• 한국전산유체공학회:학술대회논문집
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• 2011.05a
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• pp.58-64
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• 2011

The objective of this paper is to investigate the gravity effect on the shape characters of natural supercavity. A finite difference solver along with an implicit, dual time, preconditioned, three-dimensional algorithm has been used to solve the two-phase Navier Stokes equations. Numerical solutions were performed for natural supercavitating flow past a disk for different cavitation and Froud numbers. The numerical results were compared with corresponding analytical results in quantitative manner and it was found that the shape of supercavity was reasonably predicted Numerical results indicated that the gravity effect can induce the asymmetry of supercavity. The asymmetry was apparent when the froud number was smaller so that for constant cavitation number when we reduced the froud number the opt of the axis of supercavity increased. Moreover, for specific froud number a decrease in cavitation number resulted in an increase in the offset of the supercavity Numerical results revealed that for froud number greater than 25 the gravity effect is negligible.

• Journal of Preventive Medicine and Public Health
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• v.56 no.4
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• pp.303-311
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• 2023

Traditional mediation analysis, which relies on linear regression models, has faced criticism due to its limited suitability for cases involving different types of variables and complex covariates, such as interactions. This can result in unclear definitions of direct and indirect effects. As an alternative, causal mediation analysis using the counterfactual framework has been introduced to provide clearer definitions of direct and indirect effects while allowing for more flexible modeling methods. However, the conceptual understanding of this approach based on the counterfactual framework remains challenging for applied researchers. To address this issue, the present article was written to highlight and illustrate the definitions of causal estimands, including controlled direct effect, natural direct effect, and natural indirect effect, based on the key concept of nested counterfactuals. Furthermore, we recommend using 2 R packages, 'medflex' and 'mediation', to perform causal mediation analysis and provide public health examples. The article also offers caveats and guidelines for accurate interpretation of the results.

• Journal of Acupuncture Research
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• v.33 no.1
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• pp.47-56
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• 2016

Objectives : This study examined the effects of Bee venom on apoptosis in NCI-H157 human lung cancer cells and for promoting the apoptosis effects of Natural killer cell. Methods : Bee venom and Natural killer-92 cells were cultured either separately from or together with NCI-H157 cells for 24 hours. To figure out whether Bee venom enhances the cytotoxic effect of Natural Killer-92 cells, a cell viability assay was conducted. To observe the changes in Death receptors, apoptotic regulatory proteins and Nuclear $Factor-{\kappa}B$, western blot analysis was conducted. To observe the effect of Bee venom through an extrinsic mechanism, a transfection assay was conducted. Results : 1. Natural killer-92 cells and Bee venom significantly inhibited the growth of NCI-H157 cells and co-culture had more inhibitory effect than the separate culture. 2. Expressions of Fas, DR3, DR6, Bax, caspase-3, caspase-8, cleaved caspase-3, cleaved caspase-8 were increased, and expressions of Bcl-2 and cIAP were decreased. More efficacy was observed in co-culture than in separate culture. 3. Nuclear $Factor-{\kappa}B$ activation was clearly decreased. And co-culture showed much less activation than separate culture. 4. As a result of treatment for DR-siRNA, the reduced cell viability of NCI-H157 cells and the activity of Nuclear $Factor-{\kappa}B$ were increased. With this, it can be seen that Bee venom and Natural killer-92 cells have an effect on the cancer cells through the extrinsic mechanism. Conclusion : Bee venom is effective in inhibiting the growth of human lung cancer cells. Furthermore Bee venom effectively enhances the functions of Natural killer cells.

• Steel and Composite Structures
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• v.32 no.3
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• pp.305-312
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• 2019

In this study, we investigated the effect of fatigue crack propagation of the beams which have a vital importance in engineering applications, on the natural frequency of the system. Beams which have a wide range of applications, are used as fundamental structural elements in engineering structures. Therefore, early detection of any damages in these structures is of vital importance for the prevention of possible destructive damages. One of the widely used methods of early detection of damages is the vibration analysis of the structure. Hence, it is of vital importance to detect and monitor any changes in the natural frequencies of the structure. From this standpoint, in this study we experimentally investigated the effect of fatigue crack propagation on beams produced from 4140 steel, of the natural frequency of the beam. A crack was opened on the $8{\times}16{\times}500mm$ beam using a 3 mm long and 0.25 mm wide wire erosion. The beam, then, underwent 3 point bending tests at 10 Hz with a dynamic fatigue device and its natural frequencies were measured in scheduled intervals and any changes taking place on the natural frequencies of the beam were measured. This data allowed us to identify and measure the crack occurring on the beam subjected to dynamic loading, during the propagation phase. This method produced experimental data. The experimental data showed that the natural frequency of the beam decreased with the propagation of the fatigue crack on the beam.

• Fire Science and Engineering
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• v.23 no.6
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• pp.82-90
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• 2009

Natural smoke ventilator is one of domestic prescriptive methods to be used to exhaust smoke in case of fire in a high-rise buildings. The goal of this study is to evaluate the stack effect and the smoke exhaust performance in high-rise buildings with the opening of natural smoke ventilators using computer modeling technology, thus to estimate its effectiveness as a tool of smoke exhaust. For this purpose, the pressure differential in a domestic high-rise building with natural smoke ventilators was experimentally measured to analyze the stack effect with the closure or the opening of natural smoke ventilators and to calculate compensated air leakage of the building. Computer modeling based on experimentally measured data was carried out to estimate effectiveness of natural smoke ventilators in high-rise buildings using CONTAMW network program.

• Biomolecules & Therapeutics
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• v.4 no.3
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• pp.291-295
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• 1996

For the screening of antidiabetic effect, this study was carried out to some natural products by measurements of glucose level. MeOH and $CH_2Cl_2$ extracts of natural products were investigated for the effect on glucose level of $N_2$-STZ diabeted Rat. Among the natural products, Dioscorea Rhizoma, Trichosanthes Radix, Nelumbis Semem and Lycii Fructus were shown a remarkable antidiabetic effect.

• 한국태양에너지학회:학술대회논문집
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• 2009.11a
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• pp.123-129
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• 2009

In these days, the green building movement caused by the energy crisis is increasing, passive design is getting mere and more attention as it provides many possibilities for energy conservation. Moreover, with the increasing social intention for healthy life, the demand for indoor air Quality is increasing in Korea. As result, the ventilation system which can provide the sound outdoor air constantly has been obliged in Korea. So, the hybrid system which using natural power and mechanical power and makes up for the shortage of mechanical and natural ventilation attracts people's attention in Korea. As a hybrid ventilation system, in this study, the stack effect driven hybrid ventilation system in high-rise residential building will be suggested. And in this paper, the theoretical review for hybrid ventilation system suggested in this study will be addressed. Especially, the characteristics of pressure distribution and airflow caused by stack effect in high-rise residential building and the possibility of natural ventilation as results of stack effect will be described.

• Environmental Analysis Health and Toxicology
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• v.1 no.1
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• pp.47-54
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• 1986

The immunopotentiating effect of ethanol extract, butanol fraction and petroleum ether extract of Panax ginseng on the immunotoxicity of benzo(a)pyrene were investigated in mice. A single administration of benzo(a)pyrene induced an apparent but relatively transient reduction in HY titer, Arthus reaction, delayed type hypersensitivity, rosette forming cell and natural killer cell activity Ethanol extract very significantly restored HY titer, Arthus reaction. RFC and natural killer cell activity. Butanol fraction have no effect. But petroleum ether extract very significantly restored humoral and cellular immune response and especially natural killer cell activity.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.237.1-237.1
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• 2000

• Journal of computational fluids engineering
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• v.3 no.1
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• pp.73-81
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• 1998

The effect of vertical or horizontal throughflow on natural convection in horizontal porous layer was investigated. The computations were performed by employing Darcy-Brinkman-Forchheimer equation to consider the effect of inertia and viscous effect. The patterns of streamlines and isotherms are observed by changing the strength of throughflow. The vertical throughflow stabilizes the natural convection in porous layer. It also disturbs the developing vertical and horizontal velocity component of natural convection cell and increases the critical modified Rayleigh number. The horizontal throughflow influences the stabilization of natural convection in porous layer much more than the vertical throughflow. And it changes a stable convection into a oscillatory convection.