• Journal of Pharmaceutical Investigation
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• v.36 no.1
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• pp.45-51
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• 2006

A rapid, selective and sensitive reversed-phase HPLC method for the determination of dipyridamole in human serum was developed, validated, and applied to the pharmacokinetic study of dipyridamole. Dipyridamole and internal standard, loxapine, were extracted from human serum by liquid-liquid extraction with diethyl ether and analyzed on a Nova Pak $C_{I8}$ column with the mobile phase of 40 mM ammonium acetate:methanol:acetonitrile (35:35:30)(v/v/v, pH 7.8). Detection wavelength of 280 nm and flow rate of 1.0 mL/min were fixed for the study. The assay robustness for the changes of mobile phase pH, organic solvent content, and flow rate was confirmed by $3^3$ factorial design using a fixed dipyridamole concentration (50 ng/mL) with respect to its peak area and retention time. And also, the ruggedness of this method was investigated at three different laboratories using same quality control (QC) samples. This method showed linear response over the concentration range of 2-2000 ng/mL with correlation coefficients greater than 0.999. The lower limit of quantification using 0.5 mL of serum was 2 ng/mL, which was sensitive enough for pharmacokinetic studies of dipyridamole. The overall accuracy of the quality control samples ranged from 103.94 to 105.86% for dipyridamole with overall precision (% C.V.) being 4.60-11.49%. The relative mean recovery of dipyridamole for human serum was 97.64%. Stability studies showed that dipyridamole was stable during storage, or during the assay procedure in human serum. The peak area and retention time of dipyridamole were not significantly affected by the changes of mobile phase pH, organic solvent content, and flow rate under the conditions studied. This method showed good ruggedness (within 15% C.V.) and was successfully used for the analysis of dipyridamole in human serum samples for the pharmacokinetic studies of orally administered Dimor tablet (75 mg as dipyridamole) at three different laboratories, demonstrating the suitability of the method.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.171-174
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• 2005

According as marine leisure industry has developed and the demand of leisure culture has increased rapidly, a desire about service which supply marine safety and connect marine information is enlarging. The performance of personal mobile device has improved and been evolved by composition terminal. So, it became possible that storage and expression of multimedia information as well as simple communication facility. Domestic wireless internet has given development strain to developer and contents Provider(CP) because of different platform. And this has become hindrance factor of wireless internet activation. But, recently, the use of WIPI(Wireless Internet Platform for Interoperability), the wireless internet standard platform, could use different wireless application programs and also guarantee the independency for hardware. We wish to develop contents of download form that supply geographic information of Electronic Navigational Chart(ENC) in the marine that is digitalized to carrying along terminal of WIPI base and various informations for marine leisure. For this, DB that offer ENC and additional information should be constructed. Also, we need server (CPS; Contents provider Server) that offer required contents. In this paper, we design web retrieval agent which store request information to database. When consumer required necessary information through personal mobile device, CPS can inform that by real time. So, we wish to develop agent component that parse informations in various World Wide Webs, and store to database.

• Journal of Digital Convergence
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• v.11 no.12
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• pp.381-386
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• 2013

As the new variation malicious codes of android platform are drastically increasing, the preparation plan and response is needed. We proposed a high-interaction client honeypot that applied to the android platform. We designed flow for the system. Application plan and the function was analyze. Each detail module was optimized in the Android platform. The system is equipped with the advantage of the high-interaction client honeypot of PC environment. Because the management and storage server was separated it is more flexible and expanded.

• Plant Journal
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• v.16 no.3
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• pp.37-41
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• 2020

Lately old LNG carriers increased and ship price is getting down. So Interest for reuse and modification of used LNG carriers is growing. Also the needs for replacement of old power plant is increasing. Additionally eco friendly fuel such as LNG become attractive. Consequently gas power plant is getting much more popular than before. So in this research planning, we consider the floating power plant by modifying LNG carriers. This plant has the various function including storage, power plant and bunkering fuction etc. Through this multifunctional plant, we are ready for the old power plant shutdown and energy crisis in the future when we can supply the urgent mobile floating power plant quickly in time.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.5 no.4
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• pp.703-719
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• 2011

In multi-user wireless communication systems, adaptive modulation and scheduling are promising techniques for increasing the system throughput. However, a mass of wireless recourse will be occupied and spectrum efficiency will be decreased to feedback channel quality indication (CQI) of all users in every subcarrier or chunk for adaptive orthogonal frequency division multiplexing (OFDM) systems. Thus numerous limited feedback schemes are proposed to reduce the system overhead. The recently proposed compressive sensing (CS) theory provides a new framework to jointly measure and compress signals that allows less sampling and storage resources than traditional approaches based on Nyquist sampling. In this paper, we proposed two novel CQI feedback schemes based on general CS and subspace CS, respectively, both of which could be used in a wireless OFDM system. The feedback rate with subspace CS is greatly decreased by exploiting the subspace information of the underlying signal. Simulation results show the effectiveness of the proposed methods, with the same feedback rate, the throughputs with subspace CS outperform the discrete cosine transform (DCT) based method which is usually employed, and the throughputs with general CS outperform DCT when the feedback rate is larger than 0.13 bits/subcarrier.

• Biomolecules & Therapeutics
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• v.13 no.2
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• pp.90-94
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• 2005

Prazosin hydrochloride is an antihypertensive drug with selective ${\alpha}_1$-adrenoreceptor blocking effects. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of prazosin in human plasma. A reversed-phase C18 column was used for the separation of prazosin and terazosin (internal standard) with a mobile phase composed of water, acetonitrile and triethylamine(75:25:0.1, V/V;pH5.0) at a flow rate of 1.5 ml/min. the fluorescence detector was set at excitation and emissionwavelengths of 250 and 370 nm, respectively. Intra-and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 0.5 ng/ml. Good recovery (>80%) was seen in plasma. Prazosin was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study in plasma after oral administration of a single 2-mg dose as prazosin base to 16 healthy volunteers. The maximum plasma concentration of prazosin was 23.1 ${\pm}$ 16.5 ng/ml at 2.1 h, and the mean area under the curve and elimination half-life were calculated to be 108.4 ${\pm}$ 74.2 ng ${\cdot}$hr/ml and 2.5 ${\pm}$ 0.6 h, respectively.

• Journal of Korea Multimedia Society
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• v.10 no.1
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• pp.1-12
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• 2007

To use multimedia data in restricted resources of mobile environment, any management method of MPEG-7 documents is needed. At this time, some XML clustering methods can be used. But, to improve the performance efficiency better, a new clustering method which uses the characteristics of MPEG-7 documents is needed. A new clustering improved query processing speed at multimedia search and it possible document storage about various application suitably. In this paper, we suggest a new clustering method of MPEG-7 documents for effective management in multimedia data of large capacity, which uses some semantic relationships among elements of MPEG-7 documents. And also we compared it to the existed clustering methods.

• Journal of Korea Multimedia Society
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• v.5 no.3
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• pp.307-315
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• 2002

As growing the population of the Internet, e-mail should provide various types of media, and the size of e-mail including multimedia data becomes larger and larger Furthermore, the multimedia e-mail has been used through various communication terminals including mobile devices. The main objectives of this thesis is designing and Implementing efficient mail server which should provide high performance and scalability in terms of storage capacity and the number of mail users. This thesis proposes a cluster-based mail server architecture which has a load-balance node using. If address forwarding for distributing incoming mail messages into distributed mail server nodes.

• Journal of Korea Multimedia Society
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• v.7 no.8
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• pp.1017-1024
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• 2004

Ubiquitous system requires intelligent environment and system that perceives context in a proactive manner. This paper describes proactive retrieval method using context patterns in ubiquitous computing. And as the user's contexts change, new information is delivered proactively based on user's context patterns. For proactive retrieval, we extract context patterns based on sequential pattern discovery and association rule in data mining. By storing only information to be needed in near future using the context patterns, we solved the problem of speed and storage capacity of mobile devices in ubiquitous computing. We explain algorithms and an example. Several experiments are performed and the experimental results show that our method has a good information retrieval.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.05a
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• pp.281-284
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• 2003

Development of internet had centered on that offer universality of expression. But, graphic processing of expression center has many inconveniences because of method that is not structural in World Wide Web. Announced SVG that is XML application to permit efficient expression and storage of vector graphic expression, share in W3C to supplement these things. Therefore, because using SVG document in this treatise, edit vector graphic through interface that could edit expressed graphic object directly structural edit and screen that is offered in graphic edit system form and designed SVG edit system to express. This system may use usefully to efficient XML graphics processing on the GIS system and Mobile service environment and so on.