• Journal of Life Science
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• v.14 no.3
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• pp.385-390
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• 2004

Chitosan is abundant polysaccharide polymer in nature Chitosan has been the subject of much research regarding its potential as a nutritional adjunct and pharmaceutical ingredient. In the present study, we examined fracture-healing process with chitosan administration and low calcium diet in rats. Left femur was fractured and fixed with intramedullary pin. The rats were fed normal diet or low calcium diet and administered chitosan with the doses of 0, 50, 100 and 150ng/ml orally 5 times a week for 10 weeks. Soft X-ray and mechanical testing of all fractured femora was taken. Radiographical finding showed that the callus formation and process of fracture healing was present in all the fractured femora. Mechanical testing indicated that the maximum load and stiffness of femur in rat fed low calcium diet was lower than those of that in rat fed normal diet. No difference in maximum load and stiffness of fractured femora in chitosan treated rat were observed as compared to vehicle treated rat. Chitosan or/and low calcium diet did not affect the ratio of fractured/unfractured femur about maximum load and stiffness. The results suggest that chitosan dose not affect the bone mechanical strength and the process of fracture healing. Low calcium diet does decrease the bone mechanical strength.

• Journal of the Korean Institute of Intelligent Systems
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• v.25 no.1
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• pp.7-14
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• 2015

To implement an automatic picking system (APS) in distribution center with high precision and high dynamics, this paper presents a high gain observer-based robust speed controller design for a linear induction motor (LIM) drive. The force disturbance as well as the mechanical parameter variations such as the mass and friction coefficient gives a direct influence on the speed control performance of APS. To guarantee a robust control performance, the system uncertainty caused by the force disturbance and mechanical parameter variations is estimated through a high gain disturbance observer and compensated by a feedforward manner. While a time-varying disturbance due to the mass variation can not be effectively compensated by using the conventional disturbance observer, the proposed scheme shows a robust performance in the presence of such uncertainty. A Simulink library has been developed for the LIM model from the state equation. Through comparative simulations based on Matlab - Simulink, it is proved that the proposed scheme has a robust control nature and is most suitable for APS.

• Knowledge Management Research
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• v.21 no.3
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• pp.105-121
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• 2020

With regard to the development of new drugs, what is most important for a Korean Biotech, where no global sales network has been established, is decision-making related to out-licensing of new drugs. The probability of success for each clinical phase is different, and the licensing amount and its royalty vary depending on which clinical phase the licensing contract is made. Due to the nature of such a licensing contract and Biotech's weak financial status, it is a very important decision-making issue for a Biotech to determine when to license out to a Big Pharma. This study defined a model called 'optimal timing for out-licensing of new drugs' and the results were derived from the decision tree analysis. As a case study, we applied to a Biotech in Korea, which is conducting FDA global clinical trials for a first-in-class new drug. Assuming that the market size and expected market penetration rate of the target disease are known, it has been shown that out-licensing after phase 1 or phase 2 of clinical trials is a best alternative that maximizes Biotech's profits. This study can provide a conceptual framework for the use of management science methodologies in pharmaceutical fields, thus laying the foundation for knowledge and research on out-licensing of new drugs.

• Applied Chemistry for Engineering
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• v.23 no.5
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• pp.450-455
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• 2012

The paper includes the utlization of an activated carbon as a potential adsorbent to remove a hazardous fluorescein dye from an aqueous solution. Batch adsorption experiments were carried out for the removal of fluorescein dyes using a granular activated carbon as an adsorbent. The effects of various parameters such as pH, amount of adsorbent, contact time, initial concentration and temperature of the adsoprtion system were investigated. The experimental results revealed that activated carbon exhibit high efficiencies to remove fluorescein dyes from the aqueous solution. The equilibrium process can be well described by Freundlich isotherm in the temperature range from 298 K to 318 K. From adsorption kinetic experiments, the adsorption process followed a pseudo second order kinetic model, and the adsorption rate constant ($k_2$) decreased with increasing the initial concentration of fluorescein. The free energy of adsorption ${\Delta}G^0$), enthalpy ${\Delta}H^0$), and entropy (${\Delta}S^0$) change were calculated to predict the nature adsorption. The estimated values for ${\Delta}G^0$ were -17.11~-20.50 kJ/mol over an activated carbon at 250 mg/L, indicated toward a spontaneous process. The positve value for ${\Delta}H^0$, 33.2 kJ/mol, indicates that the adsorption of fluorescein dyes on an activated carbon is an endothermic process.

• International Commerce and Information Review
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• v.14 no.2
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• pp.249-269
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• 2012

The focus of our work is to identify and understand the drivers of alliance performance so that businesses can maximize their chances of a successful alliance-an area that has received little attention in empirical modeling. Although both conceptual and applied research on alliances has increased, an empirically tested comprehensive theoretical model that explains alliance performance has yet to be developed. Using five salient perspective, namely market power theory, transaction cost theory, the resource-based view, institutional theory, real option theory, this paper attempts to provide a theoretical rationale linking motives of global alliance networks on firm's capabilities, partner's capabilities, operating structures, and performances of Korean companies. The key contribution of this study is that it paints a picture of what matters in driving alliance performance. Our work shows the complex nature of driving performance and the interplay of firm's capabilities, partner's capabilities, and operating structures for understanding alliance performances. This study has given us a small but significant step forward towards understanding the intricacies of alliance performance. We are now better able to understand the respective roles played by various alliance factors and derive insights that lead to improved alliance performance.

• Journal of Korea Water Resources Association
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• v.56 no.3
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• pp.225-233
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• 2023

Urban rivers and their surrounding environments have been altered due to factors such as rapid economic growth and urban development. This alteration have caused the rivers to lose their original value and become exposed to various pollution, resulting decrease in citizens' quality of life. This study aims to estimate citizens' Willingness To Pay (WTP) for water quality improvement in Suyeong River in Busan. To estimate the non-market value of the Suyeong River, the WTP of Busan citizens for water quality improvement was estimated, applying Contingent Valuation Method (CVM). The WTP for improving the water quality from Grade 4(polluted water) to Grade 2(game fish like bass can live in it) was estimated using the water quality ladder concept of the US Environmental Protection Agency, assuming annual donations for five years. For the CVM, the logistic distribution and Spike Model were adopted. As a result, citizens residing in the surrounding area of Suyeong River expressed a higher WTP. Considering more than half of the Busan citizens are aware of the "conservation of nature and ecosystems" as a major function of the Suyeong River, this higher WTP could serve as a basis for improving the value of urban rivers.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4D
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• pp.469-476
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• 2008

Recently, TOD gains popularity as a traffic solution measure of high density urban regeneration projects. The purpose of this study is to investigate traffic impacts of high density TOD projects, and to identify the issues to be resolved. For a case study, it chooses Gangnamgucheong station in Gangnam area served by two subway lines, and designates 400m radius from the station as a site for high-density development. The MOEs chosen for this study is traffic volume, time, distance, speed, and mode share. The SECOM model is adopted for traffic simulation. The analysis results show that high-density TOD is an effective tool for traffic improvement even with only one station area being implemented. It is found that the traffic volume increases near the station in nature where high-density development occurs, but it declines overall in the rest of Gangam area. The total travel time and distance of passenger vehicles decline, meaning that the traffic condition becomes better than before. With regulation on parking supply, the improvement becomes more vivid. In terms of the changes of traffic speed, both alternatives show 4.1% increase in speed, but the difference between alternatives is not quite noticeable because of the induced vehicle demand driven to the streets with improved traffic condition. The mode share changes occur for the benefit of subway ridership, because the study station is equipped with two subway line services. When mixed with parking supply restriction, the impact becomes clearer.

• The Journal of the Convergence on Culture Technology
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• v.10 no.4
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• pp.169-174
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• 2024

This study purports to identify the factors that contribute to the classification of age groups or generations of Koreans. Independent variables such as respondents' attitudes toward welfare, attitudes toward equity, education level, perception of inequality in Korean society, tax awareness, and health status are included in the model that were put into the analysis with the main interest. Since this study does not construct any hypothesis prior to analysis, the nature of this study can be said exploratory. The data utilized for the analysis are from the 17th year of the Korean Welfare Panel collected in 2022, and a linear discrimination analysis technique will be used. First and foremost, a theoretical review of the generational classification will be conducted through domestic and international literature in the past. To date, there is no quantitative studies in Korea that have a significant influence on the generational classification. Therefore, in this study, a theoretical review of political tendencies and values, which are estimated to have a significant influence on the generational classification, that is, the difference between generations, will be significant. The perception and attitude toward welfare will be discussed in the review of values. Next, analysis models, analysis techniques, and variables to be used in the analysis will be introduced. After

• Journal of The Korean Association For Science Education
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• v.25 no.3
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• pp.400-410
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• 2005

According to the cognitive conflict process model, student anxiety factor is known to have both positive and negative effects on student response behaviors in a conflict situation for conceptual change learning. However, there is little research that reveals what type of anxiety, either constructive or destructive, is related when conducting step-by-step experiments to resolve cognitive conflicts. This study attempted to learn the characteristic of explanatory hypothesis according to anxiety type after conducting five step-by-step experiments related to action and reaction concept. Results found that students who belonged to the types of 'conviction in logical misconception', 'insisting on additional variables', and 'reasonable modification' suggested explanatory hypothesis close to physical nature. On the other hand, those who showed the other five types of anxiety ('compatible predictions', 'dependence on others', 'fusion of past experience', 'lack of confidence', and 'conflict with past experience') suggested temporary supported hypothesis or simple explanatory hypothesis according to student intuition and simple observation. These results indicate that students in the above-mentioned five categories need more external interactions with instructors based on the type of anxiety related to student behavior. In addition, the results present student characteristics which instructors should be more attentive to when using step-by-step experiments to resolve cognitive conflicts.

• Korean Journal of Social Welfare
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• v.37
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• pp.357-379
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• 1999

In recent years, the subject of peer rejection in school settings has received increased attention in the massmedia and counseling literature. This study focused on the effect of individual and environmental factors on peer rejection. Dependent variable was the number of perpetrating peer rejection and independent variables were psychological, behavioral, familial factors, exposure of peer rejection and perception about school policies. Ordered Probit model was employed because of the nature of limited dependent variable. The data were collected from 714 middle-school student in Seoul. Major findings were as follows. First of all, the adolescents who has aggression and problematic behaviors in school were more likely to participate in peer rejection. Second, negative parent-children relationships and the family structure didn't have significant effects on peer rejection. And there were not a significant effect of attitude toward academic value and academic achievement on peer rejection. Third, environmental risk factors such as negative peer relationship and the exposure to rejection had a significant increasing effect on peer rejection. But consistent school policies didn't have a significant effect. In conclusion, this study confirmed that peer rejection in school settings was affected by school environment such as negative-peer relationship, and exposure to rejection. Therefore, comprehesive and systematic intervention programs should be required to ensure that all the pupils at school have a right to learn in a safe and fear-free environment.