• Korean Journal of Fisheries and Aquatic Sciences
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• v.29 no.6
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• pp.920-922
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• 1996

• Journal of Life Science
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• v.6 no.2
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• pp.129-134
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• 1996

The development of fish feed is essential to aquaculture. Recently, yeast, dhlorella and plankton have been studied and development as the feed of the fry fishes, But, these biological feeds cause the nutritional unbalance to fry fishes, rotifer or artemia. Therefore, to solve these problems, microcapsules with micron sizes were prepared for enhancing the nutritional values of artemia and rotifer which are used as the feed of fry fishes. Microparticle oil capsules were prepared by the complex coacervation technique. The method to make the optimal size of microcapsule which the artemia and rotifer can be easily taken was wvaluated. The size of oil microcapsule in the range of 5-70$\mu$m was obtained by the agitation conditions during coacervation. Capsule size and size distribution were dependent on the agitation speed and agitation time, respectively.

• KSBB Journal
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• v.26 no.1
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• pp.69-77
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• 2011

In this study, poly (L-lactic acid) (PLLA) microparticles containing gemcitabine hydrochloride were prepared by a supercritical fluid process, called aerosol solvent extraction system (ASES), utilizing supercritical carbon dioxide as antisolvent. The influence of process parameters such as temperature, pressure, $CO_2$ and solution flow rate, solution concentration, and feed ratio of drug to polymer on the morphology and characteristics of the microparticles was studied in detail. The gemcitabine-loaded microparticles exhibited a spherical shape with a smooth surface. The entrapment efficiency of gemcitabine increased with increasing temperature, solution concentration and $CO_2$ flow rate and with decreasing drug/polymer feed ratio. The maximum drug loading obtained from the ASES process was found to be about 11%. The ASES-processed PLLA microparticles containing gemcitabine showed a relatively high initial burst due to the presence of surface pores on the microparticles and the poor affinity between drug and polymer.

• Clean Technology
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• v.15 no.4
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• pp.233-238
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• 2009

Supercritical fluid processes have gained great attention as a new and environmentally-benign method of preparing the microparticles of energetic materials like explosives and propellants. In this work, RDX (cyclotrimethylenetrinitramine) was selected as a target explosive. The microparticle formation of RDX using supercritical anti-solvent (SAS) recrystallization process was performed and the effect of operating variables on the size and morphology of prepared particles was observed. N,N-Dimethylformamide was used as organic solvent for dissolving the RDX. The size of the RDX particles decreased remarkably up to less than $10\;{\mu}m$ by SAS recrystallization. In the range of operating conditions of the SAS process studied in this work, the finest RDX particles were obtained at 313.15K, 150 bar, and 15wt% RDX concentration in feed solution.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.8
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• pp.88-93
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• 2020

The goal of this study is to determine the influence of major factors on the spiral surface microparticle injection machining of cylindrical specimens by the statistical method ANOVA. Before the experiment, rod-shaped test specimens and jigs for helical surface spraying were prepared, and the surface roughness was measured with a surface roughness meter. The injection particle, nozzle diameter, and injection pressure were the primary parameters of the experiment. Other factors that were considered were injection height, injection time, revolutions, and feed distance. The surface roughness after machining was measured, and the effects of the surface roughness data on the primary factors were determined with ANOVA.

• Clean Technology
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• v.13 no.1 s.36
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• pp.34-45
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• 2007

Phase behavior of the ternary systems of water-insoluble simvastatin drug, which is well known to be effective drugs for hypercholesterolemia therapy, in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated to present a guideline of establishing operating conditions in the particle formation of the drugs by a supercritical anti-solvent recrystallization process utilizing dichloromethane as a solvent and carbon dioxide as an anti-solvent. The solubilities of simvastatin in the mixtures of dichloromethane and carbon dioxide were determined as functions of temperature, pressure and solvent composition by measuring the cloud points of the ternary mixtures at various conditions using a high-pressure phase equilibrium apparatus equipped with a variable-volume view cell. The solubility of the drug increased as the dichloromethane composition in solution and the system pressure increases at a fixed temperature. A lower solubility of the drug was obtained at a higher temperature. The second half of this work is focused on the particle formation of the simvastatin drug by a supercritical anti-solvent recrystallization process in a cylindrical high-pressure vessel equipped with an impeller. Microparticles of the simvastatin drug were prepared as functions of pressure (8 MPa to 12 MPa), temperature (303.15 K, 313,15 K), feed flow rate of carbon dioxide, and stirring speed (up to 3000 rpm), in order to observe the effect of those process parameters on the size and shape of the drug microparticles recrystallized.