• Journal of Korean Society of Transportation
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• v.27 no.1
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• pp.27-34
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• 2009

The operational effect of traffic signal control improvement was evaluated using the Two-Fluid Model. The parameters engaged in the Two-Fluid Model becomes food indicators to measure the quality of traffic flow due to the improvement of traffic signal operation. A series of experiment were conduced for the 31 signalized intersections in Uijeongbu City. To estimate the parameters in the Two-Fluid Model the trajectory informations of individual vehicles were collected using the CORSIM and Run Time Extension. The test results showed 35 percent decrease of average minimum trip time per unit distance. One of the parameters in the Two-Fluid Model is a measure of the resistance of the network to the degraded operation with the increased demand. The test result showed 28 percent decrease of this parameter. In spite of the simulation results of the arterial flow, it was concluded that the Two-Fluid Model is useful tool to evaluate the improvement of the traffic signal control system from the macroscopic aspect.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.31 no.1
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• pp.13-23
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• 2005

This study was performed to investigate mistletoe extract-induced apoptosis in oral squamous cell carcinoma. In vivo study, HN22 cells were xenografted in nude mice. After tumor was experimentally induced, mistletoe extract was directly injected on the tumor mass. The specimens were evaluated using light and transmission electron microscopes. In vitro study, HN22 cells were cultured and exposed to mistletoe extract. The cells were evaluated using transmissin electron microscope. To evaluate apoptotic cells, flow cytometric analysis was done. The results were obtained as follows: 1. Light microscopic view of tumor mass showed necrosis at 2-4 weeks. 2. Transmission electron micrographs of tumor mass showed apoptosis and necrosis. 3. In TEM view of cell lines, necrosis and apoptosis were shown with mistletoe extract at $300{\mu}g/ml$, apoptosis was shown with mistletoe extract at $100{\mu}g/ml$. 4. In flow cytometric analysis, early and late apoptosis was shown when using caspase-3Ab and annexin-V, but no significant change was noted when using mebstain and Apo2.7 Ab. In this study, mistletoe extract induced necrosis and apoptosis in the tumor mass was induced by HN22 cells, early and late apoptosis in vitro study. Mistletoe extract was likely to induce cell death in oral squamous cell carcinoma through apoptosis.

• International Journal of Highway Engineering
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• v.18 no.1
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• pp.119-129
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• 2016

PURPOSES : The purpose of this study is to develop a methodology for estimating additional carbon emissions due to freeway incidents. METHODS : As our country grows, our highway policy has mainly neglected the environmental and social sectors. However, with the formation of a national green growth keynote and an increase in the number of people interested in environmental and social issues, problems related to social issues, such as traffic accidents and congestion, and environmental issues, such as the impact of air pollution caused by exhaust gases that are emitted from highway vehicles, are beginning to be discussed. Accordingly, studies have been conducted on a variety of environmental aspects in the field of road transport, and for the quantitative calculation of greenhouse gas emissions, using various methods. However, in order to observe the effects of carbon emissions, microscopic simulations must use many difficult variables such as cost, analysis time, and ease of analysis process. In this study, additional greenhouse gas emissions that occur because of highway traffic accidents were classified by type (incident handling time, number of lanes blocked, freeway level of service), and the annual additional emissions based on incidents were calculated. According to the results, congestion length and emissions tend to increase with an increase in incident clearance time, number of occupied lanes, and worsening level of service. Using this data, we analyzed accident data on the Gyeong-bu Expressway (Yang-Jae IC - Osan IC) for a year. RESULTS : Additional greenhouse gas emissions that occur because of highway traffic accidents were classified by type (incident handling time, number of lanes blocked, freeway level of service) and annual additional emissions caused by accidents were calculated. CONCLUSIONS : In this study, a methodology for estimating carbon emissions due to freeway incidents was developed that incorporates macroscopic flow models. The results of the study are organized in the form of a look-Up table that calculates carbon emissions rather easily.

• Journal of Microbiology and Biotechnology
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• v.31 no.2
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• pp.217-225
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• 2021

This study aimed to investigate the neuroprotective effects of 1-methoxylespeflorin G11 (MLG), a pterocarpan, against glutamate-induced neurotoxicity in neuronal HT22 hippocampal cells. The protective effects of MLG were evaluated using MTT assay and microscopic analysis. The extent of apoptosis was studied using flow cytometric analysis performed on the damaged cells probed with annexin V/propidium iodide. Moreover, mitochondrial reactive oxygen species (ROS) were assessed using flow cytometry through MitoSOXTM Red staining. To determine mitochondrial membrane potential, staining with tetramethylrhodamine and JC-1 was performed followed by flow cytometry. The results demonstrated that MLG attenuates glutamate-induced apoptosis in HT22 cells by inhibiting intracellular ROS generation and mitochondrial dysfunction. Additionally, MLG prevented glutamate-induced apoptotic pathway in HT22 cells through upregulation of Bcl-2 and downregulation of cleaved PARP-1, AIF, and phosphorylated MAPK cascades. In addition, MLG treatment induced HO-1 expression in HT22 cells. These results suggested that MLG exhibits neuroprotective effects against glutamate-induced neurotoxicity in neuronal HT22 cells by inhibiting oxidative stress and apoptosis.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.5
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• pp.14-28
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• 2018

Thanks to technical improvement on the vehicle to vehicle communication and the intelligent transportation system, gradual introduction of the autonomous vehicles is expected soon in the market. The study analyzes the autonomous vehicles' impacts on the network efficiencies. In order to measure the network efficiencies, the study applies the sequential procedures that combines the microscopic and macroscopic simulations. The microscopic simulation attends to the capacity changes due to the autonomous vehicles' proportions on the roadway while the macroscopic simulation utilizes the simulation results in order to identify the network-wide improvement. As expected, the autonomous vehicles efficiently utilizes the existing capacity of the roadway than the human driving does. Particularly, the maximum capacity improvements are expected by the 190.5% on the expressway. The significant capacity change is observed when the autonomous vehicles' proportions are about 80% or more. These improvements are translated into the macroscopic model, which also yields overall network efficiency improvement by the autonomous vehicles' penetration. However, the study identifies that the market debut of the autonomous vehicles does not promise the free flow condition, which implies the possible needs of the system optimal routing scheme for the era of the autonomous vehicles.

• Journal of Korean Society of Transportation
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• v.25 no.2 s.95
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• pp.73-81
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• 2007

The purpose of this paper is to perform a basic study on the interaction between lanes, which can be achieved through analyzing traffic breakdown at the microscopic level. Using aerial photographic data for the microscopic analysis, this study analyzed the characteristics of traffic flow at a merging area. This research produced aggregated traffic data such as flows, speeds, and densities in 30 second intervals by lane for the macroscopic analysis and individual headway data by lane for the microscopic analysis. The paper contains an analysis of lane characteristics through flows, speeds, densities, and headway variations and also investigates the influence of ramp flows on mainline flows with space-time diagrams. Firstly, the merging area in this study is divided into three sections: before-merging, during-merging, and after-merging. The transition process was analyzed at each lane. Secondly, the breakdown was observed in detail with data divided in 50-foot units. The breakdown was checked through the relationships between ramp and freeway mainline flows, various techniques were proposed to analyze the breakdown, and the formation of breakdown was introduced as three stages in this study. In the near future, the findings of this study could contribute to determining the dynamic capacity on freeways by easily understanding changeable traffic breakdown patterns over time and space.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.10 no.4
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• pp.107-115
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• 2011

Since 2009 The Korean National Police Agency has been pushed "permissive left-turn" forward in order to making progress in Korean traffic operations system. Preceding researches manuals and guidelines present 6 standards(# of accidents # of lanes, pedestrian volume sight # of permissive left-turn lanes vehicle volume) as installation permissive left-turn. But in practical affairs it is most important that secure enough Gap-time between permissive left-turn vehicle and opposite through lane vehicle to make permissive left-turn vehicle move safer and more efficiently. This study suggests applying gap acceptance theory in microscopic model to permissive left-turn installation standards. Analysis methods of this study are field data survey statistical analysis and microscopic simulation analysis. This study collected field data by using AVI recording and measured permissive left-turn vehicle intersection passing time(T1) and against the opposite through lane vehicle Gap-time(T2). And statistical analysis performed about two values that measured before to predict the functionality between T1 and T2. These studies to overcome the limit of sample size carried out a microscopic simulation(VISSIM) plan and collect more samples to input statistical analysis.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.10 no.4
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• pp.11-23
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• 2011

The objective of this paper is to develop a daily pattern clustering algorithm using historical traffic data that can reliably detect under various traffic flow conditions in urban streets. The developed algorithm in this paper is categorized into two major parts, that is to say a macroscopic and a microscopic points of view. First of all, a macroscopic analysis process deduces a daily peak/non-peak hour and emphasis analysis time zones based on the speed time-series. A microscopic analysis process clusters a daily pattern compared with a similarity between individuals or between individual and group. The name of the developed algorithm in microscopic analysis process is called "Two-step speed clustering (TSC) algorithm". TSC algorithm improves the accuracy of a daily pattern clustering based on the time-series speed variation data. The experiments of the algorithm have been conducted with point detector data, installed at a Ansan city, and verified through comparison with a clustering techniques using SPSS. Our efforts in this study are expected to contribute to developing pattern-based information processing, operations management of daily recurrent congestion, improvement of daily signal optimization based on TOD plans.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.38 no.2
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• pp.269-281
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• 2018

Unlike its archetype predecessor such as the Highway Capacity Manual of the United States, the Korean Highway Capacity Manual of 2013 provides the analytical models for estimating the saturation flow rates for the lane-occupying work-zones in the proximity of the signalized intersections. Direct application of the revised saturation flow rates into the classic control delay models, however, appears to produce unreasonable delay amount as traffic demand approaches lane-group capacities and surpasses them, which is common phenomena in the work-zones. Complex interaction among vehicles, lane-dropping work-zone geometry and signal operations were never accounted in the traditional control delay models, and considerable differences between the delay model outcomes and field observations are repeatedly experienced. This paper proposes the modified approaches to the delay models in the manual, exerted on all three elements of control delay, and particularly focuses on the temporal and spatial boundary expansion in comparing the simulated results to the estimated ones. Extensive microscopic simulation work and calibration effort supports the modified approaches well enough to use them in the work-zone planning and evaluation.

• Journal of Chest Surgery
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• v.13 no.4
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• pp.321-337
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• 1980

The increasing use of cardioplegic solution for the reduction of ischemic tissue injury requires that all cardiplegic solution be carefully assessed for any protective or damaging properties. This study describes functional, enzymatic and structural assessment of the efficiency of three cardioplegic solutions (Young & GIK, Bretschneider, and $K^{+}$ Albumin solution) in a Modified Isolated Rat Heart Model of cardiopulmonary bypass and ischemic arrest. Isolated rat heart were subjected to a 2-minute period of coronary infusion with a cold cardioplegic or a noncardioplegic solution immediately before and also at the midpoint of a 60-minute period of hypothermic ($10{\pm}1$. C) ischemic cardiac arrest. The results of this study were as follow: 1. Spontaneous heart beat after ischemic arrest occured 16 seconds later after Langendorff reperfusion in the Young & GIK group (n=6), and 40 second later in the Bretschneider group (n=6) and 6 minute later in the $K^{+}$ Albumin group (n=6), and 16 minute later in the control group (non-cardioplegia). A good recovery state of spontaneous heart beat was shown in the Young & GIK and Bretschneider groups. 2. The percentage of recorveries of heart function at 30 minute after postischemic working heart perfusion were : heart rate $91.6{\pm}3.1$% (P<0.01)m oeaj airtuc oressyre $83{\pm}3$% (P<0.01), coronary flow $70{\pm}8$% (P<0.05) and aortic flow flow rate $39{\pm}9.3$% (P<0.05) in the Young & GIK group. This percentage of recoveries of the Young & GIK group was significantly greater than the control group. In the Bretschneider group, the percentage of recoveries were : heart rate $87.8{\pm}7.5$%(P<0.05), peak aortic pressure $71{\pm}2.3$% (P<0.05) and aortic flow rate $33.2{\pm}6.6$%(P<0.05). hte percentage of recoveries were significantly greater than in the control group. In the $K^{+}$ Albumin group, recoveries of heart function were poor. 3. Total CPK leakage was $131.2{\pm}12.75$IU/30 min/gm. dry weight in the control group, $50.65{\pm}12.75$IU in the Young & GIK gruop, $69.40{\pm}32.21$Iu in Bretschneider group, and $103.65{\pm}15.47$IU in the $K^{+}$ Albumin group during the 30 minute postischemic Langendorff reperfusion. Total CPK leakage was significantly less (P<0.001) in the Young & GIK group, than in the control group. 4. Direct correlatin between percentage recovery of aortic flow rate and total amount of CPK leakage from Myocardium was noticed.(Correlation Coefficient r = 0.76, P<0.001). 5. Mild perivascular edema was the only finding of light microscopic study of myocardium after 60 minute ischemic arrest with cold cardioplegic solutions and hypothermla.