• Archives of Pharmacal Research
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• v.11 no.3
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• pp.213-217
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• 1988

The effects of ethanol and acetaldehyde on monoamine oxidase activity in mouse liver mitochondrial fraction were studied. In vivo, a single dose of ethanol increased the hepatic monoamine oxidase activity compared to control group, and chronic ethanol consumption also increased the enzyme activity using tyramine, benzylamine or serotonin as substrate. Acetaldehyde, the metabolite of ethanol, significantly increased monoamine oxidase activity more than ethanol did. In contrast to the in vivo results, it was found that the monoamine oxidase activity was inhibited in vitro by ethanol or acetaldehyde in the dose-dependent manner.

• The Korean Journal of Pharmacology
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• v.18 no.2
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• pp.27-32
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• 1982

To investigate the relationship between platelet monoamine oxidase activity and serum levels of testosterone and estradiol in schizophrenic patient, 78 chronic patients were compared with 135 normal controls. 1) The monoamine oxidase activity of chronic schizophrenic group was lower than normal group. 2) In normal group, there was no sex difference in monoamine oxidase activity. But in chronic schizophrenic group, the monoamine oxidase activity in male was lower than female. 3) In male schizophrenic group, the serum estradiol level was lower than normal group. 4) In female schizophrenic group, the serum testosterone level was lower than normal group. The significances of relationship between platelet monoamine oxidase activity and sex hormones are discussed.

• Journal of Food Hygiene and Safety
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• v.10 no.4
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• pp.279-282
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• 1995

Eight natural or semistynthesized monoterpenes were examined for their effects in rat brain monoamine oxidase(MAO) using benzylamine as substrate. Thujone and 3-carene were found to have the inhibition effects on rat brain MAQ activity, 38% and 95% inhibition at 103M respectively. The kinetic study on 3-carene, the most potent inhibitive type. But (+) pulegon and (-) isopulegon was found to activate MAO slightly.

• The Korean Journal of Pharmacology
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• v.25 no.1
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• pp.87-91
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• 1989

Effect of ginseng butanol fractions on the hepatic mitochondrial monoamine oxidase activity with ethanol treatment was investigated in this experiment. Ethanol treatment, either acutely or chronically, increased the hepatic mitochondrial monoamine oxidase activity compared to control group. Whereas, treatment with ginseng butanol fractions lowered the ethaol-induced monoamine oxidase activity. Acetaldehyde, the major metabolite of ethanol, significantly increased the hepatic mitochondrial monoamine oxidase activity more than ethanol did. It was also observed that ginseng butanol fractions reduced the increase of the hepatic mitochondial monoamine oxidase activity by acetaldehyde. From these results, it is suggested that ginseng butanol fractions may be associated with the modulation of the hepatic mitochondrial monoamine oxidase activity in ethanol-treated animals.

• Bulletin of the Korean Chemical Society
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• v.35 no.5
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• pp.1269-1274
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• 2014

Monoamine oxidases catalyze the oxidative deamination of dietary amines and amine neurotransmitters, and assist in maintaining the homeostasis of the amine neurotransmitters in the brain. Dysfunctions of these enzymes can cause neurological and behavioral disorders including Parkinson's and Alzheimer's diseases. To understand their physiological roles, efficient assay methods for monoamine oxidases are essential. Reviewed in this Perspective are the recent progress in the development of fluorescent probes for monoamine oxidases and their applications to enzyme assays in cells and tissues. It is evident that still there is strong need for a fluorescent probe with desirable substrate selectivity and photophysical properties to challenge the much unsolved issues associated with the enzymes and the diseases.

• The Korean Journal of Pharmacology
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• v.8 no.2
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• pp.41-47
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• 1972

Fluorides were supposed to exert a stimulatory action on the catecholamine release. In this study, the authors attempted to investigate the action of sodium fluoride on the catecholamine release from the isolated perfused cow adrenal gland and rat heart. And also the inhibitory effect of sodium fluoride on the monoamine oxidase activity in rat heart and liver mitochondria was investigated. The monoamine oxidase activity was measured by the conversion of benzylamine to benzaldehyde. The results obtained were follows; 1. Sodium fluoride stimulated the release of catecholamine from the isolated perfused cow adrenal gland and rat heart. 2. Sodium fluoride inhibited the rat heart and liver mitochondrial monoamine oxidase activity.

• YAKHAK HOEJI
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• v.29 no.6
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• pp.367-374
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• 1985

The age-related changes of monoamine contents and monoamine oxidase (MAO) activities in the whole brain and blood pressures were measured and compared every week during the ages of 5 weeks to 12 weeks in two types of animals; (1) spontaneously hypertensive rats (SHR) and (2) normotensive Sprague-Dawley rats (NR). Blood pressures in SHR began to rise at the ages of 7 or 8 weeks and were significantly higher thereafter than in NR. Abnormally low MAO activities in the brain of SHR were detected from the ages of 8 weeks. Comparisons were also made between brain monoamine-norepinephrine, dopamine and 5-hydroxytrytamine contents of SHR and those of NR at the same ages throughout the test period. In SHR, none of those monoamine values was consistently higher or lower than in NR during the test period. Protein contents of the brain between SHR and NR were not significantly different at any ages. These observations suggest that the abnormally low MAO activities in SHR brain may be one of the underlying neurological factors for the susceptibilities to hypertension and the deficit of MAO activities may be due to the changes in properties rather than in amount of this enzyme.

• Korean Journal of Pharmacognosy
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• v.37 no.4 s.147
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• pp.320-323
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• 2006

The effects of evodiamine on monoamine oxidase (MAO) activity were investigated. MAO was purified from mouse brain and the $K_m\;and\;V_{max}$ values of MAO were $78.5{\pm}5.28{\mu}M$ and $0.68{\pm}0.07$ nmol/min/mg protein, respectively (n=4). Evodiamine at $30-120{\mu}M$ showed an inhibitory effect on MAO activity using a substrate kynuramine with an $IC_{50}$ value of $104.2{\mu}M$ (n=4). Evodiamine also exhibited a non-competitive inhibition on MAO. The $K_i$ value for evodiamine was $72.5{\pm}10.8{\mu}M$ (n=4). These results suggest that evodiamine partially contributes to the regulation of monoamine content.

• The Journal of the Korean life insurance medical association
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• v.1 no.1
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• pp.84-87
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• 1984

1. Effect of bretylium on the pressor response of the whole and spinal rabbits to tyramine was observed in conditions of monoamine oxidase inhibition brought about by catron administration. 2. Bretylium increased the prossor response to tyramine in the whole and spinal rabbits. 3. Bretylium failed to increase the tyramine effect if bretylium was given after administration of catron, a monoamine oxidase inhibitor. Actually the tyramine effect was decreased by bretylium in this situation. 4. The increase of the tyramine effect by bretylium will be due to its monoamine oxidase inhibitory property, and the decrease of the tyramine effect will be due to its adrenergic neurone b1coking property.

• Herbal Formula Science
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• v.11 no.1
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• pp.99-114
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• 2003

This study aimed to investigate the effects of Chaihushugansan and Chaihuyigantang on the change of monoamine-contents in the hypothalamus of mice induced by the immobilization stress. Each formula(1.0g/kg) was injected intragastrically to mice 1 hour prior to the immobilzation stress(15 minutes) before measuring the change of monoamine-contents level in mice hypothalamus. The results were as follows: 1. DA content at control group showed significant change. CHSGS group and CHYGT group showed significant decrease.(P<0.05) 2. NE content of the control group was increased than normal group. NE content of the CHYGT group was shown a significant decrease than control group.(P<0.05) 3. DOPAC contents didn't show significant changes at any groups. 4. 5-HT contents didn't show significant changes at any groups. 5. 5-HIAA contents at CHSGS group and CHYGT group showed signifiant changes.(P<0.05, 0.01) These data revealed that chaihushugansan and chaihuyigantang might have the anti-stress effect through the control of DA and NE contents in the hypothalamus.