. Methods 352 patients enrolled in this study, and the symptoms were evaluated by 17-item Hamilton Depression Rating (HAMD-17) scale. After 1, 2, 4, 8, and 12 weeks of mirtazapine treatment, the association between ADRA1A R347C polymorphism and remission/response outcomes was evaluated. Results Treatment response to mirtazapine was significantly better in T allele carriers than C allele homozygotes after 12 weeks of mirtazapine monotherapy. The percentile decline of HAMD-17 score in T allele carriers was larger than that of C allele homozygotes. ADRA1A R347C genotypes were not significantly associated with remission. Conclusions The result showed that treatment response to mirtazapine was significantly associated with ADRA1A R347C genetic polymorphism. T allele carriers showed better treatment response than C allele homozygotes. It can be supposed that T allele carriers have a trend of better treatment response to mirtazapine monotherapy.

• Journal of Korean Neurosurgical Society
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• 제45권5호
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• pp.275-283
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• 2009

Objective : We retrospectively analyzed survival, local control rate, and incidence of radiation toxicities after radiosurgery for recurrent metastatic brain lesions whose initial metastases were treated with whole-brain radiotherapy. Various radiotherapeutical indices were examined to suggest predictors of radiation-related neurological dysfunction. Methods : In 46 patients, total 100 of recurrent metastases (mean 2.2, ranged 1-10) were treated by CyberKnife radiosurgery at average dose of 23.1 Gy in 1 to 3 fractions. The median prior radiation dose was 32.7 Gy, the median time since radiation was 5.0 months, and the mean tumor volume was $12.4cm^3$. Side effects were expressed in terms of radiation therapy oncology group (RTOG) neurotoxicity criteria. Results : Mass reduction was observed in 30 patients (65%) on MRI. After the salvage treatment, one-year progression-free survival rate was 57% and median survival was 10 months. Age(<60 years) and tumor volume affected survival rate(p=0.03, each). Acute (${\leq}$1 month) toxicity was observed in 22% of patients, subacute and chronic (>6 months) toxicity occurred in 21 %, respectively. Less acute toxicity was observed with small tumors (<$10cm^3$. p=0.03), and less chronic toxicity occurred at lower cumulative doses (<100 Gy, p=0.004). "Radiation toxicity factor" (cumulative dose times tumor volume of <1,000 Gy${\times}cm^3$) was a significant predictor of both acute and chronic CNS toxicities. Conclusion: Salvage CyberKnife radiosurgery is effective for recurrent brain metastases in previously irradiated patients, but careful evaluation is advised in patients with large tumors and high cumulative radiation doses to avoid toxicity.

• 상하수도학회지
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• 제25권4호
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• pp.581-589
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• 2011

Generally, treated water or raw water is transported into storage reservoirs which are receiving facilities of local governments from multi-regional water supply systems. A water supply control and operation center is operated not only to manage the water facilities more economically and efficiently but also to mitigate the shortage of water resources due to the increase in water consumption. To achieve the goal, important information such as the flow-rate in the systems, water levels of storage reservoirs or tanks, and pump-operation schedule should be considered based on the resonable water demand forecasting. However, it is difficult to acquire the pattern of water demand used in local government, since the operating information is not shared between multi-regional and local water systems. The pattern of water demand is irregular and unpredictable. Also, additional changes such as an abrupt accident and frequent changes of electric power rates could occur. Consequently, it is not easy to forecast accurate water demands. Therefore, it is necessary to introduce a short-term water demands forecasting and to develop an application of the forecasting models. In this study, the forecasting simulator for water demand is developed based on mathematical and neural network methods as linear and non-linear models to implement the optimal water demands forecasting. It is shown that MLP(Multi-Layered Perceptron) and ANFIS(Adaptive Neuro-Fuzzy Inference System) can be applied to obtain better forecasting results in multi-regional water supply systems with a large scale and local water supply systems with small or medium scale than conventional methods, respectively.

• 대한후두음성언어의학회지
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• 제8권2호
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• pp.166-172
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• 1997

Background : For example, aerodynamic study, vibratory study, acoustic study, neuro-muscular test and psychoacoustic evaluation, a number of objective methods are now available for assessing pathologic voice change. They help to differentiate pathologic condition from normal condition and to monitor pathologic and aging change. These laboratory analyses are used commonly to monitor speech therapy and to follow a patient's recovery after surgery. Objectives : We investigated the values of jitter, shimmer and NNE of normal person and hoarseness patients in Korea. The values of Jitter and shimmer might be meaningful parameters distinguishing pathologic vibration from normal and recovery after surgery. Materials and Methods : Statistical significance between normal control and 48 subjects taken microlaryngeal surgery were compared with Dr. speech science program that is computerized system for acoustic analysis of voice production employed to determine vocal characteristics of pitch perturbation(jitter) and amplitude perturbation(shimmer). Results : The mean normal values of jitter and shimmer were 0.226${\pm}$0.110(%), 2.200${\pm}$0.421(%) in male and 0.164${\pm}$0.060(%), 2.063 ${\pm}$0.575(%) in female. In patients with vocal nodule, the preoperative and postoperative values of jitter and shimmer were valueless. In patients with vocal polyps, the preoperative and postoperative values of jitter and shimmer were valuable. Conclusion : Dr. speech science program was effective to monitor laryngeal disease and aging changes.