• Journal of Periodontal and Implant Science
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• 제37권1호
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• pp.103-113
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• 2007

The purpose of this study was to measure the thickness of masticatory mucosa in the hard palate as a donor site for mucogingival surgery by using computerized tomography(CT), Thickness measurements were performed in 84 adult patients who took CT on maxilla for implant surgery and 24 standard measurement points were defined in the hard palate according to the gingival margin and mid palatal suture. Radiographic measurements were utilized after calibration for standardization. Data were analyzed to determine the differences in mucosal thickness by gender, age, tooth positions and depth of palatal vault. The results of this study were as follows: 1. Mean thickness of palatal masticatory mucosa was $3.93{\pm}0.6mm$ and females had significantly thinner mean masticatory mucosa($3.76{\pm}0.56mm$) than males($4.04{\pm}0.6mm$)(p<0.05). 2. The thickness of palatal masticatory mucosa increased by aging. 3. Depending on position, masticatory mucosa thickness increased from canine to premeolar, but decreased at the first molar, and increased again in the second molar region(p<0.0001). 4. No significant difference in mean thickness of palatal masticatory mucosa were indentified between low palatal vault group and high palatal vault group(p>0.05). The results suggest that canine and premolar area appears to be the most appropriate donor site for soft tissue grafting procedure. The measurement of the thickness of palatal masticatory mucosa by using computerized tomography can offer useful information clinically but further studies in as-sessing the validity and reliability of the method using computerized tomography is needed.

• 대한치과보철학회지
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• 제37권4호
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• pp.474-493
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• 1999

According to repeated measurements and correction procedures, the accuracy of the phase-shifting profilometry was developed. At first, after 20 final models for maxillary complete denture were duplicated , the mucosa sur-faces of models were measured with the phase-shifting proflometry and each mirror view of these was calibrated. Maxillary casts were divided into 4 groups of 5 casts per each, and wax dentures with 2 sheets of baseplate wax and artificial teeth were made and then cured according to the curing method of each group. Group I ; quick curing with QC-20 acrylic resin Group II ; 9 hour curing with QC-20 acrylic resin Group III ; SR-Ivocap system Group IV ; metal base and quick curing with QC-20 acrylic resin. After curing, polishing, and storing at $37^{\circ}C$ in saline for 30 days, the forms of the impression surface of the dentures were measured with the phase-shifting profilometry. Then, the impression surface form of each denture was placed in the optimal position of com-parison with the mirror view of the same final cast. The amount and direction of distortion of each denture was analyzed and the effects of polishing and storage in each denture were compared, The obtained results were as follows : 1. In Group I, the denture was observed as the appearance distorted in the opposite direction of the mucosa and the postero-lateral part of palatal portion of the denture was observed as the appearance separated from the mucosa. Also, the buccal flanges of the denture were observed as the appearance distorted in the direction of the mucosa. 2. In Group II, the postero-lateral part of palatal portion of the denture was observed as the appearance separated slightly from the mucosa. The bilateral buccal flanges of denture were observed as the appearance distorted severely in the direction of the mucosa. 3. In Group III the bilateral part of the residual ridge crest portions and the buccal flanges of the denture were observed as the appearance distorted in the direction of the mucosa, and specially, the buccal flanges of the maxillary tuberosities were distorted severely. 4. In Group IV, the acrylic resin base of the buccal portion of the denture was observed as the appearance distorted in the opposite direction of the mucosa. 5. The phase-shifting profilometry, done with repeated measurements and correction procedures, was effective in comparing the amount and direction of distortion at every position after the laboratory work and the delivery of maxillary complete denture.

• Journal of Periodontal and Implant Science
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• 제31권3호
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• pp.641-649
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• 2001

The aim of present study was to assess the thickness of masticatory mucosa on the hard palate and tuberosity as a potential donor site for mucogingival surgery. Thickness measurement was performed in 30 dental college students who are periodontally healthy, with a recently developed, ultrasonic device(SDM). The mean age of study subjects was 23.7(range 21-29) years old and the subjects were composed of 18 males and 12 females. Eighteen standard measurement points were defined on the hard palate, located on 3 lines which ran at different distances parallel to the gingival margin. Six positions were designated on each of these 3 lines between the level of the canine and the second molar. On the tuberosity, 6 standard measurement points were defined, located on 2 lines running parallel to the gingival margin at different distances. Data were analyzed to determine differences in gender, between different positions, and between lines, by an analysis of variance. The results showed that the mucosa of the tuberosity was significantly thicker than that of the hard palate region. Gender did not influence the thickness of masticatory mucosa, either on the hard palate or the tuberosity. On the hard palate, mucosa thickness increased as the distance from the marginal gingiva increased. The mucosa over the palatal root of the maxillary first molar was significantly thinner than that at all other positions on the hard palate. Measurement error at palate was 0.25mm, at tuberosity 0.51mm. No difference in the thickness of masticatory mucosa on palate and tuberosity was found between men and women. On the hard palate, soft tissue thickness progressively increased in sites further from the gingival margin. Therefore, we may harvest more thicker graft on the tuberosity that has more masticatory mucosa thickness than hard palate, however the width may not be sufficient for using.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.147-148
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• 2002

Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis are encapsulated bacteria which encounter the respiratory mucosa and cause nasopharyngeal carriage that may lead to mild mucosal infections or severe invasive disease. (omitted)

• Journal of Oral Medicine and Pain
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• 제20권1호
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• pp.67-77
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• 1995

A Case of pemphigus bulgaris in buccal mucosa of 48 years old Korean female was reported. Final diagnosis was determined by evaluation of clinical and histopathological finding. The patient could be treated successfully by administration of prednisolone, injection of bethametasone, application of oramedy and irradiation of soft laser.

• 생명과학회지
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• 제28권9호
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• pp.1081-1091
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• 2018

자일렌이 흡입된 흰쥐 후각점막의 구조와 복합당질 특성을 조사할 목적으로 Sprague-Dawley계 수컷 흰쥐를 사용하여 300 ppm의 자일렌을 하루에 5시간씩 5일간 흡입시키고 30일까지 회복시켰다. 자일렌 흡입에 대한 후각점막의 형태적 변화를 비교하였고, PSA, UEA I, PHA-L, GSL I B4, GSL I, PNA, ECL, SBA, GSL II 및 sWGA의 10종류 렉틴을 이용한 렉틴조직화학을 실시하여 복합당질의 특성을 비교하였다. 자일렌 흡입 후 20일까지 후각상피는 상피세포의 수와 상피의 높이가 감소되는 퇴행성 변화를 보였다. 대조군에서 후각상피의 후각신경세포는 PSA, UEA I, PNA, SBA 및 sWGA에서, 지지세포는 PSA, PHA-L, GSL I, PNA, ECL, SBA, GSL II 및 sWGA에서, 그리고 후각샘은 10종류의 모든 렉틴에서 양성반응이 관찰되었다. 실험군에서 후각신경세포는 PSA, PNA 및 SBA에서 반응성이 감소하였고, 지지세포는 PSA, PNA, SBA 및 GSL II에서 반응성이 감소하였으며, 후각샘은 PSA, UEA I, GSL I 및 sWGA에서 그 반응성이 감소하였다. 결론적으로, 자일렌에 노출된 후각점막은 구조와 복합당질양상이 대조군에 비하여 많은 변화를 나타내었다. 이상의 결과들은 후각점막의 복합당질 당잔기가 자일렌 흡입 후에 변화할 수 있음을 시사한다.

• Asian-Australasian Journal of Animal Sciences
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• 제30권2호
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• pp.236-245
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• 2017

Objective: The study was to investigate the effects of alanyl-glutamine (Ala-Gln) and glutamine (Gln) supplementation on the intestinal mucosa barrier in piglets. Methods: A total of 180 barrows with initial weight $10.01{\pm}0.03kg$ were randomly allocated to three treatments, and each treatment consisted of three pens and twenty pigs per pen. The piglets of three groups were fed with control diet [0.62% alanine (Ala)], Ala-Gln diet (0.5% Ala-Gln), Gln diet (0.34% Gln and 0.21% Ala), respectively. Results: The results showed that in comparison with control diet, dietary Ala-Gln supplementation increased the height of villi in duodenum and jejunum (p<0.05), Gln supplementation increased the villi height of jejunum (p<0.05), Ala-Gln supplementation up-regulated the mRNA expressions of epidermal growth factor receptor and insulin-like growth factor 1 receptor in jejunal mucosa (p<0.05), raised the mRNA expressions of Claudin-1, Occludin, zonula occludens protein-1 (ZO-1) and the protein levels of Occludin, ZO-1 in jejunal mucosa (p<0.05), Ala-Gln supplementation enlarged the number of goblet cells in duodenal and ileal epithelium (p<0.05), Gln increased the number of goblet cells in duodenal epithelium (p<0.05) and Ala-Gln supplementation improved the concentrations of secretory immunoglobulin A and immunoglobulin G in the jejunal mucosa (p<0.05). Conclusion: These results demonstrated that dietary Ala-Gln supplementation could maintain the integrity of small intestine and promote the functions of intestinal mucosa barriers in piglets.

• 동의생리병리학회지
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• 제29권6호
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• pp.467-474
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• 2015

Allergic rhinitis is a growing tendency to increase. Following this tendency, allergic rhinitis is lively studied also in Korean oriental medicine. Bupleuri Radix (BR) has been used for many inflammatory diseases, but experimental backgrounds are not enough to treat allergic rhinitis. So in this study, effects of BR on OVA-induced allergic rhinitis model of BALB/c mice were examined. Thirty two BALB/c mice are equally devided into four groups; control group, OVA group, OVA+BR group, OVA+Cet group. The OVA, OVA+BR and OVA+Cet groups were induced allergic rhinitis by sensitizing to OVA. And then saline solution included BR (10.6 mg/kg body weight) was administered to the OVA+BR group orally. The number of nasal rubbing and nasal sneezing was evaluated for 10 days and later serological and histological changes were analyzed. Serological analysis included the serum levels of cytokines and chemokines (IL-4, IL-5, IL-12, MCP-1, MIP-2), total IgE and OVA-specific IgE levels in serum. Histological analysis included thickness of nasal septum, eosinophil counts changes of nasal mucosa, infiltration of eosinophil in nasal mucosa and histological changes of nasal mucosa. The number of nasal rubbing and nasal sneezing was significantly decreased in the OVA+BR group. The serum levels of IL-4, IL-5, MCP-1, MIP-2 were significantly decreased in the OVA+BR group but the serum levels of IL-1β had not significance. Total IgE and OVA-specific IgE levels in serum were decreased in the OVA+BR group, but total IgE levels in serum had only significance. Thickness of nasal septum, eosinophil counts of nasal mucosa and infiltration of eosinophil in nasal mucosa were significantly decreased in the OVA+BR group. From the results of this study, we think that BR has an effect on improvement of allergic rhinitis by improving nasal rubbing and nasal sneezing, reducing histological changes of nasal mucosa and infiltration of eosinophil in nasal mucosa, inhibiting increasing of the serum levels of cytokines, chemokines and total IgE.

• Journal of Oral Medicine and Pain
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• 제38권1호
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• pp.7-17
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• 2013

구강점막질환과 성격유형과의 관련성을 규명하고자 경기도 지역 대학에 재학중인 학생 393명(평균연령 $21.2{\pm}3.1$세, 남자 184명, 여자 209명)을 대상으로 MBTI 검사와 설문조사를 실시하여 다음과 같은 결과를 얻었다. 1. 미각이상(p<0.05)과 구강 건조증(p<0.01)은 외향성(E)보다 내향성(I)에서 높은 빈도를 보였다. 2. 헤르페스성 구내염, 재발성 아프타성 궤양, 설염, 미각이상, 구강 작열감 증후군, 구강 건조증은 직관형(N)보다 감각형(S)에서 빈도가 높은 경향을 보였다. 3. 16가지 성격유형 중 NF를 포함하는 유형은 구강점막질환 증상 발생빈도가 높은 경향을 보였다. 4. 구강점막질환 증상 발생 시 대처 방법에 있어서는 저절로 낫기를 기다리며 그냥 둔다는 응답이 가장 많았으며(p<.0001), 이 응답자 중 헤르페스성 구내염(p<0.01)과 미각이상(p<0.05) 경험자의 경우 내향성(I)이 외향성(E)보다 많았다. 5. 성격이 예민한 편이거나 신경질적인 경우가 구강점막질환 증상 발생빈도가 높은 경향을 보였다. 따라서 구강점막질환 치료시 환자의 개별적인 성격 유형에 맞는 지침을 개발하는 것이 필요하리라 사료된다.

• Journal of Oral Medicine and Pain
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• 제38권2호
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• pp.109-114
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• 2013

구강점막의 화학화상은 다양한 화학제품과의 접촉에 의해 일어날 수 있으며 국소 점막염, 각화성 백색병소, 출혈, 통증성조직 표면 등과 같은 임상적 특징을 나타낸다. Policresulen(알보칠$^{(R)}$)은 산부인과, 피부과, 이비인후과 영역에서 점막이나 피부의 소독 및 지혈 목적으로 사용되는 일반의약품이다. pH 0.6의 강산성을 띠고 있어서 강력한 부식제로 작용할 수 있으며 구강점막에 접촉될 경우 괴사나 화학화상과 같은 부작용을 나타낼 수 있기 때문에 사용상 세심한 주의를 요한다. 56세 여자 환자가 입술의 궤양과 부종 및 염증성 삼출물을 주소로 구강내과에 내원하였다. 이 환자는 약 10년 전부터 혓바늘이 가끔 발생하였으며 그런 경우에 알보칠$^{(R)}$을 종종 사용했었다고 하였다. 최근에는 혀와 입술의 통증 때문에 알보칠$^{(R)}$을 혀와 입술에 광범위하게 여러 차례 도포한 적이 있다고 하였다. 임상검사상 혀의 전방 1/2 부위에서 홍반성 미란 및 염증성 삼출물이 관찰되었고 상, 하순에 출혈성 가피 및 궤양이 형성되어 있었다. 알보칠 사용을 중단하게 한 후 구순부에 스테로이드 연고 도포 및 스테로이드 구강 가글액 사용 후 1주일 만에 병소는 현저히 줄어들었으며 2주 후 완치되었다. 본 증례를 통해서 일반의약품으로 쉽게 접할 수 있는 Policresulen(알보칠$^{(R)}$)의 오용으로 인한 구강점막의 출혈성 궤양의 발생 양상 및 치료과정을 소개하였으며, 구강점막에서 발생하는 화학화상에 대해 고찰하였다.