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Moderate Intensity Exercise Has More Positive Effects on The Gene Expression of Inflammasome, M1, M2 Macrophage Infiltration and Brown Adipocyte Markers Compared to High Intensity Exercise in Subcutaneous Adipose of Obese Mice Induced By High Fat Diet (비만모델에서 중강도 운동에 의한 인플라마좀, 대식세포 침윤, 갈색지방 관련 바이오 마커의 개선 효과)

  • Kim, Yong-An;Pitriani, Pipit;Park, Hee-Geun;Lee, Wang-Lok
    • Journal of Life Science
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    • v.29 no.3
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    • pp.303-310
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    • 2019
  • The purpose of the study was to compare the effect of either moderate or high intensity aerobic exercise on inflammasome, M1, M2 macrophage infiltration and brown adipocyte markers in subcutaneous adipose tissue of the high fat diet-induced obese mice. The 4 weeks male C57BL/6 mice were randomly assigned to four groups: normal diet control (NC; n=10), high-fat diet control (HC; n=10), high fat diet with moderate intensity exercise (HME; n=10), or high fat diet with high intensity exercise (HIE; n=10) groups. The high fat diet was given 60% calories from fat whereas normal diet was given 18% calories from fat. The moderate intensity exercise group (HME) was set at 10m/min in the first 2 weeks, 12m/min in 3-5 weeks and 14m/min in 6-16 weeks and the high intensity exercise group (HIE) was set at 14m/min in the first 2 weeks, 17m/min in 3-5 weeks and 18m/min in 6-16 weeks. The semi quantitative reverse transcription-polymerase chain reaction (RT PCR) was used to analyze the gene expression. The moderate intensity exercise significantly reduced the expression of NLRP3, F480, CD11c and CD86. Further, the moderate intensity exercise significantly increased CD206 and $PGC1{\alpha}$, BMP7 and PRDM. The high intensity exercise significantly reduced NLRP3, CD11c and CD86. Further, the high intensity exercise significantly increased $PGC1{\alpha}$ and BMP7. In conclusion, moderate intensity exercise has more positive effects on inflammasome, M1, M2 macrophage infiltration and brown adipocyte maskers compared to high intensity exercise in high fat diet induced obese mice.

Experimental and numerical verification of hydraulic displacement amplification damping system

  • Chung, Tracy Sau-Kwai;Lam, Eddie Siu-Shu;Wu, Bo;Xu, You-Lin
    • Structural Engineering and Mechanics
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    • v.33 no.1
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    • pp.1-14
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    • 2009
  • Hong Kong is now recognized as an area of moderate seismic hazard, but most of the buildings have been designed with no seismic provision. It is of great significance to develop effective and practical measures to retrofit existing buildings against moderate seismic attacks. Researches show that beam-column joints are critical structural elements to be retrofitted for seismic resistance for reinforced concrete frame structures. This paper explores the possibility of using a Hydraulic Displacement Amplification Damping System (HDADS), which can be easily installed at the exterior of beam-column joints, to prevent structural damage against moderate seismic attacks. A series of shaking table tests were carried out with a 1/3 prototype steel frame have been carried out to assess the performance of the HDADS. A Numerical model representing the HDADS is developed. It is also used in numerical simulation of the shaking table tests. The numerical model of the HDADS and the numerical simulation of the shaking table tests are verified by experimental results.

Canonical Correlation between Korean Traditional Postpartum Care Performance and Postpartum Health Status (산후조리 수행과 산후 건강상태간 정준상관관계)

  • Ahn, Suk-Hee
    • Journal of Korean Academy of Nursing
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    • v.35 no.1
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    • pp.37-46
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    • 2005
  • Purpose: The purpose of this longitudinal study was to examine the relationship between postpartum care performance and postpartum health status. Sample: The study subjects were 82 mothers who delivered full-term infants at 3 hospitals at P city. Data were collected for their health status at the postpartum unit and the sample was followed up to 6 weeks postpartum to collect postpartum care performance and health status. Results: Mothers rated postpartum care performance as moderate to high and especially rated the maternal role attainment the highest. Mothers experienced 4 physical symptoms and moderate levels of fatigue. In addition, they experienced moderate levels of positive affect and low levels of negative affect at both times. Canonical correlation revealed that ostpartum care performance was related to postpartum health status with 2 significant canonical variables. The first variate indicated that mothers who performed hospitality, physical and emotional recovery, self-caring, and role attainment well showed higher positive affects, lower negative affects, fewer physical symptoms, and lower levels of fatigue. The second variate showed that the greater the performance of caring and physical and emotional recovery, the fewer physical symptoms and lower levels of fatigue. Conclusion: Although Korean traditional postpartum care performance was related to postpartum health status, the further study is needed to identify the causal relationship between them. Nurses need to integrate the perspective of westernized postpartum care and Korean traditional views of postpartum approach to maintain and promote women's health.

Prevalence of the Increased Liver Enzymes in Obese Children (소아 비만이 간기능에 주는 영향)

  • Park, Seon-Mi;An, Sang-Yong;Kim, Hyeon-Mi;Hwang, Ok-Bun;Park, Dae-Jeong;Kim, Hyeon-Ju;Gang, Sun-Ju;O, Yun-Jeong;Kim, Sun-Gi
    • Journal of Korea Association of Health Promotion
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    • v.4 no.1
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    • pp.95-103
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    • 2006
  • Purpose: With remarkable increase in the prevalence of childhood obesity, nonalcoholic fatty liver disease increased, The aim of this study is to evaluate the prevalence of the increase liver enzymes, lipid levels and fasting blood glucose level in normal and obese children. Methods: A total of 2206 elementary students were grouped according to obesity index; normal group and obesity group(mild, moderate, severe). Aspartate aminotransferase(AST, SGOT) and alanine aminotrausferase(ALT, SGPT) were measured with tota1 cholesterol, triglyceride and fasting blood glucose. Results: Compared with the 2.7% of ALT > 50 IU/L in normal group, obese groups showed significantly higher prevalence; 6.7% in mild obesity group, 11.8% in moderate group and 15.0% in severe group. The prevalence of hypertriglyceremia was 12,4% in normal weight group, which is significantly lower than obesity group(mild obesity group 24.8%, moderate and severe 32.1% each). Conclusion: The prevalence of nonalcoholic fatty liver increased along with severity of obesity. Of Nutritional assessment, intervention, and preferably prevention are necessary for health promotion elementary students.

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A Study on Adolescents' Level of School Adjustment by Their Perceived Relationships with Parents, Peer and Teachers (청소년이 지각한 부모-자녀 관계, 또래 관계, 교사와의 관계가 학교생활 적응에 미치는 영향)

  • 최지은;신용주
    • Journal of the Korean Home Economics Association
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    • v.41 no.2
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    • pp.199-210
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    • 2003
  • The purpose of this study was to investigate the effects of perceived relationships of the adolescents with their parents, peer and the teachers on their school adjustment. The data were collected from 385 male and female high school students in Seoul through the questionnaire method. The major result of the study were as follows: 1. About sixty percents of the respondents came from middle-class families who were being brought up by their parents. 2. Analysis of data revealed that degrees of relationship of the respondents with their parents and peer were higher than moderate, while the degrees of relationship with teacher was found to be moderate. 3. The adolescent' overall level of school adjustment was found to be at a moderate level. 4. The adolescents' levels of school adjustment were differed by birth order, father's occupations, family structures, economic status of the family, grade point average and religion. 5. The stepwise regression analyses yielded the results that relationship with the teacher, relationship with the peer, father's caring, birth order and economic status of family were significant factors in explaining the adolescents' school adjustment. On the base of the results of the study, the following suggestions were made in order to enhance adolescents' school adjustment: 1. Teacher education focused on guidance and counseling should be included in the teacher education and training program. 2. Parents education focused on fatherhood should be more emphasized.

Effect of Serious Games on Disability Player Performance by Ability Levels (장애 아동 플레이어 능력의 차이에 따른 기능성 게임 효과의 차이)

  • Kwon, Jungmin
    • Journal of Korea Game Society
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    • v.15 no.6
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    • pp.149-156
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    • 2015
  • In this research, the effect of serious game on the task performance of adolescents with intellectual disabilities was investigated. A total of 31 students participated in a pre-post-with-control-group-design study. Results indicate that among the high-, moderate-, and low- ability students, the moderate-ability students gained the most from the game, in both speed and accuracy. From the results we can understand that game-based training has the most effect on the moderate level students. Also, the findings of this study show that serious games can be effective training tools for this population.

Design of a High Temperature Production Heat Pump System Using Geothermal Water at Moderate Temperature (중온 지열수를 이용한 고온제조 열펌프 시스템 해석 및 설계)

  • Kim, Min-Sung;Baik, Young-Jin;Park, Seong-Ryong;Chang, Ki-Chang;Lee, Young-Soo;Ra, Ho-Sang
    • 한국신재생에너지학회:학술대회논문집
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    • 2008.05a
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    • pp.638-641
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    • 2008
  • Geothermal water at moderate temperature in a range between 30 to $50^{\circ}C$ exists sparse in surroundings. Mostly they are utilized as heat or water source at spar zones in Korea. However, a large portion of used water is discarded due to its poor recovery quality and inferior application technologies. In this research, an innovative heat pump system based on the hybrid concept that combinate compression cycle and absorption cycle was investigated mathematically. The hybrid heat pump aims to recycle various kind of the heat sources at moderate temperature including geothermal water effectively. The prime objective of the simulation is to design a compression/absorption hybrid heat pump system which can make high temperature above the level of $90^{\circ}C$ and low temperature of $20^{\circ}C$ as well at the same using $50^{\circ}C$ geothermal heat water. As a result, primitive data was provided as a basis to design a prototype 3 RT class hybrid heat pump.

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Flame Structure of Moderately Turbulent Combustion in the Opposed Impinging Jet Combustor (대향분출화염의 분산화학반응 화염구조와 NOx 저감기구)

  • 손민호;조용진;윤영빈;이창진
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.26 no.10
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    • pp.1387-1393
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    • 2002
  • The measurement of velocity and stain rate field has been conducted in opposed impinging jet combustion. When a smaller diameter (5mm) orifice of pre-chamber was used, previous studies had reported that the combustion phase showed a shift from weak turbulent combustion to moderate turbulent combustion in the modified Borghi Diagram. In the case with smaller orifice diameter (5mm), NOx emission was substantially reduced by a factor 1/2 while the combustion pressure remains at the same as that in the conventional combustion. Hence, in this study, the experiment setup using PIV technique was designed to identify the relation of the strain rate distribution and NOx reduction associated with moderate turbulent combustion. As a result, it was found that the highly strained pockets are widely distributed during the combustion in the middle of chamber when the orifice diameter is 5mm. And the corresponding PDF distribution of strain rates she was the smoothly distributed strain .ate within the range of |$\pm$1000| (1/sec) rather than a spike shape about zero point. This is the unique feature observed in the combustion with 5mm orifice diameter. Therefore, it can be concluded that the substantial NOx reduction in opposed impinging combustor is mainly attributed to the strain rate distribution within the range of |$\pm$1000|resulting in the combustion phase shift to moderate turbulent combustion.

Textural Properties of Processed Foods Produced from Newly Developed Non-Glutinous Rice Cultivars

  • Ha, Mi-Sun;Roh, Yi-Woo;Hong, Kwon-Pyo;Kang, Yoon-Suk;Jung, Dong-Chae;Kim, Kwang-Ho;Park, Sang-Kyu;Ha, Sang-Do;Bae, Dong-Ho
    • Food Science and Biotechnology
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    • v.16 no.5
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    • pp.789-795
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    • 2007
  • This study was undertaken to investigate the producibility of processed foods utilizing 6 newly developed non-glutinous rice cultivars. First, cooked rice, cake, cookies, bread, and slender rice cake sticks were prepared with the newly developed cultivars; then their physicochemical and textural properties were evaluated. The rice samples had similar pasting temperatures and peak times, but different viscosities and other pasting properties. The textural analysis results suggested that 'Chucheong' was appropriate for cooked rice due to its low amylose content; hardness, and springiness; 'Ilphumbyeo' for rice cakes due to its high amylose content, moderate cohesiveness and adhesiveness, and low hardness; 'Ilphumbyeo' for cookies due to its high amount of protein, and low cohesiveness and adhesiveness; 'Ilphumbyeo' for bread due to its high amylose content, moderate hardness, and low consistency; and 'Ilphumbyeo' for the slender rice cake sticks due to its low hardness, moderate breakdown, paste viscosity, and setback.

Transtherapy for moderate to severe acne scar: a study of 2 cases

  • Sung, Soo-Hyun;Park, Jong-Hyun;Han, Chang-Hyun;Hong, Seung-Min;Park, Eun-Jung;Na, Ho-Ik;Park, Sung-Jin;Yu, Ji-Hee;Ha, Ji-Hun
    • The Journal of Korean Medicine
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    • v.36 no.4
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    • pp.122-128
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    • 2015
  • Objectives: The purpose of this study is to present effect of transtherapy which is treatment of Korean Medicine to acne scar patients. Methods: We used transtherapy to moderate and severe acne scar patients and evaluated by a Photo evaluation with 10-point score and Qualitative Global Acne Scarring Grading System. Results: After transtherapy treatment, mean of Qualitative Global Acne Scarring Grading System of patients changed from $3.5{\pm}0.71$ to $1.5{\pm}0.71$. Acne scar showed an improvement at least 8 up to 9 and mean of their acne scar improvement scores was $8.33{\pm}0.52$ on photo evaluation with 10-point score. Conclusions: This paper shows that transtherapy in the treatment of moderate to severe acne scars is beneficial for promoting skin regeneration.