• 한국산림과학회지
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• 제86권1호
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• pp.25-34
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• 1997

지구상의 잠재삼림면적을 추정하기 위한 일련의 단계로서, 적정한 식생도제작(Global Natural Vegetation Mapping, GNVM) 시스템을 선발하기 위해, Light Climatic Dataset(LCD)에 지형을 고려하지 않은 단순 시스템, LCD에 지형을 고려한 시스템, Heavy Climatic Dataset(HCD)에 지형을 고려한 시스템을 구축하고 상호 비교하였다. 3종류의 GNVM시스템은, 세계에서 관찰된 기후데이타를 구면보간법에 의해 지구면 전체의 $1^{\circ}{\times}1^{\circ}$의 격자점에 대하여 이것을 추정하고, 그 추정치로부터 식생을 구분하며, 구분의 결과를 가지고 잠재자연식생도의 출력 및 잠재자연식생의 면적을 산출한다. 3종류의 GNVM시스템을 비교한 결과, LCD에 지형을 고려한 GNVM 시스템이 잠재자연식생의 분포를 가장 잘 표현하였으며, 단순 시스템은 지형을 고려한 시스템들에 비해 온난한 지역을 과대평가하고 한랭지 및 사막지역을 과소평가하는 경향을 나타냈다. 한편, 측후소의 수에 따른 시스템간에 있어서는 HCD에 지형을 고려한 시스템이 측후소의 과밀분포로 인해 LCD에 지형을 고려한 시스템보다 습윤지역의 과대평가와 건조지역의 과소평가를 나타냈다.

• 대한토목학회논문집
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• 제43권6호
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• pp.699-708
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• 2023

원자력 발전소는 안전하게 운영될 수 있도록 설계단계에서 자연재해를 포함한 예상 가능한 모든 외부사건들이 고려되고 있다. 그러나 최근에 기후변화로 인해 설계를 초과하는 자연재해의 발생 가능성이 증가하면서 설계 당시에 예측하지 못했던 극한자연재해와 외부사건에 대해 세심한 검토가 요구되고 있다. 본 연구에서는 국내 원전 부지별 잠재적 극한자연재해를 선별하고자 하였다. 이를 위해서 원전 부지특성과 원전 부지별 외부재해로 인해 발생한 사건을 조사하고 분석하였다. 그리고 기존 문헌과 연구 자료를 조사하여 국내 원전 실정에 맞는 선별절차와 기준을 수립하였다. 본 연구에서 수립된 선별기준에 근거하여 원전 부지별로 정성적 선별을 수행하였고, 선별된 자연재해를 대상으로 정량적 선별과 현장실사를 통해 국내 원전 부지별 잠재적 극한자연재해를 선별하였다. 선별 결과, 폭우에 의한 내부침수 이외에도 강풍에 의한 풍압과 극한 공기압이 모든 부지에서 공통적인 잠재적 극한자연재해로 선별되었다. 그리고 고리부지의 경우 폭풍해일이 1순위의 잠재적 극한자연재해로 선정되었다.

• 농촌계획
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• 제9권1호
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• pp.47-53
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• 2003

The purpose of this research was to develop evaluation index of regional development for producing potential values of rural regions besides agriculture on a commercial scale. Rural regions have potential values such as preserved nature and spatial advantages and so on. For regional development, potential values should be synthetically evaluated by objective and standard index for supporting decision. For evaluation of plural functions of rural regions, evaluation index of rural regions was developed based on rural amenity. Applicability of evaluation index was studied using GIS and natural break method.

• 한국막학회:학술대회논문집
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• 한국막학회 1998년도 춘계 총회 및 학술발표회
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• pp.31-35
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• 1998

1. INTRODUCTION : Recognition and binding of organic substrates by biological molecules are of vital importance in biophysics and biophysical chemistry. Most studies of the application focused on the development of biosensors, which detected reaction products generated by the binding between enzymes and substrates. Other types of biosensors in which membrane proteins (e.g., nicotinic acetylcholine receptor, auxin receptor ATPase, maltose bining protein, and glutmate receptor) were utilized as a receptor function were also developed. In the previous study[1], the shifts in membrane potential, caused by the injection of substrates into a permeation cell, were measured using immobilized glucose oxidase membranes. It was suggested that the reaction product was not the origin of the potential shifts, but the changes in the charge density in the membrane due to the binding between the enzyme and the substrates generated the potential shifts. In this study, $\gamma$-globulin was immobilized (entrapped) in a poly($\gamma$-amino acid) network, and the shifts in the membrane potential caused by the injection of some amino acids were investigated.

• Journal of Astronomy and Space Sciences
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• 제23권3호
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• pp.209-216
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• 2006

Ion acoustic solitary wave in a plasma consisting of electrons and ions with an external magnetic field is reinvestigated using the Sagdeev's potential method. Although the Sagdeev potential has a singularity for n < 1, where n is the ion number density, we obtain new solitary wave solutions by expanding the Sagdeev potential up to ${\delta}n^4$ near n = 1. They are compressiv (rarefactive) waves and shock type solitary waves. These waves can exist all together as a superposed wave which may be used to explain what would be observed in the solar wind plasma. We compared our theoretical results with the data of the Freja satellite in the study of Wu et al. (1996). Also it is shown that these solitary waves propagate with a subsonic speed.

• Natural Product Sciences
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• 제5권4호
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• pp.165-171
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• 1999

Since reactive oxygen species (ROS) play an important role in carcinogenesis and other several human diseases, antioxidants present in consumable fruits, vegetables, and beverages have received considerable attention as cancer chemopreventive agents. Thus, in order to identify antioxidants in plant extracts, potential activity was assessed by determining with inhibition of a xanthine/xanthine oxidase assay system. Approximately 170 plant extracts of Korean herbal medicines were primarily evaluated for the potential of antioxidant activity. As a result, 13 plant extracts were found to be active $(IC_{50}$<$100\;{\mu}g/ml)$. Especially, Juncus effusus, Selaginella tamariscina, Pueraria thunbergiana and Sedum albroseum showed strong inhibitory activity in this process. Further studies for the identification of active principles from these active lead plant extracts might be warranted.

• Natural Product Sciences
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• 제19권2호
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• pp.120-126
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• 2013

Natural products have always been a pivotal source of new drug development. Dry roots of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae) is a perennial herb and is also known as Bang Pung in traditional medicine. Numerous in vitro and in vivo studies have revealed the diverse pharmacological effects of S. divaricata and its role in the treatment of various diseases. This herb has exhibited significant inhibitory effects against inflammation and associated disorders. The present study explored the ethnopharmacological applications and molecular mechanisms behind the anti-inflammatory effects of S. divaricata herb and a single compound blockade of multi-signaling inflammatory cascades. Taken together, this review provides insight into the potential role of S. divaricata against various inflammatory diseases.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.183-183
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• 1998

Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. Telomerase activation and telomere shortening in human somatic cells have been implicated in cell tumorigenesis and immortalization. In order to find the potential inhibitors against telomerase activitiy which can be used as potential anticancer agents, we screened about 100 kinds of natural products after partition into n-hexane, ethyl acetate and aqueous layers from methanol extracts. The inhibitory effects of these materials against telomerase enzyme activity were tested in 293T cell culture using telomeric repeat amplification protocol(TRAP). The incorporation of $\^$32/P-dGTP into amplified DNA was measured by adsorption to Whatman DE81 paper instead of using TRAP assay for screening the extracts of natural products. Strong effective compounds were not found in this study but DE81 filter spotting method may be a useful model for the screening. Some of the compounds which showed somewhat inhibitory effects had cytotoxic effects also.

• International Journal of Computer Science & Network Security
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• 제22권5호
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• pp.154-162
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• 2022

Digital marketing tools are actively used in managing the development of park and recreation complexes to familiarize the population with the objects of natural heritage. This article aims to empirically evaluate digital marketing tools for popularizing the park and recreational complexes. The methodology was based on the concept of ecosystem value of park and recreation complexes as a natural heritage site. These methods included: identifying and selecting websites with information about park and recreation complexes in Slovakia and Ukraine. structural analysis of the main channels of online details about natural parks. Assessing the current state of online identity of the studied sites from the perspective of Internet users. The results indicate that to manage the development of park and recreational complexes developed their driven official websites in the Internet space, on which sections structure the information with the allocation of data on tourism and recreational potential. The article identifies additional digital marketing tools for managing the development of park and recreation complexes, particularly social networks and tourist websites. There is a sufficient amount of information about tourist recreation sites within these natural parks and tourist routes. Among the main problems of the websites: the information on the websites is entirely textual, there is a lack of sufficient data on social networks, despite the created official pages, there is no video content, which was more attracted tourists and visitors, allowing a visual assessment of the tourist potential; there is a problem of many communication channels to present the natural heritage of the countries. The research proves that the website is the primary and most common digital marketing tool for natural heritage, structuring information about tourism potential and recreation.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.101-101
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• 2003

Prostaglandins (PGs) and nitric oxide (NO) produced by inducible cyclooygenase (COX-2) and nitric oxide synthase (iNOS), respectively, have been implicated as important mediators in the process of inflammation and carcinogenesis. On this line, the potential COX-2 or iNOS inhibitors have been considered as anti-inflammatory and cancer chemopreventive agents. In our continuing efforts of searching for novel cancer chemopreventive agents from natural products, we isolated natural sesquiterpenoids as potential COX-2 and iNOS inhibitors in cultured lipopolysaccharide (LPS)-activated mouse macrophage RAW 264.7 cells. Alantolactone, a natural eudesmane-type sesquiterpenoid, exhibited a potent inhibition of COX-2 (IC50 = 0.4 $\mu\textrm{g}$/$m\ell$) and iNOS activity (IC50 = 0.08 $\mu\textrm{g}$/$m\ell$) in the assay system determined by PGE2 and NO accumulation, respectively. The inhibitory potential of alantolactone on the PGE2 and NO production was well coincided with the suppression of COX-2 and iNOS protein and mRNA expression in LPS-induced macrophages. Furthermore, alantolactone inhibited NF-kB but not AP-l binding activity on nuclear extracts evoked by LPS-stimulated macrophage cells, suggesting the possible involvement of NF-kB in the regulation of COX-2 and iNOS expression. In further study with COX-2-expressing human colon HT-29 cells, alantolactone inhibited the cell proliferation, down-regulated COX-2, and inhibited the ERK phosphorylation in the early time. These results suggest that a natural sesquiterpenoid alantolactone might be a potential lead candidate for further developing COX-2 or iNOS inhibitor possessing cancer chemopreventive or anti-inflammatory activity