• 제목/요약/키워드: model-free analysis

검색결과 1,593건 처리시간 0.034초

Comparative genetic analyses of Korean bat coronaviruses with SARS-CoV and the newly emerged SARS-CoV-2

  • Na, Eun-Jee;Lee, Sook-Young;Kim, Hak Jun;Oem, Jae-Ku
    • Journal of Veterinary Science
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    • 제22권1호
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    • pp.12.1-12.11
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    • 2021
  • Background: Bats have been considered natural reservoirs for several pathogenic human coronaviruses (CoVs) in the last two decades. Recently, a bat CoV was detected in the Republic of Korea; its entire genome was sequenced and reported to be genetically similar to that of the severe acute respiratory syndrome CoV (SARS-CoV). Objectives: The objective of this study was to compare the genetic sequences of SARS-CoV, SARS-CoV-2, and the two Korean bat CoV strains 16BO133 and B15-21, to estimate the likelihood of an interaction between the Korean bat CoVs and the human angiotensin-converting enzyme 2 (ACE2) receptor. Methods: The phylogenetic analysis was conducted with the maximum-likelihood (ML) method using MEGA 7 software. The Korean bat CoVs receptor binding domain (RBD) of the spike protein was analyzed by comparative homology modeling using the SWISS-MODEL server. The binding energies of the complexes were calculated using PRODIGY and MM/GBGA. Results: Phylogenetic analyses of the entire RNA-dependent RNA polymerase, spike regions, and the complete genome revealed that the Korean CoVs, along with SARS-CoV and SARS-CoV-2, belong to the subgenus Sarbecovirus, within BetaCoVs. However, the two Korean CoVs were distinct from SARS-CoV-2. Specifically, the spike gene of the Korean CoVs, which is involved in host infection, differed from that of SARS-CoV-2, showing only 66.8%-67.0% nucleotide homology and presented deletions within the RBD, particularly within regions critical for cross-species transmission and that mediate interaction with ACE2. Binding free energy calculation revealed that the binding affinity of Korean bat CoV RBD to hACE2 was drastically lower than that of SARS-CoV and SARS-CoV-2. Conclusions: These results suggest that Korean bat CoVs are unlikely to bind to the human ACE2 receptor.

An Empirical Study on the Effect of Internal FTA Utilization Factors on Export Performance

  • In-Seong Lee
    • Journal of Korea Trade
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    • 제27권3호
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    • pp.199-216
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    • 2023
  • Purpose - This study aims to identify the internal capabilities that export companies need to possess in order to utilize FTAs and to propose ways to expand their export performance through them. To achieve this goal, the study analyzed the internal factors that affect FTA utilization from a resource-based perspective, such as Origin Management Competency, Information Acquisition Competency, contract Management Competency, and Commitment to Export, based on prior research on corporate capabilities in the field of management and FTA-related research. The study ultimately aims to confirm whether a company's FTA utilization contributes to its export performance through the management and response to its internal factors for FTA utilization. Design/methodology - To achieve the research objective, this study conducted a literature review related to FTA utilization and identified the internal factors of companies that affect FTA by classifying them into Origin Management Competency, Information Acquisition Competency, contract Management Competency, and Commitment to Export Based on this, a final research model was developed, hypotheses were set through a preliminary study survey, and conclusions were drawn by analyzing the data of 312 companies. Findings - The empirical analysis results indicate that Origin Management Competency and Contract Management Competency have a positive impact on FTA utilization, while Information Acquisition Competency and Commitment to Export do not have a statistically significant impact on FTA utilization. Based on these findings, this study suggests measures for efficient FTA utilization for companies that want to utilize FTAs. Additionally, FTA utilization has a positive impact on export performance. In other words, the extent to which companies utilize the signed agreements has a positive impact on their performance. Based on these results, this study identifies the characteristics of companies that want to utilize FTAs and proposes measures for future efficient FTA utilization. Originality/value - This study has confirmed that in order for companies to utilize FTAs, they must meet the requirements of the FTA. To this end, the study has concluded that it is important to manage and address internal factors such as Origin Management Competency, Information Acquisition Competency, contract Management Competency, and Commitment to Export to increase FTA utilization. Based on these results, it can be confirmed that it is essential for companies to have an understanding and management of the internal factors that satisfy the requirements of the FTA in order to utilize the FTA.

The finite element method for dynamics of FG porous truncated conical panels reinforced with graphene platelets based on the 3-D elasticity

  • Lingqin Xia;Ruiquan Wang;Guang Chen;Kamran Asemi;Abdelouahed Tounsi
    • Advances in nano research
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    • 제14권4호
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    • pp.375-389
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    • 2023
  • In this study, free vibration analysis of functionally graded (FG) porous truncated conical shell panels reinforced by graphene platelets (GPLs) has been investigated for the first time. Additionally, the effect of three different types of porosity distribution and five different types of GPLs patterns on dynamic response of the shell are also studied. Halpin-Tsai micromechanical model and Voigt's rule are used to determine Young modulus, shear modulus and Poisson's ratio with mass densities of the shell, respectively. The main novelties of present study are: applying 3D elasticity theory and the finite element method in conjunction with Rayleigh-Ritz method to give more accurate results unlike other simplified shell theories, and also presenting a general 3D solution in cylindrical coordinate system that can be used for analyses of different structures such as circular, annular and annular sector plates, cylindrical shells and panels, and conical shells and panels. A convergence study is performed to justify the correctness of the obtained solution and numerical results. The impact of porosity and GPLs patterns, the volume of voids, the weight fraction of graphene nanofillers, semi vertex and span angles of the cone, and various boundary conditions on natural frequencies of the functionally graded panel have been comprehensively studied and discussed. The results show that the most important parameter on dynamic response of FG porous truncated conical panel is the weight fraction of nanofiller and adding 1% weight fraction of nanofiller could increase 57% approximately the amounts of natural frequencies of the shell. Moreover, the porosity distribution has great effect on the value of natural frequency of structure rather than the porosity coefficient.

구조물의 대변형 비탄성 해석을 위한 범용 목적의 XFINAS 4절점 순수 변위 합응력 쉘요소 (A General and Versatile XFINAS 4-node Co-Rotational Resultant Shell Element for Large Deformation Inelastic Analysis of Structures)

  • 김기두;이창수
    • 대한토목학회논문집
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    • 제26권3A호
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    • pp.447-455
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    • 2006
  • 순수변위 비선형 4절점 쉘요소의 정식화를 제안하여 철근 콘크리트, 강재및 복합재료등 범용 목적의 구조물의 해석에 적합하도록 하였다. 기하강성의 정식은 2차 운동역학적 관계를 이용하여 쉘이 중립면에서 정의되었고 이러한 기하강성은 면내응력, 휨 모멘트와 수직 전단력의 형태로 구성되어 두꺼운 판 및 쉘의 해석에 효과적이다. 가정된 자연 변형률 방법을 사용하여 전단잠김 문제를 제거한 복합 쉘 요소는 얇은 판및 쉘의 경우에도 정확한 해를 구할 수 있다. 콘크리트 경우 소성이론 및 탄소성 파괴역학에 근거한 비탄성 해석이 가능하며 강재경우 폰미스의 항복이론과 이바노브의 항복이론을 이용한 소성해석이 가능하다. 복합 재료의 수직전단 강성 행렬은 평형방정식으로부터 유도하여 구성하였다. 본 연구에서 제안한 쉘 요소는 해석 예제들이 참고문헌과 잘 일치하여 정확성이 입증되었으며 범용목적의 박판구조 해석에 적합한 것으로 사료 되었다.

통초(通草)와 목통(木通) 추출물이 monosodium iodoacetate(MIA)로 유발된 골관절염 동물 모델에 미치는 효과 (Effects of Tetrapanax papyrifer stem and Akebiae quinata stem on a rat model of monosodium iodoacetate-induced osteoarthritis)

  • 이상남;서부일
    • 대한본초학회지
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    • 제38권6호
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    • pp.29-44
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    • 2023
  • Objectives : This study was planned to evaluate the therapeutic effectiveness and possible underlying mechanism of TPE (Tetrapanax papyrifer stem(inner part of the stem Extract) and AQE (Akebiae quinata stem Extract) on osteoarthritis. Methods : Osteoarthritis models were induced through intra-articular injection of MIA (monosodium iodoacetate) 50 μL with 80 mg/ml in rats. Excluding the normal group, Osteoarthritis-induced rats were divided into 4 groups (Control, INDO, TPE, AQE). The drug concentrations were indomethacin 5 mg/kg, TPE 200 mg/kg, and AQE 200 mg/kg, and were orally administered once a day for a couple of weeks. After drug supplementation, the effects of TPE and AQE were measured with serum diagnosis, western blotting, and histopathological staining. Results : It was found that the DPPH and ABTS free radical erasure ability of AQE was better than that of TPE. AQE administration improved rear limb overload and it led to relieving pain. Both PTE and AQE significantly reduced the expression of inflammatory mediators COX-2, iNOS, and inflammatory cytokine IL-1β and IL-6 by inhibiting the phosphorylation of IκBα and deactivating the pathway of NF-κBp65. On the other hand, TNF-α was significantly reduced only by administration of AQE. In addition, histopathological analysis showed that the administration of AQE compared to PTE suppressed cartilage degeneration and effectively suppressed damage to proteoglycan, a component of ECM. Conclusion : Reviewing these experimental results, TPE and AQE possessed the effect of delaying the progress of osteoarthritis and protecting cartilage. In addition, the results of this study show that AQE has a better cartilage protection effect than TPE.

계단식 어도의 난류흐름 수치해석 및 어류 소상 가능성 분석 (Numerical simulations of turbulent flow on the pool and weir type fishway and analysis of ascending possibility of fishes)

  • 권용준;류용욱;김형석
    • 한국수자원학회논문집
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    • 제56권spc1호
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    • pp.1037-1048
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    • 2023
  • 하천에 설치된 댐, 보 등과 같은 횡단구조물은 수생태계에 영향을 미치며 종적 연결성을 단절하기 때문에 어류의 이동을 확보하기 위하여 어도가 설치된다. 그러나 어도 내부의 흐름 특성 및 어종에 따라 어류의 통과효율의 차이가 발생한다. 본 연구에서는 3차원 RANS 모형과 자유수면 해석을 위한 VOF (volume of fluid)기법을 적용한 수치모형을 활용하여 계단식 어도에서 발생하는 난류흐름을 수치모의 하였다. 계단식 어도의 pool의 길이 변화 및 상류 수위 변동을 고려하였으며 이들의 변화에 따라 평균유속 및 난류운동에너지 분포를 분석하였다. 표면류 및 잠입류 특성을 잘 재현하였으며 pool의 길이가 증가하면서 표면류에서 잠입류로 변화하였고 상류 수위가 증가함에 따라 표면류 특성이 명확하게 나타났다. 어도 내 어류의 이동과 관련된 수리학적 인자는 유속 및 난류운동에너지 등이 있으며 이를 바탕으로 어류의 소상 가능성을 검토하였다.

Influence of size-anatomy of the maxillary central incisor on the biomechanical performance of post-and-core restoration with different ferrule heights

  • Domingo Santos Pantaleon;Joao Paulo Mendes Tribst;Franklin Garcia-Godoy
    • The Journal of Advanced Prosthodontics
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    • 제16권2호
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    • pp.77-90
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    • 2024
  • PURPOSE. The study aims to investigate the influence of the ferrule effect and types of posts on the stress distribution in three morphological types of the maxillary central incisor. MATERIALS AND METHODS. Nine models were created for 3 maxillary central incisor morphology types: "Fat" type - crown 12.5 mm, root 13 mm, and buccolingual cervical diameter 7.5 mm, "Medium" type - crown 11 mm, root 14 mm, and buccolingual cervical diameter 6.5 mm, and "Slim" type - crown 9.5 mm, root 15 mm, and buccolingual cervical diameter 5.5 mm. Each model received an anatomical castable post-and-core or glass-fiber post with resin composite core and three ferrule heights (nonexistent, 1 mm, and 2 mm). Then, a load of 14 N was applied at the cingulum with a 45° slope to the long axis of the tooth. The Maximum Principal Stress and the Minimum Principal Stress were calculated in the root dentin, crown, and core. RESULTS. Higher tensile and compression stress values were observed in root dentin using the metallic post compared to the fiber post, being higher in the slim type maxillary central incisor than in the medium and fat types. Concerning the three anatomical types of maxillary central incisors, the slim type without ferrule height in mm presented the highest tensile stress in the dentin, for both types of metal and fiber posts. CONCLUSION. Post system and tooth morphology were able to modify the biomechanical response of restored endodontically-treated incisors, showing the importance of personalized dental treatment for each case.

The pattern of metachronous recurrence after endoscopic submucosal dissection for gastric adenocarcinoma and dysplasias

  • Sunah Suk;Yeon Joo Seo;Dae Young Cheung;Han Hee Lee;Jin Il Kim;Soo-Heon Park
    • Clinical Endoscopy
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    • 제56권4호
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    • pp.470-478
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    • 2023
  • Background/Aims: Metachronous recurrence incidences and risk factors following endoscopic submucosal dissection (ESD) for gastric adenocarcinoma and dysplasias were investigated. Methods: Retrospective review of electronic medical records of patients who underwent gastric ESD at The Catholic University of Korea, Yeouido St. Mary's Hospital. Results: A total of 190 subjects were enrolled for analysis during the study period. The mean age was 64.4 years and the male sex occupied 73.7%. The mean observation period following ESD was 3.45 years. The annual incidence rate of metachronous gastric neoplasms (MGN) was about 3.96%. The annual incidence rate was 5.36% for the low-grade dysplasia group, 6.47% for the high-grade dysplasia group, and 2.74% for the EGC group. MGN was more frequent in the dysplasia group than in the EGC group (p<0.05). For those with MGN development, the mean time interval from ESD to MGN was 4.1 (±1.8) years. By using the Kaplan-Meier model, the estimated mean MGN free survival time was 9.97 years (95% confidence interval, 8.53-11.40) The histological types of MGN were not related to the primary histology types. Conclusions: MGN following ESD developed in 3.96% annually and MGN was more frequent in the dysplasia group. The histological types of MGN did not correlate with those of primary neoplasm.

Prognostication for recurrence patterns after curative resection for pancreatic ductal adenocarcinoma

  • Andrew Ang;Athena Michaelides;Claude Chelala;Dayem Ullah;Hemant M. Kocher
    • 한국간담췌외과학회지
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    • 제28권2호
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    • pp.248-261
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    • 2024
  • Backgrounds/Aims: This study aimed to investigate patterns and factors affecting recurrence after curative resection for pancreatic ductal adenocarcinoma (PDAC). Methods: Consecutive patients who underwent curative resection for PDAC (2011-21) and consented to data and tissue collection (Barts Pancreas Tissue Bank) were followed up until May 2023. Clinico-pathological variables were analysed using Cox proportional hazards model. Results: Of 91 people (42 males [46%]; median age, 71 years [range, 43-86 years]) with a median follow-up of 51 months (95% confidence intervals [CIs], 40-61 months), the recurrence rate was 72.5% (n = 66; 12 loco-regional alone, 11 liver alone, 5 lung alone, 3 peritoneal alone, 29 simultaneous loco-regional and distant metastases, and 6 multi-focal distant metastases at first recurrence diagnosis). The median time to recurrence was 8.5 months (95% CI, 6.6-10.5 months). Median survival after recurrence was 5.8 months (95% CI, 4.2-7.3 months). Stratification by recurrence location revealed significant differences in time to recurrence between loco-regional only recurrence (median, 13.6 months; 95% CI, 11.7-15.5 months) and simultaneous loco-regional with distant recurrence (median, 7.5 months; 95% CI, 4.6-10.4 months; p = 0.02, pairwise log-rank test). Significant predictors for recurrence were systemic inflammation index (SII) ≥ 500 (hazard ratio [HR], 4.5; 95% CI, 1.4-14.3), lymph node ratio ≥ 0.33 (HR, 2.8; 95% CI, 1.4-5.8), and adjuvant chemotherapy (HR, 0.4; 95% CI, 0.2-0.7). Conclusions: Timing to loco-regional only recurrence was significantly longer than simultaneous loco-regional with distant recurrence. Significant predictors for recurrence were SII, lymph node ration, and adjuvant chemotherapy.

정보시스템 사용과 성과에 있어서 자발성의 조절효과에 관한 연구 (A Study on the Moderating Effect of Perceived Voluntariness in the Organizational Information System Usage and Performance)

  • 이승창;이호근;정창욱;정남호;서응교
    • Asia pacific journal of information systems
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    • 제19권2호
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    • pp.195-221
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    • 2009
  • According to an industry report, a large number of organizations have invested in Organizational Information System(OIS) in the past few years. Several research results indicate that successful investments in OIS lead to productivity enhancement, while failed ones result in undesirable consequences such as financial losses and dissatisfaction among employees. In spite of huge investments, however, many organizations have failed in achieving the hoped-for returns from OIS. Thus, understanding user acceptance, adoption, and usage of new IS(Information Systems) is an important issue for IS practitioners. Indeed, study of the user acceptance of new information system has been one of the most important research topics in the contemporary IS literature. Several theoretical models are tested to examine 'user acceptance' and 'usage behavior' in IS context. While many research models incorporate 'ease of use' or 'usefulness' as important factors in explaining user acceptance, Technology Acceptance Model(TAM) has been one of the most widely applied models in user acceptance and usage behavior. Even in recent IS studies that employ theories of innovation diffusion in the area of IS implementation, a major focus has been on the user's perception of information technologies. In this research, we study 'voluntariness' as an important factor in IS acceptance by users. Voluntariness is defined as "the degree to which the use of the innovation is perceived as being voluntary, or of free will" When examining the diffusion of accepting OIS, a thoughtful consideration should be given to 'perceived voluntariness.' Current article has following research questions: 1) What models are appropriate to explain the success of OIS? and 2) How does the 'voluntariness' affect the success of OIS? In order to answer these questions, a research model is proposed to describe the detailed nature of association among three independent variables (IT usage level, task interdependency, and organizational support), a mediating variable (IS usage), a dependent variable (perceived performance), and a moderating variable(perceived voluntariness). The central claim of this article is that organizations hardly realize expected returns from OIS investments unless perceived voluntariness is effectively managed after operating OIS. As an example of OIS in this study we have selected the Intranet of Republic of Korea Air Force (ROKAF). ROKAF has implemented the Intranet in an attempt to improve communication and coordination within the organization. To test our research model and hypotheses, survey questionnaires were first sent out to 400 Intranet users. With the assistance of ROKAF, Intranet users were initially identified among its members, and subjects were randomly drawn from the pool. 377 survey responses were finally returned. The unit of measurement and analysis in this research is a personal level. Path analysis based on structural equation modeling was used to test research hypotheses. Construct validity represents accordance between the theoretical base concept of constructs and its measurement items. Tests for the reliability and discriminant validity are accepted, thus verifying our survey instrument. In this research, we have proposed a conceptual framework to highlight the importance of perceived voluntariness after organization deploys OIS. The results of our analysis present several key finding. First, all three independent variables (IT usage level, task interdependency, and organizational support) have significant effects on IS usage, which will eventually improve performance. Thus, IS usage plays a mediating role between antecedent variables (IT usage level. task interdependency, and organizational support) and performance improvement. Second, the effect of the task dependency was the highest for IS usage among the three antecedent variables. This is highly plausible since one of the Intranet's major capabilities is to facilitate communication among members within an organization. Accordingly, we conclude that the higher the task dependency, the higher Intranet usage. The effect of user's IT usage level was the second, while the effect of the organizational support was the third. Finally, the perceived voluntariness plays a pivotal role in enhancing perceived performance in personal level after launching the Intranet. Relationships among investigated variables were significantly different between groups with a high level and a low level of voluntariness. The impact of the Intranet usage on the performance was greater in the higher level voluntariness group than in the lower one. For the lower level voluntariness group, the user's IT usage had the highest effect on the Intranet usage among the three antecedent variables. In short, our study suggests that the higher the perceived voluntariness is the more IS usage will be. Perceived voluntariness was found to have a moderating effect on the relationships among user IT usage level, task interdependency, IS usage, and perceived performance, supporting all the hypotheses on the moderating effect. Most of all, user IT usage level has the strongest influence on IS usage, indicating that users with superior IT usage are more likely to enjoy a high level of perceived performance.