• Journal of Pharmaceutical Investigation
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• 제40권4호
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• pp.245-250
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• 2010

Porous poly(lactic-co-glycolic acid) microspheres (PLGA MS) have been utilized as an inhalation delivery system and a matrix scaffold system for tissue engineering. Here, gelatin (type A) is introduced as an extractable pH-responsive porogen, which is capable of controlling the porosity and pore size of PLGA microspheres. Porous PLGA microspheres were prepared by a water-in-oil-in-water ($w_1/o/w_2$) double emulsification/solvent evaporation method. The surface morphology of these microspheres was examined by varying pH (2.0~11.0) of water phases, using scanning electron microscopy (SEM). Also, their porosity and pore size were monitored by altering acidification time (1~5 h) using a phosphoric acid solution. Results showed that the pore-forming capability of gelatin was optimized at pH 5.0, and that the surface pore-formation was not significantly observed at pHs of < 4.0 or > 8.0. This was attributable to the balance between gel-formation by electrostatic repulsion and dissolution of gelatin. The appropriate time-selection between PLGA hardening and gelatin-washing out was considered as a second significant factor to control the porosity. Delaying the acidification time to ~5 h after emulsification was clearly effective to make pores in the microspheres. This finding suggests that the porosity and pore size of porous microspheres using gelatin can be significantly controlled depending on water phase pH and gelatin-removal time. The results obtained in this study would provide valuable pharmaceutical information to prepare porous PLGA MS, which is required to control the porosity.

• 한국진공학회지
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• 제13권4호
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• pp.150-156
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• 2004

Si(100) 기판 위에 RF UBM 스퍼터링 (Unbalanced Magnetron Sputtering) 방법을 이용하여 BN 박막을 증착하였다. 이온 충돌 에너지에 영향을 주는 증착 압력과 기판 바이어스 전압을 변화시켜, 증착된 BN박막의 미세구조와 압축응력의 변화를 살펴보았다. 높은 증착 압력에서는 hBN laminate의 정렬도가 기판 바이어스 전압이 증가함에 따라 선형적으로 증가한 반면, 낮은 증착 압력에서는 낮은 기판 바이어스 전압에서 hBN laminate의 정렬도가 높게 나타났다. hBN 박막의 응력 변화와 표면 형상은 hBN laminate의 정렬도와 밀접한 관계가 있는 것으로 관찰되었는데, 이의 적절한 조절에 의해 압축응력의 증가 없이도 hBN 박막 위에 cBN 상의 핵 형성이 일어날 수 있었다.

• 한국세라믹학회지
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• 제34권10호
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• pp.1083-1091
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• 1997

반응성이 좋은 미분말의 고온 초전도상을 얻고자 액상 합성법 중의 하나인 옥살산염법을 이용하였다. 본 방법을 사용하여 합성 분체의 초기 형상과 입도를 제어하였고, 개선된 균일성을 가진 Bi(Pb)-Sr-Ca-Cu-O 초전도 분말을 제조할 수 있었다. 합성된 산화물 초전도체 분말의 특성 및 pellct으로 성형후 열처리한 시편의 미세구조와 전기적특성을 조사하였다. 또한, Tape casting법에 의해 후막을 제작하여 미세구조와 전기적 특성을 관찰하였다. 합성된 분말의 입자 크기는 100~300nm 이하의 구형이었으나 대부분이 1~3 ${\mu}{\textrm}{m}$ 크기로 응집되어 있었다. 84$0^{\circ}C$로 72시간 동안 열처리한 괴상 시편의 임계저항온도는 110K였으며, 열처리한 후막의 임계전류는 각각 0.6A, 1.9A였다.

• 한국재료학회지
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• 제17권8호
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• pp.437-441
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• 2007

Preparation and morphology control of $TiO_2$ nano powders for gas sensor applications are investigated. $TiO_2$ nanopowders with rutile and anatase structures were prepared by controlling the pH value of a precursor solution without any heat treatment. The mean particle size of $TiO_2$ powders were below 10nm. The prepared $TiO_2$ nano powders were hydrothermal treated by NaOH solution. The sample was washed in HCl solution. As a result and $TiO_2$ nanotubes were formed. The lengths of $TiO_2$ nanotube were $1{\mu}m$ and the diameters were 10nm. Crystal structure and microstructure of $TiO_2$ nanotube were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscope (TEM). As-prepared $TiO_2$ nanotube powders have several advantages of nano particle size and high surface area and could be a prominent candidate for nano-sensors. The sensitivity of $TiO_2$ nanotube sensor was measured for toluene and NO in this study.

• Macromolecular Research
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• 제14권5호
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• pp.573-578
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• 2006

Three different, polymer-platinum conjugates (hydrogels, microparticles, and nanoparticles) were synthesized by complexation of cis-dichlorodiammineplatinum(II) (cisplatin) with partially succinylated glycol chitbsan (PSGC). Succinic anhydride was used as a linker to introduce cisplatin to glycol chitosan (GC). Succinylation of GC was investigated systematically as a function of the molar ratio of succinic anhydride to glucosamine, the methanol content in the reaction media, and the reaction temperature. By controlling the reaction conditions, water-soluble, partially water-soluble, and hydrogel-forming PSGCs were synthesized, and then conjugated with cisplatin. The complexation of cisplatin with water-soluble PSGC via a ligand exchange reaction of platinum from chloride to the carboxylates induced the formation of nano-sized aggregates in aqueous media. The hydrodynamic diameters of PSGC/cisplatin complex nano-aggregates, as determined by light scattering, were 180-300 nm and the critical aggregation concentrations (CACs), as determined by a fluorescence technique using pyrene as a probe, were $20-30{\mu}g/mL$. The conjugation of cisplatin with partially water-soluble PSGC, i.e., borderline between water-soluble and water-insoluble PSGC, produced micro-sized particles $<500{\mu}m$. Cisplatin-complexed PSGC hydrogels were prepared from water-insoluble PSGCs. All of the cisplatin-incorporated, polymer matrices released platinum in a sustained manner without any significant initial burst, suggesting that they may all be useful as slow release systems for cisplatin. The release rate of platinum increased with the morphology changes from hydrogel through microparticle to nanoparticle systems.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2012년도 춘계학술발표대회
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• pp.55.2-55.2
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• 2012

Intensive theoretical and experimental studies have been carried out at Korean Institute of Science and Technology (KIST) on controlling the bio absorbing rate of the Mg alloys with high mechanical strength through tailoring of electrochemical potential. Key technology for retarding the corrosion of the Mg alloys is to equalize the corrosion potentials of the constituent phases in the alloys, which prevented the formation of Galvanic circuit between the constituent phases resulting in remarkable reduction of corrosion rate. By thermodynamic consideration, the possible phases of a given alloy system were identified and their work functions, which are related to their corrosion potentials, were calculated by the first principle calculation. The designed alloys, of which the constituent phases have similar work function, were fabricated by clean melting and extrusion system. The newly developed Mg alloys named as KISTUI-MG showed much lower corrosion rate as well as higher strength than previously developed Mg alloys. Biocompatibility and feasibility of the Mg alloys as orthopedic implant materials were evaluated by in vitro cell viability test, in vitro degradation test of mechanical strength during bio-corrosion, in vivo implantation and continuous observation of the implant during in vivo absorbing procedures. Moreover, the cells attached on the Mg alloys was observed using cryo-FIB (focused ion beam) system without the distortion of cell morphology and its organ through the removal of drying steps essential for the preparation of normal SEM/TEM samples. Our Mg alloys showed excellent biocompatibility satisfying the regulations required for biomedical application without evident hydrogen evolution when it implanted into the muscle, inter spine disk, as well as condyle bone of rat and well contact interface with bone tissue when it was implanted into rat condyle.

• 한국자기학회지
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• 제16권1호
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• pp.66-70
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• 2006

본 연구에서는 음향화학법을 적용한 공침 기술을 이용, 균일한 마그네타이트 나노 입자를 합성하였다 이 방법을 통하여 합성된 마그네타이트 나노 입자를 이용하여 마그네타이트 나노 입자들이 균일하게 분산된 마이크로미터 크기의 키토산 미소구체를 제조하였다. 이 연구의 목적은 생분해성, 저독성, 생체친화성의 특징을 갖고 있는 키토산과 균일한 마그네타이트 나노 입자를 이용하여 자기공명 영상의 조영제와 혈관 폐색을 위한 혈관 색전물질 등에 활용 가능성 있는 초상자성 특성을 갖는 미소구체를 제조하는 것이다. 우리는 $1\%$ 아세트산 용액을 사용하여 키토산 용액을 제조, 마그네타이트 나노 입자들을 분산시켰다. 키토산이 알칼리 수용액에서 겔화되는 성질을 이용하여, 마그네타이트 나노 입자들이 분산된 키토산 용액을 알칼리 용액에 분무하여 초상자성 특성을 갖는 자성 키토산 미소구체를 제조하였다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.630-630
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• 2013

Recently, atomically smooth hexagonal boron nitride(h-BN) known as a white graphene has drawn great attention since the discovery of graphene. h-BN is a III-V compound and has a honeycomb structure very similar to graphene with smaller lattice mismatch. Because of strong covalent sp2bonds like graphene, h-BN provides a high thermal conductivity and mechanical strength as well as chemical stability of h-BN superior to graphene. While graphene has a high electrical conductivity, h-BN has a highly dielectric property as an insulator with optical band gap up to 6eV. Similar to the graphene, h-BN can be applied to a variety of field, such as gate dielectric layers/substrate, ultraviolet emitter, transparent membrane, and protective coatings. However, up until recently, obtaining and controlling good quality monolayer h-BN layers have been too difficult and challenging. In this work, we investigate the controlled synthesis of h-BN layers according to the growth condition, time, temperature, and gas partial pressure. h-BN is obtained by using chemical vapor deposition on Cu foil with ammonia borane (BH3NH3) as a source for h-BN. Scanning Transmission Electron Microscopy (STEM, JEOL-JEM-ARM200F) is used for imaging and structural analysis of h-BN layer. Sample's surface morphology is characterized by Field emission scanning electron microscopy (SEM, JEOL JSM-7100F). h-BN is analyzed by Raman spectroscopy (HORIBA, ARAMIS) and its topographic variations by Atomic force microscopy (AFM, Park Systems XE-100).

• 한국미생물·생명공학회지
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• 제45권1호
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• pp.1-11
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• 2017

본 논문에서는 나노셀룰로오스의 일종으로 최근 가장 주목을 받고 있는 소재인 마이크로피브릴화 셀룰로오스에 대하여 살펴보았다. 마이크로피브릴화 셀룰로오스는 리그노셀룰로오스계 바이오매스의 셀룰로오스에서 유래한 섬유로 풍부하고, 재생가능하며, 지속 가능한 천연 소재의 일종이다. 주로 물리적 전처리에 의해 생성되며, 나노미터에서 마이크로미터에 이르는 다양한 소섬유들의 결합으로 이루어져 있다. 이로 인해 마이크로피브릴화 셀룰로오스는 높은 표면적과, 높은 aspect ratio, 그리고 특이적인 용해성을 가지게 되고, 이는 전통적인 목재 산업 뿐만 아니라, 최신식의 식품/바이오/화학/의료 산업에 이르는 다양한 영역에의 적용 가능성을 보여주는 주요한 원인이 된다. 한편 이러한 응용력에도 불구하고, 아직 마이크로피브릴화 셀룰로오스는 제조 시 필요한 높은 에너지량과 반응성 조절의 어려움 때문에 상업적으로 많은 주목을 받지 못하고 있다. 따라서, 마이크로피브릴화 셀룰로오스의 기질에 대한 특성을 이해 및 구체화하고, 마이크로피브릴화 셀룰로오스의 피브릴화도를 선택하며, 표면의 개량을 선택적으로 조절할 수 있는 시스템을 개발하는 연구가 필요할 것이다. 마이크로피브릴화 셀룰로오스가 향후 우리나라의 산업 전반에 걸쳐 활용될 수 있기를 기대해 본다.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2016년도 추계학술대회 논문집
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• pp.152-152
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• 2016

Anodizing is a technology to generate thicker and high-quality films than natural oxide films by treating metals via electrochemical methods. It is a technique to develop metals for various uses, and extensive research on the commercial use has been performed for a long time. Aluminum anodic oxide (AAO) is generate oxide films, whose sizes and characteristics depending on the types of electrolytes, voltages, temperatures and time. Electrochemical manufacturing method of nano structure is an efficient technology in terms of cost reduction, high productivity and complicated shapes, which receives the spotlight in diverse areas. The sulfuric acid was used as an anodizing electrolyte, controlling its temperature to $10^{\circ}C$. The anode was 5083 Al alloy with dimension of $5(t){\times}20{\times}20mm$ while the cathode was the platinum. The distance between the anode and the cathode was maintained at 3 cm. Agitation was introduced by magnetic stirrer at 300 rpm to prevent localized temperature rise that hinders stable growth of oxide layer. In order to observe surface characteristics with applied current density, the electrolyte temperature, concentration was maintained at constant condition for $10^{\circ}C$, 10 vol.%, respectively. To prevent hindrance of stable growth of oxide layer due to local temperature increase during the experiment, stirring was maintained at constant rate. In addition, using galvanostatic method, it was maintained at current density of $10{\sim}30mA/cm^2$ for 40 minutes. The cavitation experiment was carried out with an ultrasonic vibratory apparatus using piezo-electric effect with modified ASTM-G32. The peak-to-peak amplitude was $30{\mu}m$ and the distance between the horn tip and specimen was 1 mm. The specimen after the experiment was cleaned in an ultrasonic, dried in a vacuum oven for more than 24 hours, and weighed with an electric balance. The surface damage morphology was observed with 3D analysis microscope. As a result of the investigation, differences were observed surface hardness and anti-cavitation characteristics depending on the development of oxide film with applied current density.