• Journal of Technologic Dentistry
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• v.17 no.1
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• pp.26-40
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• 1995

A survey has been performed for the dental technicians and office workers in small cities of Julla buk-do on theis problem of cough, phlegm, wheezing, nasal cattarrh & cold, and breathlessness by using SUN-81-AL survey form which is a guletionaire on respiratory symptons The results of the analysis are as follaus. 1. The complaint on cough was made by 15 dental technicians(21.4% and by 10 office workerr(16.7%). Dental technicians showed higher complaint on cough than office workers. The predietor variable for cough was the working hours for dental technicians and the period of smoking for the office sorkess. 2. The complaints on phelgm was made by 34 dental technicians(48.6%) and by 9 office workers(15.0%). The predictor variable on phelgm was the working hour for dental techniume and the period of smoking for the office workers. There was no statistically significant difference between two group on their complaint level. 3. The complaint on the breathlessnesr was made by 24 dental technicians(34.3%) and by 22 office workers(36.7%). The predictor variable on breathlessness was the period of smoking for dental technicians and the working hour for office workers. 4. The wmplaing on nasal catarrh & cold wax made by 29 dental technicians(41.4%) and 22 office workers(36.7%). The predictr variable on nasal catarrh & cold was the working hour for dental workerr, and the perird of smoking for the office workers. 5. The complaint on wheezing was made by 9 dental technicians(12.9%) and 8 office workers(13.3%). The primary predictor variable on wheezing was the working hour for both groups, and the secondary predictor variable was the period of smoking. 6. The complaint on the chest and lung dislase was made by 12 dental technicians(17.1%) and 4 office workers(6.7%) dental technicians showed bigher complaint. on chest and lung disease than the office workers. Bronchitis was the higher frequency illuess reported from both of the groups among chest and lung disease. 7. In conclusion, the predictor variable on respiratory illness was the working hour for dental techniciane, and the period of smoking for the office workers 8. 25 dental technicians(35.7%) and 9 office workers(15.0%) selected air pllution as the most urgent problem that working environment, has had. There was statistically significant difference between two groups(P<0.001)

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.45-52
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• 1996

In ancient times, respiration's perceived purpose was only to cool the blood, and nasal mucus was thought to be a discharge from the brain. Later it was demonstrated that fluids cannot travel from the brain to the nose. It appears that credit for pointing out the medical significance of bronchial secretions and the biological value of the exocrine function of the lungs belongs to Laennec. He described the “chronic idiopathic pituitous catarrh” known today as bronchorrhea, which is characterized by paroxysms of expectoration. The importance of all this is that airway secretions, and their alterations, became one of the cardinal signs of many respiratory diseases (1).

• Journal of Technologic Dentistry
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• v.11 no.1
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• pp.35-45
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• 1989

This study was carried out from June, 20, to October 22, 1988, for the purpose of researching on the complaint ratio of Respiratory symptoms of the dental laboratory technicians in Seoul. In this study, aiming to find out complaint ratio of respiratory symptoms of the dental laboratory, SNU-81-AL were applied, at random, to 193 dental laboratory technicians at 39 dental laboratories, as the research group, and to 178 clinical laboratory technicians at 10 general hospitals, as the control group, and above two groups were compared with each other. The following results were obtained from this research. 1. The quantity of respirable dust under 5$\mu$m measured at the dental laborartories was, on an average as well, 5$mg/m^3$-minimum 1.56$mg/m^3$), and the density of CO was, on an average as well, 5.0ppm(Mx 7.0-Mn 3.0). 2. The complaint ratio of five main respiratory symptoms(cough, phlegm, wheezing, nasal catarrh & cold, breathlessness) was, on an average, 44.3% at the dental laboratory technicians, phlegm was the major symptom complained by the greatest number of the technicians. 22.4% of the clinical laboratory technicians complained above 5 main respiratory symptoms, nassal catarrh & cold was the mostly complained symptoms among them. There showed a consideraly significant difference at the complaint ratio between the above 2 occupations(P<0.005). 3. There showed no paticular significant difference between male and female, at the complaint ratio of the dental laboratory technicians. However, there showed a considerable significant difference according to their sexuality, in case of the clinical laboratory technicians. 4. Considered from th view point of age, the highest age group was 20-29 with its average 48.5%, in case of dental laboratory technicians. The highest age group among the clinical laboratory technicians was over 40 age with its 28.7%. There showed no particular significant differences between to tow occupations. 5. Considered from the view point of work period, the highest work period group was 0-3 years with average 47.8%, in case of dental laboratory The highest work period group among the clinical laboratory technicians was 16 years with its 25.2%. There showed no particuar significant differences between the two occupations. 6. Considered from the view point of smoking, phlegm was complained by much more smokers than non-smokers, in both occupations. In case of non-smokers, many complained about nassal catarrh & cold. There showed no particular significant differences between the smokers and the non-smokers.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.3
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• pp.134-149
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• 2016

Objectives : Gal-Geun-Tang (GT) has been described from SANGHAN in Korean traditional medicine and known to act against cold, fever, hypertension, and nasal catarrh. However, little has yet been learned about the effect of GT on immune function. In the current study, in vitro and in vivo immunomodulatory activity of GT (water extract) was investigated.Methods : Water extract of GT induced in vitro proliferation of spleen cells and significantly increased their proliferative responses during anti-CD3 activation. Using purified splenic T and B cells, it was revealed that GT has a mitogenic activity to B cells and promotes their proliferation induced by lipopolysaccharide, whereas T cell proliferation was not triggered and GT was rather inhibitory to T cell activation caused by anti-CD3 antibody. In the presence of antigen presenting cells (APC), GT addition resulted in a significant increase of IFNγ and IL-4, but not IL-2, production. However, addition of high concentration (1,000㎍/㎖) of GT led to a marked reduction in T cell cytokine production and under such condition, GT facilitated apoptosis of T cells when examined by flow cytometry with propidium iodide staining.Results : In vivo immunomdulation of GT was also investigated using a mouse model. Following keyhole limpet hemocyanin (KLH) immunization, GT (1 ㎎/day) was orally administered for 9 days. Cell numbers in thymus, spleen and peripheral blood were not altered by GT administration, indicating that such dose is not immunotoxic. Cell numbers in draining lymph nodes (LN) and ex vivo Ag-specific proliferation of LN cells were significantly elevated by GT administration. However, any preferential stimulation of T or B and CD4⁺ or CD8⁺ T cell subpopulations was not observed in a flow cytometric analysis of LN cells. This result shows that GT does not promote in vivo B cell proliferation while GT enhances Ag-specific proliferation of LN cells, unlike what was observed in vitro.Conclusions : For a further understanding of in vivo immunomodulatory activity of GT, ex vivo cytokine production of LN cells obtained from KLH-immunized mice was evaluated. Ag-specific IFNγ production was significantly higher in GT-treated mice when compared to PBS-treated control mice. In contrast, IL-4 production in GT-treated group was comparable to control group unlike to in vitro data. In addition, GT administration did not result in any significant differences in serum levels of Ig (IgM, IgG1 and IgG2a) between GT-treated and control groups. Taken together, these data strongly support that GT promotes immune response, more profoundly type 1 helper T cell (Th1) activity and GT may be applicable for treatment of intracellular parasite infection such as viral diseases.