• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2201-2205
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• 2013

Colorectal cancer (CRC) is one of the most common cancers in many parts of the world. Its development is a multi-step process involving three distinct stages, initiation that alters the molecular message of a normal cell, followed by promotion and progression that ultimately generates a phenotypically altered transformed malignant cell. Reports have suggested an association of the phosphoinositide-3-kinase (PI3K)/Akt pathway with colon tumorigenesis. Activation of Akt signaling and impaired expression of phosphatase and tensin homolog (PTEN) (a negative regulator of Akt) has been reported in 60-70% of human colon cancers and inhibitors of PI3K/Akt signaling have been suggested as potential therapeutic agents. Around 80% of human colon tumors possess mutations in the APC gene and half of the remainder feature ${\beta}$-catenin gene mutations which affect downstream signaling of the PI3K/Akt pathway. In recent years, there has been a great focus in targeting these signaling pathways, with natural and synthetic drugs reducing the tumor burden in different experiment models. In this review we survey the role of PI3K/Akt/mTOR and Wnt signaling in CRC.

• 한국정보시스템학회:학술대회논문집
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• 한국정보시스템학회 2000년도 춘계학술대회
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• pp.107-113
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• 2000

최근 인터넷 사용 증가는 물론 그에 따른 인터넷 사이트의 증가가 가히 폭발적이라고 할 수 있다. 전자상거래도 인터넷 사용증가에 힘입어 더욱 증가 추세에 있으며 관광산업 또한 예외는 아니다. 호텔에서도 웹사이트를 구축하여 온라인 예약과 각종 서비스에 필요한 정보를 제공하고 있으며 점차 온라인 예약이 증가추세이다. 하지만 인터넷 웹사이트의 급격한 증가는 풍부하고 다양한 정보를 제공한다는 긍정적인 면과 함께 정보과다(information overload)로 인해 정보 검색 등에 많은 시간과 비용이 요구되는 문제를 낳았다. 위와 같은 환경에서 사용자를 대신하여 원하는 정보를 찾아주는 역할을 수행하는 에이전트(agent)의 개념이 도입되었다. 현재 전자상거래 분야에서 활용 중인 에이전트는 구매자가 직접 판매자와 접촉하여 자신에게 필요한 여러 가지정보를 얻고 필요에 따라서는 협상 등을 진행한 후 최종 거래를 성사시키는 ‘사람과 사람간의 일 대 일 거래 과정’중 일부분만을 지원하고 있는 실정이다. 이와 같은 현존 에이전트의 문제점을 보완하기 위해서 구매자와 판매자를 대표하는 에이전트를 개발하고 이들 에이전트간의 직접적인 정보교환, 가격협상 및 이를 바탕으로 한 의사결정까지의 거래 모델을 수립하는 것이 필요하다고 인식된다. 따라서 본 연구는 인터넷상에서 구매자와 판매자간의 거래를 대행하는 인터넷 다중 에이전트(Internet Multi-Agents)의 개발을 위한 개념적 거래 모델을 연구하고, 이를 호텔 예약 분야에 응용하기 위한 각 에이전트의 필요 조건 및 기능을 제시하고자 한다.

• Tuberculosis and Respiratory Diseases
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• 제77권4호
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• pp.161-166
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• 2014

Since tuberculosis (TB) remains a major global health concern and the incidence of multi-drug resistant (MDR)-TB is increasing globally, new modalities for the detection of TB and drug resistant TB are needed to improve TB control. The Xpert MTB/RIF test can be a valuable new tool for early detection of TB and rifampicin resistance, with a high sensitivity and specificity. Late-generation fluoroquinolones, levofloxacin, and moxifloxacin, which are the principal drugs for the treatment of MDR-TB, show equally high efficacy and safety. Systemic steroids may reduce the overall TB mortality attributable to all forms of TB across all organ systems, although inhaled corticosteroids can increase the risk of TB development. Although fixed dose combinations were expected to reduce the risk of drug resistance and increase drug compliance, a recent meta-analysis found that they might actually increase the risk of relapse and treatment failure. Regarding treatment duration, patients with cavitation and culture positivity at 2 months of TB treatment may require more than 6 months of standard treatment. New anti-TB drugs, such as linezolid, bedaquiline, and delamanid, could improve the outcomes in drug-resistant TB. Nontuberculous mycobacterial lung disease has typical clinical and immunological phenotypes. Mycobacterial genotyping may predict disease progression, and whole genome sequencing may reveal the transmission of Mycobacterium abscessus. In refractory Mycobacterium avium complex lung disease, a moxifloxacin-containing regimen was expected to improve the treatment outcome.

• 한국언어정보학회:학술대회논문집
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• 한국언어정보학회 2002년도 Language, Information, and Computation Proceedings of The 16th Pacific Asia Conference
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• pp.2-27
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• 2002

As pact of a long-ranged project that aims at establishing database-theoretic semantics as a model of computational semantics, this presentation focuses on the development of a syntactic component for processing strings of words or sentences to construct semantic data structures. For design arid modeling purposes, the present treatment will be restricted to the analysis of some problematic constructions of Korean involving semi-free word order, conjunction arid temporal anchoring, and adnominal modification and antecedent binding. The present work heavily relies on Hausser's (1999, 2000) SLIM theory for language that is based on surface compositionality, time-linearity arid two other conditions on natural language processing. Time-linear syntax for natural language has been shown to be conceptually simple and computationally efficient. The associated semantics is complex, however, because it must deal with situated language involving interactive multi-agents. Nevertheless, by processing input word strings in a time-linear mode, the syntax cart incrementally construct the necessary semantic structures for relevant queries and valid inferences. The fragment of Korean syntax will be implemented in Malaga, a C-type implementation language that was enriched for both programming and debugging purposes arid that was particluarly made suitable for implementing in Left-Associative Grammar. This presentation will show how the system of syntactic rules with constraining subrules processes Korean sentences in a step-by-step time-linear manner to incrementally construct semantic data structures that mainly specify relations with their argument, temporal, and binding structures.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2575-2580
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• 2015

Cancer is a multifaceted and genomically complex disease and rapidly accumulating high impact research is deepening our understanding related to the mechanisms underlying cancer development, progression and resistance to therapeutics. Increasingly it is being realized that genetic/epigenetic mutations, inactivation of tumor suppressor genes, overexpression of oncogenes, deregulation of intracellular signaling cascades and loss of apoptosis are some of the extensively studied aspects. Confluence of information suggested that rapidly developing resistance to therapeutics is adding another layer of complexity and overwhelmingly increasing preclinical studies are identifying different natural agents with efficacy and minimal off-target effects. We partition this multi-component review into citrus fruits and their bioactive ingredients mediating rebalancing of pro- and anti-apoptotic proteins to induce apoptosis in resistant cancer cells. We also discuss how oncogenic protein networks are targeted in cancer cells and how these findings may be verified in preclinical studies.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2001년도 가을 학술발표논문집 Vol.28 No.2 (3)
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• pp.568-570
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• 2001

최근에 들어와 그 응용분야가 확대되어 가고 있는 에이전트 소프트웨어는 점점 그 크기와 복잡성이 커져 감에 따라 소프트웨어 개발치 효율성을 필요로 하는 추세이다. 이에 따라 네트워크에 분산되고 이질적인 시스템에 존재하는 에이전트들은 자신의 정보를 효율적으로 교환할 수 있도록 하기 위해 통신 프레임웍을 필요로 하게 되었다. 본 논문에서는 네트워크에 존재하고 동일한 환경 또는 서로 다른 환경에 존재하는 에이전트들 간의 의사 소통을 위한 통신 프레임웍의 설계 및 구현을 제시한다. 기본적으로 에이전트 소프트웨어 아키텍처는 KRIL(KQML- Router Interface Labrary), Router, Facilitator로 구성되어 진다. 같은 호스트에 존재하는 에이전트들은 같은 주소를 가지기 때문에 각기 다른 Router를 가질 필요 없이 하나의 Router를 공유한다. Router는 로컬 호스트에 존재하는 에이전트들의 리스트를 유지 관리하며, 로컬 에이전트가 보낸 메시지의 수신자가 자신의 리스트에 없을 경우 Facilitator를 통해 다른 호스트에 존재하는 에이전트에 메시지를 전달한다. 서로 다른 환경에 존재하는 에이전트들 간의 통신과 스레드 관리, 병행처리와 동기화 등을 위해 KRIL은 ACE(The Adaptive Communication Environment) 라이브러리를 사용하였으며, Router와 Facilitator는 Java로 구현하였다.

• 한국염색가공학회지
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• 제9권2호
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• pp.1-9
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• 1997

This paper was carried out to introduce flame retardant and antibiotic properties to polyester(PET) and polyester/cotton(P/C) blend fabrics. PET and P/C blend fabrics were treated by a paddry-cure method in the aqueous solutions of the finishing agents(JA 6034, JA 6050, DC-5700). The corona discharge technique was applied to increase the polar group of the polymer surface. The characteristics of the treated fabric were investigated by means of scanning electron microscope (SEM) and electron spectroscopy for chemical analysis(ESCA), and water penetration time, limiting Oxygen index(LOI), and K/S value were also measured. Wettability of the fabrics was increased considerably with the corona discharge treatment. ESCA was used to elucidate the surface chemical composition of the fabrics treated with the corona discharge. Relative Ols intensity increased and oxygen was incorporated in the form of -C-O-, -C=O, and O=C-O on the polymer surface. The current study indicated that corona discharge treatment was effective for modifying the polymer surface.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권12호
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• pp.4372-4388
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• 2014

Robotic sensor network (RSN) contains mobile sensors and robots providing feasible solution for many multi-agent applications. One of the most critical issues in RSN and its application is how to effectively assign tasks. This paper presents a novel connectivity preserving hybrid task allocation strategy to answer the question particularly for RSN. Firstly, we model the task allocation in RSN to distinguish the discovering and allocating processes. Secondly, a fully distributed simple Task-oriented Unoccupied Neighbor Algorithm, named TUNA, is developed to allocate tasks with only partial view of the network topology. A connectivity controller is finally developed and integrated into the strategy to guarantee the global connectivity of entire RSN, which is critical to most RSN applications. The correctness, efficiency and scalability of TUNA are proved with both theoretical analysis and experimental simulations. The evaluation results show that TUNA can effectively assign tasks to mobile robots with the requirements of only a few messages and small movements of mobile agents.

• 한국해양바이오학회지
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• 제6권1호
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• pp.17-25
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• 2014

Periodically, harmful algal blooms (HABs) have occurred, with impacts on various areas including public health, tourism, and aquatic ecosystems, especially aquacultured and caged fisheries. To prevent or manage invasions of HABs into fish farms on an emergency basis, many methods have been proposed. Frequently over the past 30 years in coastal countries, treatments of clay and clay mixed with polyaluminum chloride (PAC) and chitosan have been tested for HAB-removal effectiveness in both the laboratory and the field. In Korea, yellow loess clay (hwangto) has been dispersed using electrolytic clay dispensers, both to decrease the amount of yellow loess clay's usage in containers and enhance HAB-removal efficiency. However, this emergency method has limitations, among which is the requirement for more effective controlling agents for field applications. Thus, in this paper, we review technologies for clay-based red tides prevention and control and their limitations, and, further, introduce next-generation algicidal technologies for the emergency protection of fish farms.

• 대한수의학회지
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• 제39권6호
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• pp.1091-1098
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• 1999

Antimicrobial susceptibility, plasmid profiles and distribution of toxA gene were investigated in Pasteurella multocida isolated from pneumonic lung lesions of swine. The bacteria were highly susceptible to norfloxacin, cabenicillin, enrofloxacin and chloramphenicol, but resistant to colistin, sulfamethoxawle/trimethoprime, bacitracin, streptomycin. Sixty percentage of the isolates was resistant more than 2 drugs used in this experiment and 21 strains (23.6%) were resistant more than 5 drugs. This phenomenon meant that they had highly multi-drugs resistance. In the analysis of plasmid profiles, nineteen strains (47.5%) of 40 P multocida isolates harbored plasmids, ranging from 53.3kb to 2.49kb in size and the plasmid profiles could be classified into 5 groups. However, there was no relationship between the size and the profile of plasmid and the resistance pattern of antimicrobial agents. Thirty strains of 39 P multocida isolates (77%) investigated by PCR harbored toxA gene. This result suggested involvement of the ToxA protein expressed from the gene in pneumonic pasteurellosis of swine.