• Child Health Nursing Research
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• 제19권2호
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• pp.76-84
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• 2013

목적 본 연구의 목적은 신생아중환자실 간호사의 모유수유에 대한 지식, 태도, 간호활동을 파악하고, 신생아집중치료실 간호사의 일반적 특성과 모유수유 특성에 따른 모유수유에 대한 지식, 태도 및 간호활동의 차이를 확인하고, 이들간의 상관관계를 파악하는 것이다. 방법 자가보고식 설문조사 방법을 적용하였으며, 서울과 대전, 대구의 총7개 대학병원의 신생아집중치료실 간호사 153명으로 자료수집 하였다. 결과 신생아집중치료실 간호사의 모유수유에 대한 지식은 59.3%의 정답율을 나타냈다. 그리고 모유수유에 대한 태도는 5점 척도에서 평점 $3.70{\pm}0.41$으로 다소 긍정적으로 확인되었다. 모유수유 간호활동은 중간정도로, 평점 $3.26{\pm}0.74$이었다. 모유수유 지식은 모유수유 태도(r=.554, p<.001) 및 모유수유 간호활동(r=.203, p=.002)과 유의한 양적 상관관계를 나타냈다. 모유수유 태도와 간호활동도 유의한 양적 상관관계를 보였다(r=.243, p=.002). 결론 본 연구의 결과는 신생아집중치료실 간호사의 모유수유 지식과 태도, 간호활동을 향상시킬 수 있도록 신생아집중치료실 간호사를 위한 모유수유 교육 프로그램 개발의 필요성을 지지한다.

• 보건교육건강증진학회지
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• 제21권4호
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• pp.109-119
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• 2004

This study was conducted to examine factors influencing mental health of middle-aged adults(N=203) in relation to sociodemographic variables, health behaviors, and social support. The survey with questionnaire was carried out for the subjects of the residents in two communities of a local city located in Gangwon-do, Korea from September 3 to 15, 2003. Data analysis procedure included stepwise multiple regression using mental health as the dependent variable, and sociodemographic variables, health behaviors, and social support as independent variables. There were significant differences in the mental health by birth place(t=-1.67, p<0.10), religion (t=2.27, p<0.05) and subjective economic status(F=2.29, p<0.10). Mental health showed significant positive correlations with both health behavior (r=0.462, p<0.001) and social support (r=0.142, p<0.05). Stepwise multiple regression analysis for mental health revealed that the most powerful predictor was health behavior(β=0.453, p<0.001). Health behavior and religion explained 24％ of the variance. The results suggest the necessity of a intervention that considers the health behaviors should be included in middle-aged adults so as to promote mental health.

• 분석과학
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• 제33권4호
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• pp.177-185
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• 2020

Human milk (HM) glycoproteins play important roles protecting infants against various pathogens. Recently, freezing HM is reported to affect some glycoproteins and freeze-drying is suggested as an alternative method. However, the effects of freeze-drying on HM glycoproteins were not evaluated yet. Six fresh HM samples were collected from three healthy mothers at 15 and 60th days of lactation from each mother. Each sample was divided into frozen and freeze-dried subgroups yielding totally 12 samples, and the glycoproteomic analysis was performed by liquid chromatography mass spectrometry. The results were compared between samples of 15 and 60th days of lactation, and before and after the freeze-drying. Totally, 203 glycoproteins were detected. The glycoprotein levels were not different between two groups of 15/60th day of lactation and before/after freeze-drying groups (P > 0.050). In addition, significant correlation of glycoprotein levels was found between the different lactation stages (r = 0.897, P < 0.001) and the status of freeze-drying (r = 0.887, P < 0.001) in a partial correlation analysis. As no significant change of HM glycoproteins was not found after the freeze-drying, we hope that introducing freeze-drying to HM banks is supported by the present study. This work was supported by the National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIP) (No.2017R1D1A1B03034270; No.2020R1A2C1005082).

• The Korean Journal of Physiology and Pharmacology
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• 제24권3호
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• pp.203-212
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• 2020

Promyelocytic leukemia (PML) gene, through alternative splicing of its C-terminal region, generates several PML isoforms that interact with specific partners and perform distinct functions. The PML protein is a tumor suppressor that plays an important role by interacting with various proteins. Herein, we investigated the effect of the PML isoforms on oncostatin M (OSM)-induced signal transducer and activator of transcription-3 (STAT-3) transcriptional activity. PML influenced OSM-induced STAT-3 activity in a cell type-specific manner, which was dependent on the p53 status of the cells but regardless of PML isoform. Interestingly, overexpression of PML exerted opposite effects on OSM-induced STAT-3 activity in p53 wild-type and mutant cells. Specifically, overexpression of PML in the cell lines bearing wild-type p53 (NIH3T3 and U87-MG cells) decreased OSM-induced STAT-3 transcriptional activity, whereas overexpression of PML increased OSM-induced STAT-3 transcriptional activity in mutant p53-bearing cell lines (HEK293T and U251-MG cells). When wild-type p53 cells were co-transfected with PML-IV and R273H-p53 mutant, OSM-mediated STAT-3 transcriptional activity was significantly enhanced, compared to that of cells which were transfected with PML-IV alone; however, when cells bearing mutant p53 were co-transfected with PML-IV and wild-type p53, OSM-induced STAT-3 transcriptional activity was significantly decreased, compared to that of transfected cells with PML-IV alone. In conclusion, PML acts together with wild-type or mutant p53 and influences OSM-mediated STAT-3 activity in a negative or positive manner, resulting in the aberrant activation of STAT-3 in cancer cells bearing mutant p53 probably might occur through the interaction of mutant p53 with PML.

• Journal of Preventive Medicine and Public Health
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• 제48권4호
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• pp.203-215
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• 2015

Objectives: This study was performed to investigate the relationship between the incidence of national notifiable infectious diseases (NNIDs) and meteorological factors, air pollution levels, and hospital resources in Korea. Methods: We collected and stored 660 000 pieces of publicly available data associated with infectious diseases from public data portals and the Diseases Web Statistics System of Korea. We analyzed correlations between the monthly incidence of these diseases and monthly average temperatures and monthly average relative humidity, as well as vaccination rates, number of hospitals, and number of hospital beds by district in Seoul. Results: Of the 34 NNIDs, malaria showed the most significant correlation with temperature (r=0.949, p<0.01) and concentration of nitrogen dioxide (r=-0.884, p<0.01). We also found a strong correlation between the incidence of NNIDs and the number of hospital beds in 25 districts in Seoul (r=0.606, p<0.01). In particular, Geumcheon-gu was found to have the lowest incidence rate of NNIDs and the highest number of hospital beds per patient. Conclusions: In this study, we conducted a correlational analysis of public data from Korean government portals that can be used as parameters to forecast the spread of outbreaks.

• 한국식생활문화학회지
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• 제20권2호
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• pp.194-203
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• 2005

This study was peformed to investigate effect of feeding experimental mixture containing chitosan, hibiscus extract and L-carnitine on body weight and lipid metabolism in rats. Forty-eight male rats(Charles River CD) of eight weeks old and weighing $336.5{\pm}2.3g$ were raised for five weeks with high fat diet(40% fat as calorie) to induce obesity. After induction of obesity, rats weighing $560.4{\pm}5.6g$ were blocked into four groups according to body weight and raised for eight weeks with diet containing either 0.09%(+1D group), 0.9%(+10D group) or 4.5%(+50D group) of experimental mixture. Aspartate aminotransferase(AST) and alanine aminotransferase(ALT), total protein and albumin were normal levels in plasma. Body weight gain and epididymal fat pad weight were lower in experimental mixture groups than control group However, weights of perirenal fat pad and brown adipose tissue were not significantly different among all groups. There was no significant difference in plasma and hepatic lipid levels among all groups. Liver citrate lyase and camitine acyltransferase activities were not significantly different among all groups, however, citrate lyase activity was tended to be decreased with increasing experimental mixture level in diet. Fecal total lipid and total cholesterol excretions were highest in +50D group, and triglyceride excretion was highest in +1D group. in conclusion, intake of experimental mixture containing chitosan, hibiscus extract and L-camitine was effective in reducing body weight and body fat, and its inhibitory effects might lead to obesity improvement.

• 한국버섯학회지
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• 제7권3호
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• pp.98-104
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• 2009

인공재배된 만가닥버섯(Hypsizygus mamoreus)과 잿빛 만가닥버섯(Lyophyllum decastes)을 ITS $I{\cdot}IV$ 부위의 염기서열에 의해 종속간 유연관계 및 RAPD 다형성을 분석하였다. ITS $I{\cdot}IV$영역부위 종속간 유연관계에서 Group1 (SPA 100, 101, 102)은 만가닥버섯에 속하였으며, Group2 (11균주) 잿빛만가닥버섯의 대조 분리군 11균주는 동일한 종으로 동정되었다. ITS결과 14개 균주 시 4개 그룹으로 분류되었으며, Cluster I과 Cluster II는 58%의 유사도를 Cluster III과 Cluster IV는 41%의 유사성을 보였다. 또한 인공 재배한 잿빛만가닥버섯의 종 다양성을 분석하기위해 RAPD를 수행한 결과 가장 수량이 양호하며 우량계통인 SPA 202는 잿빛만가닥버섯인 Lyophyllum decastes SPA 203과 그룹화 되었으며 75%의 유사성을 보여주었고, Lyophyllum decastes 공시균주인 SPA 103과 SPA 104의 유사성은 65%로 나타났다.

• 한국콘텐츠학회논문지
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• 제20권7호
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• pp.203-211
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• 2020

미국영어와 영국영어의 모음은 몇 개 모음에서 발음 차이를 보여주고 있는데 한국 학생들은 주로 미국영어에 노출되어 왔다. 이에 근거하여 본 연구에서는 미국영어 모음과 영국영어 모음을 한국 학생들이 어떻게 인지하는지 비교하기 위하여 27명의 대학생들을 대상으로 미국영어와 영국영어의 모음 인지 시험을 실시하였다. 인지 시험 결과 미국영어 모음의 전반적인 인지 정확도(64.7%)가 영국영어(54.7%)보다 더 높게 나타나서 한국 학생들이 영국영어보다 미국영어에 더 친숙한 점이 영어 모음 인지에 영향을 준다는 사실을 확인할 수 있었다. 그러나 개별 모음에서는 beat, bat, but, burt, bart, bite 단어들의 모음들에서만 미국영어 인지 정확도가 영국영어보다 높게 나타났다. 미국영어와 영국영어의 차이를 보이는 모음들 중에서는 burt, bart, bat 단어들의 모음에서만 미국영어의 인지 정확도가 영국영어보다 높았으므로 친숙도 뿐만 아니라 개별 모음의 특성도 모음 인지에 영향을 주는 것을 알 수 있었다. 미국영어와 영국영어에서 차이를 보이는 모음들의 오류 패턴을 살펴보면, burt, bart, bat의 오류 패턴이 미국영어와 영국영어에서 다르게 나타났는데, 한국 학생들이 burt, bart에서 영국영어의 종성-r 없는 발음에 어려움을 느끼는 것을 알 수 있었고 bat의 미국영어 발음과 영국영어의 발음의 차이를 잘 알지 못한다는 사실을 알 수 있었다. 그러나 미국영어와 영국영어에서 차이를 보이는 bot과 boat에서는 [ɑ]-[ɔ]-[ʌ] 혼동과 원순 모음끼리의 혼동에 기인한 오류가 미국영어와 영국영어에서 모두 공통적으로 나타났으므로 이러한 혼동이 한국 학생들의 영어 모음 인지를 어렵게 하는 것을 알 수 있었다. 본 연구의 결과를 바탕으로 학교 교실 현장에서 학생들을 대상으로 영어 모음 지도 방안에 대한 교육적인 함축점을 논의하고 있다.

• Tuberculosis and Respiratory Diseases
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• 제82권4호
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• pp.319-327
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• 2019

Background: Radial probe endobronchial ultrasound (R-EBUS), is effective for tissue diagnosis of lung lesions. We evaluated the diagnostic performance of R-EBUS both a guide-sheath and fluoroscopy and identified factors associated with accurate diagnosis. The feasibility of molecular and genetic testing, using specimens obtained by R-EBUS, was also investigated. Methods: The study retrospectively reviewed 211 patients undergoing R-EBUS without a guide-sheath and fluoroscopy, June 2016-May 2017. After excluding 27 patients of which the target lesion was not reached, 184 were finally included. Multivariate logistic regression was used, to identify factors associated with accurate diagnosis. Results: Among 184 patients, R-EBUS-guided biopsy diagnosed malignancy in 109 patients (59%). The remaining 75 patients (41%) with non-malignant results underwent additional work-ups, and 34 were diagnosed with malignancy. Based on final diagnosis, diagnostic accuracy was 80% (136/170), and sensitivity and specificity for malignancy were 76% (109/143) and 100% (27/27), respectively. In multivariate analysis, peripheral location (adjusted odds ratio [aOR], 3.925; 95% confidence interval [CI], 1.203-12.811; p=0.023), and central position of the probe (aOR, 2.435; 95% CI, 1.424-7.013; p=0.035), were associated with accurate diagnosis of malignancy. Molecular and genetic analyses were successful, in all but one case, with inadequate specimens. Conclusion: R-EBUS-guided biopsy without equipment, is effective for tissue diagnosis. Peripheral location and central position of the radial probe, were crucial for accurate diagnosis. Performance of molecular and genetic testing, using samples obtained by R-EBUS, was satisfactory.

• 한국응급구조학회지
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• 제15권1호
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• pp.65-78
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• 2011

Purpose : We investigated the career choice and the employment preparation of emergency medical technology (EMT) students. The results of study will provide the base information about the consciousness for career choice and employment of the EMT students. Method : We conducted 1,586 surveys from 665 students at six four-year colleges and 921 students at seven three-year colleges, from Aug. 27th to Oct. 31st in 2010. The result was analyzed by SPSS 18.0 using description statistics, t-test, ANOVA, Scheffe and Pearson correlation coefficient. Result : The general characteristics showed male 50.2% and female 49.8%, and first grade 34.6%, second grade 27.4%, third grade 28.2%, and fourth grade 9.8%. The 53.9% of students had experienced the hospital training and the 44.8% did the fire station training. For the choice of job, there were the 61.8% student who hope to enter the employ in fire station or public service, while 25.7% students hope to be employed in hospitals. The reason for a wish job were 'majors-related job' in 18.2% students, 'employment stability' in 17.2% and 'hit on the aptitude and talent' in 16.7%, 'appropriate salaries' in 15.9%. In the questionnaire of the University what to assist you for job preparation, they chose the 'support for get major related license', 'support for officer exam preparation' and 'support of foreign language study' in 34.6%, 16.8% and 16.6%, respectively. For achieved licence, they had a driver's license in 53.9%, BLS (basic life support) provider in 20.3%, life guard in 16.2% and scuba in 8.8%. The statistically significant correlation was identified between the awareness of University that provides job information and one's career awareness (r= .203, p<.000), the awareness that University provide job information and one's confidence in employment (r= .236, p<.000), and one's career awareness and one's confidence in employment (r = .356, p = .000). Conclusion : The most of EMT Students are well conscious of the their future employment and has prepared career to be employed their preference job.