• 제목/요약/키워드: milestone

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Lymphatic Intervention, the Frontline of Modern Lymphatic Medicine: Part II. Classification and Treatment of the Lymphatic Disorders

  • Saebeom Hur;Jinoo Kim;Lakshmi Ratnam;Maxim Itkin
    • Korean Journal of Radiology
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    • 제24권2호
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    • pp.109-132
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    • 2023
  • Lymphatic disorders encompass a broad spectrum of diseases involving the lymphatic system, ranging from traumatic lymphatic leaks to lymphatic malformations. Lymphatic disorders can be categorized into traumatic and non-traumatic disorders according to their etiology. These two categories may be further divided into subgroups depending on the anatomical location of the lymphatic pathology and their association with clinical syndromes. Thoracic duct embolization was a milestone in the field of lymphatic intervention that encouraged the application of percutaneous embolization techniques to treat leaks and reflux disorders in the lymphatic system. Additional access routes for embolization, including retrograde thoracic duct and transhepatic lymphatic access, have also been developed. This article comprehensively reviews a variety of options for the treatment of lymphatic disorders, from conservative management to the most recent embolization techniques.

Finite-Size Errect에 의한 강바성 Gd박막의 상전이온도 이동 (Phase Transition Temperature Shift of a Ferromagenetic Gadelonium Film due to the Finite-Size Effects)

  • 이일수;이의완;이상윤
    • 한국재료학회지
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    • 제3권1호
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    • pp.3-6
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    • 1993
  • Gd박막의 강자성-상자성 상전이 온도(Tc)이동을 조사했다. 강자성-상자성 상전이 온도에서 전기저항이 변화되는 변곡점을 관측하여 Tc를 결졍하였는데, 두께가 6600$\AA$인 Gd박막의 상전이 온도는 bulk상태의 Gd의 전이온도보다 4$\pm$0.$3^{\circ}C$정도 아래로 이동됨을 알았다. 이것은 강자성 Gd박막의 Tc이동에 대한 최초의 측정이며, 실험과 finite-sime scaling이론을 비교 분석했다.

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민간기관의 사고예방사업 활성화 방안 (A Study on the Role Promotion of Non-governmental Organization for Accident Prevention)

  • 백종배
    • 한국가스학회지
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    • 제15권6호
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    • pp.44-50
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    • 2011
  • 이 연구는 안전관련 민간기관을 연구범위로 하여 산재 감소와 사고예방을 위한 민간기관의 활성화 방안을 도출하기 위하여 민간기관의 운영현황과 민간기관 운영실태를 조사 정리하였다. 그 결과를 토대로 민간기관에 대한 정의, 역할과 활동, 인식을 조사하고 분석하여 산재 예방 감소를 위한 민간기관의 활성화 방안을 제시 하였다. 따라서 산재 예방과 감소를 위해 안전관련 민간기관의 역량, 전문성, 신뢰성 향상과 정부기관, 공공기관, 안전 민간기관 간의 실질적 사고 예방을 위한 역할 정립에 이정표가 될 것으로 기대되며 산재예방사업 시장의 활성화와 사고예방 정책의 수립에 활용 할 수 있을 것이다.

항만해상풍력단지 건설기술 로드맵 수립 (Construction Technology Roadmapping for Port Offshore Wind Farm)

  • 김기윤;정석재;이석준
    • 디지털융복합연구
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    • 제11권2호
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    • pp.137-148
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    • 2013
  • 본 논문의 목적은 항만해상풍력단지 건설을 위한 기술개발 로드 맵을 제시하는 것이다. FGI(Focus Group Interview)와 설문지를 이용한 AHP(Analytical Hierarchy Process) 방법을 적용해서 대/중/소 분류된 건설기술의 가중치를 도출했고, 분류된 건설기술에 대한 우선순위를 근거로 항만해상풍력단지 건설기술 로드 맵이 수립되었다. 기술 로드 맵은 항만해상풍력단지의 분류된 건설기술에 대한 R&D 사업을 달성하기 위한 20년간(2016년부터 2036년 까지)의 일정을 제시하고 있다. 이러한 건설기술 로드 맵은 녹색항만건설산업의 R&D 전략을 수립하기 위한 이정표로 활용될 수 있다.

최적 생태마을 조성을 위한 자연지형과 환경요인 적용기법 연구 (Application Methods of the Natural Topography and Environmental Facts for Building Optimum Eco-Village)

  • 연상호
    • 한국지리정보학회지
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    • 제18권4호
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    • pp.59-67
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    • 2015
  • 좁은 국토에서 최적의 생태마을 조성을 위한 여러 가지 방법이 시도되고 있다. 지형인자와 유비쿼터스 센서 네트워크에 의한 환경인자를 결합하여 새로운 최적의 생태마을 인자를 도출하고자 인간의 구체적인 정착 생태공간을 조사하고, 이것에 대한 자연적인 실제 정착 공간 분석과 비교하여 최적의 생태마을조성방안을 도출하고자 하였다. 보다 건강하고 행복한 자연공간을 활용할 수 있는 웰빙 공간구성과 더불어 생태적인 요인과 결합되어져서 자연치유가 가능한 삶의 공간을 찾아낼 수 있다는 점에서 하나의 가능한 새로운 방법으로 실측함으로써, 전 국토의 크고 작은 마을 단위의 생태마을 조성에서 하나의 새로운 이정표를 제시하였다.

Immature thymocyte antigen, JL1, as a possible immunodiagnostic and immunotherapeutic target for leukemia

  • Shin, Young Kee;Choi, Eun Young;Kim, Seok Hyung;Park, Seong Hoe
    • IMMUNE NETWORK
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    • 제1권1호
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    • pp.1-6
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    • 2001
  • The identification of tumor-specific antigens has represented a critical milestone in cancer diagnosis and therapy. Clinical research in this area for leukemia has also been driven over the past few decades by the hope that surface antigens with restricted tissue expression would be identified. Disappointingly, only a small number of the leukemic antigens identified to date, meet sufficient criteria to be considered viable immunophenotypic markers. In this paper, we nominate anti-JL1 monoclonal antibody as an immunodiagnostic and immunotherapeutic candidate for leukemia. The JL1 molecule appears to be a novel cell surface antigen, which is strictly confined to a subpopulation of limited stages during the hematopoietic differentiation process. Despite the restricted distribution of the JL1 antigen in normal tissues and cells, anti-JL1 monoclonal antibody specifically recognizes various types of leukemia, irrespective of immunophenotypes. On the basis of these findings, we propose JL1 antigen as a tumor-specific marker, which shows promise as a candidate molecule for diagnosis and immunotherapy in leukemia, and one that spares normal bone marrow stem cells.

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CRISPR/CAS9 as a Powerful Tool for Crop Improvement

  • Song, Jae-Young;Nino, Marjohn;Nogoy, Franz Marielle;Jung, Yu-Jin;Kang, Kwon-Kyoo;Cho, Yong-Gu
    • Journal of Plant Biotechnology
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    • 제44권2호
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    • pp.107-114
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    • 2017
  • Implementation of crop improvement programs relies on genetic diversity. To overcome the limited occurrence of natural mutations, researchers and breeders applied diverse methods, ranging from conventional crossing to classical bio-technologies. Earlier generations of knockout and gain-of-function technologies often result in incomplete gene disruption or random insertions of transgenes into plant genomes. The newly developed editing tool, CRISPR/Cas9 system, not only provides a powerful platform to efficiently modify target traits, but also broadens the scope and prospects of genome editing. Customized Cas9/guide RNA (gRNA) systems suitable for efficient genomic modification of mammalian cells or plants have been reported. Following successful demonstration of this technology in mammalian cells, CRISPR/Cas9 was successfully adapted in plants, and accumulating evidence of its feasibility has been reported in model plants and major crops. Recently, a modified version of CRISPR/Cas9 with added novel functions has been developed that enables programmable direct irreversible conversion of a target DNA base. In this review, we summarized the milestone applications of CRISPR/Cas9 in plants with a focus on major crops. We also present the implications of an improved version of this technology in the current plant breeding programs.

A Novel Face Recognition Algorithm based on the Deep Convolution Neural Network and Key Points Detection Jointed Local Binary Pattern Methodology

  • Huang, Wen-zhun;Zhang, Shan-wen
    • Journal of Electrical Engineering and Technology
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    • 제12권1호
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    • pp.363-372
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    • 2017
  • This paper presents a novel face recognition algorithm based on the deep convolution neural network and key point detection jointed local binary pattern methodology to enhance the accuracy of face recognition. We firstly propose the modified face key feature point location detection method to enhance the traditional localization algorithm to better pre-process the original face images. We put forward the grey information and the color information with combination of a composite model of local information. Then, we optimize the multi-layer network structure deep learning algorithm using the Fisher criterion as reference to adjust the network structure more accurately. Furthermore, we modify the local binary pattern texture description operator and combine it with the neural network to overcome drawbacks that deep neural network could not learn to face image and the local characteristics. Simulation results demonstrate that the proposed algorithm obtains stronger robustness and feasibility compared with the other state-of-the-art algorithms. The proposed algorithm also provides the novel paradigm for the application of deep learning in the field of face recognition which sets the milestone for further research.

건물 에너지 절감조치의 시뮬레이션 모델링 상세수준 (Level of Detail (LOD) for Building Energy Conservation Measures (ECMs))

  • 김선혜
    • KIEAE Journal
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    • 제15권6호
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    • pp.69-80
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    • 2015
  • Purpose: Since most simulation programs take the interface that lists up all the input variables representing all the functionalities, users must know where design variables of an Energy Conservation Measure (ECM) are located and also know what values are appropriate. This is why practitioner designers feel frustrated when they attempt to use simulation. The final objective of this study is to provide a building energy modeling guideline for practitioners in various fields such as architectural design and MEP. Method: As the first step of the modeling guideline, this study provides the Level of Detail (LOD) for simulation modeling of primary ECMs considering the design information available in each design phase. It is prepared by literature review, simulation functionality investigation, and field experts' survey. Result: The proposed simulation LOD offers a milestone at each design phases concerning what design variable and attributes need to be developed with how much of details in order to meet the project goal. Also each design team can set up a simulation usecase considering organizational characteristics based on the proposed LOD.

라이프스타일 샵의 가격대 차별화를 통한 VMD 공간구성 (VMD Spatial Composition through Cost Differentiation among Lifestyle Shops)

  • 박지예;한혜련
    • 한국실내디자인학회논문집
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    • 제27권1호
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    • pp.88-96
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    • 2018
  • The income level of people in South Korea has risen as the gross national income per capita reached the milestone of 30,000 dollars. More and more consumers try to change their houses according to their tastes just like they express themselves through clothes, bags, and other fashion items, thus pursuing value-based consumption. The changes to the housing culture including the greater percentage of one- or two-person households and the growing trend of lease and monthly rent have made consumers increase their demands for products to express their lifestyles. As a result, global lifestyle shops with characteristic and diverse concepts entered the South Korean market and were joined by South Korean fashion brands, large-sized stores, department stores, and fancy stationery manufacturers, which launched their own brands, in the expansion of lifestyle shops across the nation. Lifestyle shops have a couple of unique attributes including the relatively clear selection of target consumers and a clear set of VMD strategies accordingly. Based on a judgment that there was cost differentiation among brands, the investigator categorized the comparison and analysis criteria into high, middle, and low prices to apply case analysis. This study set out to analyze VMD strategies for spatial composition through cost differentiation among lifestyle shops, take the results into total consideration, and propose an effective and competitive VMD strategy for lifestyle shops through spatial composition elements.