• Bulletin of the Korean Chemical Society
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• 제28권12호
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• pp.2377-2381
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• 2007

Solvolyses of 3,4-dimethoxybenzenesulfonyl chloride (DSC) in water, D2O, CH3OD, and in aqueous binary mixtures of acetone, acetonitrile, 1,4-dioxane, ethanol, methanol, and 2,2,2-trifluoroethanol (TFE) have been investigated at 25.0 oC. Kinetic solvent isotope effects (KSIE) in water and in methanol and product selectivities in alcohol-water mixtures are also reported. The Grunwald-Winstein plot of first-order rate constants for the solvolyic reaction of DSC with YCl shows marked dispersions into separated lines for various aqueous mixtures. With use of the extended Grunwald-Winstein equation, the l and m values obtained are 1.12 and 0.58 respectively for the solvolyses of DSC. The relatively large magnitude of l is consistent with substantial nucleophilic solvent assistance. From Grunwald-Winstein plots the rate data are dissected approximately into contributions from two competing reaction channels. This interpretation is supported for alcohol-water mixtures by the trends of product selectivities, which show a maximum for ethanol-water mixtures. From the KSIE of 1.45 in methanol, it is proposed that the reaction channel favored in methanolwater mixtures and in all less polar media is general-base catalysed and/or is possibly (but less likely) an addition-elimination pathway. Also, the KISE value of 1.35 for DSC in water is expected for SN2-SN1 processes, with minimal general base catalysis, and this mechanism is proposed for solvolyses in the most polar media.

• 소성∙가공
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• 제23권8호
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• pp.501-506
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• 2014

Progressive shearing with blanking dies is commonly employed to produce large quantities of tiny sheet metal electronic parts. Sheet metal pins, which are narrow and long, that are sheared with a progressive die set are often twisted. The twist in the sheet metal pins, which usually occurs in the final shearing operation, generally decreases with increasing blank holding force. The blank holding forces in all shearing operations are not the same because of different shearing positions and areas. In the current study, the optimal layout of the springs in a progressive die set to minimize the twist of the sheet metal pin is proposed. In order to find the holding force acting on the tiny narrow blanks produced with the proposed springs during the shearing process, the equivalent area method is used in the structural analysis. The shearing of the sheet-metal pin was simulated to compute the twist angle associated with the blank holding force. The constraint condition satisfying the pre-set blank holding force from the previous shearing operations was imposed. A design of experiments (DOE) was numerically implemented by analyzing the progressive die structure and by simulating the shearing process. From the meta-model created from the experimental results and by using a quadratic response surface method (PQRSM), the optimal layout of the springs was determined. The twist of sheet metal pin associated with the optimal layout of the springs found in the current study was compared with that of an existing progressive die to obtain a minimal amount of twist.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2007년도 학술대회 1부
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• pp.667-674
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• 2007

Facial expressions provide significant clues about one's emotional state; however, it always has been a great challenge for machine to recognize facial expressions effectively and reliably. In this paper, we report a method of feature-based adaptive motion energy analysis for recognizing facial expression. Our method optimizes the information gain heuristics of ID3 tree and introduces new approaches on (1) facial feature representation, (2) facial feature extraction, and (3) facial feature classification. We use minimal reasonable facial features, suggested by the information gain heuristics of ID3 tree, to represent the geometric face model. For the feature extraction, our method proceeds as follows. Features are first detected and then carefully "selected." Feature "selection" is finding the features with high variability for differentiating features with high variability from the ones with low variability, to effectively estimate the feature's motion pattern. For each facial feature, motion analysis is performed adaptively. That is, each facial feature's motion pattern (from the neutral face to the expressed face) is estimated based on its variability. After the feature extraction is done, the facial expression is classified using the ID3 tree (which is built from the 1728 possible facial expressions) and the test images from the JAFFE database. The proposed method excels and overcomes the problems aroused by previous methods. First of all, it is simple but effective. Our method effectively and reliably estimates the expressive facial features by differentiating features with high variability from the ones with low variability. Second, it is fast by avoiding complicated or time-consuming computations. Rather, it exploits few selected expressive features' motion energy values (acquired from intensity-based threshold). Lastly, our method gives reliable recognition rates with overall recognition rate of 77%. The effectiveness of the proposed method will be demonstrated from the experimental results.

• 대한치과교정학회지
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• 제24권4호
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• pp.759-772
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• 1994

Orthodontists have experienced the treatment of cases with three lower incisors. Occasionally a lower incisor was either congenitally missing or so seriously damaged by injury or disease that its removal presented the best prospect for the patient. Sometimes the intentional extraction of a lower incisor is needed to produce enhanced functional and esthetic results with minimal orthodontic manipulation. Such cases have unfavorable anterior tooth size discrepancies and present difficulties in achieving good occlusal results. However such difficulties can be overcome by the sensible diagnosis and treatment plan. Three different cases are presented and the conclusions are listed. 1. It is important for orthodontist who tries to treat three lower incisor cases to measure and calculate accurately the degree of deviation of tooth size and morphology and the anterior tooth size ratio. 2. A diagnostic setup model should be made to determine whether the incisor extraction is appropriate and space closure is needed or not. It is the best way to be sure that the occlusal results, including overbite and overjet, will be acceptable and how far the degree of midline deviation is. It also shows the amount of interproximal reduction to achieve an acceptable occlusal result. 3. The class I relationship between the upper canine and the lower one must be obtained to establish the canine rise during eccentric movement by the concept of mutually protective occlusion. It also helps to maintain the stable occlusal result.

• 한국정보통신학회논문지
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• 제4권2호
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• pp.307-312
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• 2000

ATM은 비동기 시분할 다중화와 통계적 다중화 특성을 기존의 데이터 통신분야에 도입함으로써 데이터와 음성, 영상과 같은 멀티미디어 등의 다양한 통신들을 유연하게 서비스할 수 있다. ATM 서비스는 트래픽 특성과 요구되는 서비스 품질에 따라 CBR, VBR, UBR, ABR로 구분하는데 그 중 ABR 서비스는 최소의 대역폭을 보장하고 가용 대역폭을 최대 셀 전송률까지 높여 트래픽을 전송할 수 있으며, 셀 손실을 줄이기 위해 피드백 정보를 활용하여 트래픽을 제어한다. 본 논문에서는 피드백 정보를 위한 예측제어 알고리즘을 제시한다. ATM 스위치에서 발생한 피드백 정보가 역 방향 노드에 도착하기 위해 긴 지연시간을 갖는 경우에, ATM 스위치에서 큐 길이의 증가로 인한 혼잡상황이 발생할 수 있으며 또한 큐 길이의 시간 대비 변화량이 크게 된다. 이 논문에서 제시한 예측제어 알고리즘들은 예시적인 피드백 제어방식으로 시간 대비 큐 길이함수의 기울기와 이전의 큐 변화량을 이용하여 미래의 큐 길이를 예측하려 하였으며, 시뮬레이션 결과 본 논문에서 제시한 제어 알고리즘은 효과적임이 증명되었다.

• 아동학회지
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• 제13권2호
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• pp.217-228
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• 1992

The purpose of this study is to examine the effects of early full-time nonparental care during infancy/toddlerhood on children's socioemotional behaviors during the preschool period. Subjects for this study were 105 three- to five-year-olds from middle-class families in the U. S. A. Children were assigned to one of three groups according to their early care history. Children's social interactions with peers and caregivers during indoor free-play sessions in day care centers were observed for 20 minutes. The head teachers rated the children's social and emotional behaviors on two questionnaires. Mothers completed the Attachment Q-sort for attachment assessment for the preschoolers. In addition, mothers were asked to fill out a questionnaire on their parenting practices. Children who had received full-time nonparental care during infancy and/or toddlerhood were rated by their teachers as being more intellectually competent than children who did not receive full-time nonparental care during first three years of life. They were, however, rated by teachers and were observed by the researcher as being more aggressive than children with no full-time nonparental care. These children were observed to engage in less wandering/onlooking behaviors than children who had not had any full-time nonparental care. Children's attachment security scores and dependency scores did not differ as a function of early nonparental care histories. When the effects of early care patterns, sex of child, and current attachment security to mothers on aggressive behaviors of the preschoolers were examined by a hierarchical regression model, then any "pure" effects of nonparental care and of attachment security on child aggression were minimal after controlling for family background, child care center quality, and maternal childrearing practices. Strong buffering factors for the preschool children (family characteristics, parenting styles, and high quality nonparental care) mediated a possible risk factor of early nonparental care and promoted optimal outcomes for the children.

• 한국융합학회논문지
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• 제9권7호
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• pp.25-31
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• 2018

온라인 뉴스는 기존의 신문을 대체하였고, 우리가 정보에 접근하고 공유하는 방법에 큰 변화를 가져왔다. 뉴스 웹사이트들은 사용자가 댓글을 남길 수 있는 기능을 오랜 시간동안 제공하였고, 그 중 몇몇 뉴스 웹사이트에서는 뉴스 기사들에 대한 사용자의 반응들을 크라우드소싱(crowdsource)하기 시작했다. 감정분석 분야에서는 텍스트에 반영된 감정과 반응들을 컴퓨팅적으로 모델링하기 위한 시도를 하고 있다. 본 연구에서는 뉴스 기사에 대한 반응들이 뉴스 본문과 수학적인 상관관계를 갖는지 밝히기 위해, 사용자로부터 생성된 다섯 가지의 감정 라벨(label)을 사용하여 10가지 카테고리(category)에 해당하는 100,000개 이상의 뉴스 기사들을 분석한다. 본 연구에서는 전처리과정이 최소한으로 필요하고 기계학습이 적용하지 않아도 되는 간단한 감정 분석 알고리즘(algorithm)을 제안한다. 우리는 이 모델이 한국어와 같은 형태론적으로 복잡한 언어에도 효과적이라는 것을 증명한다.

• Journal of Preventive Medicine and Public Health
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• 제43권4호
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• pp.330-340
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• 2010

Objectives: This study aims to evaluate and explain the socioeconomic inequalities of all-cause mortality after breast cancer surgery in South Korea. Methods: This population based study included all 8868 females who underwent radical mastectomy for breast cancer between January 2002 and June 2003. Follow-up for mortality continued from January 2002 to June 2006. The patients were divided into 4 socioeconomic classes according to their socioeconomic status as defined by the National Health Insurance contribution rate. The relationship between socioeconomic status and all-cause mortality after breast cancer surgery was assessed using the Cox proportional hazards model with adjusting for age, the Charlson’s index score, emergency hospitalization, the type of hospital and the hospital ownership. Results: Those in the lowest socioeconomic status group had a significantly higher hazard ratio of 2.09 (95% CI =1.50 - 2.91) compared with those in the highest socioeconomic group after controlling for all the identifiable confounding variables. For allcause mortality after radical mastectomy, all the other income groups showed significantly higher 3-year mortality rates than did the highest income group. Conclusions: The socioeconomic status of breast cancer patients should be considered as an independent prognostic factor that affects all-cause mortality after radical mastectomy, and this is possibly due to a delayed diagnosis, limited access or minimal treatment leading to higher mortality. This study may provide tangible support to intensify surveillance and treatment for breast cancer among low socioeconomic class women.

• 생태와환경
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• 제40권4호
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• pp.527-536
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• 2007

In this study, we applied 10-metric health assessment model, based on the Index of Biological Integrity (IBI) during 2006 in the Changwon Stream, which is located in the Changwon city, Gyeongnam province, S. Korea, and then compared with water quality data. The Index of Biological Integrity (IBI) in the Changwon Stream varied from 18 to 38 in the watershed depending on the sampling location and averaged 30.3 (n=6) during the study. Analysis of tolerance guilds showed that the proportion of sensitive species was 13%, but tolerant and intermediate species were 34% and 53%, respectively. Qualitative Habitat Evaluation Index (QHEI) averaged 43.3 (range: 65-104, n=6) indicating non-supporting condition, based on the criteria of U.S. EPA (1993). Values of QHEI showed a typical longitudinal decreases from the headwater reach to the downstream location, except for Site 1 with a low QHEI value by artificial habitat by concrete construction. Minimum QHEI was found in Site 4 where fish diversity was minimal. Conductivity increased continuously along the gradients and especially showed abrupt increases in the downstream sites along with turbidity. Stream ecosystem health of IBI matched to the values of QHEI except for S6. Low IBI values in the sites 4 and 5 was considered to be a result of combined effects of chemical pollutions and habitat degradations. Our results support the hypotheses of Plafkin et ai. (1989) that physical habitat quality directly influences the trophic structure and species richness, and is closely associated with IBI values.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3817-3825
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• 2015

Background: The human protein methyl-transferase DOT1L catalyzes the methylation of histone H3 on lysine 79 (H3K79) at homeobox genes and is also involved in a number of significant processes ranging from gene expression to DNA-damage response and cell cycle progression. Inhibition of DOT1L activity by shRNA or small-molecule inhibitors has been established to prevent proliferation of various MLL-rearranged leukemia cells in vitro, establishing DOT1L an attractive therapeutic target for mixed lineage leukemia (MLL). Most of the drugs currently in use for the MLL treatment are reported to have low efficacy, hence this study focused on various natural compounds which exhibit minimal toxic effects and high efficacy for the target receptor. Materials and Methods: Structures of human protein methyl-transferase DOT1L and natural compound databases were downloaded from various sources. Virtual screening, molecular docking, dynamics simulation and drug likeness studies were performed for those natural compounds to evaluate and analyze their anti-cancer activity. Results: The top five screened compounds possessing good binding affinity were identified as potential high affinity inhibitors against DOT1L's active site. The top ranking molecule amongst the screened ligands had a Glide g-score of -10.940 kcal/mol and Glide e-model score of -86.011 with 5 hydrogen bonds and 12 hydrophobic contacts. This ligand's behaviour also showed consistency during the simulation of protein-ligand complex for 20000 ps, which is indicative of its stability in the receptor pocket. Conclusions: The ligand obtained out of this screening study can be considered as a potential inhibitor for DOT1L and further can be treated as a lead for the drug designing pipeline.