• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.34-63
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• 2003

Occupational and environmental exposure to manganese continue to represent a realistic public health problem in both developed and developing countries. Increased utility of MMT as a replacement for lead in gasoline creates a new source of environmental exposure to manganese. It is, therefore, imperative that further attention be directed at molecular neurotoxicology of manganese. A Need for a more complete understanding of manganese functions both in health and disease, and for a better defined role of manganese in iron metabolism is well substantiated. The in-depth studies in this area should provide novel information on the potential public health risk associated with manganese exposure. It will also explore novel mechanism(s) of manganese-induced neurotoxicity from the angle of Mn-Fe interaction at both systemic and cellular levels. More importantly, the result of these studies will offer clues to the etiology of IPD and its associated abnormal iron and energy metabolism. To achieve these goals, however, a number of outstanding questions remain to be resolved. First, one must understand what species of manganese in the biological matrices plays critical role in the induction of neurotoxicity, Mn(II) or Mn(III)? In our own studies with aconitase, Cpx-I, and Cpx-II, manganese was added to the buffers as the divalent salt, i.e., $MnCl_2$. While it is quite reasonable to suggest that the effect on aconitase and/or Cpx-I activites was associated with the divalent species of manganese, the experimental design does not preclude the possibility that a manganese species of higher oxidation state, such as Mn(III), is required for the induction of these effects. The ionic radius of Mn(III) is 65 ppm, which is similar to the ionic size to Fe(III) (65 ppm at the high spin state) in aconitase (Nieboer and Fletcher, 1996; Sneed et al., 1953). Thus it is plausible that the higher oxidation state of manganese optimally fits into the geometric space of aconitase, serving as the active species in this enzymatic reaction. In the current literature, most of the studies on manganese toxicity have used Mn(II) as $MnCl_2$ rather than Mn(III). The obvious advantage of Mn(II) is its good water solubility, which allows effortless preparation in either in vivo or in vitro investigation, whereas almost all of the Mn(III) salt products on the comparison between two valent manganese species nearly infeasible. Thus a more intimate collaboration with physiochemists to develop a better way to study Mn(III) species in biological matrices is pressingly needed. Second, In spite of the special affinity of manganese for mitochondria and its similar chemical properties to iron, there is a sound reason to postulate that manganese may act as an iron surrogate in certain iron-requiring enzymes. It is, therefore, imperative to design the physiochemical studies to determine whether manganese can indeed exchange with iron in proteins, and to understand how manganese interacts with tertiary structure of proteins. The studies on binding properties (such as affinity constant, dissociation parameter, etc.) of manganese and iron to key enzymes associated with iron and energy regulation would add additional information to our knowledge of Mn-Fe neurotoxicity. Third, manganese exposure, either in vivo or in vitro, promotes cellular overload of iron. It is still unclear, however, how exactly manganese interacts with cellular iron regulatory processes and what is the mechanism underlying this cellular iron overload. As discussed above, the binding of IRP-I to TfR mRNA leads to the expression of TfR, thereby increasing cellular iron uptake. The sequence encoding TfR mRNA, in particular IRE fragments, has been well-documented in literature. It is therefore possible to use molecular technique to elaborate whether manganese cytotoxicity influences the mRNA expression of iron regulatory proteins and how manganese exposure alters the binding activity of IPRs to TfR mRNA. Finally, the current manganese investigation has largely focused on the issues ranging from disposition/toxicity study to the characterization of clinical symptoms. Much less has been done regarding the risk assessment of environmenta/occupational exposure. One of the unsolved, pressing puzzles is the lack of reliable biomarker(s) for manganese-induced neurologic lesions in long-term, low-level exposure situation. Lack of such a diagnostic means renders it impossible to assess the human health risk and long-term social impact associated with potentially elevated manganese in environment. The biochemical interaction between manganese and iron, particularly the ensuing subtle changes of certain relevant proteins, provides the opportunity to identify and develop such a specific biomarker for manganese-induced neuronal damage. By learning the molecular mechanism of cytotoxicity, one will be able to find a better way for prediction and treatment of manganese-initiated neurodegenerative diseases.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.2
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• pp.35-48
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• 2016

Individual characteristics and entrepreneurship are important factors to determine entrepreneurial intentions. Despite this, little attention has been given to external factors, which effects to venture start-up decision. This study examines the relationship between individual characteristics and entrepreneurship by moderating effect of Hofstede's cultures dimensions theory. For this, 244 copies of the questionnaire were empirically analyzed. According to the results of analysis, internal locus of control, self-efficacy were found to have positive effects on autonomy, innovativeness, pro-activeness. In addition, uncertainty avoidance of Hofstede's cultures dimensions theory were found the moderating effects on entrepreneurship and entrepreneurial intentions. Therefore, this study suggests theoretical and practical implications, as below, according to the results. Firstly, pro-activeness take a important part on venture start-up. Thus, venture start-up institution and venture managers need to develop "venture education curriculum" that fostering the pro-activeness mind of entrepreneur. Secondly, In order to anticipate entrepreneurial intentions more precisely, analyzing the interaction between environmental variables and individual variables is desirable. Lastly, in the future study of entrepreneurship, the comprehensive analysis of correlation between the factors that including three factors of entrepreneurship is need to be conducted and more effective way of readdressing the entrepreneurship is necessary.

• Journal of dental hygiene science
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• v.15 no.1
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• pp.67-76
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• 2015

This study aims to determine the factors affecting the dental service utilization of adults. The subjects in this study were 455 adults, whom a survey was conducted form May 7 to June 7, 2013. Statistical verification conducted through PASW Statistics was 18.0. The difference in the distribution of independent variables related with the dental service utilization was verified with chi-square test. Relevant factors were determined using Hierarchical logistic regression analysis. Model I is predisposing factor, Model II is predisposing factor and enabling factor. Model III is predisposing, enabling, need factor. Andersen model factor which infuences dental service utilization of adults resulted that use dental floss (OR, 2.32; CI, 1.39~3.86), use electric toothbrush (OR, 2.98; CI, 1.0~8.89), use interdental brush (OR, 2.55; CI, 1.36~4.78), self-efficacy (OR, 0.68; CI, 0.48~0.96), barriers (OR, 1.45; CI, 1.04~2.04). Predisposing factor and need factor were found to be determinants for dental service utilization in adult.

• Journal of Korean Physical Therapy Science
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• v.9 no.4
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• pp.83-94
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• 2002

Within physical therapy education, there has been increased attention to curricula and course that emphasize problem solving, clinical reasoning, and synthesis of information across traditional discipline-specific boundaries. This article describes the development implementation, and outcomes of a problem-based learning course in Physical therapy. The course was designed to help students to integrate the various elements of a physical therapy curriculum and to enhance their abilities to respond to an ever-changing health care environment. An evaluation of the course by the first 50 students who completed it revealed both strengths and weaknesses. Students responded that the course enhanced their professional behavior, including interpersonal communication skills, team work, and follow-through with professional responsibilities. The learning package was developed by the authors and implemented to a college students during three weeks of the first semester of 2001. Most studies which conducted PBL module development were short period or temporary PBL package application and evaluation rather than a whole semester's. While, this study carried on partial integrated PBL curriculum development and application with recomposing content of the two subjects to one subject Physical therapy which includes four PBL packages. This package was developed from a simple concept to complex and partial integrated PBL curriculum application systematically variable learning methods such as discussion, practice, lecture, video. There are 2 classes, each class has 25 students, in the college. Each class has 5 small groups consisting 5 students. Two tutors proceeded discussion charging each class also, they used multiple methods and materials like tutorials, self-directed learning, lecture, and video. The package is 5 grades and 5 hours per week and the rate of discussion, lecture is 4, 1 respectively. One of the most change is the increase of interaction between students and tutors. Whenever students need information and suggestion, they can visit tutors who provide reading materials and guide for the direction of self learning. Therefore, this study describes the PBL package development process and application during one semester recomposing contents of two subjects to Physical therapy concepts. Besides, it will contribute to active application of existing each subject to tutors who intend to convert as PBL methods. The study has significant meaning to show potentiality of partially integrated PBL application, using systematic PBL package development from two subjects contents. However, when students' need of yearning is over the extent of Introduction of Physical therapy and Rehabilitation medicine, tutors should set learning extent. So, there is limitation to attain completely integrated PBL education within one subject, therefore, it is high lighted to proceed development of integrated curriculum to maximize learning effects of PBL. It is exected that partial integrated PBL package development and application will distribute to prosper excellent physiotherapist in practice.

• 한국노년학
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• v.41 no.3
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• pp.309-325
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• 2021

This study explored the differences in health information verification behavior according to digital literacy and health empowerment between elderly and non-elderly groups. Targeting a total of 1,000 people in the two groups, demographic characteristics according to digital literacy and health empowerment were investigated. Interestingly, this study found that elderly people fell primarily in the category of low digital literacy and high health empowerment. However, non-elderly people were frequently found in the high digital literacy and low health empowerment category. Also, our analyses found an interaction effect in digital literacy and health empowerment on health information verification behavior in the elderly group, while the main effect of health empowerment was verified in the non-elderly group. These results imply that the elderly need to improve both digital literacy and health empowerment, while the non-elderly need to focus on developing subjective confidence through health empowerment.

• Journal of the Society of Disaster Information
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• v.20 no.1
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• pp.156-168
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• 2024

Purpose: The trend of highway traffic accidents shows a repeating pattern of increase and decrease, with the fatality rate being highest on highways among all road types. Therefore, there is a need to establish improvement measures that reflect the situation within the country. Method: We conducted accident severity analysis using Random Forest on data from accidents occurring on 10 specific routes with high accident rates among national highways from 2019 to 2021. Factors influencing accident severity were identified. Result: The analysis, conducted using the SHAP package to determine the top 10 variable importance, revealed that among highway traffic accidents, the variables with a significant impact on accident severity are the age of the perpetrator being between 20 and less than 39 years, the time period being daytime (06:00-18:00), occurrence on weekends (Sat-Sun), seasons being summer and winter, violation of traffic regulations (failure to comply with safe driving), road type being a tunnel, geometric structure having a high number of lanes and a high speed limit. We identified a total of 10 independent variables that showed a positive correlation with highway traffic accident severity. Conclusion: As accidents on highways occur due to the complex interaction of various factors, predicting accidents poses significant challenges. However, utilizing the results obtained from this study, there is a need for in-depth analysis of the factors influencing the severity of highway traffic accidents. Efforts should be made to establish efficient and rational response measures based on the findings of this research.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.209-212
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• 2008

During several years, lots of industrial and individual products have been developed based on the text or graphic LCD module which has been gave the short developing period to the developer. With the advent of home networks and intelligent robots, the need for interaction between human and instruments has been increased. Recently, goods with a TFT-LCD come out. But in spite of a simple required performance, the complicated microprocessor, such as ARM processor, is required to interface the TFT-LCD and touch screen. Our research and development is to develope an embedded TFT-LCD module in order to use or apply to the goods through the simple interface by the general users as well as the developers. We adopt the RTOS(real time operating system) in order to operate TFT-LCD independently and various communication protocols are provided in order to offer the simple interface to users and developers.

• Journal of Digital Convergence
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• v.16 no.5
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• pp.267-276
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• 2018

The purpose of this study was to identify the categories and frequencies of communication of students in nursing simulation using standard patient. Data were collected through questionnaires and video recording of communication process of 41 nursing students in simulation related to pediatric enteritis from March to June, 2017. The data were analyzed the contents and frequencies of completed communication forms by trained researcher based on Interaction Process Analysis. In result, students used communication skills in task area frequently. Communication skills, such as orientation, open question, identification, giving information, opinion, and suggestion, and eye contact, were used frequently. In an uncomfortable atmosphere such as listening to the nursing client's complaints, students showed tension and stiff appearance. Students used high quality communication skills such as empathic understanding and therapeutic touch restrictively. In conclusion, we need education strategies relating to therapeutic communication for nursing professionalism and qualitative improvement of nursing service.

• The Journal of Korean Medicine
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• v.25 no.2
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• pp.165-172
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• 2004

Objectives: Warfarin is a representative anticoagulant, and it has been the preferred drug for treating thromboembolic diseases and preventing ischemic stroke. It should be administered in a delicate manner, because combined therapy with other drugs could affect the INR (International Normalized Ratio), thus bleeding tendency might occur. Interaction with herbal medicines still remains controversial. We aimed to examine the effect of herbal medicine on INR in patients being treated with warfarin. We aimed to examine the effect of herbal medicine on INR in the patients being treated with warfarin. Methods: We enrolled subjects being treated with a combined therapy of warfarin and herbal medicine from 1 October, 2002 to 20 November, 2003 at the Department of Cardiovascular & Neurologic Diseases (Stroke Center), Hospital of Oriental Medicine, Kyung Hee Medical Center. INR was monitored per 1 to 2 weeks and the significance of change was examined by Wilcoxon signed rank test or repeated measure analysis Results: Eighty-three subjects were included in the final analysis. As a whole, their INR was not significantly changed. There were only 9 cases in which INR changed more than 1.0; 7 showed increasing tendency, and 2 showed decreasing tendency of INR. Among the 9 cases, only 5 were suspected to have a relation to herbal medicine. Conclusions: We suggest that there was no strong evidence that herbal medicine has an influence on INR, but there is a need to perform further evaluation on larger samples to reach a concrete conclusion.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2004.11a
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• pp.69-71
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• 2004

The proton therapy of radiation therapy methods using Bragg Peak which is proton beam's characteristic dose distribution can give a normal tissue lower dose than cancer, comparing with the former existing radiation therapy methods. For exact treatment and patient' safety, we need to know proton beam's position in body, but a proton beam completely stops at treatment region and proton beam's range is uncertainly made by the variety of organs having each different density, so we aren't able to find a proton beam' position by suitable methods yet. With Monte Carlo Computing Method, as a result that we had simulated prompt gamma detection system using correlation of proton beam's absorbed dose distribution about water and prompt gamma distribution by nuclear interaction occurred by collisions of proton and water's hydrogen atoms, we could confirm that a proton beam's position was able to detect by using simulated prompt gamma detection system in body on the real-time