• 생약학회지
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• 제17권2호
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• pp.161-167
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• 1986

The smear method developed by Velaskar and Chitre was modified to allow the screening of plant extracts and/or fractions for platelet anti-aggregating activity. The modified smear method was also found suitable for massive screening of pure compounds. Sample fractions prepared from various plant extracts were examined for their effects against ADP, arachidonic acid (AA) or collagen induced platelet aggregations. Several solvent fractions of plant extracts including water fraction prepared from the methanol extract of Acanthopanax sp. was inhibitory against rat platelet aggregations. The activity guided treatments and fractionations of the water fraction from A. senticosus Max yielded two anti-platelet aggregatory substances, 3, 4-dihydroxybenzoic acid (I) and its artefact ethyl 3, 4-dihydroxybenzoate(II). The inhibitory activities of I and II against rat platelet aggregation were compared with that of aspirin, a known inhibitor of platelet aggregation. Discussions also included the results of the investigations on the structural activity relationships among the various dihydroxybenzoic acid derivatives against platelet aggregations induced by either one of ADP, AA or collagen.

• 농업과학연구
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• 제24권2호
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• pp.267-274
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• 1997

산채류를 비롯한 식물자원으로부터 항혈전 성분을 탐색하기 위하여 전국일원의 농산시장 및 농촌지도소, 평창산채시험장과 한국인삼연초연구원의 실험포장으로부터 약 160점의 시료를 수집하였으며, modified smear method를 적용하여 그 methanol 추출물의 혈소판응집 저해활성을 비교하였다. Platelet rich plasma 즉 혈소판 혈장을 이용하는 modified smear method는 응집유도물질로서 ADP와 collagen을 사용하였을때 electrical impedence method와 높은 상관성을 나타내었고, 재현성도 비교적 우수하여 정제하지 않은 식물체의 조추출물의 항혈전 활성을 효율적으로 검색할 수 있었다. 참취, 개미취, 곤달비, 산마늘, 산도라지, 영양부추, 산뽕, 쇠비름, 생열귀등이 ADP와 collagen 모두 혈소판응집 저해활성을 나타내었으며, 곰취, 사철쑥, 씀바귀, 민들레, 산지치, 갯완두, 참대등은 collagen을 사용한 경우에는 저해활성이 다소 낮게 검출되었다. 반면에 참나물, 옥잠, 냉이, 메밀, 매실, 복분자, 해란초등은 오히려 혈소판응집 촉진효과를 나타내었다. 한편 DPPH법으로 활성산소 억제율을 비교한 결과 산채류중에는 고사리, 참취, 곰취, 구절초, 사철쑥, 고려엉겅퀴, 달개비, 냉이 그리고 생약재중에서는 적작약, 음양곽, 복분자등이 항산화활성이 높았다.

• 한국농공학회지
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• 제38권1호
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• pp.116-127
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• 1996

This paper dealt with FEM analysis of foundation improved with pack drain. The theory on pack drain was scrutinized and observed values in the field were compared with numerical results. Work site of Kwangyang container pier was selected as a ease study in which measurement of settlement and pore water pressure was accurately carried out. Biot's consolidation equation was selected as governing One, coupled with modified Camclay model as constitutive one. Christian and Boehmer's numerical technique was adopted. Behavior of foundation with pack drain is not simple but very complicated. Discontinuity resulted from rigidity difference between adjacent materials, smear effect and complicated boundary conditions should be considered in the behavior analysis of foundation behavior. The results of numerical analysis were influenced by smear zone. In relevant to this effect, finite element analysis was carried out using the reduced horizontal coefficient of permeability in the smear zone; The numerical results were compared with observed values in surface settlement. including pore water pressure. However only lateral di5plaoement by numerical ana1Ysis was shown since its measurement was not performed in the field. The predication of settlement to be developed later can be effectively employed for the obtimization of construction. The predication of residual settlement using the data measured in the field was made by Hoshino, Asaoka and hyperbolic method. Among them, the hyperbolic method proved best one. Settlements accorded well between numsrical and observed values while pore pressure showed a slight difference. Lateral displacement showed largest values at constant distance from ground surface. The validation of foundation analysis improved with pack drain by computer program employed in this study selecting modified Cam-clay model was satisfactorily secured.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1991년도 추계학술발표회 논문집 지반공학에서의 컴퓨터 활용 COMPUTER UTILIZATION IN GEOTECHNICAL ENGINEERING
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• pp.362-375
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• 1991

Background and Necessity of the study : For more than 20 years, the soil engineering reserach group of Chonnam National University has been performing the deformation analysis of soft clayey foundation, since the University is located near the south-western coast of Korean Peninsulla, along which tide reclamation works have been under proaressing. Associsted with the fact mentioned above, the researchers have been developing a computer program in order to carry out deformation analysis of soft foundation since early 1980. Case-studies : In this research, the Biot's equation was selected as the governing equation coupled with several constitutive models including original and modified Cam-clay models, elasto-viscoplastic model, Lade's model etc. The anisotropy of soi1 can be considered in this program. To validate the accuracy of the computer program developed a couple of case-studies were performed. These include the pilot banking, sand drain considering smear effect and compound foundation reinforced with sheet pile into soft foundation.i) The pilot banking Good results could be acquired by assuming banking load as the body force composed of finite element mesh rather than equivalent concentrated load.ii) The sand drain Due to smear, the delay of consolidation was remarkable at the early stsge. so safety for the failure of foundation should be checked for the initial step of consolidation. iii) The compound foundation Accurate results were obtained by introducing the joint element method for the soft foundation reinforced with sheet pile into soiㅣ.

• 한국지반공학회논문집
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• 제28권1호
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• pp.41-53
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• 2012

연직배수재를 타설한 지반의 압밀은 배수재 근처 지반의 투수성에 큰 영향을 받으므로 스미어 영역의 투수성이 방사방향 압밀속도를 지배한다. 본 연구에서는 기존의 이론해와 수치해석을 이용하여 스미어 영역의 압밀특성을 기준으로 새로운 방사방향 압밀해석을 수행할 수 있는 방법을 제안하였다. 제안방법에 의한 압밀해석결과는 비교란점토의 압밀특성을 기준으로 압밀해석을 하는 기존방법 보다 불확실성이 큰 $k_h/k_s$에 큰 영향을 받지 않고 신뢰성 있는 결과를 주는 것으로 관찰되었다. PVD를 설치한 부산신항만 연약지반에 대해 압밀해석 결과와 현장 계측데이터를 비교해 본 결과, 제안방법은 부산신항만 압밀속도를 잘 예측하였으며 스미어 영역의 크기는 $3d_w$ 정도로 추정되었다.

• Parasites, Hosts and Diseases
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• 제23권2호
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• pp.285-292
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• 1985

The present study has been designed as a basic study on laboratory diagnosis of giardiasis and to demonstrate a more effective method for the detection of Giardia lamblia cyst with the inherent advantages of minimizing both the number of stool examinations required and the interval of stool collections for estimating the real state of prevalence in the shortest time possible. There were 3 subject groups of 75 children each currently residing in an orphanage in Gunsan city, Jeonbuk province from which stool specimens were collected every day, every other day, and every 3 days. The procedure is as follows: 1) resuspend the InKed sample after fixation with SAF solution 2) centrifuge the sediment for 1 min. at 2, 000 rpm after straining through gauze into a tube 3) divide the sediment into 3 parts and use them for direct fecal smear, formalin-ether concentration (MGL) and zinc sulfate ($ZnSO_4$) floatation techniques. The results are summarized as follows: 1. Overall infection rate after 10 trials showed a 60% positive indication. The positive rate among children under 4 years old was significantly higher than the rate in children over 4 years old. No significant difference in rate by sex was observed. 2. The results of eBaminations by direct fecal smear and MGL techniques appeared more accurate than that obtained by $ZnSO_4$ ftoatation method as indicated by a higher positive rate. Of all three methods concerned, combinations of two demonstrated a higher positive rate than that shown by any one alone. 3. In three consecutive examinations under varying conditions such as different days, the cyst detection rate by MGL technique indicated 83%. In 5 examinations under the same varying conditions, the indicated rate was 94%. 4. The interval of stool collection proved to be insignificant for the cyst detection rate. In conclusion, both MGL method and modified fecal direct smear can provide a good cyst detection rate of G. lamblia provided that more than 3 consecutive examinations of stool under varying conditions are carried out.

• Journal of Chest Surgery
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• 제54권2호
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• pp.137-142
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• 2021

Background: Refractory empyemas with collapsed lung and persistent bronchopleural fistulas pose significant problems to thoracic surgeons and impose a substantial burden in terms of morbidity and mortality. The modified Eloesser flap procedure is a useful palliative option for clearing infections. Herein, we present our experiences with the modified Eloesser flap procedure in mixed suppurative lung pathologies with a new technique of irrigation for persistent infection. Methods: A retrospective review was carried out of 56 patients who underwent the modified Eloesser flap with continuous irrigation at Katurba Medical College. These patients had severe morbidities and were not suitable for major thoracic resection surgery, and electively underwent modified Eloesser flap surgery. Regular follow-up was done at 1, 3, 6, and 12 months. Patients with persistent infections were treated with our continuous irrigation technique. Results: The most important finding was that all patients with active sputum acid-fast bacilli-positive findings became sputum smear-negative during the first month of follow-up. Half (50%) of the patients had a patent stoma. Eleven patients had persistent infections, necessitating continuous irrigation. The infection was fully cleared after 1 month in 9 patients, while 2 patients required second irrigation and continued to receive follow-up. In the remaining 50% of the patients, the stoma closed completely, and the lung expanded fully. Conclusion: The modified Eloesser flap is a simple procedure. In suppurative pathologies, infections were well controlled and the general condition of the patients improved. Our continuous irrigation method showed promising results in patients with persistent purulent discharge.

• 대한토목학회논문집
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• 제13권4호
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• pp.227-237
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• 1993

본 연구는 vertical drain well 설치지반의 보다 더 실제적이고 합리적인 변형해석을 목적으로 drain well 타설로 인하여 발생하는 well 주변 점토층의 교란(smear)영향, well과 인접점토층의 강성차이에서 오는 접합면 변형의 불연속거동 표현이 가능한 유한요소해석 방법을 제시하고자 하는데 목적이 있다. 유한요소해석의 구성은 변형의 지배방정식으로서 Biot의 압밀이론을 근간으로 여기에 흙의 구성식과 접합요소이론을 결합하여 이루어진다. 본 논문에서 제시한 해석법의 정도는 Siriwardane과 Ghaboussi 등이 사용한 지반에 적용하여 검증한 바 있다. 여기에서는 이를 다시 모델지반과 실제지반에 대해서 유한요소해석법을 적용하여 강성이 다른 이질재료간 경계에서의 불연속변형의 영향에 따른 지반내 거동특성을 살펴보고 이것을 함께 고려한 해석법의 정도를 알아보고자 한 것이다. 그 결과는 침하에 있어서 매우 만족스럽다고 보아지지만 간극수압등에는 잘 일치하지 않는 점이 있어 앞으로의 더 많은 연구가 필요하다고 판단된다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2001년도 가을 학술발표회 논문집
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• pp.147-158
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• 2001

In general, two methods have been used to predict settlement of soft ground. One method is Terzaghi's one dimensional consolidation theory which gives time-settlement relationship using the standard consolidation test results. The other is forecasting method of ground settlement to be occured in the future using in-situ monitoring data. The above both methods have some defects in application manner or in itself especially in very deep and soft clayey ground. In view of the lessons and experiences of soft ground improvement projects, several techniques were proposed for more accurate theorectical calculation of consolidation settlement as follows ; ① Subdivision of soft ground, ② Consideration of secondary compression, ③ Using the modified compression index, etc. And also, revised hyperbolic fitting method was suggested to minimize the error of predicted future settlement. In addition, revised De-Beer equation of immediate settlement of loose sandy soil was proposed to overcome the tendency to show too small settlement calculation results by original De-Deer equation. And also, considering the various effects of settlement delay in the improved ground by vertical drains, time-settlement caculation equation(Onoue method) was revised to match the tendency of settlement delay by using the characteristics of discharge capacity decreases of vertical drain with time elapse by the pattern of hyperbolic equation.

• Parasites, Hosts and Diseases
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• 제47권3호
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• pp.315-318
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• 2009

Quantitative fecal egg counts represented as the number of eggs per gram of feces (EPG) are generally a reliable parameter to estimate the worm burden of intestinal and hepatic parasitoses. Although Haplorchis taichui (Digenea: Heterophyidae) is one of the most common minute human intestinal flukes, little is known about the relationship between EPG and the actual worm burden in patients or the severity of the disease. In the present study, fecal samples were collected from 25 villagers in northern Thailand before and after praziquantel treatment. The EPG values of each participant were determined by the modified cellophane thick smear method, and adult worms were collected from the whole stool after the treatment. Eggs per day per worm (EPDPW) of H. taichui were estimated 82 from egg counts and expelled worms. The EPG was not well correlated with the worm burden, and a reverse correlation was observed between the EPDPW and the worm burden.