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Photodynamic Therapy for Cancer without External Light Illumination by Utilizing Radioisotope-induced Cerenkov Luminescence as an Excitation Source

  • Chi Soo Kang;Md. Saidul Islam;Dohyeon Kim;Kyo Chul Lee
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.9 no.1
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    • pp.35-41
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    • 2023
  • Photodynamic therapy (PDT), in which a photosensitizer (PS), light, and molecular oxygen are essential components, is a non-invasive and highly effective cancer therapeutic method. However, PDT suffers from the penetration limit of light caused by attenuation and scattering of light through tissues constraining its use to skin and endoscopically accessible cancers. Cerenkov luminescence (CL) is defined as the light illuminated when charged particles move in a dielectric medium at a velocity greater than the phase velocity of light. It is known that medical radioisotopes in preclinical and clinical settings have enough energy to generate CL, and lately, CL has been exploited as an excitation source for PDT without external light illumination. This review introduces state of the art studies of radioisotope-based PDT for cancer, in which radioisotopes are utilized as a light source.

A Study on Simscape based 6DOF Field Robot Simulation Model (Simscape 기반 6자유도 필드로봇 시뮬레이션 모델에 관한 연구)

  • Choi, Seong Woong;Kwak, Kyung Sin;Le, Quang Hoan;Yang, Soon Yong
    • Journal of Drive and Control
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    • v.19 no.2
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    • pp.1-10
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    • 2022
  • Field robots operate in various areas, including construction, agriculture, forestry and manufacturing. Typical tasks of field robots used in various areas include excavation, flattening, and demolition. Such tasks are often accomplished in narrow alleys or indoors. In the case of field robots, there is a limit to working in a small space. Thus, to compensate for these shortcomings, many field robots equipped with Tiltrotators have recently been observed. The advantages of Tiltrotator are improved task efficiency and reduced operating time by reducing unnecessary behavior. We need simulation models that can improve the ability of new people to work and simulate tasks in advance. Thus, in this paper, we developed a simscape-based simulation model and modeling of 6DOF systems for field robots equipped with Tiltrotator. Dynamic modeling of field robot 3D models using Simcape multibody and hydraulic systems of field robots using Simcape Hydraulics were modeled. We applied a PID controller to create a control system that operates along the input angle. Simulation results show that errors occur when comparing input and output angles, but overall, they move along input angles.

Hopping Robot Using Direct-drive Method and Thermal Modeling to Analyze Motor Limitation (Direct-drive를 활용한 소형 연속 도약 로봇 및 DC모터의 열 모델을 통한 한계 분석)

  • Myeongjin Jang;Seongyo Yang;Gwang-Pil Jung
    • The Journal of Korea Robotics Society
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    • v.19 no.1
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    • pp.53-57
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    • 2024
  • A hopping robot can move through a confined environment while overcoming obstacles. To create a small hopping robot, it must be able to generate a large amount of energy and release it at the same time. However, due to the small size of the robot, there is a limit to the size of the actuator that can be used, so it is mainly used to collect energy in an elastic element and release it at once. In this paper, we propose a small hopping robot with a simplified design by removing ancillary parts and enabling continuous hopping using only a small actuator based on a direct-drive method. In addition, repeated actuation over the rated voltage can cause thermal breakdown of the actuator. To check the safety of the actuator at high voltage, we perform modeling to predict the temperature of the actuator and verify the accuracy of the modeling through experiments.

The Next Wave in Display Innovation

  • Webster, Steven C.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2008.10a
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    • pp.4-4
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    • 2008
  • The progress in flat panel displays over the last two decades has been astonishing. In just 20 years, the LCD-TV grew up from a 2-inch curiosity, to an industry that will sell about 120 million flat panel TV's this year, with viewing area up to 4000 times larger. That success is based on continuous innovation, especially in manufacturing processes. For the next decade to bring another doubling of the business, progress will need to continue in four major areas: Human factors, ecological impact, visual quality, and of course continued drive towards affordability. This talk will detail the technology advances that can allow this industry to meet those challenges. Human factors. Today, we adapt our lifestyle to our technology. People organize their offices, and their homes, around displays. We pass around mobile phones to share images, rather than experiencing them as a group. Billions of newspapers continue to be sold daily. Advances in flexible displays can lead to large portable displays. "New era projection" includes the handheld Pico Projectors that are already on the market, and will ultimately appear integrated in mobile phones the same way cameras do today. "Eco" impact. Today TV's are one of the top energy consumers in a U.S. home, and the fastest growing. Watching a large flat panel TV can cost twice as much as running a large refrigerator. With today's concern about energy consumption, regulations are starting to emerge worldwide to limit TV electrical use. Fortunately, good solutions exist in using light management films to eliminate bulbs, saving power without increasing cost. Going forward, LED backlights will drive another step downward. OLED displays might be the ultimate solution. Visual quality. The color of an LCD-TV is still often considered inferior to a far less expensive CRT. And almost all displays suffer from representing a three-dimensional world on a two dimensional surface. The technology to improve color is available today, and will likely move from premium sets into the mainstream as costs come down. 3D is now arriving in movie theaters worldwide, and that will drive up the demand for similar realistic images in home theaters. And the technology is emerging today for 3D representation to move beyond specialized applications into everyday use, on screens large and small. Affordability. The world takes cost-down miracles for granted in consumer electronics. Each of these other advances will be balanced with a drive for affordability, especially as the market grows in emerging countries. The other three challenges must be met without increasing cost. Putting this all together, the next few years will emphasize "eco friendly" designs, and enhanced images such as 3D. By 2013 we will start to see serious penetration by emissive technologies (OLED, high efficiency plasma, or other), with the "ultimate display" likely not in the market for a decade. Lots of opportunities for innovation remain ahead of us.

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A Study on the Revised Draft of Rome Convention on Compensation for Damage Caused by Aircraft to Third Parties - With Respect to the Draft Unlawful Interference Compensation Convention and the Draft General Risks Convention - (항공기에 의하여 발생된 제3자 손해배상에 관한 로마협약 개정안에 대한 고찰 - 불법방해배상협약안과 일반위험협약안을 중심으로 -)

  • Lee, Kang-Bin
    • The Korean Journal of Air & Space Law and Policy
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    • v.22 no.2
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    • pp.27-51
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    • 2007
  • The cumulative result of the work by the ICAO Secretariat, the Secretariat Study Group and the Council Special Group on the Modernization of the Rome Convention of 1952 are two draft Conventions, namely: "Draft Convention on Compensation for Damage Caused by Aircraft to Third Parties, in case of Unlawful Interference", and "Draft Convention on Compensation for Damage Caused by Aircraft to Third Parties" The core provisions of the former draft Convention are as follows: The liability of the operator is strict, that is, without the necessity of proof of fault. It would be liable for damage sustained by third parties on condition only that the damage was caused by an aircraft in flight(Article 3). However, such liability is caped based on the weight of the aircraft(Article 4). It is envisaged to create an independent organization called the Supplementary Compensation Mechanism, with the principle purpose to pay compensation to persons suffering damage in the territory of a State Party, and to provide financial support(Article 8). Compensation shall be paid by the SCM to the extent that the total amount of damages exceeds the Article 4 limits(Article 19). The main issues on the farmer draft Convention are relating to breaking away from Montreal Convention 1999, no limits on individual claims but a global limitation on air carrier liability, insurance coverage, cap of operators' strict liability, and Supplementary Compensation Mechanism. The core provisions of the latter draft Convention are as follows: the liability of the operator is strict, up to a certain threshold tentatively set at 250,000 to 500,000 SDRs. Beyond that, the operator is liable for all damages unless it proves that such damage were not due to its negligence or that the damages were solely due to the negligence of another person(Article 3). The provisions relating to the SCM and compensation thereunder do not operate under this Convention, as the operator is potentially for the full amount of damages caused. The main issues on the latter draft Convention are relating to liability limit of operator, and definition of general risks. In conclusion, we urge ICAO to move forward expeditiously on the draft Convention to establish a third party liability and compensation system that can stand ready to protect both third party victims and the aviation industry before another 9/11-scale event occurs.

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A low damage and ductile rocking timber wall with passive energy dissipation devices

  • Loo, Wei Yuen;Quenneville, Pierre;Chouw, Nawawi
    • Earthquakes and Structures
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    • v.9 no.1
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    • pp.127-143
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    • 2015
  • In conventional seismic design, structures are assumed to be fixed at the base. To reduce the impact of earthquake loading, while at the same time providing an economically feasible structure, minor damage is tolerated in the form of controlled plastic hinging at predefined locations in the structure. Uplift is traditionally not permitted because of concerns that it would lead to collapse. However, observations of damage to structures that have been through major earthquakes reveal that partial and temporary uplift of structures can be beneficial in many cases. Allowing a structure to move as a rigid body is in fact one way to limit activated seismic forces that could lead to severe inelastic deformations. To further reduce the induced seismic energy, slip-friction connectors could be installed to act both as hold-downs resisting overturning and as contributors to structural damping. This paper reviews recent research on the concept, with a focus on timber shear walls. A novel approach used to achieve the desired sliding threshold in the slip-friction connectors is described. The wall uplifts when this threshold is reached, thereby imparting ductility to the structure. To resist base shear an innovative shear key was developed. Recent research confirms that the proposed system of timber wall, shear key, and slip-friction connectors, are feasible as a ductile and low-damage structural solution. Additional numerical studies explore the interaction between vertical load and slip-friction connector strength, and how this influences both the energy dissipation and self-centring capabilities of the rocking structure.

Formulation of General Equations for Plastic Collapse Loads of Grillages under a Lateral Point Load (집중하중을 받는 Grillage의 소성 붕괴하중 산정 및 일반식 도출)

  • Hong, Ki-Sup;Kim, Ki-Sung
    • Journal of the Society of Naval Architects of Korea
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    • v.41 no.6
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    • pp.91-101
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    • 2004
  • For the grillage which is common types of structures in marine and land-based structural system, the elastic response and design methods are usually applied. However, plastic analysis and design methods are considered Tn those structures to maintain the structural stability at the limit states. In grillage design, the central intersection point load may be used as a worst loading condition. However, a point load may often move around on the grid system. in such case, the worst load point would not necessarily be at the central point. To investigate the variation of plastic collapse load according to the location of moving load between intersections, the plastic collapse loads are obtained for the three types of grillages with simply-supported ends. From the result of each case, it is confirmed that the worst load point is located between intersections. General formulae related with plastic collapse loads for the three groups of grillages with simply-supported boundaries are derived. Those plastic collapse formulae for the grillages are applied to the design of pontoon deck, and optimum design procedure is illustrated. Consequently, general formulae for the plastic collapse of grillages derived from this study can be easily applied to the plastic analysis and optimum design of similar grillages.

Spatial Structure Analysis of Traditional Periodical Market using Space Syntax Method (공간구문론을 활용한 전통정기시장 공간구조분석 -평창 대화장을 중심으로-)

  • Jeong, Dae Young;Yoon, Ah Young;Yoon, Ji Hwan;Kim, Sang Bum
    • Journal of Agricultural Extension & Community Development
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    • v.20 no.3
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    • pp.679-700
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    • 2013
  • Due to the decline of a rural community, traditional periodic markets regarded as a center of an agricultural village have been gradually downsized. While researchers have made a counterproposal to revitalize the traditional periodic markets, there has limit in examining how space structure of the traditional periodic markets affect visitors. Thus this study aims to analyze space structure and visitor circulation using a space syntax, a quantitative analysis focusing on PyeongChang Daehwa market. The finding revealed high degree of unification and clearness which means overall space structure was efficient for visitors to recognize and move across the space. However, there is required to build strategies encouraging consumption. The result of analyzing visitor circulation showed the degree of unification is the highest in visitor circulation where center of the market or main facilities is located. In sum, in order to revitalize deserted traditional periodic markets, rural communities need to work out strategies to encourage consumption and expand both information desk and convenience facilities.

A David Star Magic Square Algorithm for Efficient LED Control (효율적인 LED 제어를 위한 다윗 스타 마방진 알고리즘)

  • Lee, Kyung-Min;Lin, Chi-Ho
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.16 no.3
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    • pp.109-113
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    • 2016
  • In this paper, we propose efficient LED lighting control algorithm using a David star magic square. Such algorithms increases the power reduction, the heat efficiency and LED life cycle and the efficiency of the LED lighting control consumption. Lighting system using existing Magic square algorithm could be reduced to increase the heat efficiency of the LED because the LED lighting time of the reduced cross-lighting. but it has a limit to the lighting control. If should apply the this proposed algorithm, can reduces power consumption and increases LED life-cycle, heat efficiency of LED lighting module and efficiency of the lighting control of the LED. This paper proposed that algorithm is by using a David star magic square on the LED Matrix. Divided into twelve areas to move the pattern in constant time interval, to perform the cross rotation and inversion techniques to thereby light up. In this paper proposed algorithm of this paper was compared with existing Magic square approach. As a result, power consumption and heat-value and luminous flux was reduced as the conventional lighting system. And, the LED lighting control increase the efficiency.

Electrical Conductivity Revisited in Excess BaO into BaTiO3 (BaO 과잉량에 따른 BaTiO3의 전기전도도)

  • Yeo, Hong-Goo;Kuk, Min-Ho;Kim, Myong-Ho;Song, Tae-Kwon;Bae, Dong-Sik;Park, Tne-Gone;Lee, Soon-Il;Randall, Clive A.
    • Journal of the Korean Ceramic Society
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    • v.42 no.5 s.276
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    • pp.308-313
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    • 2005
  • In this study the electrical conductivity of excess BaO in $BaTiO_3$ was measured to investigate the relationship between defects and solubility in the temperature range of $900^{\circ}C$ to $1300^{\circ}C$ under various oxygen partial pressure. First of all, quenched $BaTiO_3$ powders of various Ba/Ti ratios were analysed by X-ray diffraction to confirm whether second phase is formed or not. As the results, we observed the solubility of BaO in the temperature range of $1200^{\circ}C$ to $1400^{\circ}C$, and it was also found that the conductivity minima move to lower $PO_2$ with increasing excess BaO within solubility limit.