• 한국신뢰성학회지:신뢰성응용연구
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• 제17권1호
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• pp.72-77
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• 2017

Purpose: The electrochemical corrosion behavior of tin oxide film coated on PET substrates has been studied under varying concentrations of acrylic acid to investigate possible corrosion in contact with the acidic environment. Method: Potentiodynamic test was performed for a commercial ITO/PET film in 0.1, 0.3, and 0.5 M of acrylic acid. The surface morphology was analyzed by scanning electron microscope (SEM) and energy dispersive spectroscopy (EDS). Results: Potentiodynamic test results showed an increase in Icorr and decrease in Ecorr value with increasing concentration of acid. Microscopic evaluation suggested the presence of certain deep cracks on the surface of the film in addition with a severe acidic attack. Conclusion: Exposure of ITO to acrylic acid resulted in the stress corrosion cracking of ITO film due to the mechanical mismatch between brittle inorganic ITO fim and a compliant organic PET substrate leading to the subsequent failure of the film.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2006년도 Spring Conference
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• pp.123-135
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• 2006

Alzheimer's disease (AD) is the most common form of dementia in the aging population and is clinically characterized by a progressive loss of cognitive abilities. Pathologically, it is defined by the appearance of senile plaques - extracellular insoluble, congophilic protein aggregates composed of amyloid $\beta$ (A$\beta$) and neurofibrillary tangles (NFTs) - inyracellular lesions consisting of paired helical filaments from hyperphosphorylated cytoskeletal tau protein as described by Alois Alzheimer a century ago. These hallmarks still serve as the major criteria for a definite diagnosis of the disease. Consequently, one of the key strategy for drug development in this disease area focuses on reducing the concentration of cerebral A$\beta$ plaque by using substances that inhibit A$\beta$ fibril formation. We focused on developing inhibitors by synthesizing several kinds of aromatic molecules. The synthetic compounds were initially screened to evaluate the effective compound by tioflavin T fluorescence assay. The selected effective compounds were tested cytotoxicity and protective effect from A$\beta$-induced neuronal toxicity by cell based MTT assay with HT22 hippocampal neurons. The BBB permeability on effectors was also tested in in vitro co-culture model(HUVEC/C6 cell line). The behavior test wea carried out in mutant APP/PS1 transgenic mouse model of Alzheimer's disease. And inhibition of A$\beta$ fibril formation by the effective compound was monitored with transmitted electron microscopic images.

• 한국결정성장학회지
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• 제19권5호
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• pp.242-245
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• 2009

종자결정을 사용하지 않고 AlN 결정을 승화법으로 성장하였으며, 결정이 성장되는 양상을 고찰하였다. AlN 결정으로 성장된 상은 다결정 상이었으며, 약 $60\sim160\;{\mu}m$의 크기를 가졌으며, $0.2\sim0.5\;{\mu}m/hr$의 성장 속도로 성장되었다. 성장된 결정구조는 AlN 결정의 결정 구조가 반영된 육방정계의 결정상으로 성장되었음을 관찰하였으며, 주상 구조(columnar structure)로 성장된 후 횡적 성장(lateral growth)하는 양상을 보이면서 대형화됨을 알 수 있었다. 성장된 결정의 표면에서는 다량의 pinhole이 관찰되었으며, 광학현미경과 SEM을 이용하여 성장 morphology의 변화과정을 고찰하였다.

• KSBB Journal
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• 제8권2호
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• pp.143-149
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• 1993

Activated carbons were used to examine their performance for the separation of undesirable colored materials from culture broth containing hyaluronic acid. Six local samples and a NORIT ROX 08 were tested, whereas the latter was mainly studied under batch and continuous modes. The optimal wavelength for the detection of colored materials was 330nm. The optimal choice of NORIT ROX 08 provided 30% colored residuals with 96% hyaluronic acid recovery of original broth in batch experiments. The nonlinear adsorption behavior of protein and colored materials with activated carbon (C) was correlated by a Langmuir equation to give 18C/24+C and 500C/892+C for protein and colored materials, respectively. It appears that colored materials were composed of 78% protein and 22% glucose residuals on the basis of clearance results. A microscopic study using a scanning electron microscope suggests that regeneration of used activated carbon with 0.1N NaOH and hot water was not satisfactory. The present study proposes that the continuous monitoring of colored materials during purification can be accomplished by Installation of a UV monitor commonly used for continuous detection of protein during the process, as resulted from the significant correlation of color (A330)=0.353protein(mg/ml)+0.1(R=99.7%).

• 대한기계학회논문집A
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• 제32권6호
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• pp.533-539
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• 2008

An high frequency induction hardening technology of vehicle body press-formed of thin sheet steel has been developed to increase the strength of vehicle body parts locally by high frequency induction heating, thereby eliminating the need for reinforcements. And this technique for increasing the tensile strength of sheet steel was practically applied to the front floor cross member and center pillar reinforcement of a passenger car. The side impact behavior has been investigated when induction hardening technology is applied to the conventional low-carbon steel and weight reduction of an automotive body is expected. In this paper, basic experiments were performed for the hat-shaped specimen under high frequency induction heating process. Martensitic transformation was found in the heating zone through microscopic observation which showed higher hardness. In addition, the hardness and strength of the center-pillar specimen made of boron steel increased remarkably by high frequency induction heating.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.72-77
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• 2001

Tensile residual stress happen by difference of coefficients of thermal expansion between fiber and matrix is one of the serious problems in metal matrix composite(MMC). In this study, TiNi fiber was used to solve the tensile residual stress as the reinforced material. TiNi fiber improves the tensile strength of composite by occurring compressive residual stress in matrix using shape memory effect of it. Pre-strain was added to generate compressive residual stress inside TiNi/A16061 composite. It was also evaluated the effect of compressive residual stress corresponding to pre-strains variation. AE technique was used to clarify the microscopic damage behavior at high temperature and the effect of pre-strain difference of TiNi/A16061 shape memory alloy composite.

• 한국분무공학회지
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• 제11권3호
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• pp.140-146
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• 2006

The objective of this work is to analyze the atomization and evaporation characteristics of dimethyl ether(DME) fuel for the application of HCCI diesel engine. In order to investigate the spray behavior of DME fuel, the macroscopic and microscopic characteristics were investigated in terms of spray development, spray tip penetration, impingement time, SMD, and axial mean velocity under the various injection timing and ambient conditions. For the illumination of spray, the spray visualization system was composed of a Nd:YAG laser and an ICCD camera and laser-sheet method was used. The atomization characteristics of DME fuel are analyzed by using phase Doppler particle analyzer (PDPA) system It was reveal that the spray development of DME is slower and rapidly disappeared as elapsed time after start of injection at the same injection duration. The impingement timing of diesel fuel was fester than that of DME fuel. The comparison of spray atomization characteristics in both fuels shows that diesel fuel has a large SMD value that DME.

• 한국표면공학회지
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• 제51권2호
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• pp.104-109
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• 2018

Fe-2 wt.%Ni alloys were fabricated by metal powder injection molding, and their oxidation behavior at $600-700^{\circ}C$ for 30 h in air was studied in order to find the effect of the small addition of Ni in the iron matrix on the high-temperature oxidation. Oxide scales that formed after oxidation consisted primarily of $Fe_2O_3$, where microscopic voids were scattered. Nickel was segregated initially at the scale/matrix interface, and later at the lower part of the $Fe_2O_3$ scale. At $600^{\circ}C$, Fe-2wt.%Ni alloys oxidized parabolically initially, and linearly after 15 h. At $650-700^{\circ}C$, they oxidized linearly from the initial period. Although Fe-2wt.%Ni alloys oxidized slower than pure iron, their oxidation rates were relatively fast.

• Composites Research
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• 제24권3호
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• pp.6-11
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• 2011

본 논문은 복잡한 형상으로 드레이핑 성행된 직물 복합재료 구조의 국부적 물성 변화 및 재료거동 예측을 위한 방법을 제시하였다. 제안된 방법을 적용하기 위해 대퇴골 골 간단 부 골절치료용 고정판을 대상으로 선정하였다. 드레이핑 공정 종 발생하는 재료의 거시적/미시적 변형에 의한 국부적 재료물성 변화를 다양한 실험을 통해 검증하고, 그 결과를 복잡한 형상을 가지는 고정판의 정적/피로 거동 예측에 활용하였다. 본 논문은 복잡한 형상을 가지는 복합재료 구조물의 설계 및 성능평가에 유용한 정보와 해석방법을 제시할 것으로 기대된다.

• 터널과지하공간
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• 제29권6호
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• pp.542-557
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• 2019

암석의 성인과 변성에 따른 내부구조의 마이크로 특성은 암반의 거동 특성에 영향을 미친다. 본 연구에서는 암석 내부의 구성물질의 분포 특성을 반영하는 엑스레이 단층(X-ray CT) 이미지에 기초한 새로운 암석특성의 평가방안을 고찰하였다. 암석의 불균질 특성 및 이방성 특성의 정량화, 암석의 구성광물 입자의 크기분포 및 형상특성, 공극이미지를 이용한 유동해석, 암석내부의 노출되지 않은 절리면 거칠기 평가 등 전통적인 암석의 시험법으로 측정하기 어려웠던 중요한 암석의 특성들이 X-ray CT 이미지의 분석을 통하여 평가될 수 있다.