• Environmental Engineering Research
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• 제24권2호
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• pp.298-308
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• 2019

This work deals with the membrane fouling mode and the unclogging in seawater ultrafiltration process. The identification of the fouling mechanism by modeling the experimental flux decline was performed using both the classical models of Hermia and the combined models of Bolton. The results show that Bolton models did not bring more precise information than the Hermia's and the flux decline can be described by one of the four Hermia's models since the backwash interval is ${\leq}60$ min. An experimental screening study has been then conducted to choose among 5 parameters (backwash interval, duration, pulses and the flow-rate or injected hypochlorite concentration) those that are the most influential on the fouling and the net water production. It has emerged that fouling is mainly affected by the backwash interval; its prolongation from 30 to 60 min engenders an increase in the reversible fouling and a decrease in the irreversible fouling. This later is also significantly reduced when the hypochlorite concentration increases from 4.5 to 10 ppm. Moreover, the net water production significantly increases with increasing the filtration duration up to 60 min and decreases with decreasing the backwash duration and backwash flow-rate from 10 to 40 s and from 15 to ${\geq}20L.min^{-1}$, respectively.

• Mass Spectrometry Letters
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• 제9권4호
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• pp.91-94
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• 2018

Bilin tetrapyrroles are metabolic products of the breakdown of porphyrins within a species. In the case of mammals, these bilins are formed by the catabolism of heme and can be utilized as either biomarkers in disease or as an indicator of human waste contamination. Although a small subset of bilin tandem mass spectrometry reports exist, limited data is available in online databases for their fragmentation. The use of fragmentation data is important for metabolomics analyses to determine the identity of compounds detected within a sample. Therefore, in this study, the fragmentation of bilins generated by positive ion mode electrospray ionization is examined by collision-induced dissociation (CID) as a function of collision energy on an FT-ICR MS. The use of the FT-ICR MS allows for high mass accuracy measurements, and thus the formulas of resultant product ions can be ascertained. Based on our observations, fragmentation behavior for hemin, biliverdin and its dimethyl ester, phycocyanobilin, bilirubin, bilirubin conjugate, mesobilirubin, urobilin, and stercobilin are discussed in the context of the molecular structure and collision energy. This report provides insight into the identification of structures within this class of molecules for untargeted analyses.

• 영어영문학
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• 제59권4호
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• pp.645-666
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• 2013

In the history of the study of Shakespeare's texts the eighteenth century marked the emergence of editors, and in the history of Shakespearean editing Edmond Malone's emphasis on documentary evidence inaugurated a new stage. Malone's antiquarian scholarship sought to establish Shakespeare in the theatrical context of his age and a historically informed view of the physical circumstances under which he wrote his plays. Malone's editorial use of historical sources in terms of Shakespeare's past formulated a new mode of ascertaining his authorship: the construction of Shakespeare as a man of the theatre as well as of literature. Malone was the first scholar to recognize Shakespeare's merits as an actor, and to introduce the concept of the theatrical Shakespeare, which has become the scholarly norm since. In this respect this paper is designed to demonstrate that Malone's editorial principle and practice are characteristic of the identification of the factual documents of Shakespeare's biography, the authentication of his material to attain his true text, and the construction of his personal experiences through intensive readings of his plays. In conclusion, Malone's new criteria laid the foundation for the progress towards authorizing Shakespeare, thereby canonizing him as a figure of the theatrical and literary authority.

• 환경생물
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• 제39권2호
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• pp.160-168
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• 2021

Doublesex and mab-3 related transcription factor(dmrt) play crucial roles in sex determination and sex differentiation in vertebrates and invertebrates. Although dmrt genes have been identified in vertebrates, little is known about aquatic invertebrates. In this study, two dmrt genes, namely, Dc_dmrt93B and Dc_dmrt99B, were identified from brackish water flea, Diaphanosoma celebensis. Transcriptional changes were observed in the dmrt genes when the flea was exposed to bisphenol(BP), an endocrine disruptor. Sequence and phylogenetic analyses showed that both dmrt genes contained two conserved domains, namely, DM and DMA, closely clustered with those of Daphnia spp. Additionally, a significant increase in the Dc_dmrt99B mRNA expression level was observed upon exposure to intermediate concentrations of BP (bisphenol A>bisphenol S=bisphenol F, p<0.05), while the expression of Dc_dmrt93B mRNA was slightly modulated. These findings imply that the two dmrt genes may be involved in sex differentiation of D. celebensis. Furthermore, it was found that the ability of BP to modulate dmrt genes could affect development and reproduction. This study provides a basis for understanding the function of the dmrt genes and the molecular mode of action of BP in small crustaceans.

• Molecules and Cells
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• 제45권4호
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• pp.243-256
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• 2022

Transcriptional regulation, a core component of gene regulatory networks, plays a key role in controlling individual organism's growth and development. To understand how plants modulate cellular processes for growth and development, the identification and characterization of gene regulatory networks are of importance. The SHORT-ROOT (SHR) transcription factor is known for its role in cell divisions in Arabidopsis (Arabidopsis thaliana). However, whether SHR is involved in hypocotyl cell elongation remains unknown. Here, we reveal that SHR controls hypocotyl cell elongation via the transcriptional regulation of XTH18, XTH22, and XTH24, which encode cell wall remodeling enzymes called xyloglucan endotransglucosylase/hydrolases (XTHs). Interestingly, SHR activates transcription of the XTH genes, independently of its partner SCARECROW (SCR), which is different from the known mode of action. In addition, overexpression of the XTH genes can promote cell elongation in the etiolated hypocotyl. Moreover, confinement of SHR protein in the stele still induces cell elongation, despite the aberrant organization in the hypocotyl ground tissue. Therefore, it is likely that SHR-mediated growth is uncoupled from SHR-mediated radial patterning in the etiolated hypocotyl. Our findings also suggest that intertissue communication between stele and endodermis plays a role in coordinating hypocotyl cell elongation of the Arabidopsis seedling. Taken together, our study identifies SHR as a new crucial regulator that is necessary for cell elongation in the etiolated hypocotyl.

• Wind and Structures
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• 제34권5호
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• pp.451-467
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• 2022

The flow around a high-speed train with three underbody structures in the bogie area is numerically investigated using the improved delayed detached eddy simulation method. The vortex structure, pressure distribution, flow field structure, and unsteady velocity of the wake are analyzed by vortex identification criteria Q, frequency spectral analysis, empirical mode decomposition (EMD), and Hilbert spectral analysis. The results show that the structures of the bogie and its installation cabin reduce the momentum of fluid near the tail car, thus it is easy to induce flow separation and make the fluid no longer adhere to the side surface of the train, then forming vortices. Under the action of the vortices on the side of the tail car, the wake vortices have a trend of spanwise motion. But the deflector structure can prevent the separation on the side of the tail car. Besides, the bogie fairings do not affect the formation process and mechanism of the wake vortices, but the fairings prevent the low-speed fluid in the bogie installation cabin from flowing to the side of the train and reduce the number of the vortices in the wake region.

• Advances in concrete construction
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• 제13권3호
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• pp.223-231
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• 2022

The problem is formulated by applying the Kirchhoff's conception for shell theory. The longitudinal modal displacement functions are assessed by characteristic beam ones meet clamped-clamped end conditions applied at the shell edges. The fundamental natural frequency of rotating functionally graded cylindrical shells of different parameter versus ratios of length-to-diameter and height-to-diameter for a wide range has been reported and investigated through the study with fractions laws. The frequency first increases and gain maximum value with the increase of circumferential wave mode. By increasing different value of height-to-radius ratio, the resulting backward and forward frequencies increase and frequencies decrease on increasing height-to-radius ratio. Moreover, on increasing the rotating speed, the backward frequencies increases and forward frequencies decreases. The trigonometric frequencies are lower than that of exponential and polynomial frequencies. Stability of a cylindrical shell depends highly on these aspects of material. More the shell material sustains a load due to physical situations, the more the shell is stable. Any predicted fatigue due to burden of vibrations is evaded by estimating their dynamical aspects.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권5호
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• pp.1301-1316
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• 2024

In modern warfare, missiles play a pivotal role but typically spend the majority of their lifecycle in long-term storage or standby mode, making it difficult to detect failures. Preemptive detection of missiles that will fail is crucial to preventing severe consequences, including safety hazards and mission failures. This study proposes a contamination-based stacking ensemble model, employing the local outlier factor (LOF), to detect such missiles. The proposed model creates multiple base LOF models with different contamination values and combines their anomaly scores to achieve a robust anomaly detection. A comparative performance analysis was conducted between the proposed model and the traditional single LOF model, using production-related inspection data from missiles deployed in the military. The experimental results showed that, with the contamination parameter set to 0.1, the proposed model exhibited an increase of approximately 22 percentage points in accuracy and 71 percentage points in F1-score compared to the single LOF model. This approach enables the preemptive identification of potential failures, undetectable through traditional statistical quality control methods. Consequently, it contributes to lower missile failure rates in real battlefield scenarios, leading to significant time and cost savings in the military industry.

• 감성과학
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• 제13권1호
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• pp.21-32
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• 2010

이 연구는 그림 자료의 근접성(고근접 vs. 저근접)에 따른 제시여부와 읽기모드(단순읽기 vs. 요약읽기)에 따른 학습자의 인지부하 차이를 검증하기 위한 것이다. 특히, 이 연구에서는 전기피부반응을 통하여 인지부하의 정도를 측정하였다. 실험참가자는 34명(통제집단=17명, 실험집단=17명)이었으며 고근접 조건과 저근접 조건에 대한 반복구획요인설계를 적용하였다. 또한 각 실험조건에서 측정된 과제난이도 지각점수를 공변량으로 투입하여 학습자의 사전지식에 의한 영향력을 통제하였다. 그림 자료의 근접성의 정도에 따라서 고근접 그림 자료와 저근접 그림 자료가 순차적으로 제시되었다. 처음에는 단순읽기 모드가 제시되었고 이후에 요약읽기를 수행하였다. 전기피부반응은 단순읽기와 요약읽기에서 모두 측정되었다. 이 연구의 종속변수는 전기피부반응과 지각된 난이도였다. 연구결과에 따르면 고근접 자료가 제시된 조건에서는 유의미한 차이를 발견할 수 없었다. 그러나 저근접 조건에서는 그림 자료의 제시여부 및 읽기모드 사이에서 유의미한 차이가 있었다. 즉, 저근접 조건에서는 텍스트만 제시하는 것보다는 그림 자료가 제시될 때 전기피부반응이 올라갔다. 또한 단순 읽기 보다 요약읽기에서 더 높은 전기피부반응이 측정되었다. 이 연구의 결과는 저근접 그림은 인지부하를 유발하는 요인이 될 수 있으며 읽기모드가 복잡해지면 인지부하가 높아질 수 있음을 보여주는 것이다. 동일한 자료를 활용한다고 하더라도 인지과정의 복잡성 정도에 따라서 인지부하가 달라질 수 있다는 것이다. 그러나 학습성취과 같은 과제수행 요인과 더 높은 난이도에서의 인지부하 측정에 대한 후속연구가 필요하다.

• 지능정보연구
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• 제20권2호
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• pp.93-107
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• 2014

대부분의 인터넷 쇼핑몰은 자사 고객의 관심 분야를 파악하고 이를 상품 추천에 효과적으로 활용하기 위해 많은 노력을 기울이고 있다. 하지만 고객이 회원 가입 시 직접 입력한 개인 정보는 신뢰하기가 어렵고, 고객의 구매 패턴을 통해 파악한 관심 분야 정보는 자사 사이트 내에 진입한 이후에만 보인 한정된 패턴이라는 측면에서 해당 고객의 다양한 관심분야를 제대로 나타낸다고 보기 어렵다. 이러한 한계를 극복하기 위해 본 연구에서는 고객의 평소 인터넷 사용 기록을 통해 최근 방문 사이트들의 주제를 분석함으로써, 고객의 실제 관심 분야를 파악할 수 있는 방안을 제시하였다. 또한 토픽 분석을 통해 각 사이트의 주제를 도출하고 도출된 주제를 다시 동시 방문자 관점에서 군집화 함으로써, 고객 관점에서 의미가 있는 상위 수준의 새로운 테마를 발굴하기 위한 방법론을 제안하였다. 연구의 특징은 유사주제 중심의 군집화라는 기존 연구와는 달리 사용자 관점의 관심주제 중심 군집화라 할 수 있다. 향후 사용자 중심의 카테고리 설계를 비롯한 새로운 관점의 고객군 정의 등 보다 높은 차원의 마케팅 전략 수립에 활용이 가능할 것으로 기대된다. 사용자 관점의 이슈 군집화 과정은 크롤링, 토픽 분석, 액세스 패턴 분석, 네트워크 병합, 네트워크 변환 및 군집화와 같은 여섯 가지 주요단계로 구성되어있다. 이를 위해 텍스트 마이닝과 소셜 네트워크 분석 기법을 활용한 비정형 텍스트를 기반으로한 빅데이터의 활용 방법을 모색하였다. 제안 방법론의 실무 적용 가능성을 평가하기 위해, 국내 최대 포털 뉴스 사이트의 방문자 2,177명의 1년간 방문 기록과 뉴스기사 대한 분석을 수행하고 그 결과를 요약하여 제시하였다.