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Systems Biology and Emerging Technologies Will Catalyze the Transition from Reactive Medicine to Predictive, Personalized, Preventive and Participatory (P4) Medicine

  • Galas, David J.;Hood, Leroy
    • Interdisciplinary Bio Central
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    • v.1 no.2
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    • pp.6.1-6.4
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    • 2009
  • We stand at the brink of a fundamental change in how medicine will be practiced. Over the next 5-20 years medicine will move from being largely reactive to being predictive, personalized, preventive and participatory (P4). Technology and new scientific strategies have always been the drivers of revolutions and this is certainly the case for P4 medicine, where a systems approach to disease, new and emerging technologies and powerful computational tools will open new windows for the investigation of disease. Systems approaches are driving the emergence of fascinating new technologies that will permit billions of measurements on each individual patient. The challenge for health information technology will be how to reduce this enormous amount of data to simple hypotheses about health and disease. We predict that emerging technologies, together with the systems approaches to diagnosis, therapy and prevention will lead to a down turn in the escalating costs of healthcare. In time we will be able to export P4 medicine to the developing world and it will become the foundation of global medicine. The "democratization" of healthcare will come from P4 medicine. Its first real emergence will require the unprecedented integration of biology, medicine, technology and computation. as well as societal issues of major importance: ethical, regulatory, public policy, economic, and others. In order to effectively move the P4 scientific agenda forward new strategic partnerships are now being created with the large-scale integration of complementary skills, technologies, computational tools, patient records and samples and analysis of societal issues. It is evident that the business plans of every sector of the healthcare industry will need to be entirely transformed over the next 10 years.and the extent to which this will be done by existing companies as opposed to newly created companies is a fascinating question.

Dynamic Programming Algorithm Path-finding for Applying Game (게임 적용을 위한 Dynamic Programming 알고리즘 길찾기)

  • Lee, Se-Il
    • Journal of the Korea Society of Computer and Information
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    • v.10 no.4 s.36
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    • pp.213-219
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    • 2005
  • In order to move NPC's to target location at game maps, various algorithm including A* has been used. The most frequently used algorithm among them is A* with fast finding speed. But A* has the following problems. The first problem is that at randomly changing map, it is necessary to calculate all things again whenever there are any changes. And when calculation is wrong, it is not possible to search for target. The second problem is that it is difficult to move avoiding dangerous locations damaging NPC such as an obstruction. Although it is possible to avoid moving to locations with high weight by giving weight to dangerous factors. it is difficult to control in case NPC moves nearby dangerous factors. In order to solve such problems, in this thesis, the researcher applied Dynamic Programming to path-finding algorithm. As the result of its application, the researcher could confirm that the programming was suitable for changes at the map with random change and NPC's avoided the factors being dangerous to them far away. In addition. when compared to A*, there were good results.

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A study on the development of oil skimming ship for large quantity of oil pollution (대형 오염방제 선박의 개발에 관한 연구)

  • 권기생
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.2 no.1
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    • pp.57-65
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    • 1996
  • The latest date, No. 1 YouII was grounded and sunk into the sea at MAMHYUNGJEDO ( South brother Island) in Sep. 21. 1995, and M.V. Sea Prince of V.L.C.C also made a big oil poullution accident owing to Typhoon "Paei" at front sea of Yeu Choun on Jul. 25. 1995. The large or small scall scale of oil poullution accident frequently was occurred about 300-350 cases per ine(1) year. The countries advanced in marine relations like as, nited Kingdom and Japan, have perfect system The country of expert education, training and oil recovery equipments in oil poullution accidents. The large quantity oil skimming ship's basic condition need general skimming ship which was high speed and large quantity skimming ability , and hve to store the recovered oil into tanks This oil skimming shop are composit the skimmer whuch move up and down according to the wace movements, storage tank which storage the recovered oil in after side, transfer pump which transformed from flooding tank to separating tank and separating tank which separated the oil mixtures, Also there are cylindrical floated which keep the auto positing, gate which keep the auto positing, gate which protect and guide the recovering oil from sea and balance weight for skimmer balance. Also there are cylindrical floated which keep the auto positing, gate which protect and guide the recovering oil from sea and balance weight for skimmer balance. The important arrangement is twin arm which moved by two hinge and move te skimming unit by wave movement. In gate of inside, made long wear in the gate bellow position, there are also connected the flexible hose for oil mixtures drop. The separating tank composited with multi-divided bulkhead for ffective oil and sea water separating by settling and flotation principle. As use the above natural princile and equipment, we can remove the large quantity oil by developed oil skimming ship.ming ship.

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Post-purchase Evaluation on the Maternity Wear on the Current Korean Market by Survey and Wear test

  • Park, Soon-Jee;Lee, Hee-Jung;Suh, Chu-Yeon
    • Journal of Fashion Business
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    • v.11 no.3
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    • pp.15-34
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    • 2007
  • This study was designed to collect a precise information concerning to the preference and evaluations after usage of pregnant Korean woman for the maternity wear bysurvey and wear tests. Through the survey, 212 respondents were asked to answer what type of maternity wear they prefer and what requirements for maternity wear design are important. According to the results of survey, the mostly preferred maternity wear items were pants and one-piece dress. Korean customers for maternity wear usually pay more for the one-piece dress than other items and they also usually put on medium price pants and low-price blouse. Concerning to the purchase criteria, it may be said that design and movability, fit factors are the buying decision criteria of great weight for Korean pregnant women. Special function most desired was thermal insulation, followed by buffer action, electromagnetic shield and quickly water-absorbent and dry property. Preferred maternity wear design details were flat collar, slightly fitted waist and empire style, gather skirt, rubber band waist. Wear test was performed for two kinds of blouse (BL) and one-piece dress (OP), and threekinds of pants (PT), which have different design details respectively. According to the wear test for ready-to-wear maternity garments, the garment which considers well the characteristics of Korean pregnant women body shape earned much higher score no matter of brands or prices. Generally, high-priced national brands received an excellent evaluation in design aspect, but not satisfied with comfort to move.

Local Governments′ Housing Information System (지방정부의 주택정보서비스체계구축방안 및 사례연구)

  • 윤혜정
    • Journal of the Korean housing association
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    • v.15 no.2
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    • pp.27-34
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    • 2004
  • The purpose of this study has two folds. For the local government it gives a guide to establish the housing information system, which provides various housing information in order to promote service to the public on Internet. It also gives a guide for the local government to collect the fundamental data from local housing market and provide them to the policy makers as well as the housing producers (landlords, builders and owner-occupiers). Contents of housing information system website for the local government consist of three main parts. The first part provides housing policy and local housing market information to the upper level local government as well as housing producers. The second part provides housing information for the people who are looking for houses to move the own. Final part provides the procedures of building construction and development plan for landlords to the public. In case of Pyongtaek-City, this study makes them by cluster analysis of houses and households moving pattern as the Internet contents. Housing markets of Pyongtaek-City divide 3 sectors by housing type, tenure type and housing supply ratio etc. And populations prefer to move intra sectors. According to this information, policy-makers should define local housing problems and find solutions and housing producers can supply the house just in sites and in time. In conclusion, local government should provide valuable housing information based on local housing market research to the public for the effective housing policy. As local housing market is formed by various factors it is needed for local government to research housing sub-markets due to apply these research results to the local government for the future.

Data Dissemination Protocol Considering Target Mobility in Ubiquitous Sensor Network (유비쿼터스 센서 네트워크 환경에서 감지대상의 이동성을 고려한 데이터 전달 프로토콜)

  • Suh Yu-Hwa;Kim Ki-Young;Shin Young-Tae
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.3A
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    • pp.311-320
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    • 2006
  • This paper proposes DDTM for USN having end-point mobility. The existing network protocols did not consider target's and sink's mobility. So it requires flooding and path update whenever targets or sinks move. This can lead to drain battery of sensors excessively and decrease lifetime of USN. DDTM is the protocol based on TTDD considering sink's mobility. TTDD provides sink's mobility efficiently by using the grid structure, but it requires the high energy because of reconstructing the grid structure whenever targets move. In this way, the proposed protocol can decrease a consumption of energy, since it reuses the existing grid structure of TTDD, if the target moves in local cell. We compare DDTM with TTDD under the total message and the energy consumption by using a discrete analytical model for cost analysis. Analytical results demonstrated that our proposed protocol can provide the higher efficiency on target's mobility.

A Novel Cell Selection Technique Based on Game Theory for Femtocell System Resource Optimization (펨토셀시스템 자원 최적화를 위한 게임이론 기반 기지국 선택 기법)

  • Jang, Jeong-Gyu;Sohn, Insoo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.39A no.11
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    • pp.652-659
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    • 2014
  • In this paper, we propose an access point selection method for mobile users in LTE-femtocell system. In wireless communication system, users want to receive good data service. In LTE-femtocell system, if users move a little, users can experience different data service. The proposed access point selection method help that if users move a little, users obtain the high capacity and that user selects access point that other user have not selected much and so obtains higher data service. We simulated in order to prove performance of the proposed access point selection metod. Simulation results show that in a situation that users are concentrated in order to obtain better data service users are seen scattered look. As a result, we confirm that the proposed access point selection method provides good data service to users.

Enlargement of EU and Migration of Workers (EU 확대와 노동 이동)

  • Mun, Nam-Cheol
    • Journal of the Economic Geographical Society of Korea
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    • v.10 no.2
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    • pp.182-196
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    • 2007
  • EU has pursued of the economic growth and the promotion of jobs by a free movement of workers. The free labour mobility brings a sustainable economic development through the creating jobs and the acquisition of a new knowledge and technology, but it also produces the geographical unequality of the movement of workers. And the enlargement of the EU redistributes geographically the flow of labour mobility. The flow of labour movement within EU changes to the structure of mobility that moves from the North to the North instead of the movement from the South to the North as an economic development in the South and an economic transformation to the service and hightech industry in the North. The mobility of unskilled workers has diminished, but the mobility of expert workers has increased. The flow of labour movement within EU has a structure hierarchic that the experts labour move from the North to the North, and the unskilled labour move from the South to the North and from the northern Africa to the South of Europe.

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An Open-Loop Power Control Algorithm for On-The-Move Terminal in Satellite Communication Systems (위성통신 시스템에서 이동형 위성단말을 위한 개루프 전력제어 알고리즘)

  • Lee, Ho-Sub;Park, Hyung-Won;Yoon, Wonsik
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.18 no.9
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    • pp.2298-2306
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    • 2014
  • In this paper, we propose an open loop power control algorithm to control transmission power of the On-The-Move(OTM) Satcom terminal in GEO satellite communication environment. The proposed algorithm identifies the current channel state restricted by an obstacle or an antenna depointing loss based on the received beacon signal strength. On the basis of the determined signal attenuation causes, the OTM Satcom terminal turns off the RF output when an antenna tracking is failed. If the OTM Satcom terminal experiences a channel blockage by an obstacle, the terminal spreads the transmit data to increase data reception probability. To evaluate the performance of the proposed algorithm, we compare an adjacent satellite interference level and an outage probability. The results show the performance of the proposed algorithm is better than that of the conventional algorithm.

Evaluation of Sphere Faced Type Piston Nipple for Water Feed of Poultry (양계 급수용 구면 피스톤 니플의 성능 평가)

  • Kim, Key-Sun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.8 no.5
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    • pp.961-967
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    • 2007
  • Automatic water feeding system for chickens is the one of the most important devices at poultry farms. Chickens drink water directly from a water feeder nipple of the automatic water feeder. Check valve inside the water feeder nipple is open when they drink water and is closed otherwise. There are two types of nipples. One is the piston nipple, and the other is the ball nipple. Because the nipple stick in the ball nipple can move freely, the sloping mechanism of the ball nipple works well. but it has complicated mechanism. On the other hand, the piston nipple has very simple structure, but its movement is limited so it can move only up-and-down. To overcome those limitation, the piston nipple with sphere valve seat face (sphere face piston nipple) has been developed and is just distributed at domestic markets. The experimental performance test of the commercialized sphere piston nipple has been conducted, and compared with the performance of the ball nipple and the piston nipple which are domestic products. As the result, sphere piston nipple shows excellent performance compared to that of the piston nipple but its performance is similar to ball type nipple.

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