• Molecules and Cells
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• v.41 no.8
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• pp.799-807
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• 2018

Emerging evidence has suggested that cellular crosstalk between RNF168 and poly(ADP-ribose) polymerase 1 (PARP1) contributes to the precise control of the DNA damage response (DDR). However, the direct and reciprocal functional link between them remains unclear. In this report, we identified that RNF168 ubiquitinates PARP1 via direct interaction and accelerates PARP1 degradation in the presence of poly (ADP-ribose) (PAR) chains, metabolites of activated PARP1. Through mass spectrometric analysis, we revealed that RNF168 ubiquitinated multiple lysine residues on PARP1 via K48-linked ubiquitin chain formation. Consistent with this, micro-irradiation-induced PARP1 accumulation at damaged chromatin was significantly increased by knockdown of endogenous RNF168. In addition, it was confirmed that abnormal changes of HR and HNEJ due to knockdown of RNF168 were restored by overexpression of WT RNF168 but not by reintroduction of mutants lacking E3 ligase activity or PAR binding ability. The comet assay also revealed that both PAR-binding and ubiquitin-conjugation activities are indispensable for the RNF168-mediated DNA repair process. Taken together, our results suggest that RNF168 acts as a counterpart of PARP1 in DDR and regulates the HR/NHEJ repair processes through the ubiquitination of PARP1.

• Journal of Korea Trade
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• v.25 no.3
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• pp.65-86
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• 2021

Purpose - This paper empirically investigates the relationship between the corporate value chain and performance of non- financial businesses of South Korean stock market companies. It aims to explore the evidence that can be used to infer the relationship between value chains and corporate performance in the case of firms forming a value chain with other companies with the means of an equity investment or a special business relationship. Design/methodology - Non-financial corporations listed from 2011 to 2017 on the securities market of South Korea are analyzed. The data used for analysis are found for transactions with the related party by year for all the corporations of non-financial industries in the securities market. Multiple analysis attempts are conducted including the relationship between the value chain and productivity, corporate value, risk-adjusted corporate value, and mediation effects of productivity. The empirical model employs sixteen variables including the value chain index which identifies its impact on various aspects of business performances. Findings - The results of this study clearly supports the phenomenon that corporate productivity and value are enhanced when the corporation expands its value chain established with domestic related firms and overseas companies. Such a positive effect is statistically significant even after the possible risk factors that accompany the expansion of value chain were considered, and productivity plays the role as a medicating variable in the effect of the value chain on the corporation values. Originality/value - The findings of this study confirms that domestic companies' expansion of their value chain centered on the related firms overseas that helped them in terms of the maximization of their productivity and corporate values. This study shows that Korean government's policy on expanding the corporate GVC can enhance the productivity and value of firms. The expansion of value chain and its impact on business performance has not been explored thoroughly, although it is getting more and more important in the global trade operation.

• Journal of Convergence for Information Technology
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• v.9 no.1
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• pp.86-91
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• 2019

Block chains began by recognizing the danger of centralized control of financial systems after the 2008 financial crisis. From the beginning of 2008, blockchain has been developing a lot of attention and technology, starting with a tremendous innovation called cryptographic destruction based on technology, a block chain called Bitcoin. However, the vulnerability has also been discovered over time and the damage has been repeated. But in the fourth industry of the 21st century, many advances and technologies based on them are expected to emerge. Therefore, this paper proposes new analytical transaction protocols for vulnerabilities in cryptographic currency transactions. The proposed transaction protocol is a way to authenticate once again at the end of the transaction and the transaction is concluded with this authentication. It presents countermeasures by adding security elements between users to the transaction process rather than internal security to transaction vulnerabilities.

• Journal of Microbiology and Biotechnology
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• v.29 no.1
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• pp.141-150
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• 2019

The spatial landmark protein Bud8 plays a crucial role in bipolar budding in the budding yeast Saccharomyces cerevisiae. The unconventional yeast Yarrowia lipolytica can also bud in a bipolar pattern, but is evolutionarily distant from S. cerevisiae. It encodes the protein YALI0F12738p, which shares the highest amino acid sequence homology with S. cerevisiae Bud8, sharing a conserved transmembrane domain at the C-terminus. Therefore, we named it YlBud8. Deletion of YlBud8 in Y. lipolytica causes cellular separation defects, resulting in budded cells remaining linked with one another as cell chains or multiple buds from a single cell, which suggests that YlBud8 may play an important role in cell separation, which is distinct from the function of Bud8 in S. cerevisiae. We also show that the YlBud8-GFP fusion protein is located at the cell membrane and enriched in the bud cortex, which would be consistent with a role in the regulation of cell separation. The coiled-coil domain at the N-terminus of YlBud8 is important to the correct localization and function of YlBud8, as truncated proteins that do not contain the coiled-coil domain cannot rescue the defects observed in $Ylbud8{\Delta}$. This finding suggests that a new signaling pathway controlled by YlBud8 via regulation of cell separation may exist in Y. lipolytica.

• International Journal of Computer Science & Network Security
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• v.22 no.12
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• pp.37-50
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• 2022

Modern supply chains include multiple activities from collecting raw materials to transferring final products. These activities involve many parties who share a huge amount of valuable data, which makes managing supply chain systems a challenging task. Current supply chain management (SCM) systems adopt digital technologies such as the Internet of Things (IoT) and blockchain for optimization purposes. Although these technologies can significantly enhance SCM systems, they have their own limitations that directly affect SCM systems. Security, performance, and scalability are essential components of SCM systems. Yet, confidentiality and scalability are one of blockchain's main limitations. Moreover, IoT devices are lightweight and have limited power and storage. These limitations should be considered when developing blockchain-based IoT-SCM systems. In this paper, the requirements of efficient supply chain systems are analyzed and the role of both IoT and blockchain technologies in providing each requirement are discussed. The limitations of blockchain and the challenges of IoT integration are investigated. The limitations of current literature in the same field are identified, and a secure and scalable blockchain-based IoT-SCM system is proposed. The proposed solution employs a Hyperledger fabric blockchain platform and tackles confidentiality by implementing private data collection to achieve confidentiality without decreasing performance. Moreover, the proposed framework integrates IoT data to stream live data without consuming its limited resources and implements a dualstorge model to support supply chain scalability. The proposed framework is evaluated in terms of security, throughput, and latency. The results demonstrate that the proposed framework maintains confidentiality, integrity, and availability of on-chain and off-chain supply chain data. It achieved better performance through 31.2% and 18% increases in read operation throughput and write operation throughput, respectively. Furthermore, it decreased the write operation latency by 83.3%.

• Journal of English Language & Literature
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• v.56 no.6
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• pp.1295-1310
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• 2010

In her "After Language Poetry: Innovation and Its Theoretical Discontents" in Contemporary Poetics (2007), Marjorie Perloff spotted Steve McCaffery's and Lyn Hejinian's points of reference and opacity/transparency in poetic language, and theorizes in her perspicacious insights that poetic language is not a window, to be seen through, a transparent glass pointing to something outside it, but a system of signs with its own semiological interconnectedness. Providing a critique and contextualizing Perloff's argument, the purpose of this paper is to introduce a topological model for poetry, language, and theory and further to elaborate the relation between the theory and the practice of language poetry in terms of "the revolution of language." Jacques Lacan's poetics of knowledge and of the topology of the mind, in particular, that of "extimacy," can articulate the way how language poetry problematizes the opposition between inside and outside in the substance of language itself. In fact, as signifiers always refer not to things, but to other signifiers, signifiers becomes unconscious, and can say more than they actually says. The original signifiers become unconscious through the process of repression which makes a structure of multiple and polyphonic signifying chains. Language poets use this polyphonic language of the Other at Freudian "Another Scene" and Lacan's "Other." When the reader participates the constructive meanings, the locus of the language writing transforms itself into that of the Other which becomes the open field of language. The language poet can even manage to put himself in the between-the-two, a strange place, the place of the dream and of the Unheimlichkeit (uncanny), and suture between "the outer skin of the interior" and "the inner skin of the exterior" of the impossible real of definite meaning. The objective goal of the evacuation of meaning is all the same the first aspect suggested by the aims of the experimentalism by the language poetry. The open linguistic fields of the language poetry, then, will be supplemented by The Freudian "unconscious" processes of dreams, free associations, slips of tongue, and symptoms which are composed of this polyphonic language. These fields can be properly excavated by the methods and topological mapping of the poetics of extimacy and of the klein bottle.

• Journal of Digital Convergence
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• v.20 no.3
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• pp.325-331
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• 2022

As IoT devices are used in various ways in an edge network environment, multiple studies are being conducted that utilizes the information collected from IoT devices in various applications. However, it is not easy to apply accurate IoT data immediately as IoT data collected according to network environment (interference, interference, etc.) are frequently missed or error occurs. In order to minimize mistakes in IoT data collected in an edge network environment, this paper proposes a management technique that ensures the reliability of IoT data by randomly generating signature values of IoT data and allocating only Security Information (SI) values to IoT data in bit form. The proposed technique binds IoT data into a blockchain by applying multiple hash chains to asymmetrically link and process data collected from IoT devices. In this case, the blockchainized IoT data uses a probability function to which a weight is applied according to a correlation index based on deep learning. In addition, the proposed technique can expand and operate grouped IoT data into an n-layer structure to lower the integrity and processing cost of IoT data.

• Journal of Periodontal and Implant Science
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• v.29 no.3
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• pp.507-519
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• 1999

The ultimate objective of periodontal treatment is to stop disease progression and to regenerate destroyed periodontal tissues and thereby regain normal function. Growth factors are naturally found polypetides which stimulate many cellular activities pertaining to wound healing by acting as signal molecule in controlling cell movement, proliferation, and matrix production. Platelet derived growth factor (PDGF) is 28,000-35,000 Da molecular weight dimeric protein with 2 long positively charged polypeptide chains connected by sulfide bonds. The purpose of this study is to evaluate histologically the initial guided tissue regeneration in a periodontal defect f a beagle dog treated with a biodegradable membrane formed with polylactic acid (poly-L-lactic acid) and polyglycolic acid loaded with 200ng/$cm^2$ platelet derived growth factor. 2 beagle dogs were used in he experiment. $5mm{\times}6mm$ alveolar bone defect was formed in upper and lower canines and third premolars and a reference notch was placed. PDGF-BB non-containing membrane was used as control. Each defect was randomly assigned to the test roup or the control group. The dogs were sacrificed 3 weeks after membrane placement. Toluidine blue and multiple staining was done for histological analysis. In the 3 week specimen in the control group, no new one formation could be seen. Small amount f bone resorption below the notch could be seen. In the notch, loose connective tissue with infiltration of inflammatory cells could be seen. Also thin discontinuous new cementum could be seen and the membrane still retained its structure. Where PDGF-BB containing membrane was used, new bone formation could be seen in the notch at weeks and also continuous thin cementum could be seen. PDL cells were observed between new bone and new cementum and some were attached to bone and cementum. These results suggest that new bone and cementum formation seen when PDGF-BB loaded membrane was used was due to inhibition of downgrowth of epithelial cells and also due to continuous release of the growth factor. Further study on the resorption characteristics of the membrane nd the release characteristics of the PDGF-BB is necessary. Also, development of a membrane easier to use clinically is necessary.

• The KIPS Transactions:PartC
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• v.12C no.5 s.101
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• pp.623-632
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• 2005

In ad-hoc network, there is no fixed infrastructure such as base stations or mobile switching centers. The security of ad-hoc network is more vulnerable than traditional networks because of the basic characteristics of ad-hoc network, and current muting protocols for ad-hoc networks allow many different types of attacks by malicious nodes. Malicious nodes can disrupt the correct functioning of a routing protocol by modifying routing information, by fabricating false routing information and by impersonating other nodes. We propose a routing suity mechanism based on one-time digital signature. In our proposal, we use one-time digital signatures based on one-way hash functions in order to limit or prevent attacks of malicious nodes. For the purpose of generating and keeping a large number of public key sets, we derive multiple sets of the keys from hash chains by repeated hashing of the public key elements in the first set. After that, each node publishes its own public keys, broadcasts routing message including one-time digital signature during route discovery and route setup. This mechanism provides authentication and message integrity and prevents attacks from malicious nodes. Simulation results indicate that our mechanism increases the routing overhead in a highly mobile environment, but provides great security in the route discovery process and increases the network efficiency.

• Korean Chemical Engineering Research
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• v.46 no.2
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• pp.316-329
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• 2008

Recently the increased attention pays on the processing of multiple, relatively low quantity, high value-added products resulted in adoption of batch process in the chemical process industry such as pharmaceuticals, polymers, bio-chemicals and foods. As there are more possibilities of the improvement of operations in batch process than continuous processes, a lot of effort has been made to enhance the productivity and operability of batch processes. But the chemical process industry faces a range of uncertainties factors such as demands for products, prices of product, lead time for the supply of raw materials and in the production, and the distribution of product. And global competition has made it imperative for the process industries to manage their supply chains optimally. Supply chain management aims to integrate plants with their supplier and customers so that they can be managed as a single entity and coordinate all input/output flows (of materials, information) so that products are produced and distributed in the right quantities, to the right locations, and at the right time.The objective of this study is to solve the purchase, distribution, production planning and scheduling problem, which minimizes the total costs of production, inventory, and transportation under uncertainty. And development of SCM model in chemical industry including batch mode operations. Through that, the enterprise can respond to uncertainty. Also integrated process optimal planning and scheduling model for manufacturing supply chain. The result shows that, the advantage of supply chain integration are quality matters seen by customers and suppliers, order schedules, flexibility, cost reduction, and increase in sales and profits. Also, an integration of supply chain (production and distribution system) generates significant savings by trading off the costs associated with the whole, rather than minimizing supply chain costs separately.