• 제목/요약/키워드: nano-structure

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Nano and micro structures for label-free detection of biomolecules

  • Eom, Kil-Ho;Kwon, Tae-Yun;Sohn, Young-Soo
    • 센서학회지
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    • 제19권6호
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    • pp.403-420
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    • 2010
  • Nano and micro structure-based biosensors are promising tool for label-free detection of biomolecular interactions with great accuracy. This review gives a brief survey on nano and micro platforms to sense a variety of analytes such as DNA, proteins and viruses. Among incredible nano and micro structure for bio-analytical applications, the scope of this paper will be limited to micro and nano resonators and nanowire field-effect transistors. Nanomechanical motion of the resonators transducers biological information to readable signals. They are commonly combined with an optical, capacitive or piezo-resistive detection systems. Binding of target molecule to the modified surface of nanowire modulates the current of the nanowire through electrical field-effect. Both detection methods have advantages of label-free, real-time and high sensitive detection. These structures can be extended to fabricate array-type sensors for multiplexed detection and high-throughput analysis. The biosensors based on these structures will be applied to lab-on-a-chip platforms and point-of-care diagnostics. Basic concepts including detection mechanisms and trends in their fields will be covered in this review.

전기화학적 방법을 통한 다공성 코발트 박막 합성 (Preparation of Porous Cobalt Thin Films by Using an Electrochemical Method)

  • 하성혁;신헌철
    • 한국표면공학회지
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    • 제53권6호
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    • pp.312-321
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    • 2020
  • Morphology of porous cobalt electro-deposits was systematically investigated as functions of cobalt precursors in the plating bath and applied cathodic current density with a special focus on cobalt nano-rod formation. It was proved that the concentration of cobalt precursor plays little effect on the morphology of cobalt electro-deposits at relatively low plating current density while it significantly affects the morphology with increasing plating current density. Such a dependence was discussed in terms of the kinetics of two competitive reactions of cobalt reduction and hydrogen evolution. Cobalt nano-rod structure was created at specific ranges of cobalt precursor content and applied cathodic current density, and its diameter and length varied with plating time without notable formation of side branches which is usually found during dendrite formation. Specifically, the nano-rod length was preferentially increased in relative short plating time (<15 s), resulting in higher aspect ratio of nano-rod with plating time. Whereas, both the nano-rod length and diameter were increased nearly at the same level in a prolonged plating time, making the aspect ratio unchanged. From the analysis of crystal structure, it was confirmed that the cobalt nano-rod preferentially grew in the form of single crystal on a dense poly-crystalline cobalt thin film initially formed on the substrate.

Thin Film Micromachining Using Femtosecond Laser Photo Patterning of Organic Self-assembled Monolayers

  • Chang Won-Seok;Choi Moo-Jin;Kim Jae-Gu;Cho Sung-Hak;Whang Kyung-Hyun
    • International Journal of Precision Engineering and Manufacturing
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    • 제7권1호
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    • pp.13-17
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    • 2006
  • Self-Assembled Monolayers (SAMs) formed by alkanethiol adsorption to thin metal film are widely being investigated for applications as coating layer for anti-stiction or friction reduction and in fabrication of micro structure of molecules and bio molecules. Recently, there have been many researches on micro patterning using the advantages of very thin thickness and etching resistance of Self-Assembled Monolayers in selective etching of thin metal film. In this report, we present the several machining method to form the nanoscale structure by Mask-Less laser patterning using alknanethiolate Self-Assembled Monolayers such as thin metal film etching and heterogeneous SAM structure formation.

Properties and Structure of High Frequency Soft Magnetic Nano-composite Films

  • Ohnuma, Shigehiro;Masumoto, Hiroshi
    • Journal of Magnetics
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    • 제16권4호
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    • pp.403-407
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    • 2011
  • Metal-insulator type, nano-granular soft magnetic films have been reviewed from the viewpoint of high frequency magnetic materials. The formation of nano-granular structure is related to the magnitude of heat of formation of intergranule materials. Variation of the ratio of granule phase to intergranule phase in the film is found to produce various characteristics in the magnetic properties of the film. The HRTEM observation reveals that neighboring granules in the film with above 60 at.% Co, contact at considerable points and the films show soft magnetic properties which are explainable in terms of the random anisotropy model for nano-crystalline materials. Addition of Ni group elements in Co-O based films enhances their anisotropy field up to 400 Oe and they exhibit excellent frequency response of permeability. Also, large electromagnetic noise suppression effect is demonstrated as one of their potential applications.

유기소자의 신뢰성에 영향을 주는 유해 자외선을 차단하기 위한 ALD기반 기능성 브래그반사경 구조 (ALD-based Functional Bragg Reflector Structure to Block Harmful Ultraviolet Rays that Affect the Reliability of Organic Devices)

  • 김현우;이형준;장승미;윤형준;이도균;이용민;박상연;정지훈;임석준;권정현
    • 반도체디스플레이기술학회지
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    • 제22권4호
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    • pp.103-107
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    • 2023
  • To solve the reliability problem of organic devices that are often used outdoors, multifunctional gas barriers that block reactive gases such as moisture and oxygen and reflect harmful light such as ultraviolet rays are needed. In this study, ALD nanolaminate-based optically functional n-DBR was developed to overcome the poor gas permeability of polymer substrates and protect organic devices from harmful light. n-DBR not only achieved a WVTR of 8.76 × 10-6 g·m-2·day-1, but also showed a visible light transmittance of 94.3% and an ultraviolet ray blocking ability of 2.67%. In particular, n-DBR based on a nanolaminate structure maintained its permeability characteristics even in a high temperature and high humidity environment despite being used as a layer of Al2O3. This functional barrier Structure can not only be used as a functional encapsulation barrier for the reliability of organic devices, but can also be used as a tinting film for vehicles.

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기판온도에 따른 Co-22%Cr 합금박막의자가정렬형 나노구조 (Self-Organized Nano Structure in Co-22% Cr Alloy Thin Films with Substrate Temperatures)

  • 송오성;이영민
    • 한국표면공학회지
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    • 제34권6호
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    • pp.531-536
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    • 2001
  • Co-22 %Cr alloy films are promising for high-density perpendicular magnetic recording media with their perpendicular anisotropy and large coercivity of 3000 Oe. We observed that a self organized nano structure (SONS) of fine ferromagnetic Co-enriched phase and paramagnetic Cr-enriched phase appears inside the grain of Co-Cr magnetic alloy thin films at the elevated substrate temperature after do-sputtering. The periodic fine Co-enriched phase and Cr-enriched phase is the plate shape of 80 (equation omitted)-wide and 1000 (equation omitted)-long. Cr-enriched phases are located at the center of grains. We prepared 5000 (equation omitted) -thick Co-22 %Cr films on polyimide substrate with varying substrate temperature of $ 30^{\circ}C$, $ 150^{\circ}C$ ,200 $^{\circ}C$, $300^{\circ}C$, and $400^{\circ}C$, respectively. A transmission electron microscope equipped with energy dispersive X-ray analyzer is employed to observe the microstructure of each samples after Co-enri-ched phase are etched selectively. The self organized nano structure of Co-enriched and Cr-enriched lamellar is observed above the substrate temperture of $150^{\circ}C$. No compositional change is observed with substrate temperature. The compositional phase separation in self organized structure becomes clear as the substrate temperature increases. Our results implies that the self organized nano structure in Co-22 %Cr film is ideal for ultra high density recording media by recording selectively on Co-enri-ohed phase.

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SOI edge channel과 나노 점을 갖는 나노 구조의 기억소자 (A Nano-structure Memory with SOI Edge Channel and A Nano Dot)

  • 박근숙;한상연;신형철
    • 전자공학회논문지D
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    • 제35D권12호
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    • pp.48-52
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    • 1998
  • 본 논문에서는 SOI 기판 위에 새롭게 제안된 측면 채널과 나노 점을 갖는 나노 구조의 기억소자를 제작하였다. Top-silicon의 측면이 채널영역이 되고 나노 점이 이 채널 영역의 위에 반응성 이온 식각(RIE)에 의해 형성되는 구조를 가지는 이 소자는 측면 채널(edge channel)의 너비가 SOI기판의 열산화에 의해 얇아진 top-silicon의 두께에 의해 결정되고, 나노 점의 크기는 반응성 이온 식각(RIE) 및 전자선 직접 묘화에 의해 결정된다. 제작된 나노 구조 소자의 I/sub d/-V/sub d/, I/sub d/-V/sub g/ 특성 및 -20V에서 +14V까지의 게이트 전압 영역에서 문턱전압의 변화 범위가 약 1V정도 되는 기억소자의 특성을 얻었다.

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울금의 주요 성분인 커큐민과 나노 마이셀링 기법 적용 염화 커큐민의 트랜스타이레틴 활성 부위에 대한 결합 친화도 비교분석 (Molecular Docking Affinity Comparison of Curcumin and Nano-micelled Curcumin with Natural Sea Salt on Transthyretin)

  • 김동찬;송표
    • 생명과학회지
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    • 제26권2호
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    • pp.253-258
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    • 2016
  • 본 연구에서는 울금의 주요 성분인 커큐민과 나노 마이셀링 기법을 적용한 신규 조성물인 염화 커큐민(NMC)의 트랜스타이레틴(TTR) 단백질 활성 부위에 대한 in silico 분자 결합 친화도를 비교 분석하였다. 우선 NMC신규 조성물의 결정학적 구조를 광학 및 전자현미경을 활용하여 관찰하였을 때, 나노 마이셀링 적용 NMC 결정은 일반 천일염에 비하여 색상 및 질감이 전체적으로 균일화 되었고, 천일염과 NMC성분이 강하게 일체화되어 기간이 상당히 경과 되더라도 쉽게 분리가 되지 않는 고기능성 안전성 구조물이 형성되었다. TTR단백질의 3차원 구조 활성 부위에 대한 in silico 분자 결합 친화도는 NMC가 일반 커큐민에 비하여 상대적으로 높은 결합 친화도를 나타나었고, pharmacophore 모델링 분석에서도 NMC가 일반 커큐민에 비하여 TTR 활성 부위에서 현저하게 pharmacophore 각도의 차이가 나타났었으며 패턴 또한 밀집된 특징을 나타내었다. 결론적으로, 나노 마이셀링 적용 NMC가 일반 커큐민에 비하여 상대적으로 우수하게 TTR 단백질의 활성 부위에 결합하는 것을 확인하였고, 이는 TTR 활성에 의해 유도되는 질병 조절 물질로의 적용 가능성이 있다고 판단된다. 결론적으로 일반 커큐민과 같은 생리 활성 효능 성분에 나노 마이셀링 기법을 적용하므로서 효율적인 결합 타깃 단백질 활발 조절 및 이러한 성분을 활용한 기능성 식품 산업에 나노 마이셀링 기법을 효율적으로 적용할 수 있음을 확인하였다.