• Biotechnology and Bioprocess Engineering:BBE
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• 제7권3호
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• pp.163-170
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• 2002

This report describes the use of a transtubular bioreactor to study the relative effects of diffusion versus perfusion of medium on antibody production by a hybridoma cell line. The study was performed with a high-density cell culture maintained in a serum-free, low-protein medium for 77 days. It was determined that the reactor possessed a macro-mixing pattern residence time distribution similar to a continuous stirred tank reactor (CSTR), However, due to the arrangement of the medium lines in the reactor, the flow patterns for nutrient distribution consist of largely independent medium path lengths ranging from short to long. When operated with cyclic, reversing, transtubular medium flow, some regions of the reactor (with short residence times) are more accessible to medium than others (with long residence times). From this standpoint, the reactor can be divided into three regions: a captive volume, which consists of medium primarily delivered via diffusion; a lapped volume, which provides nutrients through unilateral convection; and a swept volume, which operates through bilateral convection. The relative sizes of these three volumes were modified experimentally by changing the period over which the direction of medium flow was reversed from 15 min (larger captive volume) to 9 h (larger swept volume). The results suggest that antibody concentration increases as the size of the diffusion-limited (captive) volume is increased to a maximum at around 30 min with a sharp decrease thereafter. As reflected by changes in measured consumption of glucose and production of lactate, no significant difference in cellular metabolism occurred as the reactor was moved between these different states. These results indicate that the mode of operation of the transtubular bioreactor may influence antibody productivity under serum-free, low-protein conditions with minimal effects on cellular metabolism.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제12권5호
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• pp.286-299
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• 2006

모델링 시뮬레이션 그리고 센서 장비 기술의 지속적인 발전으로 최근에 매우 높은 해상도를 갖는 방대한 크기의 볼륨 데이타들이 일반화되고 있다. 과학적 가시화 분야에서, 이러한 데이타를 고성능 병렬 컴퓨터를 사용하여 효과적으로 가시화하기 위한 다양한 대화식 실시간 기법들이 제안되어 왔다. 본 논문에서는 모바일 클라이언트, 게이트웨이, 병렬 렌더링 서버로 구성되는 모바일 볼륨 가시화 시스템의 개발에 관해 설명한다. 모바일 클라이언트는 병렬 렌더링 서버에게 전달할 렌더링 / 뷰잉 파라미터를 설정할 수 있는 기능뿐만 아니라, 관심이 있는 특정 영역을 점진적으로 높은 해상도의 영상을 이용해 탐색할 수 있는 기능을 제공한다. 게이트웨이는 안정적인 서비스를 위해 모바일 클라이언트와 병렬 렌더링 서버 사이에서 주고받는 요청과 응답을 관리하는 역할을 한다. 병렬 렌더링 서버는 클라이언트로부터 전달받은 렌더링 컨텍스트를 이용하여 정의된 특정 부분 볼륨을 가시화하고, 고해상도의 최종 영상을 클라이언트에게 되돌려 주는 작업을 수행한다. 제안된 시스템은 PDA를 갖고 있는 여러 사용자가 협력작업(CSCW) 모드를 통해 동시에 볼륨 데이타 가운데 공통으로 관심을 갖는 특정 부분, 렌더링 컨텍스트, 그리고 최종 영상을 공유할 수 있도록 설계되었다.

• Journal of Korean Neurosurgical Society
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• 제42권4호
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• pp.286-292
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• 2007

Objective : Gamma Knife Stereotactic Radiosurgery (GK SRS) has become an important treatment modality for vestibular schwannomas. We evaluated the tumor control rate, patterns of tumor volume change and preservation of hearing following low-dose radiation for vestibular schwannomas in a homogeneous cohort group in which the mean marginal dose was 12 Gy. Methods : A total of 59 patients were enrolled in this study. All enrolled patients were followed-up for at least 5 years and the radiation dose was 11-13 Gy. Regular MRI, audiometry and clinical evaluations were done and tumor volumes were obtained from MRI using the OSIRIS program. Results : The tumor control rate was 97%. We were able to classify the patterns of change in tumor volume into three categories. Transient increases in tumor volume were detected in 29% of the patients and the maximum transient increase in tumor volume was identified at 6 to 30 months after GK SRS. The transient increases in tumor volume ranged from 121% to 188%. Hearing was preserved in 4 of the 12 patients who had serviceable hearing prior to treatment. There were no other complications associated with GK SRS. Conclusion : Low-dose GK SRS was an effective and safe mode of treatment for vestibular schwannomas in comparison to the previously used high-dose GK SRS. Transient increases in tumor volume can be identified during the follow-up period after low-dose GK SRS for vestibular schwannomas. Physicians should be aware that these increases are not always indicative of treatment failure and that close observation is required following treatments. Unfortunately, a satisfactory hearing preservation rate was not achieved by reducing the radiation dose. It is thought that hearing preservation is a more sophisticated problem and further research is required.

• 대한치과교정학회지
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• 제35권5호
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• pp.388-397
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• 2005

이 연구는 기존의 두부방사선사진에서 사용되었던 계측점들을 3차원으로 재구성한 CT자료에서 다시 정의하고, 그 점들의 재현도를 조사함으로써. 재현성이 높고 해부학적 특징을 잘 표현하는 점들을 제안하고자 시행하였다. 3차원 영상에서 상대적 좌표 값을 구하기 위해 어느 4점도 같은 평면에 존재하지 않는 7개의 고정점을 선정하여 기준 좌표계를 설정하였다. V works 4.0 (Cybermed inc., Seoul. Korea)을 이용하여 고정점과 1점 설정을 위한 volume model (voxel size=4*4*2, threshold value-639)을 형성한 후 계측점을 선택하였으며. 나머지 점들은 모두 volume mode의 MPR 창을 이용하여 선정하였다 이렇게 선정한 계측점을 V 녁ㅎㄷ교 (Cybermed Inc.. Seoul, Korsa)로 이출하여 각 점의 상대적 공간 좌표 값을 구하였다 모든 자료는 2주 간격으로 2번 측정한 후 재현도를 계산하였다 각 계측점의 재현도는 x축 $0.13\~1.24mm$, y축 $0.23\~1.53mm$, z축 $0.15\~1.81mm$로 유사한 범위를 보였다 재현도가 우수한 것은 고정점을 이용한 1점이며 봉합에 의해 정의되는 J점의 재현도가 비교적 낮게 나타났다.

• 한국통신학회논문지
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• 제27권4B호
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• pp.372-378
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• 2002

본 논문에서는 Ku 대역 위성 중계기용 도파관형 협대역 채널 여파기를 설계, 제작하였으며 2단 반시형 등화기를 사용하여 대역 내에서의 군지연 및 진폭 변화를 최소화하였다. 주파수 선택도 규격을 만족시키기 위하여 채널 여파기는 8차 타원 응답형으로 설계하였으며 무게 및 부피 최소화를 위하여 여파기와 등화기 공히 원통형 공동의 TEl13 모드의 수직, 수평 편파를 이용하는 이중모드 공진기로 설계하였다. 제작한 채널 여파기와 등화기는 위성 중계기에 적용 가능한 성능을 나타내었다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.191-194
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• 1997

Passive, semi-active and active dampers have been used to dissipate energy in mechanical systems. Semi-active dampers have higher performance than passive dampers and require lower power to operate than active dampers. Its damping characteristics can be changed appropriately for varying conditions. In this paper, we developed a semi-active damper based on Magnetorheological(MR) fluid. MR fluid has a variable damping characteristics proportional for the magnetic field intensity. It has several advantages such as high strength, low viscosity, robustness in impurities and wide temperature range of operational stability. We designed a constrained rotary MR damper base on valve mode which can dissipate more energy per unit volume. The system with Bingham characteristics is obtained and proved by the experiment.

• 대한교통학회지
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• 제14권1호
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• pp.81-99
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• 1996

This study aims to assess the potential competition among road, rail, and coastal transport under various scenarios concerning the future inland container transport systems in Pusan-KyungIn corridor. For this SP approaches are adopted to collect data from shippers and carriers, and multinomial logit models are estimated at disaggragate level. The results of the analysis indicate that the SP data are reliable, and that the mode choice models estimated are valid. The results also indicate that the most effective policy to divert the freight volume from road to other modes is to reduce freight rates for the railway, and is to transport time for the coastal water with improved reliability.

• Journal of electromagnetic engineering and science
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• 제18권1호
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• pp.46-51
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• 2018

In this paper, a planar printed hybrid short/open-ended slot antenna with capacitive coupling feed strips is proposed for hepta-band mobile applications. The proposed antenna is comprised of a slotted ground plane on the top plane and two capacitive coupling feed strips with a chip inductor on the bottom plane. At the low frequency band, the short-ended long slot fed by strip 1 generates its half-wavelength resonance mode, whereas the T-shaped open ended slot fed by strip 2 generates its quarter-wavelength resonance mode for the high frequency band. The antenna provides a wide bandwidth covering GSM850/GSM900/DCS/PCS/UMTS/LTE2300/LTE2500 operation bands. Moreover, the antenna occupies a small volume of $15mm{\times}50mm{\times}1mm$. The operating principle of the proposed antenna and the simulation/measurement results are presented and discussed.

• 융복합기술연구소 논문집
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• 제3권1호
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• pp.25-29
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• 2013

The purpose of this paper is to determine the fuel change and weight change impact on the fuel economy and emission characteristic of ICE (Internal Combustion Engine) vehicle. According to fuel type, fuel consumption and emission characteristics were measured and fuel used in this paper was gasoline, diesel, and LPG. Four vehicles with different weight were tested and the fuel economy were compared and analyzed by using scatter graph. Test was carried out using chassis dynamometer, CVS (Constant Volume Sampler), and emission measurement system. Diesel vehicle less emited $CO_2$ compared to gasoline and LPG. Even if same $CO_2$ between gasoline and LPG, there are difference fuel economy depending on carbon proportion of specific fuel. The heavier weight of vehicle, the worse of fuel economy and Better fuel economy performance on highway driving mode.

• 동력기계공학회지
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• 제6권3호
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• pp.11-16
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• 2002

This paper describes the power performance and emission characteristics of the high speed direct injection diesel engine (2.9 litter displacements) driven by soybean oil asknown a bio diesel fuel. The results were compared to diesel fuel with blending bio diesel fuels. The soybean bio diesel fuel was added in the diesel fuel in concentration varying from 25% to 75% volume rates. We measured the emissions according to ECE 13 mode and full load, fixedengine speed. When the 25% bio diesel fuel was used, NOx emission at the ECE 13 mode test slightly decreased compared with diesel base engine. Over engine speed of 2000 rpm, the level of unburned hydrocarbon(HC) and carbon monoxide(CO) were the same to the diesel engine. Smoke emission decreased asthe blending bio diesel fuel rate increased.