• Korean Journal of Optics and Photonics
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• v.14 no.5
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• pp.555-564
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• 2003

WDM thin film filters for fiber optical communication were designed using Fabry-Prot type multiple cavity filters and an equivalent thin film technique. As the number of cavities in multiple cavity filters increases, it becomes difficult to design the filters due to a great number of variables (the number of cavities, period of reflectors, order of spacers). To solve the problem of design, we treated the fewest variables, regarding symmetrical thin films as equivalent layers, and we applied structural and numerical formulas based on an analysis method of multiple cavity filters. The equivalent thin film technique was able to provide systematic and quantitative design of the WDM thin film filters.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.11
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• pp.966-977
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• 2015

This paper presents a novel modified coaxial cavity resonator and its application to bandpass filters with compact size and improved quality factor(Q-factor). The proposed resonator is made up of ${\Gamma}-shape$ or curved four inner conductive posts within a single cavity, which provides quadruplet to realize bandpass filter. No metallic walls inside the cavity are required, and thus the utilization efficiency of the cavity space is improved. As a result, the unloaded Q can be approximately 15 % higher in comparison to the conventional coaxial resonator, or more than 35 % volume saving can be achieved while maintaining the similar Q-factor value with the conventional designs. In addition, due to the multiple cross-coupling occurring within the cavity, including the source-to-load coupling, four flexible transmission zeros can be created to realize different filtering functions. Simulations as well as experimental results of four- and eight-pole filters are presented to validate this attractive design concept. Good agreement between measured and computed results is obtained.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.1
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• pp.61-70
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• 2009

We have examined the effects of certain mutations of the selectivity filter and of the membrane helix M2 on $Ba^{2+}$ blockage of the inward rectifier potassium channel, Kir 2.1. We expressed mutant and wild type murine Kir 2.1 in Chinese hamster ovary(CHO) cells and used the whole cell patch-clamp technique to record $K^+$ currents in the absence and presence of externally applied $Ba^{2+}$. Wild type Kir2.1 was blocked by externally applied $Ba^{2+}$ in a voltage and concentration dependent manner. Mutants of Y145 in the selectivity filter showed little change in the kinetics of $Ba^{2+}$ blockage. The estimated $K_d(0)$ was 108 ${\mu}M$ for Kir2.1 wild type, 124 ${\mu}M$ for a concatameric WT-Y145V dimer, 109 ${\mu}M$ for a WT-Y145L dimer, and 267 ${\mu}M$ for Y145F. Mutant channels T141A and S165L exhibit a reduced affinity together with a large reduction in the rate of blockage. In S165L, blockage proceeds with a double exponential time course, suggestive of more than one blocking site. The double mutation T141A/S165L dramatically reduced affinity for $Ba^{2+}$, also showing two components with very different time courses. Mutants D172K and D172R(lining the central, aqueous cavity of the channel) showed both a decreased affinity to $Ba^{2+}$ and a decrease in the on transition rate constant(${\kappa}_{on}$). These results imply that residues stabilising the cytoplasmic end of the selectivity filter(T141, S165) and in the central cavity(D172) are major determinants of high affinity $Ba^{2+}$ blockage in Kir 2.1.