• 대한임상검사과학회지
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• 제52권2호
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• pp.136-142
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• 2020

세균의 항균제 내성율은 지난 몇십년 동안 지속적으로 상승하였으며 mobile genetic elements를 통한 항균제내성인자들의 전파는 다제내성세균의 출현 및 확산을 가중시켰다. 본연구에서는 임상검체에서 분리된 aminoglycoside에 비감수성 대장균 33주를 대상으로 mobile genetic elements를 통해 전파될 수 있는 aminoglycoside 내성인자를 조사하였다. 16S ribosomal RNA methyltransferases (RMTases)와 aminoglycoside-modifying enzyme (AME)유전자가 PCR과 DNA 염기서열분석을 통해 검출되었다. 그 결과 aac(3')-II 유전자(54.5%)를 포함하고 있는 균주가 제일 많았으며 그 다음으로 aph(3')-Ia 유전자(18.2%)가 많았고 aac(6')-Ib 유전자(15.2%)를 포함하는 균주도 있었다. RMTase 유전자는 본 연구에서는 검출되지 않았다. aac(3')-II 유전자를 포함하고 있는 18균주 중 17균주가 gentamicin에 내성을 보였으며 이중 16균주는 tobramycin에도 내성을 보였다. aac(6')-Ib 유전자를 포함하고 있는 5균주는 모두 tobramycin에 내성을 보였다. 본 연구에서 AME 유전자를 획득하는 것은 사람에서 분리된 대장균이 aminoglycoside에 내성을 나타내는 중요한 기전 중 하나임이 확인되었다. 사람으로부터 분리된 세균을 대상으로 지속적으로 항균제 내성인자를 조사하는 것은 내성세균의 확산을 막는데 필요할 것으로 사료된다.

• 한국생태학회:학술대회논문집
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• 한국생태학회 1999년도 국제 Symposium 및 '99 춘계 공동 학술 발표대회
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• pp.65-65
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• 1999

• East Asian mathematical journal
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• 제1권
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• pp.65-70
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• 1985

• 한국통신학회:학술대회논문집
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• 한국통신학회 2004년도 하계종합학술발표회논문초록집
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• pp.337-337
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• 2004

• 한국도로학회:학술대회논문집
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• 한국도로학회 2005년도 학술발표회 논문집
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• pp.401-406
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• 2005

• Design & Manufacturing
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• 제2권5호
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• pp.25-29
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• 2008

Almost all injection molds have multi-cavity runner system for mass production, which are designed with geometrically balanced runner system in order to accomplish filling balance between cavity to cavity during processing. However, even though geometrically balanced runner is used, filling imbalance have been observed. Filling imbalance could be decreased by modifying processing conditions such as injections rate, mold temperature, injection pressure, melt temperature that are related to shear, viscosity. In this study, a series of experiment was conducted to investigate filling imbalance variation when modifying runner layout and ploymer and to determine which processing condition influences as the primary cause of filling imbalance in geometrically balanced runner system. The filling imbalance was desreased up to result range of $3{\leq}DFI{\leq}8(%)$ by using a new runner system for balanced filling.

• 한국정밀공학회지
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• 제26권3호
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• pp.98-102
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• 2009

Almost all injection molds have multi-cavity runner system for mass production, which are designed with geometrically balanced runner system in order to accomplish filling balance between cavity to cavity during processing. However, even though geometrically balanced runner is used, filling imbalance has been observed. Filling imbalance could be decreased by modifying processing conditions such as injections rate, mold temperature, injection pressure, melt temperature that are related to shear, viscosity. In this study, a series of experiment was conducted to investigate filling imbalance variation when modifying runner layout and polymer and to determine which processing condition influences as the primary cause of filling imbalance in geometrically balanced runner system. The filling imbalance was decreased up to result range of $3{\leq}DFI{\leq}8(%)$ by using a new runner system for balanced filling.

• Clinical and Experimental Pediatrics
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• 제53권11호
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• pp.936-941
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• 2010

The systematic approach to pharmacologic treatment is typically to begin with the safest, simplest, and most conservative measures. It has been realized that the more rapidly inflammation is under control, the less likely it is that there will be permanent sequelae. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of initial treatment for inflammation. In addition, the slow-acting antirheumatic drugs (SAARDs) and disease-modifying antirheumatic drugs (DMARDs) have efficacy of anti-inflammatory action in children with chronic arthritis. New therapeutic modalities for inflammation, such as etanercept and infliximab, promise even further improvements in the risk/benefit ratio of treatment. It is not typically possible at the onset of the disease to predict which children will recover and which will go on to have unremitting disease with lingering disability or enter adulthood with serious functional impairment. Therefore, the initial therapeutic approach must be vigorous in all children.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.712-717
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• 2007

This study deals with the TE(Transmission Error) of gear tooth profile by modifying a profile and lead of a surface of tooth. First, we experimentally confirmed that the TE is a synthesis of the sliding velocity between both gears. Since various types of TE appear in the experiments, we introduced definition of transmission error and the optimism design by modifying a surface parameters. The test stand's performance is then evaluated through a series of multiple torque transmission error tests. Comparisons are made between data recorded before and after the test stand's redesign, and subsequently repeatability studies are performed to verify the veracity of the measured data. Finally, the experimental results are compared to the analytical predictions of two different gear analysis programs.

• 산업경영시스템학회지
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• 제37권3호
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• pp.43-50
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• 2014

In this paper, we deal with a single machine scheduling problems integrating with step deterioration effect and a rate-modifying activity (RMA). The scheduling problem assumes that the machine may have a single RMA and each job has the processing time of a job with deterioration is a step function of the gap between recent RMA and starting time of the job and a deteriorating date that is individual to all jobs. Based on the two scheduling phenomena, we simultaneously determine the schedule of step deteriorating jobs and the position of the RMA to minimize the makespan. To solve the problem, we propose a hybrid typed genetic algorithm compared with conventional GAs.