• 공업화학
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• 제9권7호
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• pp.1079-1084
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• 1998

우레탄 생성반응의 동역학을 조사하기 위해 지방족 이소시아네이트인 4,4'-dihexyl methane diisocyanate($H_{12}MDI$)와 1 관능기 알코올인 n-hexanol간의 반응을 실험적 측정과 수학적 모델링을 통해 연구하였다. 실험은 dibutyltin dilaurate(DBTDL)을 촉매로, 톨루엔을 용매로 온도, 촉매농도, [NCO]/[OH] 비 등을 변화시키면서 실시하였고, 반응동역학은 NCO기와 OH기의 반응에 의한 우레탄 생성반응 및 NCO기와 우레탄간의 반응에 의한 allophanate 생성반응 등 2가지 2차반응식으로 모사하였다. 반응속도상수는 Runge-Kutta 4th order 방법에 의한 전산모사방법으로 계산하였다. 대부분의 조건에서 실험치와 계산치가 잘 일치하여 본 연구에서 제안하는 반응 모델과 속도상수 계산방법이 적절함을 알 수 있었다. 또한 NCO기 90% 전환율에서 allophante/urethane의 비를 계산하였는데 대부분의 조건에서 20% 이상의 높은 값이 얻어져 allophanate 생성반응이 우레탄 물성에 중요한 영향을 미칠 수 있음을 알 수 있었다.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.104-104
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• 2003

As an effort to direct differentiation of human embryonic stem (hES, MB03) cells to dopamine-producing neuronal cells, Nurr1 was transfected using conventional transfection protocol into MB03 and examined the expression of tyrosine hydroylase (TH) after differentiation induced by retinoic acid (RA) and ascorbic acid (AA). Experimentally, cells were transfected with linearized Nurr1 cDNA in pcDNA3.1 (+)-hygovernight followed by selection in medium containing hygromycin-B (150 $\mu$/ml). Expression of Nurr1 mRNA was confirmed by RT-PCR and protein by immunocytochemistry in the drug resistant clones. In order to study the effect of Nurr1 protein on the differentiation pattern of ES cells, one of the positive clones (MBNr24) was allowed to form embryoid body (EB) for 2 days and were induced to differentiate for another 4 days using RA (1 $\mu M$) and AA (50 mM) (2-/4+ protocol) followed by selection in N2 medium for 10 or 20 days. After 10 days in N2 medium, cells immunoreactive to anti-GFAP, anti-TH, or anti-NF200 antibodies were 38.8%, 11%, and 20.5%, respectively. After 20 days in N2 medium, cells expressing GFAP, TH, or NF200 were 28%, 15% and 44.8%, respectively but approximately 9% of MB03 expressed TH protein when the cells were induced to differentiate using a similar prorocol, These results suggest that ectopic expression of Nurr1 enhances generation of TH+ cells as well as neuronal cells when hES cells were differentiated by 2-/4+ protocol.

• 대한치과기공학회지
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• 제37권3호
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• pp.115-120
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• 2015

Purpose: The purpose of this study is a finite element analysis of supporting bone according to custom abutment angle. Methods: Implant fixture was selected with a diameter of 4 mm and the length of 13 mm. The fixture and abutment was designed by a combination of the abutment screw clamping force to produce a custom abutment model of $0^{\circ}$, $15^{\circ}$, $25^{\circ}$ and $35^{\circ}$. The loading condition of 176 N was applied to the lingual surface of the crown, near to the incisor edge, and horizontal load. An oblique load of $90^{\circ}$ was applied long axis of the implant fixture analyze the stress of supporting bone. Results: The result of mechanical analysis was observed that the supporting bone stress analysis of the horizontal load, the von Mises stress values (MPa) are given in the order of TH00 (432.6) > TH25 (418.0) > TH15 (417.4) > TH35 (415.8), the oblique load, the von Mises stress values are given in the order of TO00 (459.3) > TO15 (399.6) > TO25 (374.8) > TO35 (343.4) Conclusion: The $35^{\circ}$ abutment over the current clinical tolerance limits will be available for clinical application.

• 한국자동차공학회논문집
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• 제6권5호
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• pp.211-221
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• 1998

Thermal behavior on the cylinder block of a 4-cylinder, 4-stroke 2.0L SOHC gasoline engine was numerically and experimentally analyzed. The numerical calculation was performed using the finite element method. The cylinder block was modelled as a three dimensional finite element by considering its geometry. The physical domain was devided into hexahedron elements. 16 thermocouples were installed at points of 2mm inside from cylinder wall near top ring of piston in cylinder block, which points have suffered major thermal loads and suggested as proper measurement points for engine design by industrial engineers. Under full load and 9$0^{\circ}C$ coolant temperature condition, temperature behavior of cylinder block according to engine speed were analyzed. The results showed that temperature rose gradually to conform to a function of 2nd~4th order of engine speed at intake side, exhaust and siamese side, respectively. As engine load was changed from 100 to 50% by 25% step, temperature curve also conformed to 2nd~7th order function of engine speed. Temperature differences by load condition were similar among 100, 75% and 50%. Under full load and coolant temperature of 11$0^{\circ}C$, temperature behavior were also analyzed and the result also showed conformance to 2n d~7th order function of engine speed. Temperature curve was transferred in parallel upwards corresponding coolant temperature rise.

• 한국유기농업학회지
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• 제6권1호
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• pp.99-108
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• 1997

The aim of this experiment was to investigate the effect of applying times of cattle slurry on dry matter yield of Orchardgrass, when cattle slurry applied at rates of 30m3(average mineral nitrogen fertilizer equivalent to 120kg) per ㏊ in different dressing times, such as S1(1st and 2nd growth), S2(1st and 3rd growth), S3(1st and 4th growth), S4(2nd and 3rd growth), S5(2nd and 4th growth) and S6(application for 3rd and 4th growth). The results were as follows. 1. The average annual yields of dry matter were produced 6.36~7.42 ton per ㏊ in 1995~1997 when cattle slurry applied at rates of 30m3(average mineral nitrogen fertilizer equivalent to 120kg) per ㏊ in different dressing times, especially these tendency were shown higher annual dry matter in S4 plot9application for 2nd and 3rd growth). Those were higher 2.48~3.54 tons or 1.22~2.28 tons per ㏊ than the yields from non-fertilizing or phosphrous and potassium fertilizing. 2. Relative yields of annual dry matter in cattle slurry application plots were 164(S2 plot)~191(S4 plot)% in comparing with non-fertilizing plot. 3. Dry matter yields according to cutting frequency were highest at the 2nd cut(1.50 ton) and were in the order 3rd cut(0.95 ton)>4th cut(0.75 ton)>1st cut(0.69 ton/㏊). Also, those of cattle slurry application plot per ㏊ were in the order 2nd cut(2.02~2.73 tons)>3rd cut(1.56~2.08 tons)>4th cut(1.07~1.68 tons)>1st cut(1.11~1.45 tons/㏊). 4. Relative yields of annual dry matter in cattle slurry application plots were 164~219, 161~210, 143~212 and 135~182% at the 3rd, 1st, 4th and 2nd cut, respectively in comparing with non-fertilizing plot. 5. The efficiencies of nitrogen on dry matter yield(kg DM/kg N) were 18.1, 21.3 and 34.5kg DM/kg N when cattle slurry applied to Orchardgrass at rates of 30m3 (average mineral fertilizer equivalent to 120 kg) per ㏊ in 1993, 1994 and 1995, respectively, especially these tendency were shown higher efficiencies in S4 plot(application for 2nd 3rd growth). On the other hand, those of the same level fertilization of mineral nitrogen were 43.8, 19.2 and 13.4 kg DM/kg N in 1993, 1994 and 1995, respectively.

• 전자공학회논문지C
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• 제34C권4호
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• pp.26-35
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• 1997

This paper proposes a multi-bit $\Sigma\Delta$ modulator arcitecture which eliminates signal clipping problem. To avoid signal clipping, the output values of intgrators are monitored and modified by a reference value. This oepration is recorded as a digital code to restore actual signal value. Due to the digital code, the substraction of feedback value from the multi-bit quantizer can be calculated by a digital adder and this simplifies dAC operation making the accurate DAC of conventional multi-bit $\Sigma\Delta$ modulator scheme unnecessary. These features make N-th modulator can be implemented by sharing an integrator among N stages to decrease the required chip area. As an experimental example, a 4th order .sum..DELTA. modulator with oversampling ratio of 64 was simulated to show over 130 DB SNR at rail-to-rail input sinusoidal signal.

• 대한수학회지
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• 제44권6호
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• pp.1429-1440
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• 2007

Let ${K^{(\vec{p};N)}_{\vec{n}}(x)}$ be a multiple Kravchuk polynomial with respect to r discrete Kravchuk weights. We first find a lowering operator for multiple Kravchuk polynomials ${K^{(\vec{p};N)}_{\vec{n}}(x)}$ in which the orthogonalizing weights are not involved. Combining the lowering operator and the raising operator by Rodrigues# formula, we find a (r+1)-th order difference equation which has the multiple Kravchuk polynomials ${K^{(\vec{p};N)}_{\vec{n}}(x)}$ as solutions. Lastly we give an explicit difference equation for ${K^{(\vec{p};N)}_{\vec{n}}(x)}$ for the case of r=2.

• 전기학회논문지
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• 제67권7호
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• pp.962-968
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• 2018

In this study, we developed novel indicators to assess postoperative pain based on PPG derivative waveform. As the candidate indicator of postoperative pain assessment, the time from the start of beating to the n-th peak($T_n$) and the n-th peak amplitude($A_n$) of the PPG derivative were selected. In order to verify derived indicators, each candidate indicator was derived from the PPG of 78 subjects before and after surgery, and it was confirmed whether significant changes were observed after surgery. Logistic classification was performed with each proposed indicator to calculate the pain classification accuracy, then the classification performance was compared with SPI(Surgical Pleth Index, GE Healthcare, Chicago, US). The results showed that there were significant differences(p < 0.01) in all indicators except for $T_3$ and $A_3$. The coefficient of variation(CV) of every time-related indicators were lower than the CV of SPI(30.43%), however, the CV in amplitude-related parameters were higher than that of SPI. Among the candidate indicators, amplitude of the first peak, $A_1$, showed that highest accuracy in post-operative pain classification, 68.72%, and it is 15.53% higher than SPI.

• Journal of Nutrition and Health
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• 제31권1호
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• pp.5-12
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• 1998

This study was designed to examine how dietary protein levels affect organ growth and protein metabolism in early and normally weaned rats. Early and normally weaned rats separated fro the dam on the 15th and 121st day postpartum, respectively. were fed diets containing three levels of protein : low(10%) , normal (20%),and high(40%) . On the 35th day, the weight and DNA, RNA and protein contents in brain , liver, and kidney were determined to ascertain organ and cellular growth. Furthermore, serum total protein , albumin , $\alpha$-amino N and creatine and urinary urea N, and creatinine were determined in order to ascertain protein metabolism and renal functions. Dietary protein levels were not observed to significantly affect total DNA content, which may represent an index of cell number in the liver, brain and kidney. Fresh weight and protein/DNA ratio, which may represent indices of cell size, significantly increased in proportion to dietary protein in the kidney. As for the early weaned rats , the liver cell size significantly decreased. Dietary protein levels and weaning periods did not affect serum total protein and albumin . However, serum urea-N significantly increased in proportion to dietary protein levels whereas serum $\alpha$-amino N was decreased by early weaning . Nitrogen retention was lower in early weaned rats fed low or high levels of protein than in normally weaned rats. The results demonstrate that low or high levels of dietary protein have less desirable effects on protein metabolism in prematurely weaned rats.

• 한국소음진동공학회논문집
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• 제21권1호
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• pp.9-17
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• 2011

In this paper, the general equation of motion of damped sandwich beam with multi-viscoelastic material layer was derived based on the equation presented by Mead and Markus. The viscoelastic layer, which has characteristics of complex shear modulus, was assumed to be dominantly under shear deformation. The equation of motion of n-layered damped sandwich beam in bending could be represented by (n+3)th order ordinary differential equation. Finite element model for the n-layered damped sandwich beam was formulated and programmed using higher order shape functions. Several numerical examples were implemented to show the effects of damped material.