• Nuclear Engineering and Technology
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• 제47권6호
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• pp.738-745
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• 2015

The catalytic exchange of hydrogen isotopes between hydrogen and water has been known to be a very useful process for the separation of tritium from tritiated water. For the process, a highly active hydrophobic catalyst is needed. This study provides an effective fabrication method of size-controlled platinum/poly[styrene-divinylbenzene-tri(propylene glycol) diacrylate] [Pt/poly(SDB-TPGDA)] hydrophobic catalyst beads with a narrow size distribution. Platinum nanoparticles were prepared by ${\gamma}$-ray-induced reduction in the aqueous phase first, and then uniformly dispersed in SDB-TPGDA comonomer after the hydrophobization of platinum nanoparticles with alkylamine stabilizers. The porous Pt/poly(SDB-TPGDA) hydrophobic catalyst beads were synthesized by the UV-initiated polymerization of the mixture droplets prepared in a capillary-based microfluidic system. The size of as-prepared catalyst beads can be controlled in the range of $200-1,000{\mu}m$ by adjusting the flow rate of dispersed and continuous phases, as well as the viscosity of the continuous phase. Sorbitan monooleate and cyclohexanol were used as coporogens to control the porosities of the catalyst beads.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제51권9호
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• pp.449-454
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• 2002

A rectangular straight microchannel, integrated with the resistance temperature detectors(RTDs) for temperature sensing and a micro-heater for generating the Temperature gradient along the channel, was fabricated. Its dimension is 57${\mu}{\textrm}{m}$(H)$\times$200${\mu}{\textrm}{m}$(W)$\times$48,050${\mu}{\textrm}{m}$(L), and RTDs were placed at the inner-channel wall. Si wafer was used as a substrate. For the fabrication of RTDs, 5300$\AA$ thick Pt/Ti layer was sputtered on a Pyrex glass wafer. Finally, the glass wafer was bonded with Si wafer by anodic bonding, so that the RTDs are located inside the microchannel. Temperature coefficient of resistance(TCR) values of the fabricated Pt-RTDs were 2800~2950ppm$^{\circ}C$ and the variation of TCR value In the range of O~10$0^{\circ}C$ was less than 0.3％. Therefore, it was proved that the fabricated Pt-RTDs without annealing were excellent as temperature sensors. The temperature distribution in the microchannel was investigated as a function of mass flow rate and heating power. The temperature increase rate diminished with decreasing the applied power and increasing the mass flow rate. It was confirmed from the comparison with the simulation results that the temperature measured inside the microchannel is more accurate than measuring the temperature measured at the outer wall. The proposed temperature sensing method and microchannel are expected to be useful in microfluidics researches.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.277.1-277.1
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• 2013

Molecular diagnostics consists of three processes, which are a sample pretreatment, a nucleic acid amplification, and an amplicon detection. Among three components, sample pretreatment is an important process in that it can increase the limit of detection by purifying nucleic acid in biological sample from contaminants that may interfere with the downstream genetic analysis such as nucleic acid amplification and detection. To achieve point-of-care virus detection system, the sample pretreatment process needs to be simple, rapid, and automatic. However, the commercial RNA extraction kits such as Rneasy (Qiagen) or MagnaPure (Roche) kit are highly labor-intensive and time-consuming due to numerous manual steps, and so it is not adequate for the on-site sample preparation. Herein, we have developed a rotary microfluidic system to extract and purify the RNA without necessity of external mechanical syringe pumps to allow flow control using microfluidic technology. We designed three reservoirs for sample, washing buffer, and elution buffer which were connected with different dimensional microfluidic channels. By controlling RPM, we could dispense a RNA sample solution, a washing buffer, and an elution buffer successively, so that the RNA was captured in the sol-gel solid phase, purified, and eluted in the downstream. Such a novel rotary sample preparation system eliminates some complicated hardwares and human intervention providing the opportunity to construct a fully integrated genetic analysis microsystem.

• 대한기계학회논문집B
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• 제38권12호
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• pp.1035-1042
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• 2014

엔진 마찰 저감은 엔진 개발의 중요한 항목이 되어왔다. 엔진의 기계적 마찰 손실 중 피스톤계의 마찰이 40~55%에 해당하고, 피스톤 부분의 마찰을 제거할 수 있다면 투입되는 전체 에너지의 5% 정도 향상시킬 수 있다. 엔진의 마찰 손실을 감소시키기 위해서 각 요소에서의 마찰 수준, 이에 영향을 미치는 인자에 대한 분석 및 다른 엔진들과의 비교분석이 필요하다. 하지만 기존 연구에서 마찰이 발생하는 윤활막의 연구들이 유체역학 바탕의 모델링에서 수행해 왔으나, 피스톤계의 윤활막이 크게는 마이크로에서 작게는 나노단위의 영역에 해당하므로 분자들간의 상호관계를 고려할 필요가 있다. 따라서, 본 연구에서는 엔진 실린더 라이너를 따라 형성하는 유막의 운동을 미시적으로 접근하여 분자들간의 상호작용에 따른 마찰변화를 제시하고자 한다.

• 공업화학
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• 제16권2호
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• pp.238-242
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• 2005

본 연구에서 soft lithographic mothed 기술을 사용하여 마이크로채널을 만들기 위해 polydimethylsiloxane (PDMS)와 SU-8 감광제를 사용하였다. 외부전압과 채널너비에 대한 영향을 조사하기 위하여 마이크로채널의 너비를 $100{\mu}m,\;200{\mu}m,\;300{\mu}m$로 제작하였으며, 각각의 마이크로채널에 외부전압을 걸어 유체의 속도를 측정하였다. 그 결과 동일한 너비를 갖는 마이크로채널에 외부전압을 변화시켰을 때, 외부전압이 증가할수록 유체의 속도가 증가하였다. 이는 외부전압이 증가할수록 계면에서의 전기이중층이 압축되어 제타전위의 값이 증가하기 때문인 것으로 해석된다. 또한, 동일한 외부전압에서 마이크로채널의 너비가 증가할수록 유체의 속도가 증가하는 것으로 나타났다. 이는 채널 너비의 증가가 내부의 저항을 감소시켜 유체의 속도가 보다 빠르게 나타나는 것으로 판단된다.

• Korean Chemical Engineering Research
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• 제57권1호
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• pp.58-64
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• 2019

본 연구는 주사기 바늘 기반의 미세유체 장치에서 균일한 polyethylene glycol diacrylate (PEGDA) 입자를 제조하는 새로운 방법을 소개한다. 미세유체 장치는 다양한 규격의 기성품들을 별도의 장비없이 조립하여 제작된다. 이 미세유체 장치에서 광개시제를 포함한 PEGDA 분산상과 오일의 연속상의 부피유속을 제어하여 단분산성 PEGDA 액적을 형성한다. PEGDA 액적은 장치의 말단에서 자외선 조사에 의해 입자로 중합된다. 입자의 크기는 부피유속과 미세유체 장치의 규격을 조절하여 손쉽게 제어되며 입자의 단분산도는 변동계수(coefficient of variation)값이 2.57%로 계산된다. PEGDA입자의 생물학적 응용을 증명하기 위해서 세포를 함입시키고 증식과 생존을 관찰한다.

• Geomechanics and Engineering
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• 제19권1호
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• pp.11-20
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• 2019

The use of electrokinetic dissipation method to study the fluid flow law in micro-pores is of great significance to reservoir rock microfluidics. In this paper, the micro-capillary theory was combined with the coupling model of the seepage field and the current field under the excitation of the harmonic signal, and the coupling theory of the electrokinetic effect under the first-order approximation condition was derived. The dissipation equation of electrokinetic dissipation and viscous resistance dissipation and its solution were established by using Green's function method. The physical and mathematical models for the electrokinetic dissipation of reservoir rocks were constructed. The microscopic mechanism of the electrokinetic dissipation of reservoir rock were theoretically clarified. The influencing factors of the electrokinetic dissipation frequency of the reservoir rock were analyzed quantitatively. The results show that the electrokinetic effect transforms the fluid flow profile in the pores of the reservoir from parabolic to wavy; under low-frequency conditions, the apparent viscosity coefficient is greater that one and is basically unchanged. The apparent viscosity coefficient gradually approaches 1 as the frequency increases further. The viscous resistance dissipation is two orders of magnitude higher than the electrokinetic effect dissipation. When the concentration of the electrolyte exceeds 0.1mol/L, the electrokinetic dissipation can be neglected, while for the electrolyte solution (<$10^{-2}M$) in low concentration, the electrokinetic dissipation is very significant and cannot be ignored.

• Korean Chemical Engineering Research
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• 제59권4호
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• pp.639-643
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• 2021

본 연구에서는 3차원 다층 미세유체 디바이스를 제작하기 위한 접착제로서 불소화 에틸렌 프로필렌(fluorinated ethylene propylene, FEP) 나노입자를 연구하였다. FEP 분산 용액을 1500 rpm에서 30초 동안 단순 스핀 코팅하여 기판에 3 ㎛ 두께의 균일하게 분포된 FEP 나노 입자 층을 형성하였다. FEP 나노입자는 300 ℃에서 1시간 동안 열처리 후 소수성 박막으로 변형되었으며, FEP 나노입자를 이용하여 제작된 폴리이미드 필름 기반 미세유체 디바이스는 최대 2250 psi의 압력을 견디는 것을 확인하였다. 마지막으로 기존의 포토리소그래피로 제작하기 어려운 16개의 마이크로 반응기로 구성된 3차원 다층 미세유체 디바이스를 FEP가 코팅된 9개의 폴리이미드 필름을 간단한 1단계 정렬로 성공적으로 구현하였다. 개발된 3차원 다층 미세유체 디바이스는 화학 및 생물학의 다양한 응용을 위한 고속대량 스크리닝, 대량 생산, 병렬화 및 대규모 미세유체 통합과 같은 강력한 도구가 될 가능성이 있습니다.

• Korean Chemical Engineering Research
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• 제60권1호
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• pp.139-144
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• 2022

본 연구는 미세유체기술을 기반으로 매우 간단하고 효율적인 단분산성 하이드로젤 마이크로 입자 제조 방법을 제안하였다. 구체적으로, 유리모세관 미세유체장치 내에서 형성된 이중에멀젼은 자외선기반 자유라디칼 중합에 의해 빠르게 고형화가 이루어진다. 수용액에 분산됨과 동시에 계면활성제의 부족으로 인해 얇은 오일쉘은 자발적으로 분리되어, 단분산성 하이드로젤 입자를 형성하였다(C.V.=1%). 본 연구의 결과는 water-in-oil (w/o) 단일에멀젼 기반의 제조 방법과 달리 오일 부피를 최소한으로 사용하여 크기 및 조성 제어가 가능한 단분산성 하이드로젤 입자의 제조가 달성될 수 있음을 보여준다. 마지막으로, 상도표를 기반으로 미세유체장치 내 유동 패턴에 대한 심층 연구는 상대적인 부피 유속들 간의 중요한 상관관계를 나타내며 하이드로젤 마이크로 입자의 안정적인 제조를 위한 실험적 근거를 제시하였다.

• 대한방사성의약품학회지
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• 제8권2호
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• pp.95-101
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• 2022

Microfluidic radioimmunoassay (RIA) platform called µ-RIA spends less reagent and shorter reaction time for the analysis compared to the conventional tube-based radioimmunoassay. This study reported the design of µ-RIA chips optimized for the gamma counter which could measure the small samples of radioactive materials automatically. Compared with the previous study, the µ-RIA chips developed in this study were designed to be compatible with conventional RIA test tubes. And, the automatic gamma counter could detect radioactivity from the ¹²⁵I labeled anti-PSA attached to the chips. Effects of the multi-layer microchannels and two-phase flow in the µ-RIA chips were investigated in this study. The measured radioactivity from the ¹²⁵I labeled anti-PSA was linearly proportional to the number of stacked chips, representing that the radioactivity in µ-RIA platform could be amplified by designing the chips with multi-layers. In addition, we designed µ-RIA chip to generate liquid-gas plug flow inside the microfluidic channel. The plug flow can promote binding of the biomolecules onto the microfluidic channel surface with recirculation in the liquid phase. The ratio of liquid slug and air slug length was 1 : 1 when the ¹²⁵I labeled anti-PSA and the air were injected at 1 and 35 µL/min, respectively, exhibiting 1.6 times higher biomolecule attachment compared to the microfluidic chip without the air injection. This experimental result indicated that the biomolecular reaction was improved by generating liquid-gas slugs inside the microfluidic channel. In this study, we presented a novel µ-RIA chips that is compatible with the conventional gamma counter with automated sampler. Therefore, high-throughput radioimmunoassay can be carried out by the automatic measurement of radioactivity with reduced radiowaste generation. We expect the µ-RIA platform can successfully replace conventional tube-based radioimmunoassay in the future.