• Title/Summary/Keyword: network structure

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Sustained release of alginate hydrogel containing antimicrobial peptide Chol-37(F34-R) in vitro and its effect on wound healing in murine model of Pseudomonas aeruginosa infection

  • Shuaibing Shi;Hefan Dong;Xiaoyou Chen;Siqi Xu;Yue Song;Meiting Li;Zhiling Yan ;Xiaoli Wang ;Mingfu Niu ;Min Zhang;Chengshui Liao
    • Journal of Veterinary Science
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    • v.24 no.3
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    • pp.44.1-44.17
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    • 2023
  • Background: Antibiotic resistance is a significant public health concern around the globe. Antimicrobial peptides exhibit broad-spectrum and efficient antibacterial activity with an added advantage of low drug resistance. The higher water content and 3D network structure of the hydrogels are beneficial for maintaining antimicrobial peptide activity and help to prevent degradation. The antimicrobial peptide released from hydrogels also hasten the local wound healing by promoting epithelial tissue regeneration and granulation tissue formation. Objective: This study aimed at developing sodium alginate based hydrogel loaded with a novel antimicrobial peptide Chol-37(F34-R) and to investigate the characteristics in vitro and in vivo as an alternative antibacterial wound dressing to treat infectious wounds. Methods: Hydrogels were developed and optimized by varying the concentrations of crosslinkers and subjected to various characterization tests like cross-sectional morphology, swelling index, percent water contents, water retention ratio, drug release and antibacterial activity in vitro, and Pseudomonas aeruginosa infected wound mice model in vivo. Results: The results indicated that the hydrogel C proved superior in terms of cross-sectional morphology having uniformly sized interconnected pores, a good swelling index, with the capacity to retain a higher quantity of water. Furthermore, the optimized hydrogel has been found to exert a significant antimicrobial activity against bacteria and was also found to prevent bacterial infiltration into the wound site due to forming an impermeable barrier between the wound bed and external environment. The optimized hydrogel was found to significantly hasten skin regeneration in animal models when compared to other treatments in addition to strong inhibitory effect on the release of pro-inflammatory cytokines (interleukin-1β and tumor necrosis factor-α). Conclusions: Our results suggest that sodium alginate -based hydrogels loaded with Chol-37(F34-R) hold the potential to be used as an alternative to conventional antibiotics in treating infectious skin wounds.

Reexamination of Coach-Athlete Relationship Maintenance Scale in Pro Baseball (프로야구 코치-선수관계 유지 척도 재검증)

  • Huh, Jin-Young;Choi, Hun-Hyuk
    • 한국체육학회지인문사회과학편
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    • v.55 no.1
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    • pp.221-233
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    • 2016
  • The purpose of this study was to prove a development and initial validation of the korean version of coach-athlete relationship maintenance scale that originated from the work of Rhind & Jowett(2012) in pro baseball. The items were then administered to 132 Participants(29 coaches and 103 athletes) completed the questionnaires of the coach-athlete relationship maintenance in First preliminary investigation. Maximum likelihood estimate was used to identify the latent underlying structure. In order to verify the validity of Korean version of coach-athlete relationship maintenance was administered to an independent sample of 273 coaches and athletes. Pro baseball coach-athlete relationship maintenance is consisted of six factors(25 items) with conflict management, motivational, preventative, openness/assurance, support, and social network. SPSS18.0 and AMOS16.0 were used to analyze the exploratory factor analysis, confirmatory factory analysis and internal consistency, test-retest with bootstrapping using of the data in this study. The results of the pro baseball coach-athlete relationship maintenance scale had six factors with 25 items, and each six factor was positively correlated. Overall, this study verified pro baseball coach-athlete relationship maintenance questionnaire. Thus, suggest that path of comparing the differences between the first division and farm team by using the test of the structural model invariance across the groups.

A Study on the Status of Use and Value of 'Saemi' in Sacheon Alluvial Fan (사천 선상지 '새미'의 이용 실태 및 가치 고찰)

  • Kim, Dohyun;Jeong, Myeong Cheol;Seo, Ki Chun
    • Journal of the Korean Institute of Rural Architecture
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    • v.24 no.4
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    • pp.85-95
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    • 2022
  • This study is about the story of 'Saemi', existing in the Sacheon Alluvial fan area. Saemi is a local word for Dumbeong, which is the traditional water irrigation facilities in this area that could be formed according to the geographical characteristics of a Alluvial fan site. In the meantime, although Saemi has been an important source of water, related research has been mainly done from an ecological point of view. Accordingly, the researcher paid attention to the functional aspects of Saemi itself, grasped its location, distribution status, and usage including the construction method, and considered its intrinsic value through classification and characteristic analysis of Saemi. As a result of five field surveys from September 2021 to October 2022, 129 Saemies remained in the Sacheon alluvial fan area. According to the structure and shape, Saemi could be divided into basic type, complex type, and buried type. The basic type was subdivided into bucket-type and stairs-type along with the complex type, and the buried type was subdivided into all buried-type and some buried-type. Saemies were mainly distributed at the distal end of the Sacheon alluvial fan site, individual Saemies were built on farmland, and common Saemies were usually built along roadsides adjacent to villages. The reason why the Saemies are concentrated at the distal end is the geographical characteristics of the alluvial fan where the water underflows. Saemi was an important multifunctional water supply source equivalent to the main water source for people at the distal end of the pond who did not receive a stable supply of water from the reservoir. Saemi was at the center of the underground water irrigation network agricultural system in the Sacheon alluvial fan area according to the principles of 'bbaeim(drop out)' and 'gaepim(pooling)' It has provided a foundation for establishing itself as an appropriate technology in this area. Such Saemi contributed to the rural landscape and agricultural biodiversity through its own system and served as a public interest function. It is necessary to know, conserve, manage, and continuously utilize the value of this Saemi as an agricultural heritage.

A study on the preparation and analysis of cordierite by sol-gel method (졸-겔법에 의한 코디어라이트 제조와 분석에 관한 연구)

  • Chun, Kyung Soo;Lee, Young Hwan
    • Analytical Science and Technology
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    • v.21 no.2
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    • pp.123-128
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    • 2008
  • The golden turbid solution of cordierite precursor was obtained by using magnesium ethoxide in sol-gel method, while the clear solution of cordierite precursor was obtained when 5%-$Zr(OC_3H_7)_4$ solution was used in the sol-gel reaction. $SiO_2$ component was confirmed by infrared spectra showing $1045cm^{-1}$ and the stretching vibration of gelish $SiO_4$ showed $1140cm^{-1}$ and $940cm^{-1}$. The component of $Al_2O_3$ showed at $580cm^{-1}$ and network structure of $Al_2O_6$ showed at $680cm^{-1}$. The component of MgO was confirmed at $575cm^{-1}$ as the stretching vibration. X-ray diffraction analysis showed ${\mu}$-cordierite crystal was showed up at temperature above $1000^{\circ}C$ at the mole ratio of cordierite precursor and water (1:5). ${\mu}$-Cordierite and ${\alpha}$-cordierite were coexisted at $1050^{\circ}C$ for the mole ratio of cordierite precursor and ammonia (1:5) while ${\alpha}$-cordierite was only existed at $1100^{\circ}C$ for the same mole ratio as mentioned above.

Extending StarGAN-VC to Unseen Speakers Using RawNet3 Speaker Representation (RawNet3 화자 표현을 활용한 임의의 화자 간 음성 변환을 위한 StarGAN의 확장)

  • Bogyung Park;Somin Park;Hyunki Hong
    • KIPS Transactions on Software and Data Engineering
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    • v.12 no.7
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    • pp.303-314
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    • 2023
  • Voice conversion, a technology that allows an individual's speech data to be regenerated with the acoustic properties(tone, cadence, gender) of another, has countless applications in education, communication, and entertainment. This paper proposes an approach based on the StarGAN-VC model that generates realistic-sounding speech without requiring parallel utterances. To overcome the constraints of the existing StarGAN-VC model that utilizes one-hot vectors of original and target speaker information, this paper extracts feature vectors of target speakers using a pre-trained version of Rawnet3. This results in a latent space where voice conversion can be performed without direct speaker-to-speaker mappings, enabling an any-to-any structure. In addition to the loss terms used in the original StarGAN-VC model, Wasserstein distance is used as a loss term to ensure that generated voice segments match the acoustic properties of the target voice. Two Time-Scale Update Rule (TTUR) is also used to facilitate stable training. Experimental results show that the proposed method outperforms previous methods, including the StarGAN-VC network on which it was based.

Scale Development of Family Strength for Dual-Earner Families with Children (자녀가 있는 맞벌이가정의 건강성 척도 개발 연구)

  • Song, Hyerim;Koh, Sun-Kang;Kang, Eunju
    • Journal of Family Resource Management and Policy Review
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    • v.27 no.3
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    • pp.1-19
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    • 2023
  • This study aims to develop a family strength scale for dual-earner families with young children. Based on existing theories of family strength and a review of related literature, we draw on 80 items to measure the strength of dual-earner families. Using a sample of 747 people, all members of dual-earner families with young children, we examined the items' factor structures. Using the statistical method, we checked the validity and reliability of these items. The final scale consisted of four domains with a total of 49 items : basic foundation (basic structure, economic life, and resource management), parenting, social interest and participation (citizenship, volunteer, leisure, network), work-life balance (balance between work and family, sharing the family role, equal division of role). The developed scale can be used in the field, such as in the Healthy Family Support Center or Family Center, in the context of education, counseling, or consulting for dual-earner families. In order to enhance the usefulness and efficiency of the scale, the adequate education system for the professionals who handle this scale in the field and updated data are required.

Study on Establishment of a Monitoring System for Long-term Behavior of Caisson Quay Wall (케이슨 안벽의 장기 거동 모니터링 시스템 구축 연구 )

  • Tae-Min Lee;Sung Tae Kim;Young-Taek Kim;Jiyoung Min
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.27 no.5
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    • pp.40-48
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    • 2023
  • In this paper, a sensor-based monitoring system was established to analyze the long-term behavioral characteristics of the caisson quay wall, a representative structural type in port facilities. Data was collected over a period of approximately 10 months. Based on existing literature, anomalous behaviors of port facilities were classified, and a measurement system was selected to detect them. Monitoring systems were installed on-site to periodically collect data. The collected data was transmitted and stored on a server through LTE network. Considering the site conditions, inclinometers for measuring slope and crack meters for measuring spacing and settlement were installed. They were attached to two caissons for comparison between different caissons. The correlation among measured data, temperature, and tidal level was examined. The temperature dominated the spacing and settlement data. When the temperature changed by approximately 50 degrees, the spacing changed by 10 mm, the settlement by 2 mm, and the slope by 0.1 degrees. On the other hand, there was no clear relationship with tidal level, indicating a need for more in-depth analysis in the future. Based on the characteristics of these collected database, it will be possible to develop algorithms for detecting abnormal states in gravity-type quay walls. The acquisition and analysis of long-term data enable to evaluate the safety and usability of structures in the event of disasters and emergencies.

Very Short- and Long-Term Prediction Method for Solar Power (초 장단기 통합 태양광 발전량 예측 기법)

  • Mun Seop Yun;Se Ryung Lim;Han Seung Jang
    • The Journal of the Korea institute of electronic communication sciences
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    • v.18 no.6
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    • pp.1143-1150
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    • 2023
  • The global climate crisis and the implementation of low-carbon policies have led to a growing interest in renewable energy and a growing number of related industries. Among them, solar power is attracting attention as a representative eco-friendly energy that does not deplete and does not emit pollutants or greenhouse gases. As a result, the supplement of solar power facility is increasing all over the world. However, solar power is easily affected by the environment such as geography and weather, so accurate solar power forecast is important for stable operation and efficient management. However, it is very hard to predict the exact amount of solar power using statistical methods. In addition, the conventional prediction methods have focused on only short- or long-term prediction, which causes to take long time to obtain various prediction models with different prediction horizons. Therefore, this study utilizes a many-to-many structure of a recurrent neural network (RNN) to integrate short-term and long-term predictions of solar power generation. We compare various RNN-based very short- and long-term prediction methods for solar power in terms of MSE and R2 values.

Analysis of Genetic Diversity across Newly Occupied Habitats within the Goryeong Population of Pungitius kaibarae Using the Mitochondrial Cytb Gene (미토콘드리아 Cytb 유전자를 이용한 잔가시고기의 신규 서식지 고령 회천 집단의 유전적 다양성 분석)

  • Kang-Rae Kim;Mu-Sung Sung;Yujin Hwang;Myeong Seok Lee;Ju Hui Jeong;Heesoo Kim;Jeong-Nam Yu
    • Korean Journal of Ichthyology
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    • v.35 no.4
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    • pp.217-223
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    • 2023
  • The 886-bp sequence of the mitochondrial region encoding the cytb gene was used to identify the origin of the Goryeong (GR) population of Pungitius kaibarae and to characterize genetic diversity and structure among wild populations. The GR population showed the lowest haplotype diversity (Hd=0.000), while the highest haplotype diversity was confirmed at 0.755 among the Goseoung (GS) population. Nucleotide diversity ranged was the highest diversity at 0.00291 in the GS population and the lowest diversity at 0.00000 in the GR population. The GR population was genetically closest to the Pohang (PH) population. The haplotype network confirmed that the GR population was most similar to the PH population. The GR population also clustered with the PH population with high bootstrap support (98%) in a phylogenetic tree. We thus conclude that the GR population is derived from a population similar to the PH population.

A Study on Policy Trends and Location Pattern Changes in Smart Green-Related Industries (스마트그린 관련 산업의 정책동향과 입지패턴 변화 연구)

  • Young Sun Lee;Sun Bae Kim
    • Journal of the Economic Geographical Society of Korea
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    • v.27 no.1
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    • pp.38-52
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    • 2024
  • Digital transformation industry contributes to the improvement of productivity in overall industrial production, the smart green industry for carbon neutrality and sustainable growth is growing as a future industry. The purpose of this paper is to explore the status and role of the industry in the future industry innovation ecosystem through the analysis of the growth drivers and location pattern changes of the smart green industry. The industry is on the rise in both metropolitan and non-metropolitan areas, and the growth of the industry can be seen in non-metropolitan and non-urban areas. In particular, due to the smart green industrial complex pilot project, the creation of Gwangju Jeonnam Innovation City, and the promotion of new and renewable energy policies, the emergence of core aggregation areas (HH type) in the coastal areas of Honam and Chungcheongnam-do, and the formation of isolated centers (HL type) in the Gyeongsang region, new and renewable energy production companies are being accumulated in non-metropolitan areas. Therefore, the smart green industry is expected to promote the formation of various specialized spokes in non-urban areas in the future industrial innovation ecosystem that forms a multipolar hub-spoke network structure, where policy factors are the triggers for growth.