• Bulletin of the Korean Chemical Society
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• 제29권2호
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• pp.342-346
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• 2008

Aurintricarboxylic acid (ATA) prevents apoptosis in a wide range of cell types, including PC12 cells. ATA is known to increase the phosphorylation level of IGF-1 receptor (IGF-1R) and downstream signaling proteins. ATA can translocate across the plasma membrane of PC12 cells and inhibit protein tyrosine phosphatases (PTPs) and, therefore, it is not clear whether ATA exerted its antiapoptotic effect through activation of IGF-1R or by inhibition of cytosolic PTPs. When PC12 cells, deprived of serum, were treated with Fab fragment of anti-IGF-1R antibody to prevent the binding of ATA to the extracellular domain of IGF-1R, ATA was found to penetrate into the cytosolic space of the cells. Under these conditions, the survival-promoting effects of ATA were abolished, and the increase of phosphorylation and characteristic cleavage of IGF-1R were not observed. These results indicate that the antiapoptotic effect of ATA in PC12 cells is due to the binding of ATA to the extracellular domain of IGF-1R and subsequent activation of the IGF-1R, not inhibition of cytosolic PTP(s).

• Journal of Preventive Medicine and Public Health
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• 제29권3호
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• pp.439-449
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• 1996

성인 남성 근로자들에 있어서 비만지표의 변화와 혈청지질치 변화와의 관련성을 평가하기 위하여, 대구시에 소재한 1개 회사의 남성 근로자 208명을 연구 대상자로 선정하였다. 1995년 7월에 신장, 체중, 허리둘레, 엉덩이둘레를 재고 혈압을 측정하였으며, 혈청 총 콜레스테롤, 중성지방, HDL-콜레스테롤 등을 검사하고 LDL-콜레스테롤, 심근경색지수를 계산하였다. 이를 1991년도에 검사된 기초 자료들과 비교하였다. 1. 4년간 체중이 1.63kg, 허리둘레가 3.61cm, 엉덩이둘레가 4.23cm, BMI가 $0.52kg/m^2$, Katsura 지수는 0.02만큼 유의하게 증가했지만, 허리 엉덩이둘레비는 0.021만큼 유의한 감소가 있었다(p<0.01). 총 콜레스테롤은 15.09mg/이, 중성지방 20.43mg/dl, HDL-콜레스테롤 9.40mg/dl, 그리고 심근경색지수는 2.87mg/dl 만큼 유의하게 증가하였다. (p<0.01). LDL-콜레스테롤은 3.50mg/dl 만큼 증가하였으나 유의하지는 않았다. 2. BMI 변화 및 Katsura 지수의 변화와 총 콜레스테롤의 변화(r=0.174, p<0.05), BMI 변화와 중성지방의 변화(r=0.374, p<0.01), 그리고 체중의 변화와 심근경색지수의 변화(r=-0.173, p<0.05)가 상대적으로 강한 상관성을 보였다. 허리 엉덩이둘레비 변화는 총 콜레스테롤 변화량과 양의 상관관계(r=0.162, p<0.05)를 보였지만 다른 혈청지질치들과는 유의한 관련성이 없었다. 3. 생활습관의 변화를 보정하고도 중성지방은 체중 (r=0.262, p<0.01), BMI(r=0.267, p<0.01) Katsura 지수(r=0.258, p<0.01)와 유의한 관련성이 있었다. 심근경색지수의 변화는 체중(r=-0.143, p<0.05), BMI(r=-0.158, p<0.05), Katsura 지수(r=-0.144, p<0.05)와 유의한 음의 관련성이 있었다. 이 중 BMI가 가장 큰 상관계수 값을 보였다. 4. 1991년의 허리 엉덩이둘레비로 분류한 경우, 상체형 비만군이 그렇지 않은 군에 비해 HDL-콜레스테롤과 심근경색지수의 증가폭이 유의하게 더 낮았다(p<0.05). Katsura 지수의 경우도 유사한 결과를 보였다. BMI로 분류한 경우에도 역시 비만군이 그렇지 않은 군에 비해 HDL-콜레스테롤, 심근경색지수 값들의 증가폭이 유의하게 낮았다(p<0.05 또는 p<0.01). 중성지방은 BMI로 분류한 경우 비만한 군의 증가폭이 유의하게 높았다(p<0.05). 이상의 결과로 보아, 성인 남성 근로자들에서 혈청 지질치 변화에 대한 비만도의 지표로는 BMI가 허리 엉덩이둘레비나 Katsura 지수보다 더 적절할 것으로 생각된다.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2008년도 한국우주과학회보 제17권2호
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• pp.29.3-29.3
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• 2008

1RXS J062518.2+733433. The X-ray data was obtained in April 6, 2006 with the XMM-Newton and the optical data with CCD R filter at the 1m telescope of the Lemonsan observatory in 2005-2006 for 11 nights. This source is classified as a magnetic cataclysmic variable with a spin period of 1187.3 s in the optical region. We determine the spin period to be $1187.26\pm0.11$ s using the X-ray data, which is well consistent with the optical studies. However, we find that the pulse profile of the data (0.2-10 keV) folded at the period is different from the quasi-sinusoidal optical profile and is dependent on the selected X-ray energy bands. The results of period searching with times of extrema will be also presented.

• 한국응급구조학회지
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• 제17권2호
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• pp.29-41
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• 2013

Purpose : The purpose of this study was to investigate the effectiveness of cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) education for school teachers by questionnaire survey including the knowledge, self-efficacy and skills of CPR and AED after basic life support (BLS) education. Methods : The subjects were school teachers who participated in BLS education from 24 Nov. to 1 Dec. 2012. They completed the self-reported questionnaire based on BLS skill checklist. Results : There was a statistically significant increase in the knowledge(p <.001), self-efficacy (p <.001) and skills(p <.001) of CPR and AED after BLS education. The correlation existed conspicuously between knowledge versus self-efficacy(r =.409, r =.387), knowledge versus skill(r =.442, r =.084), and self-efficacy versus skills (r =-.148, r =.047) of CPR and AED before and after BLS education. Conclusion : After BLS education, most of the participants found the program was easy and useful to perform. Participants had the willingness to do CPR and AED and wanted to teach BLS to others. It is necessary to provide BLS education for school teachers by systematic approach.

• 임상간호연구
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• 제25권3호
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• pp.265-274
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• 2019

Purpose: The purpose of this study was to identify the effects of psychological acceptance and social support on posttraumatic growth in stomach cancer patients. Methods: The questionnaires were administered from January 14 to February 11, 2015 to 123 subjects who had stomach cancer surgery six months prior. SPSS statistics 21.0 software was used to analyze the data for t-test, ANOVA, Pearson's correlations, Scheffé test and multiple regression analysis. Results: The results of this study are as follows: The major factors related to posttraumatic growth included gender (t=-2.72, p=.007), age (r=-.21, p=.016), having a religion (t=-3.40, p<.001), perceived importance of religion (r=.43, p<.001), seriousness of cancer diagnosis (r=.25, p=.005) and impact of cancer diagnosis (r=.32, p<.001). There were significant relationships between psychological acceptance (r=.18, p=.041) and social support (r=.32, p<.001) on posttraumatic growth. Significantly influential factors of posttraumatic growth were age (β=-.19, p=.021), perceived importance of religion (β=.41, p<.001) and family support (β=.29, p<.001), which together accounted for 36.5% of the variance in posttraumatic growth. Conclusion: The result of current study indicated that age, importance of religion, and family support influenced posttraumatic growth. Based on the findings of this study, developing nursing intervention programs focusing on increasing posttraumatic growth in stomach cancer patients is recommended.

• 한국산학기술학회논문지
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• 제16권12호
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• pp.8767-8775
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• 2015

본 연구는 대학생의 진로스트레스, 진로선택몰입 및 진로결정 자기효능감과의 관계를 파악하기 위한 서술적 조사연구이다. 연구대상은 P시에 소재한 4년제 대학생 293명을 대상으로 구조화된 설문지를 이용하여 2015년 5월 6일부터 5월 29일까지 자료를 수집하였다. 수집된 자료는 SPSS 23.0 프로그램을 이용하여 서술적 통계, t-test, ANOVA, Pearson,s correlation coefficient, Hierarchical regression analysis로 분석하였다. 연구결과 대상자의 진로스트레스는 진로선택몰입(r=-.731, p<.001)과 진로결정 자기효능감(r=-.449, p<.001)과 유의한 음의 상관관계가 있었으며, 진로스트레스에 영향을 미치는 요인은 학년(${\beta}$=.99, p<.017)과 진로선택몰입(${\beta}$=-.707, p<.001)이었다. 그러므로 대학생의 진로스트레스를 감소시키기 위해서는 진로선택몰입과 진로결정 자기효능감을 향상시키기 위한 교육프로그램이 필요하다.

• Bulletin of the Korean Chemical Society
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• 제35권11호
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• pp.3181-3187
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• 2014

A series of 3,4-dihydroquinazoline derivatives with anti-cancer activities against human colon cancer HT-29 cell were subjected to three-dimensional quantitative structure-activity relationship (3D-QSAR) studies using the comparative molecular similarity indices analysis (CoMSIA) approaches. The most potent compound, BK10001 was used to align the molecules. As a result, the best prediction was obtained with CoMSIA combined electrostatic, hydrophobic, and hydrogen-bond acceptor fields ($q^2=0.648$, $r^2=0.882$). This model was validated by an external test set of six compounds giving satisfactory predictive $r^2$ values of 0.879. This model would guide the design of potent 3,4-dihydroquinazoline derivatives as anti-cancer agent for the treatment of human colon cancer.

• 한국전자파학회논문지
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• 제29권11호
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• pp.857-867
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• 2018

현재 레이다의 발전 형태는 기존의 능동위상배열에서 디지털형 위상배열로 진화하고 있다. 디지털형 위상배열은 수신빔을 자유롭게 구성할 수 있는 장점이 있다. 이를 가능하게 하려면 각각의 복사소자별 수신신호가 디지털화되어야 한다. 본 논문에서는 이를 위한 디지털 송수신모듈을 설계 및 제작하고 시험결과를 제시하여 가능성을 확인하고자 한다. 디지털 송수신모듈은 4개의 송수신 채널을 포함한 쿼드팩 형태로 구성하였다. 고출력 송신을 위해 각 채널별로 GaN 소재의 고출력증폭소자(HPA)를 사용하였으며, 송신파형 발생과 수신신호 디지털변환을 위해 송수신 집적소자를 적용한 디지털 회로를 적용하였다. 제작한 결과, 각 채널별로 송신출력은 350 W 이상, 수신이득은 47 dB, 수신잡음지수 2 dB 이하를 만족하였다. 또한 모듈 내에서 최종 광신호로 변환된 수신출력을 저장하고, 분석하여 수신 특성을 확인하였다.

• 한국자원식물학회지
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• 제29권6호
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• pp.658-669
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• 2016

Rice blast, caused by a fungus Magnaporthe oryzae, is one of the most devastating diseases of rice worldwide. Analyzing the valuable genetic resources is important in making progress towards blast resistance. Molecular screening of major rice blast resistance (R) genes was determined in 2,509 accessions of rice germplasm from different geographic regions of Asia and Europe using PCR based markers which showed linkage to twelve major blast R genes, Pik-p, Pi39, Pit, Pik-m, Pi-d(t)2, Pii, Pib, Pik, Pita, Pita/Pita-2, Pi5, and Piz-t. Out of 2,509 accessions, only two accessions had maximum nine blast resistance genes followed by eighteen accessions each with eight R genes. The polygenic combination of three genes was possessed by maximum number of accessions (824), while among others 48 accessions possessed seven genes, 119 accessions had six genes, 267 accessions had five genes, 487 accessions had four genes, 646 accessions had two genes, and 98 accessions had single R gene. The Pik-p gene appeared to be omnipresent and was detected in all germplasm. Furthermore, principal component analysis (PCA) indicated that Pita, Pita/Pita-2, Pi-d(t)2, Pib and Pit were the major genes responsible for resistance in the germplasm. The present investigation revealed that a set of 68 elite germplasm accessions would have a competitive edge over the current resistance donors being utilized in the breeding programs. Overall, these results might be useful to identify and incorporate the resistance genes from germplasm into elite cultivars through marker assisted selection in rice breeding.

• Bulletin of the Korean Chemical Society
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• 제29권7호
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• pp.1303-1310
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• 2008

Inhibitors of farnesyltransferase (FT), a key enzyme in the post-translational modifications of Ras proteins, have been extensively studied as novel anticancer agents in the preclinical stages, some of which are currently in clinical development. Previously, it has been reported that a novel FT inhibitor LB42907 inhibits Ras farnesylation in the nanomolar range in vitro. The aim of this study was to assess the antitumor efficacy of LB42907 in vitro and in vivo. Anchorage-independent growth of various human tumor cell lines was potently inhibited by treatment with LB42907, comparable to other FT inhibitors in clinical development. In the nude mouse, oral administration of LB42907 demonstrated potent antitumor activity in several human tumor xenograft models including bladder, lung and pancreas origin. Interestingly, significant tumor regression in EJ (bladder) and A549 (lung) xenografts was induced by LB42907 treatment. The effectiveness of LB42907 was also investigated in simultaneous combination with paclitaxel, vincristine, cisplatin or gemcitabine against NCI-H460, A549, and HCT116 cells in vitro using median-effect analysis. LB42907 markedly synergized with most anticancer drugs tested in this study in NCI-H460 cell. In contrast, LB42907 displayed antagonism or partial synergism with these drugs in A549 and HCT116 cells, depending on the class of combined drugs and/ or the level of cytotoxicity. Our results demonstrate that LB42907 is an effective antitumor agent in vitro and in vivo and combination of LB42907 with other chemotherapeutic drugs results in synergistic or antagonistic effects mainly in a cell line-dependent manner. Further preclinical study is warranted.