• The Plant Pathology Journal
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• 제27권2호
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• pp.170-182
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• 2011

Plants possess multiple resistance mechanisms that protect themselves against pathogen attack. To identify unknown components of the defense machinery in Arabidopsis, gene-expression changes were monitored in Arabidopsis thaliana under 18 different biotic or abiotic conditions using a DNA microarray representing approximately 25% of all Arabidopsis thaliana genes (www.genevestigator.com). Seventeen genes which are early responsive to salicylic acid (SA) treatment as well as pathogen infection were selected and their T-DNA insertion mutants were obtained from SALK institute. To elucidate the role of each gene in defense response, bacterial pathogen Pseudomonas syringae pv. tomato (Pst) DC3000 was inoculated onto individual T-DNA insertion mutants. Four mutants exhibited decreased resistance and five mutants displayed significantly enhanced resistance against Pst DC3000-infection as measured by change in symptom development as compared to wild-type plants. Among them, member of uridin diphosphate (UDP)-glycosyltransferase (UGT) was of particular interest, since a UGT mutant (At1g05680) showed enhanced resistance to Pst-infection in Arabidopsis. In systemic acquired resistance (SAR) assay, this mutant showed enhanced activation of SAR. Also, the enhanced SAR correlated with increased expression of defense-related gene, AtPR1. These results emphasize that the glycosylation of UGT74E2 is a part of the SA-mediated disease-resistance mechanism.

• 시스템엔지니어링학술지
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• 제13권2호
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• pp.9-17
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• 2017

Concept development of a real-time Field Programmable Gate Array (FPGA)-based switched Ethernet data communication network for the Man-Machine Interface System (MMIS) is presented in this paper. The proposed design discussed in this research is based on the systems engineering (SE) approach. The design methodology is effectively developed by defining the concept development stage of the life-cycle model consisting of three successive phases, which are developed and discussed: needs analysis; concept exploration; and concept definition. This life-cycle model is used to develop an FPGA-based time-triggered Ethernet (TTE) switched data communication network for the non-safety division of MMIS system to provide real-time data transfer from the safety control systems to the non-safety division of MMIS and between the non-safety systems including control, monitoring, and information display systems. The original IEEE standard 802.3 Ethernet networks were not typically designed or implemented for providing real-time data transmission, however implementing a network that provides both real-time and on-demand data transmission is achievable using the real-time Ethernet technology. To develop the design effectively, context diagrams are implied. Conformance to the stakeholders needs, system requirements, and relevant codes and standards together with utilizing the TTE technology are used to analyze, synthesize, and develop the MMIS non-safety data communication network of the APR1400 nuclear power plant.

• 한국정밀공학회지
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• 제19권9호
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• pp.111-117
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• 2002

In most machining companies, operators decide the cutting condition, a pair of spindle speed (5) and table federate (F) by experience and subjective judgment. As cutting conditions are determined by operators' experience and ability, inconsistent cutting conditions are given in same operating conditions. The objective of this study is to develop the cutting condition decision system which utilizes shop data and predicts tool life by neural network and eventually leads to the optimal cutting condition. The production time per piece is considered for an optimization object. We will discuss the process of an optimal cutting condition decision by neural network. By this process, a series of shop data is stored. And neural network is constructed for prediction of tool life and the optimal cutting condition is recommended from a cutting condition decision system using the stored shop data. The results show that the developed system is rational in searching the optimal cutting conditions on job operations.

• Genomics & Informatics
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• 제19권1호
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• pp.4.1-4.9
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• 2021

Lip and oral cavity cancer, which can occur in any part of the mouth, is the 11th most common type of cancer worldwide. The major obstacles to patients' survival are the poor prognosis, lack of specific biomarkers, and expensive therapeutic alternatives. This study aimed to identify the main genes and pathways associated with lip and oral cavity carcinoma using network analysis and to analyze its molecular mechanism and prognostic significance further. In this study, 472 genes causing lip and oral cavity carcinoma were retrieved from the DisGeNET database. A protein-protein interaction network was developed for network analysis using the STRING database. VEGFA, IL6, MAPK3, INS, TNF, MAPK8, MMP9, CXCL8, EGF, and PTGS2 were recognized as network hub genes using the maximum clique centrality algorithm available in cytoHubba, and nine potential drug candidates (ranibizumab, siltuximab, sulindac, pomalidomide, dexrazoxane, endostatin, pamidronic acid, cetuximab, and apricoxib) for lip and oral cavity cancer were identified from the DGIdb database. Gene enrichment analysis was also performed to identify the gene ontology categorization of cellular components, biological processes, molecular functions, and biological pathways. The genes identified in this study could furnish a new understanding of the underlying molecular mechanisms of carcinogenesis and provide more reliable biomarkers for early diagnosis, prognostication, and treatment of lip and oral cavity cancer.

• Molecules and Cells
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• 제42권8호
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• pp.579-588
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• 2019

Gene set enrichment analysis (GSEA) is a popular tool to identify underlying biological processes in clinical samples using their gene expression phenotypes. GSEA measures the enrichment of annotated gene sets that represent biological processes for differentially expressed genes (DEGs) in clinical samples. GSEA may be suboptimal for functional gene sets; however, because DEGs from the expression dataset may not be functional genes per se but dysregulated genes perturbed by bona fide functional genes. To overcome this shortcoming, we developed network-based GSEA (NGSEA), which measures the enrichment score of functional gene sets using the expression difference of not only individual genes but also their neighbors in the functional network. We found that NGSEA outperformed GSEA in identifying pathway gene sets for matched gene expression phenotypes. We also observed that NGSEA substantially improved the ability to retrieve known anti-cancer drugs from patient-derived gene expression data using drug-target gene sets compared with another method, Connectivity Map. We also repurposed FDA-approved drugs using NGSEA and experimentally validated budesonide as a chemical with anti-cancer effects for colorectal cancer. We, therefore, expect that NGSEA will facilitate both pathway interpretation of gene expression phenotypes and anti-cancer drug repositioning. NGSEA is freely available at www.inetbio.org/ngsea.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권4호
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• pp.1224-1248
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• 2022

In various sensor network applications, such as climate observation organizations, sensor nodes need to collect information from time to time and pass it on to the recipient of information through multiple bounces. According to field tests, this information corresponds to most of the energy use of the sensor hub. Decreasing the measurement of information transmission in sensor networks becomes an important issue.Compression sensing (CS) can reduce the amount of information delivered to the network and reduce traffic load. However, the total number of classification of information delivered using pure CS is still enormous. The hybrid technique for utilizing CS was proposed to diminish the quantity of transmissions in sensor networks.Further the energy productivity is a test task for the sensor nodes. However, in previous studies, a clustering approach using hybrid CS for a sensor network and an explanatory model was used to investigate the relationship between beam size and number of transmissions of hybrid CS technology. It uses efficient data integration techniques for large networks, but leads to clone attacks or attacks. Here, a new algorithm called SBEA (Snowball Endurance Algorithm) was proposed and tested with a bow. Thus, you can extend the battery life of your WSN by running effective copy detection. Often, multiple nodes, called observers, are selected to verify the reliability of the nodes within the network. Personal data from the source centre (e.g. personality and geographical data) is provided to the observer at the optional witness stage. The trust and reputation system is used to find the reliability of data aggregation across the cluster head and cluster nodes. It is also possible to obtain a mechanism to perform sleep and standby procedures to improve the life of the sensor node. The sniffers have been implemented to monitor the energy of the sensor nodes periodically in the sink. The proposed algorithm SBEA (Snowball Endurance Algorithm) is a combination of ERCD protocol and a combined mobility and routing algorithm that can identify the cluster head and adjacent cluster head nodes.This algorithm is used to yield the network life time and the performance of the sensor nodes can be increased.

• 한국정밀공학회지
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• 제15권11호
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• pp.189-198
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• 1998

Recently, monitoring of tool life is a matter of common interesting because tool life affects precision, productivity and cost in machining process. Especially flank wear has a direct effect on cutting mechanism, so the various pattern of cutting force is obtained experimentally according to variation of wear condition. By investigating cutting force signal, AR(Autoregressive) modeling and correlation dimension analysis is conducted in turning operation. In this modeling and analysis, we extract features through 6th AR model, correlation integral and normalized correlation integral. After the back-propagation model of the neural network is utilized to monitor tool life according to flank wear. As a result. a very reliable classification of tool life was obtained.

• Journal of the Korean Data and Information Science Society
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• 제25권6호
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• pp.1207-1219
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• 2014

본 연구의 목적은 1) 보험전문가인 보험회사에 근무하는 임직원들이 가지고 있는 채널의 유형, 채널평가 항목, 보험 상품과 보험판매 시 요구되는 채널특성들간의 적합성에 대한 의견을 가지고 생명보험업계와 손해보험업계 각각 2-mode 소셜네트워크 데이터를 구성하고 2) 생명보험업계와 손해보험업계 2-mode 소셜 네트워크 데이터를 1-mode 소셜 네트워크 데이터로 변환하여 생명보험업계와 손해보험업계 두 소셜 네트워크의 구조와 네트워크 특성 변수들을 찾아 비교 분석하고, 소셜 네트워크 기반 측면에서의 생명보험사와 손해보험사의 판매채널 전략의 방향을 제시하고자 한다. 보험 판매채널의 평가에 의한 소셜 네트워크를 비교한 결과, 생명보험업계 소셜 네트워크가 손해보험업계 소셜 네트워크보다 더욱 강한 연결을 보였다. 즉 생명보험업계의 소셜 네트워크의 중심성 변수들이 손해보험업계의 것 들 보다 모두 높게 나타나 생명보험회사들은 채널전략 운영 측면에서 한 방향으로 움직이기가 수월함을 보이는 반면, 손해보험사들은 회사의 규모나 처한 환경에 따라 판매채널 전략이 다를 수 있어 각사의 개별적인 보험 판매 채널전략을 운영해야 함을 의미한다.

• IEIE Transactions on Smart Processing and Computing
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• 제5권3호
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• pp.185-192
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• 2016

Today, the Internet has penetrated almost all the ins and outs of social life, has changed work, communications, social influence and the lifestyle of humankind. However, it is still short of flexibility, transparency etc., due to network address translator overuse, masschanges, uncomfortable protocols, and so on. Hence, more research is necessary into future telecommunications networks based on contemporary networks accompanied by new requisitions and new designs that are compatible with today's and tomorrow's demands. This paper researches a new vision of the telecommunication network of the future, its effects on human life and society, and the targets to achieve a new generation network (NwGN). In the paper, we also propose orientation towards an NwGN from the current networks, especially with Vietnam's telecommunications networks.

• 정보통신설비학회논문지
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• 제10권3호
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• pp.86-91
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• 2011

Wireless sensor network (WSN) is a distributed self-organizing network which contains a large number of tiny multi-functional sensor nodes. The network life time is an important issue in WSN because every sensor node has a constraint on electric supply. In this paper, an energy consumption model is described and a GA-based algorithm will be used to optimize the energy consumption by analyzing the working model of sensor nodes. The model will provide an effective reference of working pattern for WSN. This algorithm is evaluated through analysis and simulations.