• Toxicological Research
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• v.21 no.2
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• pp.107-113
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• 2005

[ $BARODON^{(R)}$ ] is a multi-purpose, high functional alkali solution made by mixing and liquid-ionizing silicon, calcium, sodium, borax, organic carbon chemicals and silver. In this study, we have investigated the apoptotic potential and mechanistic insights of $BARODON^{(R)}$ in human gastric cancer cell line (AGS cells). In MTT assay, $BARODON^{(R)}$ reduced cell viability in AGS cells. Morphological features of apoptosis with marked cytoplasmic vacuolation and appearance of apoptotic peaks in flow cytometry were observed in AGS cells with$BARODON^{(R)}$ treatment. In addition, $BARODON^{(R)}$ induced apoptosis of stomach cancer cell is related to bax up-regulation, caspase 7 protease activation and subsequent cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that BARODON can induce the apoptosis of AGS cells through modulation of bcl-2 family and the activation of intrinsic caspase cascades, indicating that it is potentially useful as a anti-cancer agent.

• Restorative Dentistry and Endodontics
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• v.27 no.4
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• pp.421-431
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• 2002

C-shaped canal configuration is very difficult to treat because that clues about preoperative canal anatomy cannot be ascertained from clinical crown morphology and limited information can be derived from radiographic examination. This study was done to get more informations about the root and canal configuration of C-shape root by 3-dimensionally reconstructing for the purpose of enhancing success rate of endodontic treatment. 30 mandibular molars with C-shaped root were selected. Six photo images from occlusal, apical, mesial, distal, buccal, lingual directions and radiographic view were taken as preoperative ones to compare them with 3-D image. After crown reduction to the level of 1-2mm over pulpal floor was performed, teeth were stored in 5.25% sodium hypochlorite solution for the removal of pulp tissue and debris. They were cleaned under running water, allowed to bench dry and embedded in a self-curing resin. This resin block was serially ground with a microtome (Accutom-50, Struers, Denmark) and the image of each level was recorded by digital camera (FinePix S1-pro, Fuji Co., Japan). The thickness of each section was 0.25mm. Photographs of serial sections through all root canal were digitized using Adobe Photoshop 5.0 and then minimum thickness of open and closed sites were measured (open site is the surface containing occluso-apical groove closed site is oppsite). After dizitization using 3-D Doctor (Able software Corp, USA). 3D reconstruction of the outer surface of tooth and the inner surface of pulp space was made. Canal classsification of C-shaped roots was performed from this 3-D reconstructed image. The results were as follows : 1. Most C-shape rooted teeth showed lingual groove (28/30). 2 According to Vertuccis' calssification, type I, II, III, IV, VII were observed. but also new canal types suck as 2-3-2, 1-2-3-2. 2-3-2-1, 2-3-2-3 were shown. 3 There was little difference in minimum thickness on coronal and apical portions, but open site were thinner than closed site on mid portion. Conclusively, 3D reconstruction method could make the exact configurations of C-shape root possible to be visualized and analyzed from multi-directions. Data from minimum thickness recommend cleaning and shaping be more carefully done on dangerous mid portion.

• Korean Journal of Construction Engineering and Management
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• v.16 no.4
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• pp.118-128
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• 2015

Recently BIM technology has been expanded for using in construction project. Due to the high-cost of BIM infrastructure development, lack of regulations, lack of process and so forth, usage of BIM has been delayed than initial expectations. In design phase, especially, collaboration based on BIM system has been a key factor for successful next generation building project. Through the analysis of current research trends about IT technologies, virtualization and BIM service, data exchange such as drawings, 3D model, object data, properties using cloud computing and virtual server system is defined as a most successful solution. The purpose of this study is to enable the cloud computing BIM server to provide several main functions such as editing models, 3D model viewing and checking, mark-up and snapshot in high-performance quality by proper design of VDI system. Concurrent client connection performance is a main technical index of VDI. Through testing of test-bed server client, developed VDI system's multi-connect control is evaluated. Performance-test result of BIM server VDI effect to development direction of cloud computing BIM service for commercialization.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.3 no.4
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• pp.95-107
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• 1983

The general purpose programs are in their fixed algorithm and theory of mechanics which can not be altered without painful program modifications. Users are usually guided by user's manual for data input. The several symbolic manipulation programs for structural analysis are introduced recently. These programs allow users to include a wide class of solution algorithm and to specify, by means of some symbolic manipulation, a combination of analytical steps to suit a particular problem. As they can solve a single domain problem, a large computer is usually needed. The scope of this study is to develop an efficient symbolic manipulation program with space beam element, plate bending element and eigen value routines. The incorporated Substructure capability and generation capability of finite element characteristic arrays (e.g., stiffness matrix, mass matrix) enables users to analyse multidomain problem with small computer. The program consists of modulized independent processors, each having its own specific function and is easily modified, eliminated and added. The processors are efficiently handling data by the Data base approach which is the concept of integrated program network(IPN).

• International Journal of Highway Engineering
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• v.5 no.4 s.18
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• pp.1-11
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• 2003

Recently, the new pavement design method considering Korean environment and the specification for improving performance of pavement are being developed in Korea. The Jointed Concrete Pavement Program Applying Load Discretization Algorithm (called HEART-JCP) is one of the results of Korea Pavement Research Project in Korea. HEART-JCP program is developed to analyze various loading condition using the load discretization algorithm without mesh refinement. In addition, it can be modified easily into multi-purpose concrete pavement nidyses program because of the modularized structure characteristic of HEART-JCP. The program consists of basic program part and load discretization part. In basic program part, the displacement and stress are computed in the concrete slab, sub-layer, and dowel bar, which are modeled with plate/shell element, spring element and beam element. In load discretization program part, load discretization algorithm that was used for the continuum solid element is modified to analyze the model with plate and shell element. The program can analyze the distributed load, concentrated load, thermal load and body load using load discretization algorithm. From the result of verification and sensitivity study, it was known that the loading position, the magnitude of load, and the thickness of slab were the major factors of concrete pavement behavior as expected. Since the result of the model developed is similar to the results of Westergaard solution and ILLISLAB, the program can be used to estimate the behavior of jointed concrete pavement reasonably.

• Journal of Korean Society of Transportation
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• v.22 no.2 s.73
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• pp.27-39
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• 2004

The purpose of this paper presents realistic policy alternative about recent tendency to decrease of subway-users and diminution of use efficiency which are serious problems of Busan Subway. Several policy alternatives have been studied until now, such as subway transfer impedance solution plan, introduction of subway to transfer fare discounting policy, and etc.. But, those policy alternatives are difficult to carried out, because they are less effective and overburden to financial aspect. Therefore, I made use of research on subway utilization to presuppose service improvement, as an alternative, in the transfer fare discounting system between bus and subway which might be powerful influence over subway-users. To verify this proposed study, I took advantage of Stated Preference(SP) where I estimated fare revenue and effects on fluctuation of subway-users with nested logit model based on research results. Suitable alternatives are as follows: First, If municipal government carries out transfer fare discounting policy without shortening in-vehicle time and out-of-vehicle time transfer fare, it is reasonable to discount transfer fare 50% off on the assumption of financial support as much as \6.700 million annually. Secondly, in case of application of multi-factors at a time, transfer fare discounting and in & out vehicle time, it is preferred to have no charge for transfer option with financial support as much as expected income-loss \5,600 million.

• Journal of Intelligence and Information Systems
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• v.10 no.2
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• pp.147-163
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• 2004

For the purchase of a cheaper product on the Internet, many customers have been trying to search online shopping mall sites and visit comparison-pricing shops that compare prices and other criteria of the product. Others have been participating into online auction markets or group-buying markets. However, a lot of online shopping malls, auction markets, and group-buying markets provide the same product with different prices. Since these marketplaces have different price settlement mechanism, it is very difficult for the customers to determine marketplace to purchase, considering different kinds of marketplaces at the same time. To overcome such limitations, decision rules and solution procedures for purchase decision making are necessary, which can cover multiple marketplaces simultaneously. For this purpose, purchase decision making in each market must be conducted to maximize customer's utility, and conflicts with other marketplaces must be resolved. Therefore, we have developed the rules and methods that can negotiate cooperatively the purchase decision making in several marketplaces, and designed an architecture of Intelligent Buyer Agent and a message structure to support the idea.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.1
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• pp.53-68
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• 2004

Protein deposit buildup on soft contact lenses(SCLs) is responsible for discomfort, optical defects and is even damaging to the eye. To better understand protein deposit formation on SCL, we investigated the pattern of protein attachment on patient-worn SCLs and the effect of the protein on the contact angle of SCLs and the transmission of visible light. This study used data from a clinical trial where subjects wore either daily-wear SCL(etafilcon A, N=40) for various period up to 14 days, or extended-wear SCL(balafilcon A, N=40) for 8 h day or night. The adsorption of protein in daily-wear SCLs was significantly increased in patient-worn time-dependent manner although the lenses were cleaned everyday by using the multi-purpose SCL solution. After 2 weeks wearing, the protein on the SCL influenced the contact angle of the lenses. Furthermore, the transmission of visible light of the lenses decreased up to almost 7%. Extended-wear SCLs worn during the closed eye condition were found to deposit significantly more protein than SCLs worn during the open eye condition. The amounts of protein adsorbed both after daily SCL wear and after overnight SCL wear were not affected the contact angle and the transmission of visible light of the lenses. The protein deposit buildup on SCL related to the corneal temperature and pH of tear fluid.

• Journal of Korean Tunnelling and Underground Space Association
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• v.18 no.2
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• pp.213-220
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• 2016

The needs for the utilization of space in the urban ara due to the increasing population and traffic volume. A Double-deck tunnel can be an appropriate solution. Geosynthetics are inevitably installed between ground and tunnel lining, therefore, geosynthetic-soil interface is also comprises. Dynamic shear behavior of geosynthetic-soil interface affects the dynamic behavior of tunnel, and experimental study is required since the behavior is very complicated. In this study, chemical factors such as acid and basic element in the groundwater and temperature are considered in the laboratory test. Multi-purpose Interface Apparatus(M-PIA) is utilized and submerging periods are 60 and 960 days. Consequently, dynamic shear degradation of geosynthetic-soil interface considering chemical and thermal factors are verified.

• Journal of the Korean Applied Science and Technology
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• v.37 no.2
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• pp.192-205
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• 2020

The purpose of this study is to verify the structural relationship empirically among self-esteem, self-efficacy and life satisfaction of college students who answered that they had high academic stress. SPSS 23.0 and AMOS 21.0 were used to achieve the objectives of this study. In SPSS 23.0, frequency analysis to analyze demographic characteristics, correlation analysis to verify multi-collinearity among the questionnaire scales, and reliability verification to determine the reliability of questionnaire questions were conducted. In AMOS 21.0, confirmatory factor analysis was conducted to verify the construct validity of factors and to verify the causal relationship between variables. To determine the goodness of fit of the model, the 𝑥² test and the goodness-of-fit index were used. Judging. First, the self-efficacy of college students with high academic stress group through swimming class was positively influenced on self-esteem. Second, the self-efficacy of college students with high academic stress group through swimming class was positively influenced on life satisfaction. Third, the self-esteem of college students with high academic stress group through swimming class was found to affect life satisfaction. This study has significance in demonstrating the problem of academic stress of Korean university students and in proposing expansion of the physical education class as a solution.