• 제목/요약/키워드: miR-205

검색결과 50건 처리시간 0.026초

치과위생사의 근골격계질환 자각증상과 인간공학적 평가 (Evaluation of the Ergonomic Method and Musculoskeletal Symptoms in Dental Hygienist)

  • 오나래;김해경;정미애
    • 한국콘텐츠학회논문지
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    • 제12권9호
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    • pp.234-243
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    • 2012
  • 본 연구의 목적은 치과위생사의 근골격계 증상과 작업관련 요인과의 연관성을 알아보고자 한다. 자기기입식 설문지는 서울, 경기, 대구, 포항의 210명 치과위생사를 대상으로 2011년 8월1일부터 12일까지 조사를 실시한 후 회수하여 응답이 불분명하거나 크게 사고를 당한 5명을 제외한 205명을 연구대상자로 선정하였다. 수집된 자료의 분석은 SPSS WIN 18.0 프로그램을 이용하여 교차분석 및 로지스틱 회귀분석을 하였고 인간공학적 분석은 RULA 와 REBA를 사용하여 수행되었다. 연구대상자의 205명중 신체 한 부위라도 근골격계 증상을 경험한 사람은 196명으로 95.6%의 총경험률을 나타내었고, 근골격계 증상 경험은 오른쪽 목과 어깨사이가 82.4%로 가장 높았다. 목부위가 78%, 오른쪽 어깨가 69.8%, 오른쪽 손목이 66.3% 순으로 나타났다. 치과에서의 작업환경 개선은 치과위생사의 근골격계 질환을 예방하는데 필요하다. 스켈링 position별 점수는 술자 7시 방향에서 점수가 높았고, 교정장치 결찰작업 중 설측 교정결찰 작업의 REBA Total score가 12점으로 Action Level 5 에 해당 되었다.

Supplementation with psyllium seed husk reduces myocardial damage in a rat model of ischemia/reperfusion

  • Lim, Sun Ha;Lee, Jongwon
    • Nutrition Research and Practice
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    • 제13권3호
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    • pp.205-213
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    • 2019
  • BACKGROUND/OBJECTIVES: Myocardial infarction (MI) is caused by extensive myocardial damage attributed to the occlusion of coronary arteries. Our previous study in a rat model of ischemia/reperfusion (I/R) demonstrated that administration of arabinoxylan (AX), comprising arabinose and xylose, protects against myocardial injury. In this study, we undertook to investigate whether psyllium seed husk (PSH), a safe dietary fiber containing a high level of AX (> 50%), also imparts protection against myocardial injury in the same rat model. MATERIALS/METHODS: Rats were fed diets supplemented with PSH (1, 10, or 100 mg/kg/d) for 3 d. The rats were then subjected to 30 min ischemia through ligation of the left anterior descending coronary artery, followed by 3 h reperfusion through release of the ligation. The hearts were harvested and cut into four slices. To assess infarct size (IS), an index representing heart damage, the slices were stained with 2,3,5-triphenyltetrazolium chloride (TTC). To elucidate underlying mechanisms, Western blotting was performed for the slices. RESULTS: Supplementation with 10 or 100 mg/kg/d of PSH significantly reduces the IS. PSH supplementation (100 mg/kg/d) tends to reduce caspase-3 generation and increase BCL-2/BAX ratio. PSH supplementation also upregulates the expression of nuclear factor erythroid 2-related factor 2 (NRF2), and its target genes including antioxidant enzymes such as glutathione S-transferase mu 2 (GSTM2) and superoxide dismutase 2 (SOD2). PSH supplementation upregulates some sirtuins ($NAD^+$-dependent deacetylases) including SIRT5 (a mitochondrial sirtuin) and SIRT6 and SIRT7 (nuclear sirtuins). Finally, PSH supplementation upregulates the expression of protein kinase A (PKA), and increases phosphorylated cAMP response element-binding protein (CREB) (pCREB), a target protein of PKA. CONCLUSIONS: The results from this study indicate that PSH consumption reduces myocardial I/R injury in rats by inhibiting the apoptotic cascades through modulation of gene expression of several genes located upstream of apoptosis. Therefore, we believe that PSH can be developed as a functional food that would be beneficial in the prevention of MI.

요양병원 인증제 평가를 경험한 간호사들의 직무 스트레스 및 소진이 이직의도에 미치는 영향 (Factors Influencing Turnover Intention of Nurses after Evaluation for Certification at Geriatric Hospitals: Focused on Job Stress and Burnout)

  • 최은정;박지원;조미림
    • 한국산학기술학회논문지
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    • 제17권3호
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    • pp.438-449
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    • 2016
  • 본 연구는 요양병원 인증제 평가를 경험한 간호사의 직무스트레스 및 소진이 이직의도에 미치는 영향에 대해 파악하기 위한 서술적 상관관계 연구이다. K대학교 기관생명윤리위원회에서 승인을 받았으며, 자료수집은 2015년 4월 1일부터 8월 31일까지이며, 자료는 SPSS/WIN 18.0 프로그램을 이용하여 분석하였다. 연구 대상자는 B광역시와 경상남 북도 소재한 15개 요양병원에서 205명의 간호사를 대상으로 하였다. 직무스트레스 평균은 5점 만점에 3.83, 소진의 평균은 5점 만점에 2.92이었으며, 이직의도 평균은 5점 만점에 3.12였다. 이직의도와 직무스트레스(r=.356, p<.001), 소진(r=.729, p<.001)은 유의한 상관관계가 있었으며, 소진은 이직의도에 53%의 설명력을 보였다(${\beta}=.729$). 이 연구의 결론을 통해 요양병원 인증제를 경험한 요양 병원 간호사의 이직의도를 감소시키기 위해 주요한 요인인 소진을 낮추기 위한 중재 프로프램 개발이 지속적으로 수행되어야 할 것이다.

치과위생사의 직무스트레스에 관한 분석요인 (A Factor Analysis on Job Stress Level in Dental Hygienists)

  • 김지화;오나래;정미애
    • 한국산학기술학회논문지
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    • 제13권3호
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    • pp.1220-1228
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    • 2012
  • 본 연구는 치과위생사가 경험하는 직무 스트레스 정도와 직무만족도 및 상관관계를 파악 하여 치과위생사 직무만족도를 높여 양질의 의료서비스를 제공하고, 치과위생사 개인의 발전과 건강 증진에 필요한 기초자료를 마련하고자 본 연구를 시행하였다. 2011년 8월 1일부터 12일까지 전국(서울, 경기, 대구, 포항)의 종합병원, 치과병원, 치과의원의 치과위생사 210명을 대상으로 자기기입식 설문지 조사를 시행한 후 205명에 대해서 분석 하였다. 수집된 자료는 SPSS WIN 15.0 프로그램을 이용하여 분석하였다. 그 결과 직무스트레스 중에는 평균이 '직무요구'가 2.71로 가장 높게 나타났다. 치과위생사의 빌딩관련 건강자각도와 직무스트레스의 영역별 관계에 대해 살펴본 결과는 중추신경계 증상은 물리환경(r=.281, p<.001)과 직무요구(r=.281, p<.001), 관계갈등(r=.163, p<.05), 조직체계(r=.166, p<.05), 보상 부적절(r=.267, p<.001), 그리고 직무스트레스(r=.311, p<.001)와 통계적으로 유의미한 정적 상관관계를 보였다. 전체적으로 빌딩관련 건강자각도는 물리환경(r=.259, p<.001)과 직무요구(r=.311, p<.001), 관계갈등(r=.172, p<.05), 조직체계(r=.158, p<.05), 보상 부적절(r=.197, p<.01), 그리고 직무스트레스(r=.275, p<.001)와 통계적으로 유의한 상관관계를 보였다. 치과위생사에 대한 근무환경 중 실내공기오염저감 및 스트레스를 예방할 수 있는 근무환경 개선의 기초자료로 활용함으로써 치과위생사의 정신건강 및 삶의 질 향상으로 양질의 의료서비스 제공에 기여할 수 있을 것으로 판단된다.

고객불량행동, 직무소진, 긍정심리자본이 간호사의 직무착근도에 미치는 영향 (The Effects of Customer's Badness Behavior, Job Burnout, Positive Psychological Capital on Job Embeddedness of Nurses)

  • 권정옥;강정미
    • 한국산학기술학회논문지
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    • 제21권8호
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    • pp.205-214
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    • 2020
  • 본 연구의 목적은 고객불량 행동, 직무소진, 긍정심리자본이 간호사의 직무착근도에 미치는 영향을 파악하기 위함이다. 자료수집은 2개 광역시에 소재한 종합병원 3곳에 근무하는 간호사 198명을 대상으로 구조화된 설문지를 이용하여 2019년 7월 1일부터 7월 31일까지 실시하였다. 자료분석 방법은 SPSS 21.0 통계프로그램을 이용하여 t-test, ANOVA, Scheffe' test, Pearson's correlation coefficients 및 Multiple regression으로 분석하였다. 분석 결과, 고객불량 행동은 직무소진과 유의한 정적 상관관계(r=.24, p=<.001), 긍정심리자본(r=-.37, p=<.001), 직무착근도(r=-.48, p=<.001)와는 유의한 부적 상관관계가 있었고, 직무소진은 긍정심리자본(r=-.44, p=<.001), 직무착근도(r=-.31, p=<.001)와 유의한 부적 상관간계, 긍정심리자본은 직무착근도(r=.49, p=<.001)와 유의한 정적 상관관계가 있었다. 회귀분석 결과, 직무착근도에 유의한 영향을 미치는 요인은 개인적 특성 중 직위(β=-.19, p=.001)와 독립변인 중고객불량 행동(β=-.34, p<.001), 긍정심리자본(β=.32, p=.004)이었고, 이들 변인은 직무착근도를 38% 설명하는 것으로 확인되었다. 본 연구결과를 기반으로 간호사의 직무착근도를 높이기 위해서는 고객불량 행동을 근절하고 관리하기 위한 전략을 개발하고, 긍정심리자본을 강화하고 발전시킬 수 있는 다양한 프로그램 개발이 필요하다.

홀스타인에서 BSE (bovine spongiform encephalopathy) 검사용 뇌 조직 채취를 위한 진동톱 사용례 (A case of using a vibrating saw to collect brain tissue for BSE (bovine spongiform encephalopathy) test in Holstein)

  • 이종원;이은미;이정우;정은혜;도재철;허성은
    • 한국동물위생학회지
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    • 제39권3호
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    • pp.205-210
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    • 2016
  • BSE (bovine spongiform encephalopathy)-like symptoms salivation, gait disorder, and the downer syndrome occurred to 8 heads of cattle at six cattle farms in Gyeonju, east eastern Gyeongsang province in 2013. Eight brain tissue samples using a vibration saw (Multimaster$^{(R)}$ FEIN, Germany) were collected referring to "The brain removal technique of transmisible spongiform encephalopathy sampling DVD" by Animal And Plant Quarantine Agency. Brain removal techinque using a vibration saw on the thick, solid frontal bone of cattle is more convenient for incision and removal than an ax for BSE testing.

Rapid detection and Quantification of Fish Killing Dinoflagellate Cochlodinium polykrikoides (Dinophyceae) in Environmental Samples Using Real-time PCR

  • Park, Tae-Gyu;Kang, Yang-Soon;Seo, Mi-Kyung;Kim, Chang-Hoon;Park, Young-Tae
    • Fisheries and Aquatic Sciences
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    • 제11권4호
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    • pp.205-208
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    • 2008
  • The mixotrophic dinoflagellate Cochlodinium polykrikoides was reported to be linked to major fish kills in Korea and Japan since the 1990s. Rapid and sensitive detection of microalgae has been problematic because morphological identification of dinoflagellates requires light microscopic and scanning electron microscopic observations that are time consuming and laborious compared to real-time PCR. To address this issue, a real-time PCR probe targeting the ITS2 rRNA gene was used for rapid detection and quantification of C. polykrikoides. PCR inhibitors in water column samples were removed by dilution of template DNA for elimination of false-negative reactions. A strong association between cell quantification using real-time PCR and microscopic counts suggests that the real-time PCR assay is an alternative method for cell estimation of C. polykrikoides in environment samples.

고등학생의 자아존중감이 장애인에 대한 낙인에 미치는 영향 (A Study on the Effect of High School Students' Self-esteem on Perceived Stigma toward People with Disabilities)

  • 김미진
    • 한국농촌간호학회지
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    • 제10권2호
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    • pp.59-73
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    • 2015
  • Purpose: This study was done to investigate the effect of self-esteem on perceived stigma in high school students toward people with disabilities. Methods: The participants in this study were 140 high school students from Gyeonggi Province. Data were collected during May 2013. Structured questionnaires were used for data collection. Data were analyzed using descriptive by statistics, t-test, ANOVA, Pearson correlation coefficients, and simple regression analysis with the SPSS 19.0 program. Results: The major findings of this study are as follows: There was a significant relationship between stigma toward people with disabilities and self-esteem among the high school students (r=-.205, p=.015). There was also a significant relationship between relationships with friends (r=.291, p<.001), health statement (r=.400, p<.001) and self-esteem among the high school students. Self-esteem explained 3.5% of the variance in high school students' stigma toward people with disabilities (F=6.041, p=.015). Conclusion: Findings of this study suggest a need to develop education to increase self-esteem as a strategy to decrease high school students' stigma toward people with disabilities. Also, findings of this study suggest the need for repeated study on the relationship between self-esteem and stigma toward people with disabilities among adults.

치근 우식 수복에 사용되는 심미성 수복물의 변연누출에 관한 연구 (A STUDY ON THE MARGINAL LEAKAGE OF ESTHETIC RESTORATIVE MATERIALS ON ROOT CARIES RESTORATION)

  • 한진순;임미경
    • Restorative Dentistry and Endodontics
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    • 제18권1호
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    • pp.205-213
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    • 1993
  • The purpose of the study was to evaluate the degree of the marginal leakage of esthetic restorative materials on root caries restoration. 120 cavities were prepared to $90^{\circ}$ butt joint on all margins on the crown and root portion, and divided into 4 groups. The four groups of cavity were filled with Amalgam(Dongmuyung Dental Alloy Co., Ltd, KOREA), Silux$^{(R)}$(3M Co., USA)-Scotch Bond 2$^{(R)}$(3M Co., USA), Silux$^{(R)}$-All Bond$^{(R)}$(BISCO USA), and GC Fuji II$^{(R)}$(G-C Co., JAPAN) respectively. The apical margin of the preparation was finished to leave a flash of restorative material. The coronal margin of the preparation was finished not to leave a flash of restorative material. All specimens were sectioned longitudinally with Isomet Low speed saw(Buether Ltd, USA). The degree of dye penetration was evaluated as the parameter of marginal leakage under the stereoscope. The results were as follows. 1. At the enamel and dentin/cementum margins, the margin were finished to leave a flash of material showed less marginal leakage than that were finished not to leave a flash of material (P<0.001). 2. The enamel margins showed less marginal leakage than the dentin/cementum margins(P<0.001). 3. There was no significant difference in the degree of the marginal leakage between Silux$^{(R)}$-Scotch Bond 2$^{(R)}$ group and Silux$^{(R)}$-All Bond$^{(R)}$ group.

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암 환자의 지각된 스트레스, 분노표현방식과 우울간의 관계 (A Correlational Study among Perceived Stress, Anger Expression, and Depression in Cancer Patients*)

  • 이평숙;손정남;이용미;박은영;박지선
    • 대한간호학회지
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    • 제35권1호
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    • pp.195-205
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    • 2005
  • Purpose: This study was to identify the relationship between perceived stress, anger expression, and level of depression in cancer patients. Method: A cross-sectional descriptive study design was used. Data was collected by uestionnaires from 185 in- and out-patients who were diagnosed with cancer at 3 university hospitals and the National Cancer Center using Spielberger et al.’s Anger Expression Scale, Cohen, Kamarch & Mermelstein's Perceived Stress, and Derogatise's SCL-90. The data was analyzed using descriptive statistics, Pearson correlation coefficient, and stepwise multiple regression with SAS/PC. Result: The perceived stress in cancer patients indicated a significant positive correlation to anger-in(r=.288, p=.000), anger-out(r=.232, p=.001), and depression(r=.68, p=.000), but no significant correlation to anger-control. The anger-in of cancer patients showed a significant positive relationship to anger-out(r=.53, p=.000), and depression(r=.383, p=.000), but no significant correlation to anger-control. Anger-out showed a significantly negative correlation to anger-control (r=-.248, p=.001) and a positive correlation to depression (r=.240, p=.001). The most significant predictor which influenced depression in cancer patients was perceived stress, followed by anger-in and hobby, and these factors explained their depression with a variance of 54%. Conclusion: These results suggested that cancer patients with a high degree of perceived stress are likely to be high in anger-out and anger-in. Perceived stress and anger-in are major factors which affect depression in cancer patients.