• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1999년도 추계종합학술대회 논문집
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• pp.468-471
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• 1999

In this paper, we present a solution for combining multiple neural networks. Each neural network is trained with different features. And the neural networks are combined by four methods. The recognition rates by four combination methods are compared. The experimental results for handwritten digit recognition shows that the combination at hidden layers by single layer neural network is superior to any other methods. The reasons of the results are explained.

• 한국정보과학회논문지:소프트웨어및응용
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• 제26권1호
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• pp.93-93
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• 1999

Researches on digit recognition have been conducted actively for a long time because the classes to recognize are much fewer than other character sets and because it is very likely thatthe digit recognition can be applied to many problems in real world, The recent studies on designingrecognition system with high performance are in progress with two different aspects. One is toconstruct a recognizer using several features at the same time, and the other is to use severalrecognizers. In this paper, we propose a multistage combination method to recognize the unconstrainedhandwritten numerals. The method is a two-stage combination method which uses multiplecombination methods at the same time unlike the existing methods with only one combination method.The recognizers are first combined by several combination methods of different classes simultaneously,and then the results of them are combined by another combination method to generate a final result.Five recognizers and eight combination methods are used in the proposed system. The experimentalresults showed that the recognition rates on CENPARMI and CEDAR data were 97.75% and 98.6%,respectively and the recognition performance could be improved as the process passed through stages,We could get the best performance by combining the combination methods of different classes, whichmeans there are a complementary relation among them, The proposed method can be considered asan extended version of the existing combination methods.

• 정보관리학회지
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• 제19권4호
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• pp.35-51
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• 2002

본 논문에서는 다중 모델 기계학습 기법을 이용하여 자동 문서 분류의 성능과 신뢰도를 향상시킬 수 있는 연구와 실험 결과를 기술하였다. 기존의 다중 모델 기계 학습법들이 훈련 데이터 또는 학습 알고리즘의 편향에 의한 오류를 극복하고자 한 것인데 비해 본 논문에서 제안한 메타 학습을 이용한 하이브리드 다중 모델 방식은 이 두 가지의 오류 원인을 동시에 해소하고자 하였다. 다양한 문서 집합에 대한 실험 결과. 본 논문에서 제안한 하이브리드 다중 모델 학습법이 전반적으로 기존의 일반 다중모델 학습법들에 비해 높은 성능을 보였으며, 다중 모델의 결합 방식으로서 메타 학습이 투표 방식에 비해 효율적인 것으로 나타났다.

• International Journal of Aeronautical and Space Sciences
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• 제10권1호
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• pp.75-82
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• 2009

In this parer, we propose a new way of improving DGNSS service using combination of multiple SBAS information. Because SBAS uses Geostationary Earth Orbit (GEO) satellites, it has very large coverage but it can be unavailable in urban canyon because of visibility problem. R. Chen solved this problem by creating Virtual Reference Stations (VRS) using the SBAS signal [1]. VRS converts SBAS signal to RTCM signals corresponding its location, and broadcast the converted RTCM signals over the wireless internet. This method can solve the visibility problem cost effectively. Furthermore it can solve DGNSS coverage problem by creating just a transmitter instead of a reference station. Developing above method, this paper proposes the methods that integrate two or more SEAS signals into one RTCM signal and broadcast it. In Korea, MSAS signal is available even though it is not officially certified for Korean users. As a Korean own SBAS-like system, there is the internet-based KWTB (Korean WADGPS Test Bed) which we developed and released at ION GNSS 2006. As a result, virtually two different SBAS corrections are available in Korea. In this paper, we propose the integration methods for these two independent SBAS corrections and present the test results using the actual measurements from the two systems. We present the detailed algorithm for these two methods and analyze the features and performances of them. To verify the proposed methods, we conduct the experiment using the logged SBAS corrections from the two systems and the RINEX data logged at Dokdo monitoring station in Korea. The preliminary test results showed the improved performance compared to the results from two independent systems, which shows the potential of our proposed methods. In the future, the newly developed SBASs will be available and the places which can access the multiple SBAS signals will increase. At that time, the integration or combination methods of two or more SBASs will become more important. Our proposed methods can be one of the useful solutions for that. As an additional research, we need to extend this research to the system level integration such as the concept of the decentralized W ADGPS.

• 생물정신의학
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• 제7권2호
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• pp.131-139
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• 2000

Even the pharmacotherapy is more effective than placebo for the treatment of depression, the outcome of pharmacoltherapy remains unsatisfactory for many patients. Apart from side effects, there are two major limitations of antidepressant therapy. One is the delayed onset of improvement and another is partial response. In order to address these clinical dilemmas, many psychiatrists more commonly employ add-on therapy. In past, the practice of using multiple drugs to enhance treatment response was called polypharamcy, and was disparaged as poor clinical practice. However, with improved understanding of how drugs affects the central nervous system and increased communication in journals and on computer networks about the relative merits of specific combinations, the scientific basis for the combining drugs is being defined. Indeed, the use of multiple medications as a stratege to enhance response has become both acceptable and widespread now a days. It is now referred to more positively as add-on therapy, co-medication, combination therapy, or drug augmentation. Thus, as the methods of practical strategies for treatment of depression, switching classes antidepressant drugs, combination therapy, augmentation strategies and brief treatment algorithm will be presented with items of considerations. However, when combination of drugs being tried, knowledges about the action of mechanism, pharamcokinetics, and pharmacodynamics are essential to cope with the possible adversive reactions and to get the appropriate responses for the treatment of depressive symptoms.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3163-3166
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• 2015

Background: Patients with refractory or relapsed multiple myeloma are considered to have a very poor prognosis, and new regimens are needed to improve this setting. Pomalidomide is a new immunomodulatory drug with high in vitro potency. Immunomodulatory drugs are hypothesized to act through multiple mechanisms. Here we performed a systemic analysis to evaluate pomalidomide-based chemotherapy (pomalidomide in combination with low-dose dexamethasone) as salvage treatment for patients with refractory and relapsed multiple myeloma. Methods: Clinical studies evaluating the efffectiveness of pomalidomide based regimens on response and safety for patients with refractory and relapsed multiple myeloma were identified using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: For pomalidomide based regimens, 4 clinical studies which including 291 patients with refractory and relapsed multiple myeloma were considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 41.2% (120/291). Major adverse effects were hematologic toxicity, including grade 1 or 2 anemia, leucopenia and thrombocytopenia with pomalidomide based treatment. No treatment related death occurred. Conclusion: This pooled analysis suggests that pomalidomide in combination with low-dose dexamethasone is active with good tolerability in treating patients with refractory or relapsed multiple myeloma.

• 동의생리병리학회지
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• 제26권4호
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• pp.432-436
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• 2012

Among a number of factors related to the effect of acupuncture and moxibustion treatment, prescriptions do important work. Traditional eastern doctors also placed emphasis on prescriptions of acupuncture and moxibustion, and a lot of experiences have been accumulated. The method forms prescriptions of Sa-am acupuncture therapy pivots on five transport points. Studies show prescriptions are made on the basis of the theory of 'Wang Xiang Xiu Qiu Si'(旺相休囚死) used engendering and restraining of five phases, and it is considered the principle of transformed prescriptions through this theory. Because there is still no study analyzing prescriptions of Sa-am acupuncture by existing principles, we report opinion about Combination principle of points in them. 1. We studied history of acupuncture and moxibustion, development and kinds of points' Combination principle. 2. Around Combination principles of points in Classic of Difficult Issues and Internal Classic, we analyzed and compared between Combination principles of points in Sa-am acupuncture therapy and them in Korea and overall acupuncture methods. 1. There were many Combination principles of acupunture point combination in Classic of Difficult Issues, Internal Classic and Korea acupuncture methods. For example, Point combination of the same meridian, Point combination of the different meridian, Exterior-Interior point combination, Point combination of the same name meridian, Point combination of the multiple meridian, Point combination of Adjacent and Distant points, Left-Right point combination, Anterior-Posterior point combination, Superior-Inferior point combination, Brook point and Stream point combination, Triple energizer point combination, Eight meeting point combination, Five transport point combination, Source-Connecting point combination, Alram point and Transport point combination, Mother-Sun meridian combination, Empirical point combination, Important point combination, Point combination according to syndrome. 2. Existing Combination principles of points in prescriptions of Sa-am acupuncture therapy included every rule. 3. They could be evidences that prescriptions of Sa-am acupuncture therapy are forms inheriting and developing acupuncture and moxibustion treatments.

• 대한수학회보
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• 제51권5호
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• pp.1433-1451
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• 2014

In this paper we study the existence of multiple periodic solutions of second-order ordinary differential equations. New results of multiplicity of periodic solutions are obtained when the nonlinearity may cross multiple consecutive eigenvalues. The arguments are proceeded by a combination of variational and degree theoretic methods.

• 한국임상약학회지
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• 제32권1호
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• pp.13-19
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• 2022

Background: The use of combination therapy and fixed-dose combination therapy is increasing for the treatment of type 2 diabetes. Sodium glucose cotransporter-2 inhibitor (SGLT2i) is a drug class used in combination with metformin. Methods: Type 2 diabetes patients on SGLT2i/metformin combination therapy were extracted from the 2019 Health Insurance Review & Assessment Service-National Patients Sample. On July 1, 2019, SGLT2i and metformin fixed-dose combination (SGLT2i/metformin FDC) and two-pill combination (TPC) groups were identified, and a chi-square test and multiple logistic regression were performed. Results: Of total 2,992 patients, 1,077 (36%) were prescribed SGLT2i/metformin FDC and 1,915 (64%) were prescribed TPC. We found that the most common comorbidities were in the order of dyslipidemia, gastrointestinal disease, and hypertension. Multiple logistic regression analysis showed that the use of SGLT2i/metformin FDC was lower than TPC in patients with diabetic neuropathy (OR=0.76, p=0.008). Clinic (OR=2.09, p<0.001) and general hospital (OR=1.40, p=0.019) showed higher tendency to prescribe SGLT2i/metformin FDC compared to tertiary hospital. The tendency of prescribing SGLT2i/metformin FDC was lower in Kyeonggi (OR=0.79, p=0.037), Gyeongsang (OR=0.77, p=0.025) and Chungcheong (OR=0.68, p=0.007) than Seoul. Conclusion: Factors related to the use of SGLT2i/metformin FDC in patients with type 2 diabetes were complication, medical institution and region. The tendency to prescribe SGLT2i/metformin FDC was relatively higher in clinics than in tertiary general hospitals and in Seoul than in other regions.

• 한국문헌정보학회지
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• 제31권3호
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• pp.135-146
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• 1997

일반적으로 주어진 정보 요구에 대하여 서로 다른 사용자는 서로 다른 질의를 생성할 수 있으며, 또는 한명의 사용자가 통제어의 사용 여부에 따라 서로 다른 질의를 생성할 수 있다. 최근 정보 검색 분야의 연구들은 이러한 서로 다른 질의 표현은 서로 다른 문서 집합을 검색함을 보여준다. 본 논문에서는 하나의 사용자 질의에 대하여 다양한 적합성 피드백 방법을 적용함으로써 다중의 질의들을 자동으로 생성한 후, 생성된 다중 질의들을 다시 하나의 질의로 결합하는 방법을 제안한다. 또한 실험을 통하여 자동으로 생성된 다중의 질의들을 결합함으로써 보다 높은 검색 효과를 얻을 수 있음을 입증한다.