• Title/Summary/Keyword: natural products

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Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton

  • Tanjung, Mulyadi;Tjahjandarie, Tjitjik Srie;Mardhiyyah, Shola;Rahman, Ghinsha Zakatina;Aldin, Muhammad Fajar;Saputri, Ratih Dewi;Ahmat, Norizan
    • Natural Product Sciences
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    • v.28 no.1
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    • pp.40-43
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    • 2022
  • Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1-3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 μM.

Analysis of the Conditions and Products of Natural Dyeing Internet Shopping Malls (천연염색전문 인터넷 쇼핑몰 현황 및 상품 분석)

  • Lee, Mi-Suk;Chung, Kyung-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.34 no.7
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    • pp.1205-1219
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    • 2010
  • This study analyzes the conditions and products of internet shopping malls that sell natural dyeing products. In this study, 98 natural dyeing internet shopping malls were selected. The results of this study are as follows. The locations of the internet shopping malls were Gyeonggi-do, Seoul, Jeollanam-do, Gyeongsangbuk-do, Gwang-ju (city), Daegu (city), Busan (city), Gyeongsangnam-do, and Jeju-do. The most frequent dyes of the natural dyeing products were loess, followed by charcoal, indigo, and persimmon. Indigo was most frequently used in Seoul, with loess and charcoal most frequent in Gyeonggi-do. Persimmon, indigo, loess, and charcoal were mainly used in Jeollanam-do, with persimmon and loess in the Gyeongsangbuk-do, and persimmon in Jeju-do. The highest ordered product categories were accessories, followed by adult clothing, interior decoration products, and bedding. The most frequent products were bedclothes, followed by scarves, female shirts, blouses, pillows, female jackets, and vests. Regarding the price of products, 150,000-200,000 won was the highest for the Saenghwal Hanbok, with 10,000-30,000 won for underwear, 30,000-60,000 won for accessories, and 100,000-150,000 won for bedding. Concerning product information, 58.2% of internet shopping malls offer the product size and almost half of them did not show the properties or directions for handling the product. Based on the research results, the problems of the conditions and products of natural dyeing internet shopping mall were derived. The results show that the natural dyes of internet shopping malls lacked regional symbolism, the products were not specialized, and product information was not fully offered to consumers. To solve these problems, the strategies for marketing the promotion of the natural dyeing internet shopping mall were, ‘Using natural dyes from local resources’, ‘Market oriented and specialized item design’, and ‘Offer right product information’.

Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators

  • Han, Yujia;Liu, Jingjing;Ahn, Sungjin;An, Seungchan;Ko, Hyejin;Shin, Jeayoung C.;Jin, Sun Hee;Ki, Min Won;Lee, So Hun;Lee, Kang Hyuk;Shin, Song Seok;Choi, Won Jun;Noh, Minsoo
    • Biomolecules & Therapeutics
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    • v.28 no.5
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    • pp.397-404
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    • 2020
  • Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.

Study on The Anti-HSV(Herpes Simplex Virus) Activity of Natural complex Products (한약 탕제를 이용한 항 Herpes virus 제제의 개발 연구)

  • Park, Kap-Joo;Kang, Bong-Joo;Shin, Soon-Shik;Nam, Bong-Hyun;Kim, Nam-Joo
    • Korean Journal of Oriental Medicine
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    • v.1 no.1
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    • pp.495-508
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    • 1995
  • In order to search for anti-HSV agents from natural complex products, we extended the number of specimens. Both methanol extract and boiling water extract of the natural complex products were screened to detect anti-HSV activity by MTT assay. Anti-HSV activities of thirteen natural complex products extracted by methanol and boiling water were screened. Three of 13 natural complex products extracted by methanol showed efficacy against HSV. Natural complex products showing anti-HSV activities as methanol extracts were No.3, 6, 11 and their Sl were 323.809, 2811.041 and 708.20. As water boiling extracts, No.8 and No.11 have displayed Sl of 16.45 and 60.39 respectively. Especially anti-HSV activities of natural complex products extracted by methanol No.6 was stronger than other ones.

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Sleep-Aids Derived from Natural Products

  • Hu, Zhenzhen;Oh, Seikwan;Ha, Tae-Woo;Hong, Jin-Tae;Oh, Ki-Wan
    • Biomolecules & Therapeutics
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    • v.26 no.4
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    • pp.343-349
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    • 2018
  • Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural products with minimal unwanted effects have been preferred for the treatment of acute and/or mild insomnia, with additional benefits of overall health-promotion. Basic and clinical researches on the mechanisms of action of natural products have been carried out so far in insomnia treatments. Recent studies have been focusing on diverse chemical components available in natural products, with an interest of developing drugs that can improve sleep duration and quality. In the last 15 years, our co-workers have been actively looking for candidate substances from natural products that can relieve insomnia. This review is, therefore, intended to bring pharmacological data regarding to the effects of natural products on sleep duration and quality, mainly through the activation of $GABA_A$ receptors. It is imperative that phytochemicals will provide useful information during electroencephalography (EEG) analysis and serve as an alternative medications for insomnia patients who are reluctant to use conventional drugs.

Flavonoid Constituents and Their Antioxidant Activity of Laportea bulbifera Weddell (혹쐐기풀의 Flavonoid 성분 및 항산화 효과)

  • Yang, Min-Cheol;Choi, Sang-Zin;Lee, Sung-Ok;Chung, Ae-Kyung;Nam, Jung-Hwan;Lee, Kyu-Ha;Lee, Kang-Ro
    • Korean Journal of Pharmacognosy
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    • v.34 no.1 s.132
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    • pp.18-24
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    • 2003
  • The repeated column chromatographic separation of the MeOH extract of Laportea bulbifera Weddell resulted in the isolation of five flavonoids. Structures of the isolated compounds have been identified as $isorhamnetin-7-O-{\alpha}-L-rhamnoside$ (1), $isorhamnetin-3-O-{\alpha}-L-rhamnoside$ (2), $isorhamnetin-3,7-O-{\alpha}-L-dirhamnoside$ (3), $isorhamnetin-3-O-{\alpha}-L-rhamnopyranosyl-(1{\rightarrow}2)-{\beta}-galactopyranoside$ (4), $isorhamnetin-3-O-{\alpha}-rhamosyl-(1{\rightarrow}2)-rhamnoside$ (5) by spectroscopic means.