• Asian-Australasian Journal of Animal Sciences
• /
• 제28권11호
• /
• pp.1662-1668
• /
• 2015

We investigated differences between effects of natural- and bucket-suckling methods on basal serum oxytocin (OT) and cortisol concentrations, and the effect of OT concentration on affiliative and investigative behavior of calves to a novel object. Ten Japanese Black calves, balanced with birth order, were allocated evenly to natural-suckling (NS) and bucket suckling (BS) groups. Blood samples were collected at the ages of 1 and 2 months (1 week after weaning) calves, and serum OT and cortisol concentrations were measured using enzyme-linked immunosorbent assay and enzymeimmunoassay tests, respectively. Each calf at the age of 2 months (2 weeks after weaning) was released into an open-field with a calf decoy, and its investigative and affiliative behaviors were recorded for 20 minutes. In 1-month-old calves, the basal serum OT concentration ($25.5{\pm}4.9$ [mean${\pm}$standard deviation, pg/mL]) of NS was significantly higher than that of BS ($16.9{\pm}6.7$) (p<0.05), whereas the basal cortisol concentration ($5.8{\pm}2.5$ [mean${\pm}$standard deviation, ng/mL]) of NS was significantly lower than that in BS ($10.0{\pm}2.8$) (p<0.05). Additionally, a negative correlation was noted between serum OT and cortisol concentrations in 1-month-old calves (p = 0.06). Further, the higher serum OT concentration the calves had at 1 month old, the more investigative the calves were at 2 months old but not affiliative in the open-field with a calf decoy. Thus, we concluded that the natural suckling method from a dam elevates the basal serum OT concentration in calves, and high serum OT concentrations induce investigative behavior and attenuate cortisol concentrations.

• 공학교육연구
• /
• 제15권5호
• /
• pp.98-107
• /
• 2012

As the dropout rate of university students is gradually increasing, the studies on exploring the status, characteristics, reasons, and countermeasures of dropout of university students are currently grabbing high attention. This paper analyzes the relationship between the admission types and dropout of university students, mainly focused on engineering students. The analysis shows that the dropout rate of engineering students admitted through the scheduled-time admission procedures is quite higher than that of students admitted through non-scheduled-time admission procedures, the dropout rate of engineering students admitted from the vocational high schools is higher than that of students from the academic high schools, and the dropout rate of engineering students admitted from the liberal art high school tracks is higher than that of students from the natural science high school tracks. From the results, we could find out that student-support programs need to be carefully provided for the engineering university students according to their admission types and underlying backgrounds.

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2006년도 한국약용작물학회 공동춘계학술발표회
• /
• pp.578-579
• /
• 2006

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권24호
• /
• pp.10557-10563
• /
• 2015

It is well known that conventional chemotherapy and radiation therapy can result in toxicity to both normal cells and tumor cells, which causes limitations in the application of these therapeutic strategies for cancer control. Novel and effective therapeutic strategies for cancers with no or low toxicity for normal cells are a high priority. Therefore, natural products with anticancer activity have gained more and more attention due to their favorable safety and efficacy profiles. Pre-clinical and clinical studies have demonstrated that several representative natural compounds such as resveratrol, epigallocatechin-3-gallate, curcumin, allicin and ginsenosides have obvious anticancer potential. In this article, we summarize autophagy-associated targeting pathways of such natural products for inducing the death of cancer cells, and discuss the core autophagic pathways involved in cancer treatments. Recent advances in the discovery, evaluation and exploitation of natural compounds as therapeutic agents for cancers will provide references and support in pre-clinical and clinical application of novel natural drugs for the treatment of primary and metastatic tumors in the future.

• Clinical and Experimental Reproductive Medicine
• /
• 제43권1호
• /
• pp.15-25
• /
• 2016

Objective: In the present study, we aimed to evaluate the effects of high doses of dexamethasone (DEX) in early pregnancy on pregnancy outcomes. Methods: Pregnant BALB/c mice were treated with high-dose DEX in the experimental group or saline in the control group on gestational days (GDs) 0.5 to 4.5. Pregnant mice were sacrificed on GDs 7.5, 13.5, or 18.5 and their peripheral blood, placentas, fetuses, and uterine tissue were collected. Decidual and placenta cell supernatants were examined to evaluate the effect of DEX on the proliferation of mononuclear cells, the quantity of uterine macrophages and uterine natural killer (uNK) cells, and levels of progesterone and $17{\beta}-estradiol$, as determined by an 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay, immunohistochemistry, and enzyme-linked immunosorbent assay, respectively. We also were measured fetal and placental growth parameters on GD 18.5. Results: We found that high doses of DEX were associated with an increased abortion rate, enhancement of the immunosuppressive effect of the decidua, alterations in placental growth parameters, decreased progesterone and $17{\beta}-estradiol$ levels, and a reduced frequency of macrophages and uNK cells. Conclusion: Our data suggest that the high-dose administration of DEX during early pregnancy negatively affected pregnancy outcomes.

• 한국공간구조학회논문집
• /
• 제17권1호
• /
• pp.93-100
• /
• 2017

With increasing number construction of high-rise building which has about 40 to 60 floors there have been many kinds of problem which related with usage from vibration. To predict response acceleration, it is important to assess correct natural frequency. However, due to the noise of MEMS sensor, it is difficult to measure dynamic characteristic such as natural frequency when measuring ambient vibration using MEMS sensor within cell phone. Therefore, a comparative analysis on vibration measuring applications was performed after measuring ambient vibration of 2 skyscrappers which have height between 133.5~244.3m that are located in Seoul and Observation tower using I-jishin APP with noise reduction function of MEMS sensor in order to verify the effectiveness of low noise type vibration measurement APP.

• 한국수학교육학회지시리즈D:수학교육연구
• /
• 제1권1호
• /
• pp.95-106
• /
• 1997

Even though there are extracurricular mathematics classes for gifted students in all levels of schools in Korea, teachers cannot conduct the classes properly because the contents of the textbook are not adequate for the purpose of the classes. So, what they tend to do in the classes is just drilling with many problems which have already shown up at university entrance examinations and various mathematics competitions. The purpose of this paper is to give an example of what the content should be in "Mathematics III" (an elective subject for the science high school students according to the fifth and sixth amendment of national curriculum) and to suggest how to design the extracurricular classes for gifted students. Extracurricular classes of the ordinary secondary school as well as the elective course for the science high school can be suitably designed with choices of topics in the contents of Mathematics III.

• Journal of applied mathematics & informatics
• /
• 제32권5_6호
• /
• pp.783-790
• /
• 2014

Most distance functions, including taxicab distance, are defined on Cartesian plane, and recent studies on distance functions have been mainly focused on Cartesian plane. However, most streets in cities include not only straight lines but also curves. Therefore, there is a significant need for a distance function to be defined on a curvilinear coordinate system. In this paper, we define a new function named polar taxicab distance, using polar coordinates. We prove that this function satisfies the conditions of distance function. We also investigate the geometric properties and classifications of circles in the plane with polar taxicab distance.

• Korean Journal of Mathematics
• /
• 제22권3호
• /
• pp.567-581
• /
• 2014

Over the years, there has been much research conducted on quadratic curves and the set of points with the generalized notion of eccentricity in a plane with metrics such as taxicab distance or Chinese-checker distance. On the other hand, polar taxicab distance has been newly proposed on the polar coordinate system, a type of curvilinear coordinate system, to overcome the limitation of pre-existing metrics in terms of describing curved routes. Previous study has looked into the fundamental properties of this metric. From this point of view, we study the quadratic curves and the set of points with the generalized notion of eccentricity in a plane with polar taxicab distance.

• Journal of Microbiology and Biotechnology
• /
• 제31권10호
• /
• pp.1438-1445
• /
• 2021

A bifunctional glycoside hydrolase GH78 from the ascomycete Xylaria polymorpha (XpoGH78) possesses catalytic versatility towards both glycosides and esters, which may be advantageous for the efficient degradation of the plant cell-wall complex that contains both diverse sugar residues and esterified structures. The contribution of XpoGH78 to the conversion of lignocellulosic materials without any chemical pretreatment to release the water-soluble aromatic fragments, carbohydrates, and methanol was studied. The disintegrating effect of enzymatic lignocellulose treatment can be significantly improved by using different kinds of hydrolases and phenoloxidases. The considerable changes in low (3 kDa), medium (30 kDa), and high (> 200 kDa) aromatic fragments were observed after the treatment with XpoGH78 alone or with this potent cocktail. Synergistic conversion of rape straw also resulted in a release of 17.3 mg of total carbohydrates (e.g., arabinose, galactose, glucose, mannose, xylose) per gram of substrate after incubating for 72 h. Moreover, the treatment of rape straw with XpoGH78 led to a marginal methanol release of approximately 17 ㎍/g and improved to 270 ㎍/g by cooperation with the above accessory enzymes. In the case of beech wood conversion, the combined catalysis by XpoGH78 and laccase caused an effect comparable with that of fungal strain X. polymorpha in woody cultures concerning the liberation of aromatic lignocellulose fragments.