• Genomics & Informatics
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• v.21 no.2
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• pp.27.1-27.7
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• 2023

Recombination events complicate the evolutionary history of populations and species and have a significant impact on the inference of isolation-with-migration (IM) models. However, several existing methods have been developed, assuming no recombination within a locus and free recombination between loci. In this study, we investigated the effect of recombination on the estimation of IM models using genomic data. We conducted a simulation study to evaluate the consistency of the parameter estimators with up to 1,000 loci and analyze true gene trees to examine the sources of errors in estimating the IM model parameters. The results showed that the presence of recombination led to biased estimates of the IM model parameters, with population sizes being more overestimated and migration rates being more underestimated as the number of loci increased. The magnitude of the biases tended to increase with the recombination rates when using 100 or more loci. On the other hand, the estimation of splitting times remained consistent as the number of loci increased. In the absence of recombination, the estimators of the IM model parameters remained consistent.

• Korean Journal of Soil Science and Fertilizer
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• v.30 no.4
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• pp.314-327
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• 1997

A 2-dimensional soil water flow model was developed to describe the migration of soil moisture in drip-irrigated root zone employing cylindrical coordinate system. Several natural phenomena were incorporated into the model such as transpiration, various types of evaporation, and ponding due to the increase in irrigation rate. Model was solved numerically by finite difference method. The model was verified in several ways leading to the conclusion that it can describe the soil moisture migration in drip-irrigated root zone fairly well. From sensitivity analysis, vertical migration of soil moisture was found to move faster than the horizontal one, which indicates the vertical location just under the dripping point are adequate for measuring points of soil moisture. The pot shape of soil moisture in irrigated zone was proved to be caused by evaporation at the soil surface. Also, it was found that the hydraulic conductivity has greatly influential to the soil moisture migration, and that the soil moisture continues to migrate vertically after irrigation stops.

• Genomics & Informatics
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• v.17 no.4
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• pp.37.1-37.8
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• 2019

Isolation-with-migration (IM) models have become popular for explaining population divergence in the presence of migrations. Bayesian methods are commonly used to estimate IM models, but they are limited to small data analysis or simple model inference. Recently three methods, IMa3, MIST, and AIM, resolved these limitations. Here, we describe the major problems addressed by these three software and compare differences among their inference methods, despite their use of the same standard likelihood function.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.9
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• pp.4165-4187
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• 2016

As an emerging technology, cloud computing is a revolution in information technology that attracts significant attention from both public and private sectors. In this paper, we proposed a dynamic approach for live migration to obviate overloaded machines. This approach is applied on OpenStack, which rapidly grows in an open source cloud computing platform. We conducted a cost-aware dynamic live migration for virtual machines (VMs) at an appropriate time to obviate the violation of service level agreement (SLA) before it happens. We conducted a preemptive migration to offload physical machine (PM) before the overload situation depending on the predictive method. We have carried out a distributed model, a predictive method, and a dynamic threshold policy, which are efficient for the scalable environment as cloud computing. Experimental results have indicated that our model succeeded in avoiding the overload at a suitable time. The simulation results from our solution remarked the very efficient reduction of VM migrations and SLA violation, which could help cloud providers to deliver a good quality of service (QoS).

• Korea journal of population studies
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• v.14 no.1
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• pp.26-34
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• 1991

Migration studies that assume that decision making is done on an individual basis is overlooking the importance of the family factor. Considering that must people belong to families, it is more appropriate to view migration decision from the perspective of the family. This study analyzes the household migration decision whereby the alternatives are to stay, 10 undertake family migration or to undertake single migration of a member. In developing a conceptual model of household migration decision, it is assumed that the household's objective is to maximize household income which is a function of individual members' earnings. The benefits and costs of household migration and individual migration are identified and the household chooses the migration strategy that maximizes expected household income. When household members have conflicting earning prospects in the potential destination, the household considers single migration of the member with the best earning potentials. However, lone migration by a household member involves cost of family separation which is both monetary and psychic, and this study shows that lone migration is undertaken only when its net gains to the family are greater than the separation cost of the family. The major benefit of choosing single migration is the retention of home base in the place of origin which can serve as an insurance against the uncertainty of obtaining a job in the destination, the benefit that is unavailable in family migration. The conceptual analysis shows how a household's migration decision would depend on its members' economic roles and prospects in the destination. Besides the economic variables, social and life cycle variables of the family translate into separation costs and benefits of migration. This study indicates that one - earner family in low economic status but with good earning prospects and high separation costs is more likely to choose family migration over single migration.

• Geophysics and Geophysical Exploration
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• v.19 no.2
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• pp.76-83
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• 2016

Migration image can be distorted due to reflected waves in the source and receiver wavefields when discontinuities of input velocity model exist in seismic imaging. To remove reflected waves coming from layer interfaces, it is a common practice to smooth the velocity model for migration. If the velocity model is smoothed, however, the subsurface image can be distorted because the velocity changes around interfaces. In this paper, we attempt to minimize the distortion by reducing reflection energy in the source and receiver wavefields through acoustic impedance homogenization. To make acoustic impedance constant, we define fake density model and use it for migration. When the acoustic impedance is constant over all layers, the reflection coefficient at normal incidence becomes zero and the minimized reflection energy results in the improvement of migration result. To verify our algorithm, we implement the reverse-time migration using cell-based finite-difference method. Through numerical examples, we can note that the migration image is improved at the layer interfaces with high velocity contrast, and it shows the marked improvement particularly in the shallow part.

• Geophysics and Geophysical Exploration
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• v.13 no.4
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• pp.315-322
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• 2010

The phase-screen and the split-step Fourier migrations, which are implemented in both the frequency-wavenumber and frequency-space domains by using one-way scalar wave equation, allow imaging in laterally heterogeneous media with less computing time and efficiency. The generalized-screen migration employs the series expansion of the exponential, unlike the phase-screen and the split-step Fourier migrations which assume the vertical propagation in frequency-wavenumber domain. In addition, since the generalized-screen migration generalizes the series expansion of the vertical slowness, it can utilize higher-order terms of that series expansion. As a result, the generalized-screen migration has higher accuracy in computing the propagation with wide angles than the phase-screen and split-step Fourier migrations for media with large and rapid lateral velocity variations. In this study, we developed a 2D prestack generalized-screen migration module for imaging a complex subsurface efficiently, which includes various dips and large lateral variations. We compared the generalized-screen propagator with the phase-screen propagator for a constant perturbation model and the SEG/EAGE salt dome model. The generalized-screen propagator was more accurate than the phase-screen propagator in computing the propagation with wide angles. Furthermore, the more the higher-order terms were added for the generalized-screen propagator, the more the accuracy was increased. Finally, we compared the results of the generalizedscreen migration with those of the phase-screen migration for a model which included various dips and large lateral velocity variations and the synthetic data of the SEG/EAGE salt dome model. In the generalized-screen migration section, reflectors were positioned more accurately than in the phase-screen migration section.

• Journal of the Korea Society of Computer and Information
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• v.16 no.11
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• pp.123-135
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• 2011

The domestic market of database in Korea is estimated to be over 3.663 trillion won. The data migration is getting to be more important along with the continuous growth of the database industry. g-CRM and private recommending function are examples of the service that can be given through coupling among customer database, product database, geographic information database, and others. The core infrastructure is also the database which is integrated, perfect, and reliable. There are not enough researches on efficient way of data migration and integrating process and investigation of migrated data though trends of database in IT environment as above. In connection with this issue, we have made a model for data migration on scientific and technological contents and suggest the result of data migration process adapting that model. In addition, we verified migration's exhaustiveness, migration's consistency, and migration's coherence for investigation of migrated data and database. From the result, we conclude data migration based on proper model has a significant influence on the database consistency and the data values correctness and is essential to maintain high qualified database.

• Journal of the Korean Physical Society
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• v.73 no.9
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• pp.1219-1224
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• 2018

We investigate the evolutionary dynamics and the phase transitions of the island model which consists of subdivided populations of individuals confined to two islands. In the island model, the population is subdivided so that migration acts to determine the evolutionary dynamics along with selection and genetic drift. The individuals are assumed to be haploid and to be one of two species, X or Y. They reproduce according to their fitness values, die at random, and migrate between the islands. The evolutionary dynamics of an individual based model is formulated in terms of a master equation and is approximated by using the diffusion method as the multidimensional Fokker-Planck equation (FPE) and the coupled non-linear stochastic differential equations (SDEs) with multiplicative noise. We analyze the infinite population limit to find the phase transitions from the monomorphic state of one type to the polymorphic state to the monomorphic state of the other type as we vary the ratio of the fitness values in two islands and complete the phase diagram of our island model.

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.721-733
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• 2018

BACKGROUND: Because three-dimensional (3D) models more closely mimic native tissues, one of the goals of 3D in vitro tissue models is to aid in the development and toxicity screening of new drug therapies. In this study, a 3D skin wound healing model comprising of a collagen type I construct with fibrin-filled defects was developed. METHODS: Optical imaging was used to measure keratinocyte migration in the presence of fibroblasts over 7 days onto the fibrin-filled defects. Additionally, cell viability and growth of fibroblasts and keratinocytes was measured using the $alamarBlue^{(R)}$ assay and changes in the mechanical stiffness of the 3D construct was monitored using compressive indentation testing. RESULTS: Keratinocyte migration rate was significantly increased in the presence of fibroblasts with the cells reaching the center of the defect as early as day 3 in the co-culture constructs compared to day 7 for the control keratinocyte monoculture constructs. Additionally, constructs with the greatest rate of keratinocyte migration had reduced cell growth. When fibroblasts were cultured alone in the wound healing construct, there was a 1.3 to 3.4-fold increase in cell growth and a 1.2 to 1.4-fold increase in cell growth for keratinocyte monocultures. However, co-culture constructs exhibited no significant growth over 7 days. Finally, mechanical testing showed that fibroblasts and keratinocytes had varying effects on matrix stiffness with fibroblasts degrading the constructs while keratinocytes increased the construct's stiffness. CONCLUSION: This 3D in vitro wound healing model is a step towards developing a mimetic construct that recapitulates the complex microenvironment of healing wounds and could aid in the early studies of novel therapeutics that promote migration and proliferation of epithelial cells.