• Journal of the military operations research society of Korea
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• v.28 no.1
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• pp.67-82
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• 2002

In this paper, we consider a rule of application of PRICE(Parametric Review of Information for Costing and Evaluation) model to the environment of Korean defense industry. The PRICE model which is a computer model to estimate the cost of an acquisition program, was developed for the regulation of defense acquisition program in the United States. Therefore, it is essential for us to figure out how we can adopt it under our defense acquisition regulations. We will give an alternative method to apply the PRICE model to the mapping problem between two regulations.

• Journal of the Korea Institute of Military Science and Technology
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• v.5 no.2
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• pp.116-122
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• 2002

Electro Explosive Devices can be susceptible to electromagnetic interference. When these components are exposed to external electromagnetic fields, it may cause to induce sufficient current to generate enough heat for an inadvertent detonation. It is almost impossible to monitor the event of firing throughout the electromagnetic environment test. The survivability of EED for hazards of electromagnetic radiation is investigated. A fiber optic sensor is installed near the bridge wire after removing explosive material in order to measure the induced current on the bridge wire. The length of lead-wire of the EED fabricated is around 15 cm.

• Journal of the military operations research society of Korea
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• v.27 no.2
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• pp.124-133
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• 2001

The purpose of this study is investigate the differences among parametric and nonparametric test statistics for the tree alternative hypothesis in the randomized block design. As the results, it was found that there was no large differences among parametric and nonparametric test statistics in power when the block sizes were larger, and Hollander's statistic had better power than other nonparametric test statistics. It is recommended that Hollander's test statistic is more useful method when we have no information about the distribution of population.

• Journal of Microbiology and Biotechnology
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• v.19 no.8
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• pp.803-809
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• 2009

Recent evidence has revealed the occurrence of an apoptotic phenotype in Candida albicans that is inducible with environmental stresses such as acetic acid, hydrogen peroxide, and amphotericin B. In the present study, we found that the Chinese herbal medicine Baicalein (BE), which was one of the skullcapflavones, can induce apoptosis in C. albicans. The apoptotic effects of BE were detected by flow cytometry using Annexin V-FITC and DAPI, and it was confirmed by transmission electron microscopy analysis. After exposure to 4 ${\mu}g$/ml BE for 12 h, about 10% of C. albicans cells were apoptotic. Both the increasing intracellular levels of reactive oxygen species (ROS) and upregulation of some redox-related genes (CAP1, SOD2, TRR1) were observed. Furthermore, we compared the survivals of CAP1 deleted, wild-type, and overexpressed strains and found that Cap1p attenuated BE-initiated cell death, which was coherent with a higher mRNA level of the CAP1 gene. In addition, the mitochondrial membrane potential of C. albicans cells changed significantly (p<0.001) upon BE treatment compared with control. Taken together, our results indicated that BE treatment induced apoptosis in C. albicans cells, and the apoptosis was associated with the breakdown of mitochondrial membrane potential.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3605-3609
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• 2012

Lung cancer seriously threatens human health, so it is important to investigate gene expression changes in affected individuals in comparison with healthy people. Here we compared the gene expression profiles between smokers with and without lung cancer. We found that the majority of the expressed genes (threshold was set as 0.1 RPKM) were the same in the two samples, with a small portion of the remainder being unique to smokers with and without lung cancer. Expression distribution patterns showed that most of the genes in smokers with and without lung cancer are expressed at low or moderate levels. We also found that the expression levels of the genes in smokers with lung cancer were lower than in smokers without lung cancer in general. Then we detected 27 differentially expressed genes in smokers with versus without lung cancer, and these differentially expressed genes were foudn to be involved in diverse processes. Our study provided detail expression profiles and expression changes between smokers with and without lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6681-6686
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• 2013

Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2115-2120
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• 2012

The presence of lung cancer cells in anoxic zones is a key cause od chemotherapeutic resistance. Thus, it is necessary to enhance the sensitivity of such lung cancer cells. However, loss of efficient gene therapeutic targeting and inefficient objective gene expression in the anoxic zone in lung cancer are dilemmas. In the present study, a eukaryotic expression plasmid pUC57-HRE-JAB1 driven by a hypoxia response elements promoter was constructed and introduced into lung cancer cell line A549. The cells were then exposed to a chemotherapeutic drug cis-diamminedichloroplatinum (C-DDP). qRT-PCR and western blotting were used to determine the mRNA and protein level and flow cytometry to examine the cell cycle and apoptosis of A549 transfected pUC57-HRE-JAB1. The results showed that JAB1 gene in the A549 was overexpressed after the transfection, cell proliferation being arrested in G1 phase and the apoptosis ratio significantly increased. Importantly, introduction of pUC57-HRE-JAB1 significantly increased the chemotherapeutic sensitivity of A549 in an anoxic environment. In conclusion, JAB1 overexpression might provide a novel strategy to overcome chemotherapeutic resistance in lung cancer.

• Korea Journal of Hospital Management
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• v.21 no.4
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• pp.23-44
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• 2016

We conducted this research for the purpose of examining the effects of organizational culture on service quality and customer satisfaction in the military hospital organizations in Korea. The research samples were collected from employees in 12 military hospitals belonged to the Armed Forces Command. For the analysis we used SPSS 18.0 and AMOS 20.0 program for conducting reliability tests, confirmatory factor analysis, and structural equation model analysis in order to find the relationship between the variables analyzed. The result of this study shows that the military hospitals in Korea have strong relationship-oriented culture, but weak hierarchy-oriented culture. Among the three groups of military hospitals, innovation-oriented culture and relationship-oriented culture were the strongest in the executive agency hospital group, task-oriented culture was the strongest in the group of the he frontline hospitals and hierarchy-oriented culture was the strongest in the group of the rear area hospitals. It was found that the executive agency hospitals have the strongest service quality and customer satisfaction among the hospital groups analyzed. This research also found that relationship-oriented culture and innovation-oriented culture have a direct positive(+) effect on service quality; hierarchy oriented culture has a direct negative(-) effect on service quality; task oriented culture has a direct positive(+) effect on customer satisfaction, and service quality mediated between organizational culture and customer satisfaction. The findings from this study suggests that implementing the dynamic strategies for organizational culture with focus on service qualities is needed given that customer satisfaction in the military hospitals is highly affected by service quality.

• Journal of the Korean Society of Hazard Mitigation
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• v.6 no.2 s.21
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• pp.37-44
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• 2006

Any vehicle and equipment whose total weight is more than 40ton and its axle weight is 10ton or above is banned to cross any bridge in our country under section 54 in the Highway law. This restriction results from the accumulation and application of safety factors about which there is type specification in the "standard design vehicle". And in "standard design vehicle", Vehicle load to bridge is assumed concentrating one. Based on this restriction, there is an issue that military tank which has a total weight of 51ton (63ton in case of the US tank) can not cross any bridge. However, many research and practical examples concerned manifest that it is possible for military tanks to cross these bridges. The reasons of this issue in the current Highway law's provisions are analyzed in this paper. Correspondingly, feasibility of military tanks passing these bridges are discussed here. At last, considering economical efficiency and practicability for military, several suggestions and improving measures are put forward. This research has certain reality significance to guide bridge design considering the passage of military heavy vehicles.

• Journal of Intelligence and Information Systems
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• v.14 no.1
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• pp.85-100
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• 2008

The digital economy era is a knowledge-based society. Many organizations have been establishing KMS (Knowledge Management System), and there are no exceptions in military ones. In this study, we analyze the influencing factors for KMS utilization in a military organization, which is a specialized one. For this purpose, we investigate the current status of KMS of ROKAF (Republic Of Korea Air Force), derive problems and issues, and try to find out solutions for the KMS utilization in military organizations by analyzing a survey. At first, we derive three characteristics of the military organization that affect the knowledge sharing : formalization of organization, trust of organizational culture, and top management's will. And we verified that the users, who recognize that the top management has the will for the knowledge sharing, have high recognition for the knowledge sharing and utilize KMS more than others. This study shows that it is very important for the top management to participate in the knowledge sharing voluntarily especially in the military organization.