• Molecules and Cells
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• v.43 no.6
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• pp.539-550
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• 2020

Glioblastoma multiforme (GBM) is a fatal malignant tumor that is characterized by diffusive growth of tumor cells into the surrounding brain parenchyma. However, the diffusive nature of GBM and its relationship with the tumor microenvironment (TME) is still unknown. Here, we investigated the interactions of GBM with the surrounding microenvironment in orthotopic xenograft animal models using two human glioma cell lines, U87 and LN229. The GBM cells in our model showed different features on the aspects of cell growth rate during their development, dispersive nature of glioma tumor cells along blood vessels, and invasion into the brain parenchyma. Our results indicated that these differences in the two models are in part due to differences in the expression of CXCR4 and STAT3, both of which play an important role in tumor progression. In addition, the GBM shows considerable accumulation of resident microglia and peripheral macrophages, but polarizes differently into tumor-supporting cells. These results suggest that the intrinsic factors of GBM and their interaction with the TME determine the diffusive nature and probably the responsiveness to non-cancer cells in the TME.

• Journal of Korean Elementary Science Education
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• v.24 no.5
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• pp.558-570
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• 2005

The importance of teaching the nature of science (NOS) has been always emphasized in science education. However, the NOS is hardly taught in elementary science class. We are lacking in the strategies and materials for teaching NOS. So we designed the science drama teaching, and investigated the effects on pupils' perceptions about NOS. The subjects of this study were 185 third graders from a elementary school. The treatment group was provided with science drama lessons and the control group was provided with traditional lecture-type lessons. Their perceptions about NOS were investigated before/after the science lessons and after 3 months following them, and both of two groups were compared. The pretest results revealed that the pupils of both groups were found to have similar views on NOS. Dey had traditional views of the most items except for social construction of theories, mathematical knowledge and decision-making. After science lessons, they tended to change their views toward modem views, but the pupils of the treatment group showed more modem views than those of the control group on the observation, model, social construction of theories, predictions. After 3 months, the pupils of the control group tended to come back to their traditional views, but those of the treatment group showed tendencies that their changed views were kept up on the observation, scientific model, scientific knowledge, scientific methods, decision-making, social construction of theories, mathematical knowledge. Therefore this study suggests that science drama teaching could be one of the effective ways for teaching NOS.

• Proceedings of the KSR Conference
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• 2006.11b
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• pp.170-173
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• 2006

Requirement management is an essential process that has a significant influence on the project success. Due to the evolutionary development nature of requirement, the effective management for requirement must include change process and configuration control. This paper describes how to implement effective requirement management process to the Korea Tilting Train eXpress development with the application of a model based systems engineering tool.

• Proceedings of the KIEE Conference
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• 2001.07c
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• pp.1606-1608
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• 2001

In connection with the monitoring of the insulation degradation of the large power apparatus, a statistical treatment, such as phase resolved partial discharge analysis (PRPDA) has been established for the on-line monitoring system during the past two decades. However, it has shown some inconveniences to distinguish the nature of the PD source in power apparatus. In this regard, a novel approach based on the chaotic analysis(CAPD) is proposed describing the fundamental ideas, outcomes and different view points from conventional PRPDA. In order to make a model for the possible defects causing sudden failures in service, several types of specimen were prepared. And partial discharge signals, originated from those samples, were measured and analyzed by means of PRPDA and CAPD respectively. In this paper, it seems that the correlation between the consecutive PD pulses depending on the nature of PD could be investigated by CAPD. Therefore, it could be considered that the nature of PD source can be distinguished more distinctively when the PRPDA is combined with CAPD.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.05c
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• pp.221-224
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• 2001

In connection with the monitoring of insulation degradation of large power apparatus in order to predict their unexpected service failures, a statistical treatment, such as phase resolved partial discharge analysis(PRPDA), has been established for the on-line monitoring system during the past decades. However, this method has shown some inconveniences to distinguish the nature of the PD source in power apparatus. In this regard, a novel approach based on the chaotic analysis(CAPD) is proposed describing the fundamental ideas, outcomes and different view points from conventional PRPDA. In order to make a model for the possible defects causing sudden failures in service, several types of specimen were prepared. And partial discharge signals, originated from those samples, were measured and analysed by means of PRPDA and CAPD respectively. Throughout this paper, it seems that the correlation between the consecutive PD pulses depending on the nature of PD could be investigated by CAPD. Therefore, it could be considered that the nature of PD source can be distinguished more distinctively when the PRPDA is combined with CAPD.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.30 no.2
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• pp.131-139
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• 1985

Breeders have concerned with the nature of gene action controlling the duration of grain filling period to combine early maturity and acceptable grain yield to fit wheat into multiple cropping systems. The 4 x 4 complete diallel set of F$_1$, F$_2$ and 1/2 (BC$_1$ + BC$_2$) in crosses of winter and spring wheat cultivars was made to determine the nature of gene action involved for duration of grain filling period. Using the Jinks-Hayman model, no maternal effects were noted nor were any non-allelic interactions observed for total duration of grain filling and lag period. The actual grain filling period was influenced to some degree by such interactions. The spring cultivars Red Bobs and Siete Cerros also appeared to have more dominant genes for longer total duration of grain filling and lag period. In contrast, the winter parents Yamhill and Hyslop had more dominant genes for the longer actual grain filling period. The genes appeared to be independently distributed among the parents.

• Journal of Korean Society of Archives and Records Management
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• v.21 no.3
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• pp.1-16
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• 2021

Record continuum is a theory providing the basis for archival science in the paradigm shift to the electronic record environment. However, critical analysis of it has been hardly performed so far, as it is still in development, and its core is a new perspective on records different from the life cycle model. Therefore, for further understanding of the significance and limitations of record continuum in the electronic record environment and performance of more in-depth theoretical development, an analysis of the meaning and nature of records contained in record continuum logic is essential. Given that record continuum does not define a record separately, the meaning and nature of records it contains in the recent electronic record environment are examined through the analysis of axis and dimension in a record continuum model.

• Journal of People, Plants, and Environment
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• v.24 no.6
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• pp.551-561
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• 2021

Background and objective: Vietnam is prioritizing agricultural production for food export capacity in all national policies. As a result, for three decades, its agriculture has been making quite many remarkable achievements. Methods: The most successful one is that the nation has become one of the world's leading rice exporters and ensures its national food security. Through these endeavors, the Mekong River Delta (MRD), in particular, has emerged as a key region in ensuring national food security and rice export. Results: The new era can now see Vietnamese agriculture turning to place special emphasis on commodity quality and the improvement of the living environment. This is evidenced, for example, by the phenomenon that the MRD, as a rice basket of the whole country, is making moves back to nature-based agriculture with attempts to restore the natural ecology, including preserving and restoring local traditional rice seeds, adopting natural farming practices and minimizing the use of chemical fertilizers and pesticides. Conclusion: The case studies of nature-based farming practices in the MRD indicate that, while the national agriculture is generally developing large-scale production, the small-scale farming in the region, integrated with tourist and educational activities on-site, is meeting the demands of a highly potential domestic niche market. Moreover, this model appears to be a sustainable farming approach that defines itself as a working green livelihood for the region.

• Journal of Wetlands Research
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• v.21 no.4
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• pp.267-280
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• 2019

Adaptive Management (AM) is one of the best available approaches for managing natural resources in the presence of uncertainty. In spite of the limitations, AM has been widely applied in nature resource management policies and plans internationally, while application of AM in nature resource management in Korea is limitedly used. Accordingly, this study reviews application of AM in nature resource management research in Korea with respect to its definitions, procedures, impediments and considerations. The present study also reviews recent ecological modelling studies which is an essential component of AM approach. Finally, management of artificial sea forest, coastal wetlands and fisheries are suggested as the recommended fields to adopt AM.

• KIEAE Journal
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• v.10 no.5
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• pp.23-30
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• 2010

The residence means a given place. It is repeated that process of overcome, protection, assimilation and adaptation has applied to environmental condition. Architecture is part of environment and various. Thus there are lots of types. We need the place with uniqueness, and it is suitable for biological and humanistic environment. The living space turned to be meaningful place with design, and people start to live with nature together. Therefore design restructures whole environment and makes people to be closed with nature. We have to understand nature of environment to connect one place with the other place, and people start to put down roots certain place. Coping with social needs, we have to develop the architectural alternative which can be applied to natural condition. This study suggest sound high-density urban residential model as it function social mix.