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http://dx.doi.org/10.7314/APJCP.2015.16.8.3163

Pooled Analysis of Pomalidomide for Treating Patients with Multiple Myeloma  

Sun, Jia-Jia (The First Affiliated Hospital of Soochow University)
Zhang, Chi (The First Affiliated Hospital of Soochow University)
Zhou, Jun (The First Affiliated Hospital of Soochow University)
Yang, Hui-Lin (The First Affiliated Hospital of Soochow University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.8, 2015 , pp. 3163-3166 More about this Journal
Abstract
Background: Patients with refractory or relapsed multiple myeloma are considered to have a very poor prognosis, and new regimens are needed to improve this setting. Pomalidomide is a new immunomodulatory drug with high in vitro potency. Immunomodulatory drugs are hypothesized to act through multiple mechanisms. Here we performed a systemic analysis to evaluate pomalidomide-based chemotherapy (pomalidomide in combination with low-dose dexamethasone) as salvage treatment for patients with refractory and relapsed multiple myeloma. Methods: Clinical studies evaluating the efffectiveness of pomalidomide based regimens on response and safety for patients with refractory and relapsed multiple myeloma were identified using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: For pomalidomide based regimens, 4 clinical studies which including 291 patients with refractory and relapsed multiple myeloma were considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 41.2% (120/291). Major adverse effects were hematologic toxicity, including grade 1 or 2 anemia, leucopenia and thrombocytopenia with pomalidomide based treatment. No treatment related death occurred. Conclusion: This pooled analysis suggests that pomalidomide in combination with low-dose dexamethasone is active with good tolerability in treating patients with refractory or relapsed multiple myeloma.
Keywords
Pomalidomide; multiple myeloma; treatment; prognosis;
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