• The Plant Pathology Journal
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• 제30권2호
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• pp.136-150
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• 2014

Although multiple transcription factors (TFs) have been characterized via mutagenesis to understand their roles in controlling pathogenicity and infection-related development in Magnaporthe oryzae, the causal agent of rice blast, if and how forkhead-box (FOX) TFs contribute to these processes remain to be characterized. Four putative FOX TF genes were identified in the genome of M. oryzae, and phylogenetic analysis suggested that two of them (MoFKH1 and MoHCM1) correspond to Ascomycota-specific members of the FOX TF family while the others (MoFOX1 and MoFOX2) are Pezizomycotina-specific members. Deletion of MoFKH1 (${\Delta}Mofkh1$) resulted in reduced mycelial growth and conidial germination, abnormal septation and stress response, and reduced virulence. Similarly, ${\Delta}Mohcm1$ exhibited reduced mycelial growth and conidial germination. Conidia of ${\Delta}Mofkh1$ and ${\Delta}Mohcm1$ were more sensitive to one or both of the cell cycle inhibitors hydroxyurea and benomyl, suggesting their role in cell cycle control. On the other hand, loss of MoFOX1 (${\Delta}Mofox1$) did not show any noticeable changes in development, pathogenicity, and stress response. Deletion of MoFOX2 was not successful even after repeated attempts. Taken together, these results suggested that MoFKH1 and MoHCM1 are important in fungal development and that MoFKH1 is further implicated in pathogenicity and stress response in M. oryzae.

• 융합정보논문지
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• 제8권2호
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• pp.141-148
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• 2018

본 논문은 잊혀질 권리 구현이 지극히 이상적인 정보삭제의 개념을 벗어나 보다 현실적 구현이 될 수 있도록 다각적 관점의 실현범위를 모색하는데 목적이 있다. 국내외 법제 및 기술/서비스 동향을 문헌조사 방식으로 조사 및 비교분석하였으며, 이를 토대로 다각적 분석을 위해 서비스 실현수준, 개인정보처리자의 처리유형과 정보특성, 법제/기술을 고려한 분류 기준을 반영하였다. 그 결과, 현존하는 서비스(시스템)의 실현수준을 파악 하고 보호대상별 다각적 규제범위를 도출하였으며, 잊혀질 권리 실현범위 매트릭스(안)을 제시하였다. 본 연구는 법제 등 사회공학과 공학을 결합한 복합학문, 융합학문의 연구 분야로서 지속적으로 확대 가능하다. 정보주체의 권리인 '삭제권'의 실질적, 구체적 범위를 규명함으로써 사회적 비용에 대한 예측이 가능하고, 기술적 구현모델 및 서비스 개발을 통해 시장 확대와 인력양성에도 기여할 것으로 기대한다.

• The Journal of the Acoustical Society of Korea
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• 제21권1E호
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• pp.3-11
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• 2002

Broadcast news transcription is one of the hardest tasks in speech recognition because broadcast speech signals have much variability in speech quality, channel and background conditions. We developed a Korean broadcast news speech recognizer. We used a morpheme-based dictionary and a language model to reduce the out-of·vocabulary (OOV) rate. We concatenated the original morpheme pairs of short length or high frequency in order to reduce insertion and deletion errors due to short morphemes. We used a lexicon with multiple pronunciations to reflect inter-morpheme pronunciation variations without severe modification of the search tree. By using the merged morpheme as recognition units, we achieved the OOV rate of 1.7% comparable to European languages with 64k vocabulary. We implemented a hidden Markov model-based recognizer with vocal tract length normalization and online speaker adaptation by maximum likelihood linear regression. Experimental results showed that the recognizer yielded 21.8% morpheme error rate for anchor speech and 31.6% for mostly noisy reporter speech.

• Animal cells and systems
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• 제11권2호
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• pp.93-98
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• 2007

Gonadotropin-releasing hormone (GnRH), synthesized in the hypothalamus, plays a pivotal role in the regulation of vertebrate reproduction. Since molecular isoforms of GnRH and their receptors (GnRHR) have been isolated in a broad range of vertebrate species, GnRH and GnRHR provide an excellent model for understanding the molecular co-evolution of a peptide ligand-receptor pair. Vertebrate species possess multiple forms of GnRH, which have been created through evolutionary mechanisms such as gene/chromosome duplication, gene deletion and modification. Similar to GnRHs, GnRH receptors (GnRHR) have also been diversified evolutionarily. Comparative ligand-receptor interaction studies for non-mammalian and mammalian GnRHRs combined with mutational mapping studies of GnRHRs have aided the identification of domains or motifs responsible for ligand binding and receptor activation. Here we discuss the molecular basis of GnRH-GnRHR co-evolution, particularly the structure-function relationship regarding ligand selectivity and signal transduction of mammalian and non-mammalian GnRHRs.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1999년도 하계종합학술대회 논문집
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• pp.138-141
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• 1999

New solutions are given for the capacity and spectrum efficiency of frequency hopped spread spectrum multiple access system(FH-SSMA) in a Nakagami interference environment. In this paper we derive a exact formulation of the deletion probability for a mobile environment and analyze the system capacity and spectrum efficiency in terms of the average bit error rate(BER). It is shown that the system capacity is decreased by 52% as the Nakagami fading parameter is reduced to 0.5 and the required signal to noise ratio(SNR) is above 25dB, to get the spectrum efficiency of 0.3.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2007년도 Proceedings of ISRS 2007
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• pp.3-5
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• 2007

Many continuous queries are important to be process efficiently in a data stream environment. It is applied a query index technique that takes linear performance irrespective of the number and width of intervals for processing many continuous queries. Previous researches are not able to support the dynamic insertion and deletion to arrange intervals for constructing an index previously. It shows that the insertion and search performance is slowed by the number and width of interval inserted. Many intervals have to be inserted and searched linearly in a data stream environment. Therefore, we propose Hashed Multiple Lists in order to process continuous queries linearly. Proposed technique shows fast linear search performance. It can be utilized the systems applying a sensor network, and preprocessing technique of spatiotemporal data mining.

• 제어로봇시스템학회논문지
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• 제4권3호
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• pp.378-383
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• 1998

A FOV, that stands for "Field Of View", refers to the maximum area where a camera could be wholly seen. If a FOV of CCD camera cannot the cover overall inspection area, the overall inspection area should be divided into sub-areas of size FOV. In this paper, we propose a new neural network-based FOV generation method by using a newly modified self-organizing map(SOM) which has multiple structure based on a self-organizing map, and uses new training rule that is composed of the movement, creation and deletion terms. Then, experiment results using real PCB indicate the superiority of the method developed in this study to the existing sequential method.al method.

• 산업경영시스템학회지
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• 제15권25호
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• pp.97-101
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• 1992

This paper proposes a new procedures for assessing the influence of individual or groups of cases when any regressors are included. At first, various influence measures pickout influential cases when one regress-or is deleted. Next find influential subsets by using heuristic approach and perform group deletion. Retaining or removing any regressors may depend on the presence or absence of one or few cases. Then, we can identify the interrelationships that exist among regressors and cases and examine their impact on the fitted regression equation. We conclude with an example using fuel consumption data.

• Journal of Electrical Engineering and information Science
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• 제1권1호
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• pp.1-9
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• 1996

A key issue in spoken language processing has become the integration of speech understanding and natural language processing(NLP). This paper presents a parallel computational model for the integration of speech and NLP. The model adopts a hierarchically-structured knowledge base and memory-based parsing techniques. Processing is carried out by passing multiple markers in parallel through the knowledge base. Speech-specific problems such as insertion, deletion, and substitution have been analyzed and their parallel solutions are provided. The complete system has been implemented on the Semantic Network Array Processor(SNAP) and is operational. Results show an 80% sentence recognition rate for the Air Traffic Control domain. Moreover, a 15-fold speed-up can be obtained over an identical sequential implementation with an increasing speed advantage as the size of the knowledge base grows.

• 생명과학회지
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• 제32권3호
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• pp.241-248
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• 2022

NF-κB는 염증과 선천성 면역에 중요한 전사인자이며 anti-apoptotic gene을 유도하여 세포의 생존과 발암에도 깊이 연관되어 있으며 많은 신호전달분자 및 신호전달회로와 연결되어있다. 한편, Hsp90는 NF-κB의 활성을 조절한다는 보고가 이루어졌으나 그 구체적인 기전은 알려져 있지 않다. 본 연구에서는 IKK compelx를 구성하는 인자들의 발현 plasmid를 이용하여 NF-κB의 활성조절에서 Hsp90와 IKKγ의 연관성 및 역할을 연구하였다. 그 결과 Hsp90는 IκBα의 인산화와 분해를 촉진하여 NF-κB를 활성화시켰고, NIK과 LPS에 의한 NF-κB의 활성화는 Hsp90에 의해 더욱 활성이 증가하였다. IKKγ는 Hsp90에 의해 증가된 IκBα의 인산화와 분해를 더욱 촉진함으로써 Hsp90의 NF-κB 활성화 작용을 상승시켰다. 이러한 Hsp90와 IKKγ에 의한 NF-κB의 활성화 현상은 항상 활성화 된 상태를 유지하는 IKKβ-EE mutant를 이용한 검토에서도 입증되었다. 또한 IKKγ의 deletion mutant를 이용한 검토에서 IKKγ의 N-말단에 위치하는 IKKβ 결합부위와 C-말단에 위치하는 leucine zipper 및 zinc finger 부위는 IKKγ와 Hsp90의 NF-κB에 대한 상호협력적 촉진작용에 필요하지 않았다. 또한 Hsp90에 의해 촉진된 세포내 pro-inflammatory cytokine들의 발현은 IKKγ에 의해 더욱 상승하였다. 이러한 결과로부터 Hsp90와 IKKγ의 상호작용을 차단한다면 NF-κB의 과다활성으로 인한 질병의 예방과 치료에 도움을 줄 수 있을 것으로 사료된다.