• Biotechnology and Bioprocess Engineering:BBE
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• v.7 no.3
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• pp.163-170
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• 2002

This report describes the use of a transtubular bioreactor to study the relative effects of diffusion versus perfusion of medium on antibody production by a hybridoma cell line. The study was performed with a high-density cell culture maintained in a serum-free, low-protein medium for 77 days. It was determined that the reactor possessed a macro-mixing pattern residence time distribution similar to a continuous stirred tank reactor (CSTR), However, due to the arrangement of the medium lines in the reactor, the flow patterns for nutrient distribution consist of largely independent medium path lengths ranging from short to long. When operated with cyclic, reversing, transtubular medium flow, some regions of the reactor (with short residence times) are more accessible to medium than others (with long residence times). From this standpoint, the reactor can be divided into three regions: a captive volume, which consists of medium primarily delivered via diffusion; a lapped volume, which provides nutrients through unilateral convection; and a swept volume, which operates through bilateral convection. The relative sizes of these three volumes were modified experimentally by changing the period over which the direction of medium flow was reversed from 15 min (larger captive volume) to 9 h (larger swept volume). The results suggest that antibody concentration increases as the size of the diffusion-limited (captive) volume is increased to a maximum at around 30 min with a sharp decrease thereafter. As reflected by changes in measured consumption of glucose and production of lactate, no significant difference in cellular metabolism occurred as the reactor was moved between these different states. These results indicate that the mode of operation of the transtubular bioreactor may influence antibody productivity under serum-free, low-protein conditions with minimal effects on cellular metabolism.

• Journal of KIISE:Computing Practices and Letters
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• v.12 no.5
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• pp.286-299
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• 2006

Due to the continuing technical progress in the capabilities of modeling, simulation, and sensor devices, huge volume data with very high resolution are common. In scientific visualization, various interactive real-time techniques on high performance parallel computers to effectively render such large scale volume data sets have been proposed. In this paper, we present a mobile volume visualization system that consists of mobile clients, gateways, and parallel rendering servers. The mobile clients allow to explore the regions of interests adaptively in higher resolution level as well as specify rendering / viewing parameters interactively which are sent to parallel rendering server. The gateways play a role in managing requests / responses between mobile clients and parallel rendering servers for stable services. The parallel rendering servers visualize the specified sub-volume with rendering contexts from clients and then transfer the high quality final images back. This proposed system lets multi-users with PDA simultaneously share commonly interesting parts of huge volume, rendering contexts, and final images through CSCW(Computer Supported Cooperative Work) mode.

• Journal of Korean Neurosurgical Society
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• v.42 no.4
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• pp.286-292
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• 2007

Objective : Gamma Knife Stereotactic Radiosurgery (GK SRS) has become an important treatment modality for vestibular schwannomas. We evaluated the tumor control rate, patterns of tumor volume change and preservation of hearing following low-dose radiation for vestibular schwannomas in a homogeneous cohort group in which the mean marginal dose was 12 Gy. Methods : A total of 59 patients were enrolled in this study. All enrolled patients were followed-up for at least 5 years and the radiation dose was 11-13 Gy. Regular MRI, audiometry and clinical evaluations were done and tumor volumes were obtained from MRI using the OSIRIS program. Results : The tumor control rate was 97%. We were able to classify the patterns of change in tumor volume into three categories. Transient increases in tumor volume were detected in 29% of the patients and the maximum transient increase in tumor volume was identified at 6 to 30 months after GK SRS. The transient increases in tumor volume ranged from 121% to 188%. Hearing was preserved in 4 of the 12 patients who had serviceable hearing prior to treatment. There were no other complications associated with GK SRS. Conclusion : Low-dose GK SRS was an effective and safe mode of treatment for vestibular schwannomas in comparison to the previously used high-dose GK SRS. Transient increases in tumor volume can be identified during the follow-up period after low-dose GK SRS for vestibular schwannomas. Physicians should be aware that these increases are not always indicative of treatment failure and that close observation is required following treatments. Unfortunately, a satisfactory hearing preservation rate was not achieved by reducing the radiation dose. It is thought that hearing preservation is a more sophisticated problem and further research is required.

• The korean journal of orthodontics
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• v.35 no.5 s.112
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• pp.388-397
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• 2005

The purpose of this study was to redefine the cephalometric landmarks in three-dimensional (3D) images, which are used in orthodontic cephalometric radiography, and to evaluate the reproducibility of each landmark for 3D cephalometric analysis. Eighteen CT scans were taken at the Department of Diagnostic Radiology at Seoul National University Dental Hospital and manipulated with V works 4.0(Cybermed Inc., Seoul, Korea). The coordinate system was established using 7 reference points, with no more than 4 points on the same plane. These 7 points were generated as a volume model, the voxel size of which was 4 by 4 by 2 (threshold value=639). The cephalometric landmarks were selected at the multiplanar reformation (MPR) window on the volume mode of V works 4.0. The selected landmarks were exported to V surgery (Cybermed Inc., Seoul, Korea) for the calculation of coordinate values. All the data were taken twice with a lapse of 2 weeks by one investigator The reproducibility of each landmark was $0.17\~1.21mm$ in the x axis, $0.30\~1.53mm$. In the y axis, and $0.27\~1.81mm$ in the z axis. In all three axes, the range of error was similar. These error ranges were acceptable with regards to the pixel space and slice thickness. The most reproducible points were 1 points which were selected on the basis of the volume model. The least reproducible points were J points that were defined by sutures.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.4B
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• pp.372-378
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• 2002

In this paper, a narrow-band waveguide channel fitter has been designed and realized for Ku band satellite transponder. Group-delay and amplitude variations of the channel filter have been minimized using a 2-pole reflection type equalizer. The channel filter has been designed to have the 8-pole elliptic response for high frequency selectivity. Dual-mode technique has been adopted for reducing mass and volume of the channel filter and equalizer. The channel filter and equalizer have shown good performance for satellite transponder.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.191-194
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• 1997

Passive, semi-active and active dampers have been used to dissipate energy in mechanical systems. Semi-active dampers have higher performance than passive dampers and require lower power to operate than active dampers. Its damping characteristics can be changed appropriately for varying conditions. In this paper, we developed a semi-active damper based on Magnetorheological(MR) fluid. MR fluid has a variable damping characteristics proportional for the magnetic field intensity. It has several advantages such as high strength, low viscosity, robustness in impurities and wide temperature range of operational stability. We designed a constrained rotary MR damper base on valve mode which can dissipate more energy per unit volume. The system with Bingham characteristics is obtained and proved by the experiment.

• Journal of Korean Society of Transportation
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• v.14 no.1
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• pp.81-99
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• 1996

This study aims to assess the potential competition among road, rail, and coastal transport under various scenarios concerning the future inland container transport systems in Pusan-KyungIn corridor. For this SP approaches are adopted to collect data from shippers and carriers, and multinomial logit models are estimated at disaggragate level. The results of the analysis indicate that the SP data are reliable, and that the mode choice models estimated are valid. The results also indicate that the most effective policy to divert the freight volume from road to other modes is to reduce freight rates for the railway, and is to transport time for the coastal water with improved reliability.

• Journal of electromagnetic engineering and science
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• v.18 no.1
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• pp.46-51
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• 2018

In this paper, a planar printed hybrid short/open-ended slot antenna with capacitive coupling feed strips is proposed for hepta-band mobile applications. The proposed antenna is comprised of a slotted ground plane on the top plane and two capacitive coupling feed strips with a chip inductor on the bottom plane. At the low frequency band, the short-ended long slot fed by strip 1 generates its half-wavelength resonance mode, whereas the T-shaped open ended slot fed by strip 2 generates its quarter-wavelength resonance mode for the high frequency band. The antenna provides a wide bandwidth covering GSM850/GSM900/DCS/PCS/UMTS/LTE2300/LTE2500 operation bands. Moreover, the antenna occupies a small volume of $15mm{\times}50mm{\times}1mm$. The operating principle of the proposed antenna and the simulation/measurement results are presented and discussed.

• Journal of Institute of Convergence Technology
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• v.3 no.1
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• pp.25-29
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• 2013

The purpose of this paper is to determine the fuel change and weight change impact on the fuel economy and emission characteristic of ICE (Internal Combustion Engine) vehicle. According to fuel type, fuel consumption and emission characteristics were measured and fuel used in this paper was gasoline, diesel, and LPG. Four vehicles with different weight were tested and the fuel economy were compared and analyzed by using scatter graph. Test was carried out using chassis dynamometer, CVS (Constant Volume Sampler), and emission measurement system. Diesel vehicle less emited $CO_2$ compared to gasoline and LPG. Even if same $CO_2$ between gasoline and LPG, there are difference fuel economy depending on carbon proportion of specific fuel. The heavier weight of vehicle, the worse of fuel economy and Better fuel economy performance on highway driving mode.

• Journal of Power System Engineering
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• v.6 no.3
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• pp.11-16
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• 2002

This paper describes the power performance and emission characteristics of the high speed direct injection diesel engine (2.9 litter displacements) driven by soybean oil asknown a bio diesel fuel. The results were compared to diesel fuel with blending bio diesel fuels. The soybean bio diesel fuel was added in the diesel fuel in concentration varying from 25% to 75% volume rates. We measured the emissions according to ECE 13 mode and full load, fixedengine speed. When the 25% bio diesel fuel was used, NOx emission at the ECE 13 mode test slightly decreased compared with diesel base engine. Over engine speed of 2000 rpm, the level of unburned hydrocarbon(HC) and carbon monoxide(CO) were the same to the diesel engine. Smoke emission decreased asthe blending bio diesel fuel rate increased.