• Journal of KIISE:Software and Applications
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• v.34 no.7
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• pp.585-594
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• 2007

The back propagation algorithm took a long time to learn the input patterns and was difficult to train the additional or repeated learning patterns. So Aleksander proposed the binary neural network which could overcome the disadvantages of BP Network. But it had the limitation of repeated learning and was impossible to extract a generalized pattern. In this paper, we proposed a dynamic 3 dimensional Neuro System which was consisted of a learning network which was based on weightless neural network and a feedback module which could accumulate the characteristic. The proposed system was enable to train additional and repeated patterns. Also it could be produced a generalized pattern by putting a proper threshold into each learning-net's discriminator which was resulted from learning procedures. And then we reused the generalized pattern to elevate the recognition rate. In the last processing step to decide right category, we used maximum response detector. We experimented using the MNIST database of NIST and got 99.3% of right recognition rate for training data.

• Journal of KIISE:Software and Applications
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• v.41 no.8
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• pp.580-585
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• 2014

This paper conducts a variety of experiments for "the extraction of Korean parallel sentences using Wikipedia data". We refer to various methods that were previously proposed for other languages. We use two approaches. The first one is to use translation probabilities that are extracted from the existing resources such as Sejong parallel corpus, and the second one is to use dictionaries such as Wiki dictionary consisting of Wikipedia titles and MRDs (machine readable dictionaries). Experimental results show that we obtained a significant improvement in system using Wikipedia data in comparison to one using only the existing resources. We finally achieve an outstanding performance, an F1-score of 57.6%. We additionally conduct experiments using a topic model. Although this experiment shows a relatively lower performance, an F1-score of 51.6%, it is expected to be worthy of further studies.

• IMMUNE NETWORK
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• v.12 no.6
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• pp.269-276
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• 2012

The anti-tumor effect of monocyte-derived DC (MoDC) vaccine was studied in lung cancer model with feasible but weak Ag-specific immune response and incomplete blocking of tumor growth. To overcome this limitation, the hematopoietic stem cell-derived DC (SDC) was cultured and the anti-tumor effect of MoDC & SDC was compared in mouse lung cancer minimal residual model (MRD). Therapeutic DCs were cultured from either $CD34^+$ hematopoietic stem cells with GM-CSF, SCF and IL-4 for 14 days (SDC) or monocytes with GM-CSF and IL-4 for 7 days (MoDC). DCs were injected twice by one week interval into the peritoneum of mice that are inoculated with Lewis Lung Carcinoma cells (LLC) one day before the DC injection. Anti-tumor responses and the immune modulation were observed 3 weeks after the final DC injection. CD11c expression, IL-12 and TGF-${\beta}$ secretion were higher in SDC but CCR7 expression, IFN-${\gamma}$ and IL-10 secretion were higher in MoDC. The proportion of $CD11c^+CD8a^+$ cells was similar in both DC cultures. Although both DC reduced the tumor burden, histological anti-tumor effect and the frequencies of IFN-${\gamma}$ secreting $CD8^+$ T cells were higher in SDC treated group than in MoDC. Conclusively, although both MoDC and SDC can induce the anti-tumor immunity, SDC may be better module as anti-tumor vaccine than MoDC in mouse lung cancer.

• Progress in Medical Physics
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• v.9 no.1
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• pp.47-53
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• 1998

Nuclear Medicine Images have comparatively poor spatial resolution, making it difficult to relate the functional information which they contain to precise anatomical structures. Anatomical structures useful in the interpretation of SPECT /PET Images were radiolabelled. PET/SPECT Images Provide functional information, whereas MRI mainly demonstrate morphology and anatomical. Fusion or Image Registration improves the information obtained by correlating images from various modalities. Brain Scan were studied on one or more occations using MRI and SPECT. The data were aligned using a point pair methods and surface matching. SPECT and MR Images was tested using a three dimensional water fillable Hoffman Brain Phantom with small marker and PET and MR Image was tested using a patient data. Registration of SPECT and MR Images is feasible and allows more accurate anatomic assessment of sites of abnormal uptake in radiolabeled studies. Point based registration was accurate and easily implemented three dimensional registration of multimodality data set for fusion of clinical anatomic and functional imaging modalities. Accuracy of a surface matching algorithm and homologous feature pair matching for three dimensional image registration of Single Photon Emission Computed Tomography Emission Computed Tomography (SPECT), Positron Emission Tomography (PET) and Magnetic Resonance Images(MRD was tested using a three dimensional water fill able brain phantom and Patients data. Transformation parameter for translation and scaling were determined by homologous feature point pair to match each SPECT and PET scan with MR images.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7303-7307
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• 2015

Background: Leukemia is a common cancer among children and adolescents. Wilms' tumor gene (WT1) is highly expressed in patients with acute leukemia. It is found as a tumor associated antigen (TAA) in various types of hematopoietic malignancies and can be employed as a useful marker for targeted immunotherapy and monitoring of minimal residual disease (MRD). In this regard, WT1 is a transcription factor that promotes gene activation or repression depending on cellular and promoter context. The purpose of this study was assessment of WT1 gene expression in patients with acute leukemia, measurement of IL-12 and C3 levels in serum and evaluation of the relationship between them. Materials and Methods: We evaluated the expression of WT1 mRNA using real-time quantitative RT-PCR and serum levels of IL-12 and C3 using ELISA and nephelometry in peripheral blood of 12 newly diagnosed patients with acute leukemia and 12 controls. Results: The results of our study showed that the average wT1 gene expression in patients was 7.7 times higher than in healthy controls (P <0.05). In addition, IL-12 (P = 0.003) and C3 (P <0.0001) were significantly decreased in the test group compared to controls. Conclusions: WT1 expression levels are significantly higher in patients compared with control subjects whereas serum levels of interleukin-12 and C3 are significantly lower in patients. Wt1 expression levels in patients are inversely related with serum levels of IL-12 and C3.

• Korean Journal of Digital Imaging in Medicine
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• v.12 no.2
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• pp.119-125
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• 2010

In order to demonstrate the value of long-distance radiography, we have studied how distance affects images in chest frontal radiography and compared short-distance and long-distance images in chest lateral radiography. Cardiothoracic ratio(CTR %) of 50 patients with no disease in the chest(10 each at the age of 20~60) were evaluated in Supine AP(100 cm), Sitting AP(100 cm), Sitting AP(180 cm), and Erect PA(180 cm). In lateral radiography, we evaluated and compared left lateral radiography(100 cm and 180 cm) of the patients based on the horizontal maximum of the heart. The average value of CTR(%) were 0.48 in Erect PA(180 cm), 0.52 in Supine AP(100 cm), 0.50 in Sitting AP(100 cm), 0.49 in Sitting AP(180 cm), which were Supine AP(100 cm) > Sitting AP(100 cm) > Sitting AP(180 cm) > Erect PA(180 cm). The average value of Maximum transverse diameter of left of the cardiac(MLD), which showed how much axis of spine was slanted to the left, was 90.67 mm in Erect PA(180 cm), 103.92 mm in Supine AP(100 cm), 93.54 mm in Sitting(100 cm), 89.84 mm in Sitting AP(180 cm), 58.11 mm in the minimum value and 118.79 mm in the maximum value. The average value of Maximum transverse diameter of right side of the cardiac(MRD), which suggested how much axis of spine was slanted to the right, was 47.18 mm in Erect PA(180 cm), 48.12 mm in Supine AP(100 cm), 44.98 mm in Sitting AP(180 cm), and the minimum value 26.84 mm and the maximum value 65.30 mm. There was no standard method to calculate; therefore, the horizontal maximum of the heart was used for lateral radiography. The average value was 121.07 mm in 100 cm and 109.76 mm in 180 cm. Sitting AP(180 cm) among the types was closest to C-PA(180 cm). As a result, during C-AP radiography, long-distance radiography lessened shadow of the heart more than that of short distance, Sitting position more than Supine position.